🚨New preprint out❗️
Using human genetic data we explored IL-6 signaling as a potential target for cerebral small vessel disease (cSVD)🧬🧠
We found no convincing associations between genetically downregulated IL-6 signaling and
👉clinical outcomes
👉MRI markers
👉pathology hallmarks
of cSVD🧵
Using human genetic data we explored IL-6 signaling as a potential target for cerebral small vessel disease (cSVD)🧬🧠
We found no convincing associations between genetically downregulated IL-6 signaling and
👉clinical outcomes
👉MRI markers
👉pathology hallmarks
of cSVD🧵
December 15, 2024 at 9:44 PM
🚨New preprint out❗️
Using human genetic data we explored IL-6 signaling as a potential target for cerebral small vessel disease (cSVD)🧬🧠
We found no convincing associations between genetically downregulated IL-6 signaling and
👉clinical outcomes
👉MRI markers
👉pathology hallmarks
of cSVD🧵
Using human genetic data we explored IL-6 signaling as a potential target for cerebral small vessel disease (cSVD)🧬🧠
We found no convincing associations between genetically downregulated IL-6 signaling and
👉clinical outcomes
👉MRI markers
👉pathology hallmarks
of cSVD🧵
🧠 New paper out in Biogerontology!
We reviewed evidence linking circulating immune cells to cSVD features. Thanks to all co-authors, and the journal team!
🔗 link.springer.com/article/10.1...
More coming soon!
#Neuroimmunology #cSVD #Biomarkers #AgingBrain #Biogerontology
We reviewed evidence linking circulating immune cells to cSVD features. Thanks to all co-authors, and the journal team!
🔗 link.springer.com/article/10.1...
More coming soon!
#Neuroimmunology #cSVD #Biomarkers #AgingBrain #Biogerontology
Circulating immune cells in cerebral small vessel disease: a systematic review - Biogerontology
Cerebral small vessel disease (cSVD) refers to all pathologies of the brain’s arterioles, capillaries, and venules. cSVD is highly prevalent with ageing and is diagnosed by its characteristic neuro-im...
link.springer.com
May 10, 2025 at 5:42 AM
🧠 New paper out in Biogerontology!
We reviewed evidence linking circulating immune cells to cSVD features. Thanks to all co-authors, and the journal team!
🔗 link.springer.com/article/10.1...
More coming soon!
#Neuroimmunology #cSVD #Biomarkers #AgingBrain #Biogerontology
We reviewed evidence linking circulating immune cells to cSVD features. Thanks to all co-authors, and the journal team!
🔗 link.springer.com/article/10.1...
More coming soon!
#Neuroimmunology #cSVD #Biomarkers #AgingBrain #Biogerontology
Geschichtsstunde, Reichtagswahlen 1932
Juli: NSDAP erreicht 37,3%. Hitler wurde nicht Reichskanzler.
November: NSDAP erreicht 33,1%. Hitler wurde Reichskanzler.
Warum? Weil Konservative das so entschieden.
Merke: Nicht +/- ein paar % verschafft Nazis Macht. Konservative tun es (oder nicht).
Juli: NSDAP erreicht 37,3%. Hitler wurde nicht Reichskanzler.
November: NSDAP erreicht 33,1%. Hitler wurde Reichskanzler.
Warum? Weil Konservative das so entschieden.
Merke: Nicht +/- ein paar % verschafft Nazis Macht. Konservative tun es (oder nicht).
January 14, 2024 at 6:57 PM
Geschichtsstunde, Reichtagswahlen 1932
Juli: NSDAP erreicht 37,3%. Hitler wurde nicht Reichskanzler.
November: NSDAP erreicht 33,1%. Hitler wurde Reichskanzler.
Warum? Weil Konservative das so entschieden.
Merke: Nicht +/- ein paar % verschafft Nazis Macht. Konservative tun es (oder nicht).
Juli: NSDAP erreicht 37,3%. Hitler wurde nicht Reichskanzler.
November: NSDAP erreicht 33,1%. Hitler wurde Reichskanzler.
Warum? Weil Konservative das so entschieden.
Merke: Nicht +/- ein paar % verschafft Nazis Macht. Konservative tun es (oder nicht).
#Medsky🧪 #IDSky #Neurosky #immunosky #Publichealth Peak width of skeletonized mean diffusivity (PSMD) is an emerging automated diffusion imaging marker showing clinically relevant changes in cerebral small vessel disease (cSVD),a leading cause of stroke & #dementia with no mechanism-based treatment…
Although barely discussed outside neurology, cerebral small vessel disease is a major aging-related driver of stroke, dementia, and disability🧠
It is a major public health concern without an available treatment📈
Huge unmet clinical need❗️
It is a major public health concern without an available treatment📈
Huge unmet clinical need❗️
February 19, 2025 at 7:47 AM
#Medsky🧪 #IDSky #Neurosky #immunosky #Publichealth Peak width of skeletonized mean diffusivity (PSMD) is an emerging automated diffusion imaging marker showing clinically relevant changes in cerebral small vessel disease (cSVD),a leading cause of stroke & #dementia with no mechanism-based treatment…
I am currently at #ESOC2025 with the @csi-lab.bsky.social to present latest findings on #sleep and cerebral small vessel disease ( #CSVD )
❤️ Big thanks to the whole team for this wonderful dataset including excellent #neuroimaging 🧠
❤️ Big thanks to the whole team for this wonderful dataset including excellent #neuroimaging 🧠
May 22, 2025 at 3:30 PM
I am currently at #ESOC2025 with the @csi-lab.bsky.social to present latest findings on #sleep and cerebral small vessel disease ( #CSVD )
❤️ Big thanks to the whole team for this wonderful dataset including excellent #neuroimaging 🧠
❤️ Big thanks to the whole team for this wonderful dataset including excellent #neuroimaging 🧠
🚨 New preprint
11,000+ human brain microvessels in cSVD.
Key findings:
• Early, bimodal pericyte loss
• Endothelial activation comes later
• Venous-like microvascular shift
• Capillary density ↑
💡 Suggests a sequential vascular pathology, not parallel.
🔗 www.biorxiv.org/content/10.6...
11,000+ human brain microvessels in cSVD.
Key findings:
• Early, bimodal pericyte loss
• Endothelial activation comes later
• Venous-like microvascular shift
• Capillary density ↑
💡 Suggests a sequential vascular pathology, not parallel.
🔗 www.biorxiv.org/content/10.6...
www.biorxiv.org
March 23, 2026 at 7:52 PM
🚨 New preprint
11,000+ human brain microvessels in cSVD.
Key findings:
• Early, bimodal pericyte loss
• Endothelial activation comes later
• Venous-like microvascular shift
• Capillary density ↑
💡 Suggests a sequential vascular pathology, not parallel.
🔗 www.biorxiv.org/content/10.6...
11,000+ human brain microvessels in cSVD.
Key findings:
• Early, bimodal pericyte loss
• Endothelial activation comes later
• Venous-like microvascular shift
• Capillary density ↑
💡 Suggests a sequential vascular pathology, not parallel.
🔗 www.biorxiv.org/content/10.6...
Congrats to Joanna Wardlaw on new MRC funding for Cerebral Small Vessel Disease research. cSVD = major cause of stroke & around 40% of dementia cases; a common but neglected disorder with no effective treatment. This study will focus on 2 drugs to see if they slow/reverse cSVD. edin.ac/4j7JXNE
MRC invests in experimental medicine dementia studies
£16.5 million to help researchers, patients and industry partners work together to better understand how dementia begins and progresses.
edin.ac
December 23, 2025 at 10:55 AM
Congrats to Joanna Wardlaw on new MRC funding for Cerebral Small Vessel Disease research. cSVD = major cause of stroke & around 40% of dementia cases; a common but neglected disorder with no effective treatment. This study will focus on 2 drugs to see if they slow/reverse cSVD. edin.ac/4j7JXNE
Cerebral small vessel disease (cSVD) can cause stroke and dementia, but has no cure. With @ukdri.ac.uk, we're supporting a clinical study at @imperialcollegeldn.bsky.social to test whether XBD173, a shelved anxiety drug, can reduce brain damage in people with cSVD.
July 26, 2025 at 9:00 AM
Cerebral small vessel disease (cSVD) can cause stroke and dementia, but has no cure. With @ukdri.ac.uk, we're supporting a clinical study at @imperialcollegeldn.bsky.social to test whether XBD173, a shelved anxiety drug, can reduce brain damage in people with cSVD.
Researchers studied cerebral small vessel disease, a precursor for #dementia, across thousands of participants from four distinct groups of middle-age to older adults, validating a biomarker that can help guide research on possible treatments.
#NeuroSky #neuroscience #cSVD
#NeuroSky #neuroscience #cSVD
USC study finds new evidence linking dementia to problems with the brain’s waste clearance system
Related News Possible tool discovered to diagnose common contributor to vascular dementia October 6, 2023 Pioneering study targets Alzheimer’s disease risk factors among Californians from the Middle E...
keck.usc.edu
January 19, 2025 at 1:41 PM
Researchers studied cerebral small vessel disease, a precursor for #dementia, across thousands of participants from four distinct groups of middle-age to older adults, validating a biomarker that can help guide research on possible treatments.
#NeuroSky #neuroscience #cSVD
#NeuroSky #neuroscience #cSVD
The gutless response of ostensible countervailing political forces across the Global North to Trump and Netanyahu’s disastrous, criminal war has accomplished nothing but to hand the space for opposition and critique over shameless opportunists and antisemites now using it to brand build on bigotry.
August 4, 2026 at 12:39 PM
The gutless response of ostensible countervailing political forces across the Global North to Trump and Netanyahu’s disastrous, criminal war has accomplished nothing but to hand the space for opposition and critique over shameless opportunists and antisemites now using it to brand build on bigotry.
🚨 Hot off the press! 🚨
Our systematic review and meta-analysis on ML+CSVD for dementia diagnosis and prognosis has been published! An international collaboration, featuring @Valerie Lohner
@oparent.bsky.social
@helenagellersen.bsky.social
and many others.
doi.org/10.1186/s131...
@dzne.science
Our systematic review and meta-analysis on ML+CSVD for dementia diagnosis and prognosis has been published! An international collaboration, featuring @Valerie Lohner
@oparent.bsky.social
@helenagellersen.bsky.social
and many others.
doi.org/10.1186/s131...
@dzne.science
Machine learning applications in vascular neuroimaging for the diagnosis and prognosis of cognitive impairment and dementia: a systematic review and meta-analysis - Alzheimer's Research & Therapy
Cerebral small vessel disease (CSVD) is a common neurological condition that contributes to strokes, dementia, disability, and mortality worldwide. We conducted a systematic review and meta-analysis t...
doi.org
August 13, 2025 at 11:29 AM
🚨 Hot off the press! 🚨
Our systematic review and meta-analysis on ML+CSVD for dementia diagnosis and prognosis has been published! An international collaboration, featuring @Valerie Lohner
@oparent.bsky.social
@helenagellersen.bsky.social
and many others.
doi.org/10.1186/s131...
@dzne.science
Our systematic review and meta-analysis on ML+CSVD for dementia diagnosis and prognosis has been published! An international collaboration, featuring @Valerie Lohner
@oparent.bsky.social
@helenagellersen.bsky.social
and many others.
doi.org/10.1186/s131...
@dzne.science
New insights from the Hamburg City Health Study: VRFs like hypertension & diabetes show strong links with enlarged perivascular spaces—especially in the basal ganglia. A deeper look at the vascular underpinnings of #CSVD. Poster by Felix Nägele at #ESOC #Neuroimaging #StrokeResearch
May 22, 2025 at 3:24 PM
New insights from the Hamburg City Health Study: VRFs like hypertension & diabetes show strong links with enlarged perivascular spaces—especially in the basal ganglia. A deeper look at the vascular underpinnings of #CSVD. Poster by Felix Nägele at #ESOC #Neuroimaging #StrokeResearch
🧠💤 Sleep apnea, brain damage & memory
REM sleep hypoxemia from sleep apnea is linked to white matter damage and memory-related brain changes in older adults.
Even without symptoms, the brain feels it.
🔗 www.neurology.org/doi/10.1212/...
#SciComm #SleepApnea #BrainHealth 🧪
REM sleep hypoxemia from sleep apnea is linked to white matter damage and memory-related brain changes in older adults.
Even without symptoms, the brain feels it.
🔗 www.neurology.org/doi/10.1212/...
#SciComm #SleepApnea #BrainHealth 🧪
Association of Hypoxemia Due to Obstructive Sleep Apnea With White Matter Hyperintensities and Temporal Lobe Changes in Older Adults | Neurology
Background and ObjectivesCerebral small vessel disease (CSVD) is a leading cause of cognitive decline and functional
loss in older adults. Obstructive sleep apnea (OSA) is common in older adults, can
...
www.neurology.org
May 27, 2025 at 2:25 PM
🧠💤 Sleep apnea, brain damage & memory
REM sleep hypoxemia from sleep apnea is linked to white matter damage and memory-related brain changes in older adults.
Even without symptoms, the brain feels it.
🔗 www.neurology.org/doi/10.1212/...
#SciComm #SleepApnea #BrainHealth 🧪
REM sleep hypoxemia from sleep apnea is linked to white matter damage and memory-related brain changes in older adults.
Even without symptoms, the brain feels it.
🔗 www.neurology.org/doi/10.1212/...
#SciComm #SleepApnea #BrainHealth 🧪
This is an excellent introduction to or update on cerebral Small Vessels Disease (cSVD). A must-read journals.physiology.org/doi/full/10....
May 20, 2025 at 7:44 PM
This is an excellent introduction to or update on cerebral Small Vessels Disease (cSVD). A must-read journals.physiology.org/doi/full/10....
Cerebral small vessel disease prevalence in middle-aged individuals with type 1 diabetes nearly doubled over 7.5 years.
by Tarkkonen A, Kyläheiko I (...) Martola J et 8 al. in Diabetes Care #MedSky
📖 read the article:
by Tarkkonen A, Kyläheiko I (...) Martola J et 8 al. in Diabetes Care #MedSky
📖 read the article:
Progression of Cerebral Small Vessel Disease Among Neurologically Asymptomatic Middle-Aged Individuals With Type 1 Diabetes
OBJECTIVE. To investigate the potential progression rate of cerebral small vessel disease (CSVD) in brain MRI among neurologically asymptomatic middle-aged
diabetesjournals.org
March 26, 2025 at 8:36 AM
Cerebral small vessel disease prevalence in middle-aged individuals with type 1 diabetes nearly doubled over 7.5 years.
by Tarkkonen A, Kyläheiko I (...) Martola J et 8 al. in Diabetes Care #MedSky
📖 read the article:
by Tarkkonen A, Kyläheiko I (...) Martola J et 8 al. in Diabetes Care #MedSky
📖 read the article:
Cerebral small vessel disease #cSVD is believed to be a source of #CognitiveImpairment.
A #Korean cohort study showed that silent cSVD was independently associated with decline in executive functioning in #middle-aged through #elderly population🧠.
Full text⬇️ #Dementia #AgingPopulation
A #Korean cohort study showed that silent cSVD was independently associated with decline in executive functioning in #middle-aged through #elderly population🧠.
Full text⬇️ #Dementia #AgingPopulation
Middle-age cerebral small vessel disease and cognitive function in later life: a population-based prospective cohort study
Silent cSVD was independently associated with decline in executive functioning over
8-year follow-up period in this Korean middle-aged through elderly general population.
Future studies considering wi...
www.thelancet.com
March 17, 2025 at 4:34 AM
Cerebral small vessel disease #cSVD is believed to be a source of #CognitiveImpairment.
A #Korean cohort study showed that silent cSVD was independently associated with decline in executive functioning in #middle-aged through #elderly population🧠.
Full text⬇️ #Dementia #AgingPopulation
A #Korean cohort study showed that silent cSVD was independently associated with decline in executive functioning in #middle-aged through #elderly population🧠.
Full text⬇️ #Dementia #AgingPopulation
FRIDAY👉May 9, 2pm, DON'T MISS this #FriedmanBrainInstitute Special Seminar as hosts
@ericjnestler.bsky.social & @fanny-elahi.bsky.social welcome @institutducerveau.bsky.social's Dr. Stéphanie Debette. LEARN about cutting edge research on #vascular disease & #VCID #CSVD done at Paris Brain Institute.
@ericjnestler.bsky.social & @fanny-elahi.bsky.social welcome @institutducerveau.bsky.social's Dr. Stéphanie Debette. LEARN about cutting edge research on #vascular disease & #VCID #CSVD done at Paris Brain Institute.
May 7, 2025 at 1:41 PM
FRIDAY👉May 9, 2pm, DON'T MISS this #FriedmanBrainInstitute Special Seminar as hosts
@ericjnestler.bsky.social & @fanny-elahi.bsky.social welcome @institutducerveau.bsky.social's Dr. Stéphanie Debette. LEARN about cutting edge research on #vascular disease & #VCID #CSVD done at Paris Brain Institute.
@ericjnestler.bsky.social & @fanny-elahi.bsky.social welcome @institutducerveau.bsky.social's Dr. Stéphanie Debette. LEARN about cutting edge research on #vascular disease & #VCID #CSVD done at Paris Brain Institute.
Had our 2nd Imperial Stroke Public Involvement group of the year yesterday. Excellent discussions around SILENCE-CSVD trial. Celebrated attendance of 4 of our group members at the European life after stroke conference in Prague. #lifeafterstroke @imperialbrains.bsky.social @imperialperc.bsky.social
May 29, 2025 at 1:01 PM
Had our 2nd Imperial Stroke Public Involvement group of the year yesterday. Excellent discussions around SILENCE-CSVD trial. Celebrated attendance of 4 of our group members at the European life after stroke conference in Prague. #lifeafterstroke @imperialbrains.bsky.social @imperialperc.bsky.social
Although rarely discussed outside of neurology, cSVD is a major contributor to stroke, dementia, and late-life disability❗️
It poses a major public health burden for our aging populations, but there is no disease-modifying treatment💊
[picture source: www.ahajournals.org/doi/10.1161/... ]
It poses a major public health burden for our aging populations, but there is no disease-modifying treatment💊
[picture source: www.ahajournals.org/doi/10.1161/... ]
December 15, 2024 at 9:44 PM
Although rarely discussed outside of neurology, cSVD is a major contributor to stroke, dementia, and late-life disability❗️
It poses a major public health burden for our aging populations, but there is no disease-modifying treatment💊
[picture source: www.ahajournals.org/doi/10.1161/... ]
It poses a major public health burden for our aging populations, but there is no disease-modifying treatment💊
[picture source: www.ahajournals.org/doi/10.1161/... ]
I had no clue you were working on CSVD!!!
May 23, 2025 at 10:26 AM
I had no clue you were working on CSVD!!!
We are seeking a talented post-doc fellow to join our young group @maastrichtu.bsky.social @carimmaastricht.bsky.social #mhens to study the neurovascular unit. #brain #vascular #csvd. Check if you are eligible #MSCA and apply: lnkd.in/epnmCFU6
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
March 22, 2025 at 4:41 PM
We are seeking a talented post-doc fellow to join our young group @maastrichtu.bsky.social @carimmaastricht.bsky.social #mhens to study the neurovascular unit. #brain #vascular #csvd. Check if you are eligible #MSCA and apply: lnkd.in/epnmCFU6
Distinct ocular microvascular alterations in Alzheimer's disease and cerebral small vessel disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Distinct ocular microvascular alterations in Alzheimer's disease and cerebral small vessel disease
INTRODUCTION While both Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) involve vascular dysfunction, the ocular microvascular differences between them remain largely underinvestig...
alz-journals.onlinelibrary.wiley.com
September 9, 2026 at 9:00 AM
Distinct ocular microvascular alterations in Alzheimer's disease and cerebral small vessel disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
We carried out a systematic review and meta-analysis to examine the use of neuroimaging CSVD markers in machine learning–based diagnosis and prognosis of cognitive impairment and dementia, while also identifying methodological trends over time and barriers to clinical translation.
August 13, 2025 at 11:29 AM
We carried out a systematic review and meta-analysis to examine the use of neuroimaging CSVD markers in machine learning–based diagnosis and prognosis of cognitive impairment and dementia, while also identifying methodological trends over time and barriers to clinical translation.