Aggregates of misfolded proteins are sequestered in the aggresome via dynein transport in an aggregate size-dependent manner. Here, authors find episodic transport kinetics mediated by aggresome-dynei...

Ribonucleoprotein aggresomes exclude ribonucleases and protect mRNA to promote rapid translation reactivation and cellular recovery after stress alleviation in Escherichia coli.

This research investigates protein aggregation’s role in oocyte aging, revealing that increased UBE2V1 expression correlates with aggresome formation. Restoring UBE2V1 mitigates age-related defects in...

In this study, we reveal that macrophage-derived reactive oxygen species (ROS) can trigger the rapid formation of Salmonella aggresomes, which substantially contribute to the increased frequency of p....

White spot syndrome virus (WSSV) poses the most significant viral threat to global crustacean aquaculture. A major barrier to developing effective countermeasures is the limited understanding of its molecular pathogenesis. This study demonstrates that WSSV actively hijacks host mitochondrial quality control by triggering a stalled form of mitophagy. We identify wsv156 as a key orchestrator of this process, driving mito-aggresome formation and activating Parkin-dependent mitophagy while arresting its completion via VP26, then creating a stalled, incomplete state. Importantly, this incomplete mitophagic response is repurposed to benefit viral replication through a dual mechanism: it enhances glycolysis to fuel viral biosynthesis and concurrently suppresses host cell apoptosis to maintain cell viability. Our findings uncover a novel strategy, whereby an enveloped large DNA virus manipulates mitochondrial turnover to create a favorable replicative niche. These results deepen the mechanistic understanding of WSSV infection and highlight wsv156 as a potential target for future antiviral strategies in aquaculture.

YTHDF2 has been extensively studied as an m6A-related RNA metabolism. Here, the authors show that YTHDF2 also contributes to protein homeostasis in an m6A-independent manner by promoting the formation...

High neuronal proteostress can trigger the production of aggregate-filled exophers in C. elegans. Here authors show that such extrusion relies on aggregate-associated intermediate filaments and adaptors.

Eukaryotic cells direct toxic misfolded proteins to various protein quality control pathways based o

Immune cells employ diverse mechanisms for host defense. Macrophages, in response to TLR activation, assemble aggresome-like induced structures (ALIS). Our group has shown TLR4-signaling transcription...