For in situ cryo-electron tomography, smaller tilt increments yield better-aligned tilt-series and higher-quality tomograms, with a 3° increment resulting in optimal subtomogram averaging resolution.

Poxviruses transcribe mRNA inside a sealed core, but how it escapes was unknown. Using cryo-electron tomography and integrative modelling, the authors resolve a pore in the core wall, built from three...

Obarska-Kosinska et al. combine cryo-electron tomography, AI-assisted modeling, and crosslinking mass spectrometry to build an extended model of the human nuclear pore. They identify five additional n...

Mitochondria adapt their structure through fusion and fission, yet how their morphology and cristae architecture change as cells differentiate remains unclear. The human placenta is a valuable model for studying mitochondrial diversity within a single tissue. As epithelial trophoblast cells of the placenta differentiate, their accompanying mitochondria morphologically and functionally transform. We use array tomography to characterise mitochondrial volume and network complexity. Cryo-electron tomography reveals two distinct subpopulations of mitochondria within preparations enriched for progenitor cytotrophoblasts, and a singular, homogeneous population in the differentiated syncytiotrophoblast. We showcase the 3D topology of individual cristae through a standardised metric of “curvedness”. Proteomic analysis of isolated mitochondria identifies reduced levels of proteins involved in mitochondrial dynamics and cristae organisation complexes in the syncytiotrophoblast, accompanied by var

YouTube video by the bumbling biochemist

Two early projects: nanosecond-scale 3D fluorescence lifetime imaging, and a conductive coating that fixes charging in laser phase plate cryo-EM.

Nature Nanotechnology, Published online: 03 November 2026; doi:10.1038/s41565-026-02316-9Ptychographic atomic electron tomography determines the 3D positions of 6,648 individual carbon atoms in twisted bilayer graphene with 0.12 Å precision, revealing stacking-dependent corrugations and chiral lattice distortions resembling merons and anti-skyrmions.

The Ophthalmology Optical Coherence Tomography (OCT) Scanners Market was valued at USD 2.5 billion in 2025 and is poised to grow from USD 2.

The Optical Coherence Tomography and Fundus Camera Market was valued at USD 4.2 billion in 2025 and is poised to grow from USD 4.

Molecular Psychiatry - Cannabinoid receptor type 1 availability in individuals with a history of childhood trauma: a positron emission tomography study