Whoah
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 13, 2025 at 11:05 PM
Whoah
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
A new study provides evidence of a biological mechanism for how Epstein-Barr Virus (EBV) may trigger lupus.
EBV seems to reprogram B-cells at the beginning of a cascade that ultimately results in autoimmunity.
The authors mention that EBV is a cause of MS, and may be related to LongCOVID.
EBV seems to reprogram B-cells at the beginning of a cascade that ultimately results in autoimmunity.
The authors mention that EBV is a cause of MS, and may be related to LongCOVID.
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 13, 2025 at 1:45 AM
A new study provides evidence of a biological mechanism for how Epstein-Barr Virus (EBV) may trigger lupus.
EBV seems to reprogram B-cells at the beginning of a cascade that ultimately results in autoimmunity.
The authors mention that EBV is a cause of MS, and may be related to LongCOVID.
EBV seems to reprogram B-cells at the beginning of a cascade that ultimately results in autoimmunity.
The authors mention that EBV is a cause of MS, and may be related to LongCOVID.
Tolerance by eviction
"we report that, in mice, CD8 T cell tolerance instead results from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiate into self-tolerant mature CD8 T cells"
#Immunology #Immunosky
"we report that, in mice, CD8 T cell tolerance instead results from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiate into self-tolerant mature CD8 T cells"
#Immunology #Immunosky
CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus
Thymic eviction explains CD8 T cell tolerance and why autoreactive CD8 T cells appear in the periphery but not the thymus.
www.science.org
November 15, 2024 at 10:44 PM
Tolerance by eviction
"we report that, in mice, CD8 T cell tolerance instead results from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiate into self-tolerant mature CD8 T cells"
#Immunology #Immunosky
"we report that, in mice, CD8 T cell tolerance instead results from premature thymic eviction of immature autoreactive CD8 thymocytes into the periphery, where they differentiate into self-tolerant mature CD8 T cells"
#Immunology #Immunosky
First MS, now lupus. New study shows Epstein-Barr virus can hijack autoreactive B cells, turning them into antigen-presenting cells that activate T cells + drive systemic SLE. Targeting EBV could be a game-changer. #Lupus #MS #EBV #Autoimmunity #MedTwitter #LongCovid
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 13, 2025 at 4:36 PM
First MS, now lupus. New study shows Epstein-Barr virus can hijack autoreactive B cells, turning them into antigen-presenting cells that activate T cells + drive systemic SLE. Targeting EBV could be a game-changer. #Lupus #MS #EBV #Autoimmunity #MedTwitter #LongCovid
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus Robinson Lab Stanford
#EBV #SLE #Autoimmunity
Editor’s Summary
Epstein-Barr virus (EBV) has been making waves as a candidate driver of diseases like multiple sclerosis and Long Covid. It
#EBV #SLE #Autoimmunity
Editor’s Summary
Epstein-Barr virus (EBV) has been making waves as a candidate driver of diseases like multiple sclerosis and Long Covid. It
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 12, 2025 at 9:54 PM
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus Robinson Lab Stanford
#EBV #SLE #Autoimmunity
Editor’s Summary
Epstein-Barr virus (EBV) has been making waves as a candidate driver of diseases like multiple sclerosis and Long Covid. It
#EBV #SLE #Autoimmunity
Editor’s Summary
Epstein-Barr virus (EBV) has been making waves as a candidate driver of diseases like multiple sclerosis and Long Covid. It
Epstein-Barr virus may drive autoimmunity in lupus by infecting and reprogramming memory B cells, according to a new #ScienceTranslationalMedicine analysis of patient-derived blood samples. https://scim.ag/49orb21
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
scim.ag
November 17, 2025 at 7:00 PM
Epstein-Barr virus may drive autoimmunity in lupus by infecting and reprogramming memory B cells, according to a new #ScienceTranslationalMedicine analysis of patient-derived blood samples. https://scim.ag/49orb21
Every single case of systemic lupus erythematosus may be caused by the Epstein-Barr virus, according to a new study in Science Translational Medicine. It's estimated that 95% of people worldwide have been exposed to Epstein-Barr www.science.org/doi/10.1126/...
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 14, 2025 at 8:54 PM
Every single case of systemic lupus erythematosus may be caused by the Epstein-Barr virus, according to a new study in Science Translational Medicine. It's estimated that 95% of people worldwide have been exposed to Epstein-Barr www.science.org/doi/10.1126/...
Cell-based epitope screen identifies a novel B chain-derived Hybrid Insulin Peptide recognized by human and mouse autoreactive CD4 T cells https://www.biorxiv.org/content/10.64898/2026.09.16.752211v1
September 24, 2026 at 5:16 PM
Cell-based epitope screen identifies a novel B chain-derived Hybrid Insulin Peptide recognized by human and mouse autoreactive CD4 T cells https://www.biorxiv.org/content/10.64898/2026.09.16.752211v1
T0e: #NephJC
🔹 SLE has a broad loss of tolerance to multiple autoantigens, leading to a higher burden of autoreactive B, T, and plasma cells
🔹 LN requires combination immunotherapy to suppress numerous autoreactive clones. B cell depletion is central
www.nature.com/artic...
🔹 SLE has a broad loss of tolerance to multiple autoantigens, leading to a higher burden of autoreactive B, T, and plasma cells
🔹 LN requires combination immunotherapy to suppress numerous autoreactive clones. B cell depletion is central
www.nature.com/artic...
March 12, 2025 at 1:11 AM
T0e: #NephJC
🔹 SLE has a broad loss of tolerance to multiple autoantigens, leading to a higher burden of autoreactive B, T, and plasma cells
🔹 LN requires combination immunotherapy to suppress numerous autoreactive clones. B cell depletion is central
www.nature.com/artic...
🔹 SLE has a broad loss of tolerance to multiple autoantigens, leading to a higher burden of autoreactive B, T, and plasma cells
🔹 LN requires combination immunotherapy to suppress numerous autoreactive clones. B cell depletion is central
www.nature.com/artic...
Another major triumph for a refractory autoimmune disease—hemolytic anemia—through engineered T cells
@nejm.org
nejm.org/doi/full/10....
@nejm.org
nejm.org/doi/full/10....
CD19 CAR T-Cell Therapy for Autoimmune Hemolytic Anemia | NEJM
In patients with autoimmune hemolytic anemia (AIHA), the risk of relapse is high owing
to persistent autoreactive B-cell activity. Multirefractory AIHA is a more advanced
stage of disease that is d...
nejm.org
January 14, 2026 at 10:44 PM
Another major triumph for a refractory autoimmune disease—hemolytic anemia—through engineered T cells
@nejm.org
nejm.org/doi/full/10....
@nejm.org
nejm.org/doi/full/10....
www.science.org/doi/10.1126/...
“These EBV-infected B cells with antigen-presenting abilities had the capacity to activate autoreactive helper T cells, setting off a chain reaction where those T cells could activate other autoreactive B cells, including uninfected ones.”
#SLE #Bcell #EBV
“These EBV-infected B cells with antigen-presenting abilities had the capacity to activate autoreactive helper T cells, setting off a chain reaction where those T cells could activate other autoreactive B cells, including uninfected ones.”
#SLE #Bcell #EBV
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 13, 2025 at 2:46 AM
www.science.org/doi/10.1126/...
“These EBV-infected B cells with antigen-presenting abilities had the capacity to activate autoreactive helper T cells, setting off a chain reaction where those T cells could activate other autoreactive B cells, including uninfected ones.”
#SLE #Bcell #EBV
“These EBV-infected B cells with antigen-presenting abilities had the capacity to activate autoreactive helper T cells, setting off a chain reaction where those T cells could activate other autoreactive B cells, including uninfected ones.”
#SLE #Bcell #EBV
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
EBV-infected B cells have antigen presentation features, which can activate autoreactive helper T cells, causing autoimmunity
www.science.org/doi/...
EBV-infected B cells have antigen presentation features, which can activate autoreactive helper T cells, causing autoimmunity
www.science.org/doi/...
November 13, 2025 at 12:09 PM
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
EBV-infected B cells have antigen presentation features, which can activate autoreactive helper T cells, causing autoimmunity
www.science.org/doi/...
EBV-infected B cells have antigen presentation features, which can activate autoreactive helper T cells, causing autoimmunity
www.science.org/doi/...
Epstein-Barr virus also recently linked as likely trigger for lupus, brief summary here: www.autoimmuneinstitute.org/research_upd... and original research article here: www.science.org/doi/10.1126/....
How EBV Reprograms B Cells to Trigger Lupus
A new study shows Epstein-Barr virus reprograms autoreactive B cells, helping drive lupus autoimmunity. Findings may also clarify links to Long Covid.
www.autoimmuneinstitute.org
February 13, 2026 at 6:23 AM
Epstein-Barr virus also recently linked as likely trigger for lupus, brief summary here: www.autoimmuneinstitute.org/research_upd... and original research article here: www.science.org/doi/10.1126/....
LMU Munich researchers report EBV may help trigger MS by awakening pre existing immune cells that attack myelin, setting off brain inflammation and myelin loss years after infection.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Triggering multiple sclerosis: infection with Epstein-Barr virus activates multiple pre-existing autoreactive B and T cells - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Triggering multiple sclerosis: infection with Epstein-Barr virus activates multiple pre-existing autoreactive B and T cells
www.nature.com
April 9, 2026 at 4:18 PM
LMU Munich researchers report EBV may help trigger MS by awakening pre existing immune cells that attack myelin, setting off brain inflammation and myelin loss years after infection.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
EBV reprograms autoreactive B cells as antigen presenting cells in multiple sclerosis https://www.biorxiv.org/content/10.64898/2026.02.11.701910v1
February 13, 2026 at 2:16 AM
EBV reprograms autoreactive B cells as antigen presenting cells in multiple sclerosis https://www.biorxiv.org/content/10.64898/2026.02.11.701910v1
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/... 🧪
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 12, 2025 at 9:23 PM
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/... 🧪
The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
April 21, 2025 at 2:29 AM
The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
IFN-γ chimeric autoantibody receptor T cells broadly deplete B cells autoreactive against IFN-γ
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
May 9, 2025 at 7:15 PM
IFN-γ chimeric autoantibody receptor T cells broadly deplete B cells autoreactive against IFN-γ
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
We're only beginning to understand the relationship between the immune system and lifelong infection w/ #herpesvirus #EBV
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 14, 2025 at 2:35 PM
We're only beginning to understand the relationship between the immune system and lifelong infection w/ #herpesvirus #EBV
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus www.science.org/doi/10.1126/...
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 14, 2025 at 11:15 PM
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus www.science.org/doi/10.1126/...
7) Link to the paper:
Younis et al. 2025. Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus.
Younis et al. 2025. Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus.
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 17, 2025 at 2:02 PM
7) Link to the paper:
Younis et al. 2025. Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus.
Younis et al. 2025. Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus.
Bill suggests that in post-treatment Lyme disease (PTLD is what non-patients tend to call chronic Lyme) EBV may actually bind to neuronal tissues, leading to the neuro picture that's typical in chronic Lyme. See the alt for more.
September 11, 2026 at 6:19 PM
Bill suggests that in post-treatment Lyme disease (PTLD is what non-patients tend to call chronic Lyme) EBV may actually bind to neuronal tissues, leading to the neuro picture that's typical in chronic Lyme. See the alt for more.
@biorxivpreprint.bsky.social Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells
www.biorxiv.org/content/10.1...
Great work @maxkonigmd.bsky.social
www.biorxiv.org/content/10.1...
Great work @maxkonigmd.bsky.social
October 21, 2025 at 1:33 AM
@biorxivpreprint.bsky.social Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells
www.biorxiv.org/content/10.1...
Great work @maxkonigmd.bsky.social
www.biorxiv.org/content/10.1...
Great work @maxkonigmd.bsky.social
#Immunology by First Release @science.org
In mice, during immune responses accompanied by elevated self-antigens, autoreactive CD4 T cells must be restrained by regulatory CD4 T cells with the same antigen specificity to prevent autoimmunity.
buff.ly/3EXaXQa
In mice, during immune responses accompanied by elevated self-antigens, autoreactive CD4 T cells must be restrained by regulatory CD4 T cells with the same antigen specificity to prevent autoimmunity.
buff.ly/3EXaXQa
February 27, 2025 at 7:20 PM
#Immunology by First Release @science.org
In mice, during immune responses accompanied by elevated self-antigens, autoreactive CD4 T cells must be restrained by regulatory CD4 T cells with the same antigen specificity to prevent autoimmunity.
buff.ly/3EXaXQa
In mice, during immune responses accompanied by elevated self-antigens, autoreactive CD4 T cells must be restrained by regulatory CD4 T cells with the same antigen specificity to prevent autoimmunity.
buff.ly/3EXaXQa