#SPINA_Thyr
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spinateam.bsky.social
#SPINA_Thyr and #SPINA_Carb, two implementations of the structure parameter inference approach (SPINA), provide evidence-based improved methods for diagnosis and endotyping of endocrine diseases. Now, thoroughly tested apps for Mac and Windows are available for free download.

spina.sf.net
July 19, 2025 at 2:06 PM
spinateam.bsky.social
#SPINA_Thyr helps in decision-making to implement this algorithm.
July 26, 2025 at 1:01 PM
drjwdietrich.bsky.social
More and more studies reveal parameters of #SPINA_Thyr to be influenced by #xenobiotics and other #endocrine #disruptors. Calculating functional biomarkers of #thyroid #homeostasis may contribute to increased sensitivity in environmental toxicology. 🧪🩺

#SPINA_GD #pollutants #toxicants #environment
spinateam.bsky.social SPINA Team @spinateam.bsky.social · Nov 26
Endocrine disruptors have a strong effect on the peripheral #thyroid hormone metabolism. A recent study showed a nonlinear dose-response relationship between #PFAS and step-up deiodinase activity (#SPINA_GD).
pubmed.ncbi.nlm.nih.gov/39556482/
doi.org/10.1210/clin...
Dose-response relationship between PFAS and thyroid homeostasis parameters (FT3/FT4 and SPINA-GD). (A) Dose-response relationship between PFAS and FT3/FT4; (B) Dose-response relationship between PFAS and SPINA-GD. Analyses adjusted for age, sex, race/ethnicity, education, family income to poverty ratio, marital status, hypertension, diabetes, total calories, smoking, BMI group, urinary iodine status, and antibody positivity (TgAb positivity or TPOAb positivity).
November 26, 2024 at 10:44 PM
spinateam.bsky.social
#SPINA_Thyr predicts the prognosis of #Takotsubo syndrome. Among all predictors, #SPINA-GD showed the most significant difference.

🧪 🩺 #MedSky @medsky.social #Endocrinology
January 25, 2026 at 7:56 PM
spinateam.bsky.social
After intensive internal testing, the release candidate 1 of the #SPINA_Carb app is available. This is the "sister" app for #SPINA_Thyr, and it is provided for purposes of testing.

sourceforge.net/projects/spi...

doi.org/10.5281/zeno...

doi.org/10.5281/zeno...
Screenshot of SPINA Carb Release Candidate 1 for macOS
April 21, 2025 at 11:09 AM
spinateam.bsky.social
The R package for #SPINA has been upgraded to version 5.1. It includes both #SPINA_Thyr and #SPINA_Carb.

More information is available at cran.r-project.org/web/packages...

Packages for macOS and Linux are ready. For Windows, they will be available in a few days.

@r-foundation.bsky.social #RStats
Screenshot of the statistical environment R showing the package manager with a suggested upgrade of the SPINA package to version 5.1. Screenshot of the statistical environment R showing general information on the SPINA package in version 5.1. Screenshot of the statistical environment R showing information on SPINA.GBeta, along with demo code.
September 20, 2026 at 10:07 AM
spinateam.bsky.social
#SPINA_Thyr 4.2.1 released. This new version fixes several minor bugs. It is compatible with Windows (32 and 64 bits), macOS (Intel and Apple Silicon) and several Unix and Linux variants. spina.sourceforge.net doi.org/10.5281/zeno... doi.org/10.5281/zeno... 🩺 🧪
Screenshot of SPINA Thyr 4.2.1 on macOS Ventura 13.6.4
February 24, 2024 at 5:32 PM
spinateam.bsky.social
After #hemithyroidectomy, some patients will develop #hypothyroidism, whilst in others the #thyroid continues to function. The best parameter to predict postoperative hypothyroidism is #SPINA-GT.

#SPINA_Thyr

doi.org/10.3390/diag...
Figure: Receiver operating characteristic (ROC) curves of preoperative TSH, TSHI, SPINA-GT, remnant thyroid volume, and remnant thyroid volume-to-BSA ratio for predicting postoperative hypothyroidism after hemithyroidectomy. SPINA-GT has the highest area under the curve. Table: Univariable logistic regression analysis of predictors of postoperative hypothyroidism. SPINA-GT has the highest odds ratio and Nagelkerke R^2.
August 13, 2026 at 6:31 PM
spinateam.bsky.social
🧪 #SPINA_Thyr may be useful for monitoring of #endocrine disruptors. #SPINA_GD correlates to paraben excretion, and #SPINA-GT is modified due to exposure to butylparaben. doi.org/10.1007/s113... pubmed.ncbi.nlm.nih.gov/38038926/
Pearson correlation between paraben and thyroid hormones and IGF-1 Adjusted regression coefficient and 95% CI for change in serum thyroid and growth hormones in relation to unit-increased in Ln-parabens (ng/mL) in Taiwanese minors (N = 75) Regression coefficients (95% confidence intervals) for a change in Jostel’s TSHI, sTSHI, SPINA-GD and SPINA-GT associated with quartiles of four urinary parabens concentrations in minors.
December 2, 2023 at 4:32 PM