More and more studies reveal parameters of #SPINA_Thyr to be influenced by #xenobiotics and other #endocrine #disruptors. Calculating functional biomarkers of #thyroid #homeostasis may contribute to increased sensitivity in environmental toxicology. 🧪🩺

#SPINA_GD #pollutants #toxicants #environment

#SPINA_GD is reduced in major #depression, #bipolar disorder and #schizophrenia, whereas #SPINA_GT is elevated in schizophrenia and bipolar disorder, marking a unique profile of #thyroid_allostasis. pubmed.ncbi.nlm.nih.gov/38277991/ doi.org/10.1016/j.ps...

🧪 In #thyrotoxicosis, it is both essential and difficult to identify its pathogenesis (e.g. exogenous thyrotoxicosis, subacute thyroiditis or true hyperthyroidism). #SPINA_GD may be helpful to speed up the diagnostic work-up. This may be especially helpful in life-threatening thyroid storm.

Endocrine disruptors have a strong effect on the peripheral #thyroid hormone metabolism. A recent study showed a nonlinear dose-response relationship between #PFAS and step-up deiodinase activity (#SPINA_GD).
pubmed.ncbi.nlm.nih.gov/39556482/
doi.org/10.1210/clin...

Growing evidence supports a role of sensorimotor and autonomic #neuropathy in #syndrome_T or #SORSHOT, i.e. reduced quality of life in treated #hypothyroidism. #SPINA_GT and #SPINA_GD predict nerve function and depression.

pubmed.ncbi.nlm.nih.gov/38811750/

doi.org/10.1038/s415...

🧪 #SPINA_Thyr may be useful for monitoring of #endocrine disruptors. #SPINA_GD correlates to paraben excretion, and #SPINA-GT is modified due to exposure to butylparaben. doi.org/10.1007/s113... pubmed.ncbi.nlm.nih.gov/38038926/

#SPINA_GT, #SPINA_GD and Jostel's TSH index (#JTI or #TSHI) are predictors of survival in patients with #Takotsubo syndrome (#stress #cardiomyopathy), as recently demonstrated in the international GEIST registry. 🩺

pubmed.ncbi.nlm.nih.gov/38502972/
doi.org/10.1016/j.eb...

Total step-up #deiodinase activity (#SPINA_GD) is upregulated in metabolic syndrome, as demonstrated by a strong correlation to the triglyceride-glucose index. pubmed.ncbi.nlm.nih.gov/37946276/ doi.org/10.1186/s400... 🧪

The #kynurenine pathway is a series of chemical reactions that produce NAD+ and other mediators with immunomodulatory function. A recent study shows that this pathway is altered in autoimmune #thyroiditis. Several metabolites correlate with #SPINA_GD. 🧪 🩺 pubmed.ncbi.nlm.nih.gov/38514790/

🧪 With a cut-off value of about 28 nmol/s, total step-up #deiodinase activity (#SPINA_GD) may be used for differential diagnosis between exogenous (factitious) #thyrotoxicosis and true #hyperthyroidism.
doi.org/10.1016/j.jc...
pubmed.ncbi.nlm.nih.gov/32099819/