The final version of our multi-omics study on kidney fibrosis is out now (tinyurl.com/kidneyfibMSB). Together w/ Pepperkok + Savitski labs @embl.org, we present a time-resolved #multiomics + computational network modeling approach in combination w/ phenotypic assays to study #kidneyfibrosis

Increased Smoothened signaling promotes kidney fibrosis through inhibiting autophagy in fibroblasts

doi.org/10.1016/j.kint.2026.01.028

#OpenAccess #MedSky #NephSky #renalfibrosis #kidneyfibrosis

Big congrats to everyone involved - it was a blast! 🎊 If you're interested in #multiomics integration or #kidneyfibrosis, check it out! ⬇️

The critical role of endoplasmic reticulum stress and the stimulator of interferon genes (STING) pathway in kidney fibrosis

doi.org/10.1016/j.kint.2024.10.021

#chronickidneydisease #ckd #kidneyfibrosis #PERK

Repression of peroxisome proliferation-activated receptor γ coactivator-1α by p53 after #kidneyinjury promotes mitochondrial damage and maladaptive #kidney repair

doi.org/10.1016/j.kint.2025.02.009

#MedSky #NephSky #renalfibrosis #kidneyfibrosis #cisplatin #aki #acutekidneyinjury

Excited to share our commentary: kidney-international.org/article/S008... in @kidneyint.bsky.social on a groundbreaking study by Li et al. in @science.org. Their study uncovered how hypoxia-responsive tRNA-derived small RNAs drive renal protection via regulating #RNAAutophagy. #tDRs #KidneyFibrosis

Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis

doi.org/10.1016/j.kint.2025.08.030

#OpenAccess #NephSky #MedSky #CKD #kidneyfibrosis
@yalepathology.bsky.social

Human #Kidney #KidneyFibrosis

#SpatialTranscriptomics (Visium CosMx) + sc-/sn-RNAseq snATACseq ->
Fibrotic microenvironment gene signature predicts renal function decline

Kidney MultiOmics database
www.susztaklab.com/hk_genemap
susztaklab.com/samui
#NatureGenet 2024
www.nature.com/articles/s41...

Decoding kidney fibrosis with time-resolved multi-omics
#KidneyFibrosis #MultiOmics

Tuechler et al 2025, study led by Rainer Pepperkok @embl.org and @juliosaezrod.bsky.social

🆕 #preprintpeerreview by @reviewcommons.org

>> doi.org/10.1101/2024...

This study demonstrates that #SNAI1 overexpression induces #Proteome alterations, #Nucleolar stress, #RibosomeBiogenesis, #Senescence, & activation of the #DNAdamage response, pointing to it as a potent therapeutic target in #KidneyFibrosis. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...

Kidney fibrosis is the build-up of scar tissue after kidney injury.

Over time, it can reduce kidney function and drive CKD progression.

By detecting fibrosis-related changes earlier, biomarkers may help predict outcomes and support treatments targeting the underlying biology.

#CKD #KidneyFibrosis

Renal fibrosis drives chronic kidney disease progression.

New research shows Penicine A — a structurally unique fungal meroterpenoid — suppresses fibrosis in vitro and reveals biosynthetic clues for antifibrotic drug discovery.

Read more on ScienceDirect.

#KidneyFibrosis #NaturalProducts #CJNM

Researchers found the gut‑derived peptide corisin is elevated in diabetic kidney disease patients and that an antibody against it markedly reduced kidney fibrosis in mouse models. Read more: https://getnews.me/antibody-therapy-blocks-gut-molecule-linked-to-kidney-fibrosis/ #corisin #kidneyfibrosis

🆕New in #JExBio🆕 Engineered Red Blood Cell-Derived Extracellular Vesicles With Klotho Peptide Protect the Kidney From Fibrosis #chronickidneydisease #extracellularvesicles #kidneyfibrosis #evtherapeutics isevjournals.onlinelibrary.wiley.com/doi/epdf/10....

This week's #ThrowbackThursday in JHC: "Renal Mast Cell-Specific Proteases in the Pathogenesis of Tubulointerstitial Fibrosis."

Click to read for FREE: bit.ly/3XCbrRo

#mastcells #kidneyfibrosis #pathology

UBC9-associated SUMOylation contributes to β-catenin activation and kidney fibrosis

doi.org/10.1016/j.kint.2025.07.005

#NephSky #MedSky #renalfibrosis #kidneyfibrosis

#Snail1 shapes cellular fate!
#Proteomic analysis of SNAI1-overexpressed renal tubular cells reveals altered stress responses, #RibosomeBiogenesis, senescence, #DNAdamage and focal adhesion remodeling, expanding #Snail1’s role in #KidneyFibrosis.
#OpenAccess: doi.org/10.1016/j.ge...