The CsCDPK2–CsRBOHB regulatory module controls reactive oxygen species production specifically in vascular tissues to drive adventitious root emergence in

Abstract. Pear (Pyrus) stone cells, a major determinant of fruit quality, form via cell wall lignification. The plant hormone jasmonic acid (JA) plays a pi

Nature Metabolism, Published online: 15 September 2026; doi:10.1038/s42255-026-01633-6Author Correction: Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations

Oral cancer is the sixth most prevalent malignancy worldwide. Gold nanoparticles (AuNPs) were prepared using Lantana camara leaf extract and evaluate their in vitro anticancer activity against human…

Nature Metabolism, Published online: 15 September 2026; doi:10.1038/s42255-026-01633-6Author Correction: Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations

SLC25A21 Pathway Offers New Target for Insulin Resistance in Obesity SLC25A21 Pathway Offers New Target for Insulin Resistance in Obesity Personalized briefing Discovery of the day · Diabetes SLC25A21 regulates insulin sensitivity in subjects with obesity through ROS/AKT/KLF15-mediated alteration of GLUT4 expression Dear Dr.Vijay Viswanathan, this is your personalized scientific intelligence briefing — curated for your work in Diabetes. Key finding Medicine · Diabetes Discovery of the day This study identifies SLC25A21 as a novel regulator of insulin sensitivity in individuals with obesity, acting through a ROS/AKT/KLF15 signaling cascade that modulates GLUT4 expression.

Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data suggest that T cells depend on ROS for signal transduction. In this study, we show that tumors exploit …

SLC25A21 Regulates Insulin Sensitivity via ROS/AKT/KLF15 in Obesity Personalized briefing Discovery of the day · Diabetes SLC25A21 regulates insulin sensitivity in subjects with obesity through ROS/AKT/KLF15-mediated alteration of GLUT4 expression Dear Dr. Vijay Viswanathan, this is your personalized scientific intelligence briefing — curated for your work in Diabetes. Key finding Medicine · Diabetes · Molecular Metabolism Discovery of the day This study identifies SLC25A21 as a novel regulator of insulin sensitivity in individuals with obesity, acting through a ROS/AKT/KLF15 signaling cascade that modulates GLUT4 expression. The researchers demonstrated that SLC25A21 alters glucose uptake by influencing the transcriptional control of GLUT4, providing a mechanistic link between this mitochondrial transporter and peripheral insulin resistance.

The rapid emergence of antibiotic-resistant Staphylococcus aureus necessitates exploring alternative antimicrobial agents with multi-target mechanisms of action. In the present study, the antibacterial...

Subject: SLC25A21 Pathway Reveals New Mechanism in Obesity-Related Insulin Resistance Personalized briefing Discovery of the day · Diabetes SLC25A21 regulates insulin sensitivity in subjects with obesity through ROS/AKT/KLF15-mediated alteration of GLUT4 expression Dear Dr. Vijay Viswanathan, this is your personalized scientific intelligence briefing — curated for your work in Diabetes. Key finding Medicine · Diabetes Discovery of the day This study identifies SLC25A21 as a novel regulator of insulin sensitivity in individuals with obesity, acting through a ROS/AKT/KLF15 signaling axis that modulates GLUT4 expression. Researchers demonstrated that alterations in SLC25A21 activity directly impact glucose uptake by affecting the downstream molecular cascade controlling GLUT4 levels in adipose and muscle tissues.

Reactive oxygen species (ROS), particularly hydrogen peroxide (H2O2), are critical yet complex regulators of the nitrogen cycle. While H2O2 is known t…

Plant immune responses comprise two phases, pattern-triggered immunity (PTI) and effector-triggered immunity (ETI). Sensing of the pathogen effector by a nucleotide-binding leucine-rich repeat rec...

Zhang et al. prepare EcN-RNP hydrogel, aiming to treat IBD by inhibiting NOX2 expression via CRISPR-Cas9-mediated genome editing. The hydrogel enhances oxidative stress defense pathways and modulates glutamate and proline metabolism to reduce ROS.

Ye and colleagues engineered a human indoleamine 2,3-dioxygenase (IDO) variant, IDO268C, that selectively activates the prodrug indole-3-acetic acid (IAA) for cancer therapy. By abolishing immunosuppressive kynurenine activity while retaining oxidative potency, IDO268C induces targeted ROS-mediated cytotoxicity. This human-derived system offers a safer, non-immunogenic alternative for enzyme-activated prodrug therapy in oncology.

To counteract the reactive oxygen species (ROS) derived from host plants, pathogenic fungi employ various strategies to overcome ROS or balance redox homeostasis. Glucose metabolism is vital for fungi...