🚀 Big news! We've just published the official guidelines for submitting affinity proteomics data to PRIDE @pride-ebi.bsky.social (supported technologies Olink & SomaScan)!
Get ahead of the curve—check them out & start your submissions! 👇
🔗 github.com/PRIDE-Archiv...
#Proteomics #Olink #SomaScan
Get ahead of the curve—check them out & start your submissions! 👇
🔗 github.com/PRIDE-Archiv...
#Proteomics #Olink #SomaScan
github.com
March 28, 2025 at 7:20 AM
🚀 Big news! We've just published the official guidelines for submitting affinity proteomics data to PRIDE @pride-ebi.bsky.social (supported technologies Olink & SomaScan)!
Get ahead of the curve—check them out & start your submissions! 👇
🔗 github.com/PRIDE-Archiv...
#Proteomics #Olink #SomaScan
Get ahead of the curve—check them out & start your submissions! 👇
🔗 github.com/PRIDE-Archiv...
#Proteomics #Olink #SomaScan
Another of the plasma proteome deluge. Somascan ans olink having 0.29 correlation
Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults www.nature.com/artic...
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#proteomics #prot-paper
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#proteomics #prot-paper
February 23, 2025 at 11:55 AM
Another of the plasma proteome deluge. Somascan ans olink having 0.29 correlation
Interested in joint multiomics data?
Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq)
Check out our COMICS server
littleswissriver.shinyapps.io/generate_net...
and BLOG
www.metabolomix.com/comics/
Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq)
Check out our COMICS server
littleswissriver.shinyapps.io/generate_net...
and BLOG
www.metabolomix.com/comics/
March 16, 2025 at 1:27 PM
Interested in joint multiomics data?
Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq)
Check out our COMICS server
littleswissriver.shinyapps.io/generate_net...
and BLOG
www.metabolomix.com/comics/
Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq)
Check out our COMICS server
littleswissriver.shinyapps.io/generate_net...
and BLOG
www.metabolomix.com/comics/
A paper addressing discrepancies between Olink and SOMAscan. Most important factor explaining the (non)correlation is the % of LOD samples in Olink:
Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults
www.nature.com/articles/s41...
Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults
www.nature.com/articles/s41...
March 9, 2025 at 10:41 AM
A paper addressing discrepancies between Olink and SOMAscan. Most important factor explaining the (non)correlation is the % of LOD samples in Olink:
Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults
www.nature.com/articles/s41...
Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults
www.nature.com/articles/s41...
Wait, so somascan became standard biotools, and now will be part of Illumina?
June 24, 2025 at 10:07 PM
Wait, so somascan became standard biotools, and now will be part of Illumina?
test this technology in other diagnoses where we believe neuroinflammation to be driving cognitive symptoms: #concussion, #TBI, #stroke, #mecfs and chronic #lyme. These are incredibly promising results and I'm so grateful to the brilliant team at SomaScan as well as the
9/
9/
August 31, 2026 at 4:48 PM
test this technology in other diagnoses where we believe neuroinflammation to be driving cognitive symptoms: #concussion, #TBI, #stroke, #mecfs and chronic #lyme. These are incredibly promising results and I'm so grateful to the brilliant team at SomaScan as well as the
9/
9/
Doesn’t look like Olink and Somascan correlate well at all.
We’ve found Olink & Alamar to correlate quite well (~60%) overall. Maybe unsurprising, since both are antibody-based.
Lack of correlation b/w SomaScan & others might reveal interesting facets of the aptamer tech (protein folding, PTMs, etc) but 100% agree that infighting is bad for the field.
Lack of correlation b/w SomaScan & others might reveal interesting facets of the aptamer tech (protein folding, PTMs, etc) but 100% agree that infighting is bad for the field.
November 24, 2024 at 5:19 AM
Doesn’t look like Olink and Somascan correlate well at all.
🎉 Big news from the @pride-ebi.bsky.social Team! 🎉
We’re officially in #ASMS2025 mode and kicking things off with a major milestone:
🚀 Introducing PRIDE-AP – the first Affinity Proteomics archive!
🔗 www.ebi.ac.uk/pride/archiv...
A new home for your #Olink and #SomaScan and other non-MS data.👇
We’re officially in #ASMS2025 mode and kicking things off with a major milestone:
🚀 Introducing PRIDE-AP – the first Affinity Proteomics archive!
🔗 www.ebi.ac.uk/pride/archiv...
A new home for your #Olink and #SomaScan and other non-MS data.👇
PRIDE - PRoteomics IDEntifications Database
EMBL-EBI
www.ebi.ac.uk
June 4, 2025 at 1:45 PM
🎉 Big news from the @pride-ebi.bsky.social Team! 🎉
We’re officially in #ASMS2025 mode and kicking things off with a major milestone:
🚀 Introducing PRIDE-AP – the first Affinity Proteomics archive!
🔗 www.ebi.ac.uk/pride/archiv...
A new home for your #Olink and #SomaScan and other non-MS data.👇
We’re officially in #ASMS2025 mode and kicking things off with a major milestone:
🚀 Introducing PRIDE-AP – the first Affinity Proteomics archive!
🔗 www.ebi.ac.uk/pride/archiv...
A new home for your #Olink and #SomaScan and other non-MS data.👇
We had in the submission tool Affinity Proteomics, but it looks like the term is confusing for @pride-ebi.bsky.social users because they understand Affinity as Affinity purification. A new release of the tool is coming to make clear what we are talking about: Olink/SomaScan Proteomics Submissions
February 14, 2025 at 7:14 PM
We had in the submission tool Affinity Proteomics, but it looks like the term is confusing for @pride-ebi.bsky.social users because they understand Affinity as Affinity purification. A new release of the tool is coming to make clear what we are talking about: Olink/SomaScan Proteomics Submissions
I bet you guys have already discussed this one but it was new to me this morning and very very strange. proteomicsnews.blogspot.com/2025/04/prep...
Preprint compares 7 plasma proteomics methods - and doesn't get a single good correlation!
Title is overstated, I guess, there are some "strong correlations" but not the ones I really care about. SomaScan 11k vs 7k get a strong. Sa...
proteomicsnews.blogspot.com
April 10, 2025 at 12:34 PM
I bet you guys have already discussed this one but it was new to me this morning and very very strange. proteomicsnews.blogspot.com/2025/04/prep...
News in Proteomics Research blog post | Illumina bought SomaScan - using real money. That could buy useful things.... proteomicsnews.blogs...
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#proteomics #prot-other
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#proteomics #prot-other
Illumina bought SomaScan - using real money. That could buy useful things....
Okay. So. That rolodex of people who are interested in doing proteomics but don't want to investigate the technologies that are available ...
proteomicsnews.blogspot.com
June 26, 2025 at 8:20 AM
News in Proteomics Research blog post | Illumina bought SomaScan - using real money. That could buy useful things.... proteomicsnews.blogs...
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#proteomics #prot-other
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#proteomics #prot-other
New disruptive proteomics technology announcement! SomaScan coupled to next gen sequencing! proteomicsnews.blogspot.com/2025/05/illu...
Illumina protein prep! For when you truly do not care how much protein is in your sample!
Everyone, I think it is time to admit that the biologists have different opinions about what is important in proteomics. And maybe we're ...
proteomicsnews.blogspot.com
May 2, 2025 at 4:40 PM
New disruptive proteomics technology announcement! SomaScan coupled to next gen sequencing! proteomicsnews.blogspot.com/2025/05/illu...
9) Proteins were measured with the SomaScan assay, which uses DNA-based reagents.
Link to the paper:
Germain et al. 2025. Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/ CFS following exertion.
Link to the paper:
Germain et al. 2025. Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/ CFS following exertion.
Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/CFS following exertion
The overarching symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is post-exertional malaise (PEM), an exacerbation of symptoms f…
www.sciencedirect.com
November 15, 2025 at 8:21 AM
9) Proteins were measured with the SomaScan assay, which uses DNA-based reagents.
Link to the paper:
Germain et al. 2025. Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/ CFS following exertion.
Link to the paper:
Germain et al. 2025. Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/ CFS following exertion.
Health Rising: 'Exercise is Not Producing Muscle Damage in ME/CFS…It’s All About Muscle Repair'
'The Hanson group used SomaScan to identify approximately 6,000 proteins in a single drop of blood'
'The problem appears to be a faulty muscle repair response'
www.healthrising.org/blog/2025/12...
'The Hanson group used SomaScan to identify approximately 6,000 proteins in a single drop of blood'
'The problem appears to be a faulty muscle repair response'
www.healthrising.org/blog/2025/12...
Exercise is Not Producing Muscle Damage in ME/CFS...It's All About Muscle Repair - Health Rising
Exercised is not causing muscle damage in ME/CFS. Instead, inflammation, and problems with metabolism and poor muscle repair is producing postexertional malaise.
www.healthrising.org
December 22, 2025 at 5:55 PM
Health Rising: 'Exercise is Not Producing Muscle Damage in ME/CFS…It’s All About Muscle Repair'
'The Hanson group used SomaScan to identify approximately 6,000 proteins in a single drop of blood'
'The problem appears to be a faulty muscle repair response'
www.healthrising.org/blog/2025/12...
'The Hanson group used SomaScan to identify approximately 6,000 proteins in a single drop of blood'
'The problem appears to be a faulty muscle repair response'
www.healthrising.org/blog/2025/12...
Somascan uses synthetic DNA probes as molecular detectors, this method can precisely measure over 10,000 proteins simultaneously in blood plasma. This technique is very sensitive to changes in protein expression between timepoints that may be driving improvements in symptoms.
4/
4/
August 31, 2026 at 4:48 PM
Somascan uses synthetic DNA probes as molecular detectors, this method can precisely measure over 10,000 proteins simultaneously in blood plasma. This technique is very sensitive to changes in protein expression between timepoints that may be driving improvements in symptoms.
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(1/2) After searching 10 years for ANY evidence that SomaScan can provide ANY useful protein measurement data, my reanalysis of the data from this study found (TWO!) proteins quantified by aptamers that can be supported by real methods. this is still the dumbest f'ing way to "measure" a protein,
February 1, 2026 at 5:26 PM
(1/2) After searching 10 years for ANY evidence that SomaScan can provide ANY useful protein measurement data, my reanalysis of the data from this study found (TWO!) proteins quantified by aptamers that can be supported by real methods. this is still the dumbest f'ing way to "measure" a protein,
Plasma samples (n = 504) analysed using SomaScan, finds lysosomal expression scores discriminate #Parkinsons from controls & associated with disease severity. SUMF1 & ARRDC3 emerged as blood-based biomarkers for PD
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
September 23, 2026 at 2:56 AM
Plasma samples (n = 504) analysed using SomaScan, finds lysosomal expression scores discriminate #Parkinsons from controls & associated with disease severity. SUMF1 & ARRDC3 emerged as blood-based biomarkers for PD
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
bei ME/CFS-Patienten ermöglichen, und die Hypothese eines mit dem Immunsystem zusammenhängenden Grundmechanismus zu untersuchen, der zu einer Beeinträchtigung der Mikrozirkulation und des Energiestoffwechsels führt.
„Wir haben bei 54 ME/CFS-Patienten und 27 gesunden
„Wir haben bei 54 ME/CFS-Patienten und 27 gesunden
June 1, 2025 at 9:07 PM
bei ME/CFS-Patienten ermöglichen, und die Hypothese eines mit dem Immunsystem zusammenhängenden Grundmechanismus zu untersuchen, der zu einer Beeinträchtigung der Mikrozirkulation und des Energiestoffwechsels führt.
„Wir haben bei 54 ME/CFS-Patienten und 27 gesunden
„Wir haben bei 54 ME/CFS-Patienten und 27 gesunden
We’ve found Olink & Alamar to correlate quite well (~60%) overall. Maybe unsurprising, since both are antibody-based.
Lack of correlation b/w SomaScan & others might reveal interesting facets of the aptamer tech (protein folding, PTMs, etc) but 100% agree that infighting is bad for the field.
Lack of correlation b/w SomaScan & others might reveal interesting facets of the aptamer tech (protein folding, PTMs, etc) but 100% agree that infighting is bad for the field.
November 20, 2024 at 11:35 PM
We’ve found Olink & Alamar to correlate quite well (~60%) overall. Maybe unsurprising, since both are antibody-based.
Lack of correlation b/w SomaScan & others might reveal interesting facets of the aptamer tech (protein folding, PTMs, etc) but 100% agree that infighting is bad for the field.
Lack of correlation b/w SomaScan & others might reveal interesting facets of the aptamer tech (protein folding, PTMs, etc) but 100% agree that infighting is bad for the field.
【お仕事】NECグループのフォーネスライフが運営するlala a liveで同社のプロテオーム解析サービス「SomaScan®Assay」の紹介記事を担当しました。アプタマーで検出するという、わかる人にだけわかればいいものなのでプロテオーム解析の外注どーしよーと考えている研究者はぜひ
プロテオミクスの現在地——プロテオーム解析の未来を作るSomaScan®の技術
foneslife.com/healthcare-m...
プロテオミクスの現在地——プロテオーム解析の未来を作るSomaScan®の技術
foneslife.com/healthcare-m...
プロテオミクスの現在地——プロテオーム解析の未来を作るSomaScan®の技術 - lala a live(ララアライブ)│フォーネスライフ
プロテオーム解析の手法を選択する際のポイントについて「抗体」「質量分析」「アプタマー」それぞれの特徴をふまえて解説。世界で1,500報以上の実績を持つSomaScan®Assayについても紹介します。
foneslife.com
November 5, 2025 at 2:29 AM
【お仕事】NECグループのフォーネスライフが運営するlala a liveで同社のプロテオーム解析サービス「SomaScan®Assay」の紹介記事を担当しました。アプタマーで検出するという、わかる人にだけわかればいいものなのでプロテオーム解析の外注どーしよーと考えている研究者はぜひ
プロテオミクスの現在地——プロテオーム解析の未来を作るSomaScan®の技術
foneslife.com/healthcare-m...
プロテオミクスの現在地——プロテオーム解析の未来を作るSomaScan®の技術
foneslife.com/healthcare-m...
The generous opinion would be that it’s all in the follow-up. Sure, go run a giant somascan or olink, but hot damn you better validate the hell out of whatever 45 protein panel you discover that diagnoses Alzheimer’s disease.
February 24, 2025 at 8:36 PM
The generous opinion would be that it’s all in the follow-up. Sure, go run a giant somascan or olink, but hot damn you better validate the hell out of whatever 45 protein panel you discover that diagnoses Alzheimer’s disease.
Plasma proteomics-is there a good correlation between OLink and SomaScan? Not so much @naturecomms.bsky.social www.nature.com/articles/s41...
Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults - Nature Communications
Many recent proteomics studies use either Olink or SomaScan platforms to quantify proteins in high-throughput, but the consistency between the two is unclear. Here, the authors measure proteins in the...
www.nature.com
February 22, 2025 at 11:30 AM
Plasma proteomics-is there a good correlation between OLink and SomaScan? Not so much @naturecomms.bsky.social www.nature.com/articles/s41...
4⃣Similarities of Olink & SomaScan proteomics assays
In 3976 plasma samples from Chinese adults, the median correlation across 1,694 Olink and SomaScan-quantified 1-to-1 matched proteins was only 0.26. Whatever the two platforms measure is not the same
🔗 www.nature.com/articles/s41...
In 3976 plasma samples from Chinese adults, the median correlation across 1,694 Olink and SomaScan-quantified 1-to-1 matched proteins was only 0.26. Whatever the two platforms measure is not the same
🔗 www.nature.com/articles/s41...
February 24, 2025 at 4:09 PM
4⃣Similarities of Olink & SomaScan proteomics assays
In 3976 plasma samples from Chinese adults, the median correlation across 1,694 Olink and SomaScan-quantified 1-to-1 matched proteins was only 0.26. Whatever the two platforms measure is not the same
🔗 www.nature.com/articles/s41...
In 3976 plasma samples from Chinese adults, the median correlation across 1,694 Olink and SomaScan-quantified 1-to-1 matched proteins was only 0.26. Whatever the two platforms measure is not the same
🔗 www.nature.com/articles/s41...
My view is that there are regulatory explanations for the missing correlation between RNA and protein. That shouldn't be the case for the proteomics made by Olink and SomaScan.
February 23, 2025 at 4:04 PM
My view is that there are regulatory explanations for the missing correlation between RNA and protein. That shouldn't be the case for the proteomics made by Olink and SomaScan.
(BioRxiv All) ProtPipe2: Multi-Platform Downstream Proteomics Analysis Tool: Proteomics studies increasingly use different technologies, including mass spectrometry, the antibody-based Olink platform, and the aptamer-based SomaScan platform. However, downstream analysis often… #BioRxiv #MassSpecRSS
ProtPipe2: Multi-Platform Downstream Proteomics Analysis Tool
Proteomics studies increasingly use different technologies, including mass spectrometry, the antibody-based Olink platform, and the aptamer-based SomaScan platform. However, downstream analysis often depends on platform-specific scripts or point-and-click tools, limits flexibility and makes analyses difficult to reuse across platforms. We developed ProtPipe2, a downstream proteomics analysis framework for mass spectrometry, Olink, and SomaScan data that is available as both an R package and an interactive web application. ProtPipe2 supports quality control, preprocessing, imputation, batch correction, statistical analysis, visualization, pathway analysis, and result export. ProtPipe2 expands the original Protpipe workflow to additional proteomics platforms and provides reusable R functions for imputation, batch correction, and other downstream analyses. Its redesigned web application provides user-controlled methods and parameters through the same R-based workflow. Case studies across mass spectrometry, Olink, and SomaScan datasets demonstrated a consistent downstream analysis workflow across platforms. By supporting three proteomics platforms through both graphical and scripted workflows, ProtPipe2 makes downstream analysis easier to perform, repeat, and review. ProtPipe2 is freely available at https://nih-card.github.io/ProtPipe2/.
dlvr.it
September 22, 2026 at 6:58 AM
(BioRxiv All) ProtPipe2: Multi-Platform Downstream Proteomics Analysis Tool: Proteomics studies increasingly use different technologies, including mass spectrometry, the antibody-based Olink platform, and the aptamer-based SomaScan platform. However, downstream analysis often… #BioRxiv #MassSpecRSS