#SOX21
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cp-cellmetabolism.bsky.social
Online now: From liver to L-cell: Clinical considerations for translating hepatic ALP signaling
From liver to L-cell: Clinical considerations for translating hepatic ALP signaling
We read with great interest the study by Ye et al. describing a hitherto unappreciated hepatocyte-to-intestinal stem cell communication pathway in which liver-derived alkaline phosphatase (ALP) suppresses the differentiation of intestinal stem cells into glucagon-like peptide-1 (GLP-1)- and peptide YY (PYY)- producing L-cells through the α2δ-1/CaV1.2-SOX21 signaling axis.1 The authors provide compelling mechanistic evidence that this pathway contributes to impaired glucose homeostasis in experimental models of metabolic dysfunction-associated steatotic liver disease (MASLD), thereby identifying a potentially important mechanism through which the liver may influence both intestinal epithelial differentiation and glucose metabolism.
dlvr.it
November 3, 2026 at 7:50 PM
elfridedebaere.bsky.social
Our project will be conducted by teams from @ugent-fge.bsky.social and @uzgent.be @elfridedebaere.bsky.social Burcu Cicekdal @krisvleminckx.bsky.social Thomas Naert & Institut Imagine Jean-Michel ROZET Lucas Fares-Taie

#3Dgenome
#enhanceropathy
#Xenopus
#SOX21
#glaucoma
June 24, 2025 at 11:34 PM
morofushi1230.bsky.social
Hepatocyte-to-intestinal stem cell remote communication regulates blood glucose homeostasis: Cell Metabolism

www.cell.com/cell-metabol...
Hepatocyte-to-intestinal stem cell remote communication regulates blood glucose homeostasis
Ye et al. uncover that fatty liver exacerbates hyperglycemia through hepatocyte-to-intestinal stem cell remote communication driven by the ALP-α2δ-1/CaV1.2-SOX21 axis via the calcineurin-NFATC2 signal...
www.cell.com
June 24, 2026 at 3:01 AM
tumorscholar.bsky.social
Inhibiting hepatic ALP robustly enhances metformin’s hypoglycemic effect in diabetic disease models.

#LiverResearch #LiverSky #Hepatology
https://doi.org/10.1016/j.cmet.2026.05.012
Hepatocyte-to-intestinal stem cell remote communication regulates blood glucose homeostasis
Ye et al. uncover that fatty liver exacerbates hyperglycemia through hepatocyte-to-intestinal stem cell remote communication driven by the ALP-α2δ-1/CaV1.2-SOX21 axis via the calcineurin-NFATC2 signaling cascade, which regulates ISC differentiation and glucose homeostasis in vivo. They find inhibiti
doi.org
June 18, 2026 at 1:32 PM
cp-cellmetabolism.bsky.social
Online now: Hepatocyte-to-intestinal stem cell remote communication regulates blood glucose homeostasis
Hepatocyte-to-intestinal stem cell remote communication regulates blood glucose homeostasis
Ye et al. uncover that fatty liver exacerbates hyperglycemia through hepatocyte-to-intestinal stem cell remote communication driven by the ALP-α2δ-1/CaV1.2-SOX21 axis via the calcineurin-NFATC2 signaling cascade, which regulates ISC differentiation and glucose homeostasis in vivo. They find inhibiting hepatic ALP robustly enhances metformin’s hypoglycemic effect in diabetic disease models.
dlvr.it
June 17, 2026 at 3:42 PM
biorxiv-cancer.bsky.social
SOX21 suppresses GBM growth by repressing AP-1 regulated target genes https://www.biorxiv.org/content/10.1101/2024.07.05.601643v1
SOX21 suppresses GBM growth by repressing AP-1 regulated target genes https://www.biorxiv.org/content/10.1101/2024.07.05.601643v1
Resistance of glioblastoma stem cells (GSCs) to standard treatments is a major cause of glioblastoma
www.biorxiv.org
July 6, 2024 at 9:47 AM
biorxiv-genetic.bsky.social
Modeling the critical MCOR-causing deletion in mouse unveils aberrant Sox21 expression in developing and adult iris and ciliary body, and implicates Tgfb2 in MCOR-associated glaucoma and myopia. https://www.biorxiv.org/content/10.1101/2023.12.11.571097v1
Modeling the critical MCOR-causing deletion in mouse unveils aberrant Sox21 expression in developing and adult iris and ciliary body, and implicates Tgfb2 in MCOR-associated glaucoma and myopia. https://www.biorxiv.org/content/10.1101/2023.12.11.571097v1
Congenital microcoria (MCOR) is a rare hereditary developmental defect of the iris dilator muscle, f
www.biorxiv.org
December 12, 2023 at 5:39 PM
biorxivpreprint.bsky.social
SOX21 suppresses GBM growth by repressing AP-1 regulated target genes https://www.biorxiv.org/content/10.1101/2024.07.05.601643v1
SOX21 suppresses GBM growth by repressing AP-1 regulated target genes https://www.biorxiv.org/content/10.1101/2024.07.05.601643v1
Resistance of glioblastoma stem cells (GSCs) to standard treatments is a major cause of glioblastoma
www.biorxiv.org
July 6, 2024 at 9:47 AM
biorxivpreprint.bsky.social
Modeling the critical MCOR-causing deletion in mouse unveils aberrant Sox21 expression in developing and adult iris and ciliary body, and implicates Tgfb2 in MCOR-associated glaucoma and myopia. https://www.biorxiv.org/content/10.1101/2023.12.11.571097v1
Modeling the critical MCOR-causing deletion in mouse unveils aberrant Sox21 expression in developing and adult iris and ciliary body, and implicates Tgfb2 in MCOR-associated glaucoma and myopia. https://www.biorxiv.org/content/10.1101/2023.12.11.571097v1
Congenital microcoria (MCOR) is a rare hereditary developmental defect of the iris dilator muscle, f
www.biorxiv.org
December 12, 2023 at 5:39 PM
emeraldaperlas.bsky.social
High-sensitivity in situ detection of Sox21 reveals transcript asymmetry from the zygote stage
www.sciencedirect.com/science/arti...
High-sensitivity in situ detection of Sox21 reveals transcript asymmetry from the zygote stage
The first lineage decision in mammalian development segregates embryonic and extra-embryonic fates, yet the timing of this specification remains under…
www.sciencedirect.com
March 5, 2026 at 11:13 AM