#SNAI1
LightNews LightNews
jmschreiber91.bsky.social
Wait so SNAI1 is written as "snail" (because obviously it looks so similar) but SNAI2 doesn't look like a word so they just refer to it as "slug"??
January 11, 2025 at 3:29 PM
alexandremayran.bsky.social
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Cadherins modulate the self-organizing potential of pseudo-embryos
Gastruloids derived from ES cells mimic embryonic patterning through robust self-organization. Mayran et al. uncover that this competence depends on a cadherin switch regulated by Snai1-driven E-cadhe...
www.cell.com
November 17, 2025 at 10:37 AM
cddpress.bsky.social
“SNAI1 ablation alters integrin-mediated adhesion and endocytic fate”

The SNAI1-FOXA1 transcriptional transcriptional network regulates motility and #Invasiveness of #TNBC cells ⤵️
pubmed.ncbi.nlm.nih.gov/42586969/
August 18, 2026 at 4:40 PM
haoyin.bsky.social
#MetaplasticBreastCancer

Primary👤mammary basal epithelial cell

TGFβ inhibition (A83-01; KO Snai1, Snai2)
⏫Stasis-bypassing into a Pcad+/Ncad+ EMT but⏬metaplastic progenitorness

EZH2 inhibition enforces stasis

#BCRJournal 2024
breast-cancer-research.biomedcentral.com/articles/10....
January 10, 2025 at 8:02 PM
cancerinformatics.bsky.social
Comprehensive Computational Assessment of SNAI1 and SNAI2 in Gastric Cancer: Linking EMT, Tumor Microenvironment, and Survival Outcomes

📊 Big data meets clinical insight.
#GastricCancer #EMT #Bioinformatics #Oncology #CancerResearch #TCGA
July 11, 2025 at 1:21 PM
verbingnouns.bsky.social
I love how "Snai1/2 (snail family transcriptional repressor 1/2)" implies we'd be snails if it were accidentally inactive. Besides likely not being viable, I wonder what would actually happen... Biology is wild.
June 29, 2026 at 7:14 PM
cancerinformatics.bsky.social
🧬 How do SNAI1 & SNAI2 drive poor outcomes in gastric cancer?

This new study connects EMT, immune infiltration & survival using deep computational analysis; revealing key risk signatures & potential targets.

📖 Read more: journals.sagepub.com/doi/full/10....
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
July 11, 2025 at 1:21 PM
rridrobot.bsky.social
RRIDs were included in this in Journal of Translational Medicine paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #RRID #OpenScience
RASGEF1B suppresses hepatocellular carcinoma through the ALDH7A1/Betaine/SNAI1 metabolic‒epigenetic axis - Journal of Translational Medicine
Read the full paper: RASGEF1B suppresses hepatocellular carcinoma through the ALDH7A1/Betaine/SNAI1 metabolic‒epigenetic axis
doi.org
April 4, 2026 at 7:04 AM
rridrobot.bsky.social
The authors included RRIDs in their Cancer Science paper! Thanks for making your methods matter! #reproducibility #methodsmatter #methodsmatter
Identification of a Distal Enhancer That Regulates TGF-β–Induced SNAI1 Expression
doi.org
May 21, 2025 at 7:00 AM
genesndiseases.bsky.social
This study demonstrates that #SNAI1 overexpression induces #Proteome alterations, #Nucleolar stress, #RibosomeBiogenesis, #Senescence, & activation of the #DNAdamage response, pointing to it as a potent therapeutic target in #KidneyFibrosis. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
November 26, 2025 at 12:49 PM
rridrobot.bsky.social
A paper using RRID:Addgene_61425 was just published in Nature Communications see "Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity". RRIDs like this improve reproducibility in scientific research. #STMpublishing #OpenScience
doi.org
April 13, 2025 at 7:00 AM
olgachaim.bsky.social
Check M. :) Transitional areas with Snai1. Curious would be along the specialization such as interdigitation and desmosomes for stability towards microbiome contributions.
www.youtube.com/watch?v=YRrP...
My Axolotl Is Making A Cute Noise
YouTube video by Gary The Axolotl
www.youtube.com
December 25, 2025 at 1:18 AM
neuralgrndstate.bsky.social
Authors of the review are neural crest (NC) researchers.
They are very clear that snai1/2,..are NEURAL CREST but not 'mesenchymal specifiers'.
They still think NC migration is the consequence of EMT because of Snai1/2..are 'EMT markers'
Awesome.
@natrevmcb.nature.com
www.nature.com/articles/s41...
Neural crest gene regulatory networks as drivers of development, diversification and disease - Nature Reviews Molecular Cell Biology
Neural crest cells (NCCs) are multipotent stem cells whose activation, migration and diversification are tightly controlled by gene regulatory networks that shape NCC function in vertebrate developmen...
www.nature.com
March 6, 2026 at 4:40 AM
m1ngle.bsky.social
It’s rare to read an article where each paragraph makes the accused look guiltier and guiltier, but Snai1 Primary Products 2023 Ltd have pulled it off. Nice work, lads!
August 21, 2024 at 11:02 AM
protik.bsky.social
intrigued by the careful distinction between snail group sex and snail orgies tbh
The firm renting the space said it was a legitimate snail farming operation. The company, Snai1 Primary Products 2023 Ltd, shares its sole director, Terence Ball, with a company called BoyceBrook based in Ribchester, Lancashire. BoyceBrook’s website says its team "has a proven track record of minimising the liability for empty property rates" and describes the company as the "Canceller of the Exchequer". In 2021, the High Court ruled that a snail farm tenancy deal between a landlord in Leeds and the management company Crusader, where Mr Ball was a director, was a "sham". 'Snail orgies' Each crate contains two snails, according to L’Escargotiere, another company operated by Mr Ball, also based in Ribchester. Its website says the number of snails per crate is kept to a minimum to avoid "cannibalism, group sex and snail orgies". Mr Ball – the son of the late North West shoe shop owner and local personality Tommy Ball - told BBC News that 15 crates containing two snails each could "create
August 21, 2024 at 12:02 PM
neuralgrndstate.bsky.social
Impact of EMT is profound
EMT research reminds one of Pavlov's conditioned reflex effect
Once symbols like TWIST1/SNAI1/2..are seen/heard, the tempting EMT stuff immediately comes to mind, &becomes totally immune to the knowledge of (neuro)developmental roles of these factors
July 12, 2026 at 7:42 AM
neuralgrndstate.bsky.social
Explaining the behavior of neural crest cells using EMT might be the weirdest thing in biology😘

Why?

They say that NCCs express EMT factors TWIST1/SNAI1/2... But these are NCC markers/specifiers.

Sounds like the birds behave like a pig because they grow feathers😉

www.nature.com/articles/s41...
Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage - Nature Communications
Neural crest cells differentiate into skeletogenic mesenchyme and neuro-glial lineages, thereby contributing to craniofacial formation. Here, single-cell analysis of cranial neural crest shows that sp...
www.nature.com
July 12, 2026 at 7:35 AM
allthingstox.com
This might take more than a week to carefully read and understand, but complex transcription factor interactions important at composite motifs.

Single base changes in NFKB1 motifs alter binding?

...the pair SNAI1 (Ebox/CACCTG) and RELA (NFKB/1) showed a strong predicted interaction effect size...
January 14, 2025 at 1:44 PM
jeffmold.bsky.social
Very cool! Can you elaborate on what genes are associated with EMT and how much they are upregulated? I always find this concept so confusing and it seems like no consensus on what such genes should be? Like TWIST and Snai1/2?
December 17, 2024 at 9:45 PM
bigearthdata.ai
Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity
->Nature | More info from EcoSearch
Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity
MDA-MB-231-CAGA 12 -GFP cells were created by lentiviral, single-copy integration of CAGA 12 -GFP and isolating a single cell clone that showed good induction in response to TGF-β. pLenti-dCas9-VP64-BFP (Addgene; 196711) was packaged into lentivirus in HEK293T (ATCC) using plasmids...
www.nature.com
March 26, 2025 at 4:50 AM
moltherapy.bsky.social
#genetherapy #celltherapy
Targeting WNT5A Noncanonical Signaling Attenuates Renal Fibrosis Progression in Acute Kidney Injury
Fan and colleagues reported that WNT5A, via JNK signaling and cooperation between c-JUN and KLF5, activates SNAI1 transcription and promotes acute kidney injury (AKI) progression. Meanwhile, soluble form of WNT5A’s receptor CD146 may predict disease outcomes. Targeting WNT5A (e.g., with inhibitor Box5) can be a therapeutic strategy against AKI progression.
dlvr.it
June 28, 2025 at 6:10 AM
neuralgrndstate.bsky.social
The impact of EMT is profound. It has established very strong&solid conditioned reflexes.
Once symbols like snai1/cdh2...are heard/seen, the tempting but mythic EMT immediately comes to mind, and just can't stop the urge to explore EMT @cellpress.bsky.social

www.cell.com/cell/abstrac...
p53 safeguards chemical reprogramming of human somatic cells toward pluripotency
In contrast to its barrier role in transcription factor-driven reprogramming, p53 is indispensable for efficient chemical reprogramming, where p53-competent cells preserve their genomic integrity to a...
www.cell.com
June 13, 2026 at 3:57 AM
neuralgrndstate.bsky.social
'EMT..neural crest cells are..mesenchymal...'
Astonishing.
Migration is the intrinsic property of NCCs, and 'EMT' factors snai1/2/twist are specific/enriched in NCCs&their roles in NCCs are well-known.
So, NCCs are mesenchymal because they express genes specific to NCCs. WOW.
@natrevmcb.nature.com
June 7, 2025 at 3:18 AM
neuralgrndstate.bsky.social
e.g., if you think cancer cells with Ecad-low/negative and Snai1-high means cancer cell undergoes EMT, and then targeting EMT as a therapy, it will very possibly not work because you cannot targeting something unknown as a successful therapy.
neuralgrndstate.bsky.social Ying Cao @neuralgrndstate.bsky.social · Apr 6
Precision doesn't just mean precision at the molecular level. It also means the accuracy in interpreting data, and accuracy in understanding the properties of cancer cells.
benitezja.bsky.social JorgeBenitez @benitezja.bsky.social · Apr 1
Leveraging real-world data to advance biomarker discovery and precision oncology www.cell.com/cancer-cell/...
April 6, 2025 at 7:19 AM
neuralgrndstate.bsky.social
What the hell a poorly defined 'concept', the epithelial-mesenchymal transition, can help to understand development/pathology?

'SNAI1 promotes epithelial-mesenchymal transition ... through the PIK3R2/p-EphA2 Axis'
jeccr.biomedcentral.com/articles/10....
SNAI1 promotes epithelial-mesenchymal transition and maintains cancer stem cell-like properties in thymic epithelial tumors through the PIK3R2/p-EphA2 Axis - Journal of Experimental & Clinical Cancer ...
Background Thymic epithelial tumors (TETs) are infrequent malignancies that arise from the anterior mediastinum. Therapeutic options for TETs, especially thymic carcinoma (TC), remain relatively const...
jeccr.biomedcentral.com
December 23, 2024 at 11:58 AM