#ReplicativeSenescence
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genesdev.bsky.social
SYMPOSIUM OUTLOOK: #Telomeres at the nexus of #aging, #tumor suppression, and #inflammation: toward an understanding beyond #senescence
By Samuel Bloom & Jan Karlseder
➡️ https://bit.ly/410dJwg
##cshlsymp25 #DNAdamage #replicativesenescence #DNAreplication #crisis #cancer
August 20, 2025 at 2:31 PM
alicefrolov.bsky.social
New visualization: Telomerase (hTERT) Activity Rises Sharply in Immortalized and Germline-Competent Cell States

#Telomerase #hTERT #TelomereBiology #CellularSenescence #StemCellBiology #Immortalization #AgingBiology #ReplicativeSenescence
New visualization: Telomerase (hTERT) Activity Rises Sharply in Immortalized and Germline-Competent Cell States I am sharing a figure developed for teaching and discussion purposes that summarizes the relationship between telomerase enzymatic activity and proliferative cell state across a graded spectrum of cell types. The figure is a lollipop-style plot with the subtitle "Simulated relative telomerase activity (TRAP assay) across a spectrum of proliferative cell types." Important methodological note: the values depicted are simulated. They do not derive from a single empirical dataset or a specific TRAP assay experiment. Rather, they are constructed to illustrate a literature-grounded qualitative trend in relative telomerase activity across cell states. The figure should be interpreted as a conceptual synthesis, not as primary quantitative data. Description of the visualization The horizontal axis orders cell categories along an approximate gradient of replicative potential and telomere-maintenance competence; the vertical axis represents relative telomerase activity normalized to an arbitrary internal reference, consistent with the semiquantitative output of the telomeric repeat amplification protocol (TRAP). Each cell state is rendered as a stem terminating in a marker (the "lollipop"), which reduces the visual overplotting associated with bar representations and emphasizes the discrete magnitude at each point. The simulated distribution reproduces several well-characterized features: Terminally differentiated somatic cells (e.g., post-mitotic and quiescent lineages) exhibit negligible detectable activity, reflecting transcriptional repression of the hTERT (TERT) catalytic subunit despite constitutive expression of the hTR/TERC RNA template.
July 12, 2026 at 5:00 PM