Sharma and colleagues show that, in Caenorhabditis elegans, age-associated decline in peroxisomal function causally impairs lipid mobilization, resulting in lipid droplet accumulation, metabolic infle...

Lepr+Adrb2+ sympathetic perineurial cells coordinate leptin signalling and sympathetic output to modulate energy expenditure, thermogenesis and body weight in male mice, independent of changes to food...

Chio and colleagues describe an iron-dependent pathway with a role in the induction of cancer cachexia-linked events such as adipose browning and identify methionine sulfoxide reductase A as an import...

The study employs region-specific knockout of the glucose-dependent insulinotropic polypeptide receptor (GIPR) in either the area postrema or hypothalamus of mice to determine how GIPR agonism and ant...

Artificial intelligence-enabled quantification and analyses of brown adipose tissue (BAT) activity uncover links between BAT and a healthier metabolic profile along with lower rates of psychiatric…

Chio and colleagues describe an iron-dependent pathway with a role in the induction of cancer cachexia-linked events such as adipose browning and identify methionine sulfoxide reductase A as an…

The MRP8Cre mouse model is frequently used to investigate the biology of neutrophils. This study reports that MRP8Cre transgenic have a lower body weight and improved metabolic health, especially…

Feeding can be regulated by sensory cues. This study identifies a multi-layer circuit that mediates food sight-promoted feeding and food-related memory in mice.

A major barrier in Alzheimer's disease (AD) research is the lack of animals that recapitulate sporadic AD. The humanized amyloid-beta knock-in mice (hAß-KI) exhibit age-dependent cognitive decline…

RNA libraries were prepared using the Direct RNA Sequencing kit (SQK-RNA002). Sequencing was performed on the Oxford Nanopore PromethION P24 sequencer using the FLO-PRO002 flow cell. Sequencing was performed using MinKNOW v.22.03.4 and MinKNOW Core v.5.0.0 with a pore scan frequency of 1.5 h, active channel selection set to on and reserved pores set to on. Libraries were run for 72 h. Basecalling was performed using Bream v.7.0.9 and Guppy v.6.0.7. Data processing was performed on an Ubuntu 20.04 system. Sequencing was performed by the BioMicro Center at Massachusetts Institute of Technology. Computational analysis of long-read direct RNA-seq data Individual passing FASTQ files from the same sample were merged to generate a single FASTQ file per sample. Except in the case of JAFFAL17 v.2.2 and v.2.3, all mouse data analyses were performed using reference files from GENCODE58 release M28 (GRCm39), and all human data analyses were performed using reference files from GENCODE Release 43 (GRCh38.p13). For JAFFAL, matched reference files were downloaded from the UCSC genome browser59 and prepared using the instructions provided on the JAFFAL wiki (https://github.com/Oshlack/JAFFA/wiki). Genomic alignments for NanoPlot60 v.1.42.0 were performed using Minimap261 v.2.24 with the parameters -ax splice -uf -k14 and aligned reads were processed...

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide, are highly effective treatments for obesity and type 2 diabetes but are often associated with gastrointestinal side effects…

Kim et al. show that obesity-associated TGF-β1 establishes a persistent adipocyte transcriptional memory that sustains asprosin production. In mice, this persistent hormonal state promotes weight…