Cellulosic Fire Protection Market projected to reach USD 5.271 Billion, at a CAGR of 5.44% during 2026 to 2035, driven by Growing demand for sustainable materials enhances opportunities in the Cellulo...

Retrouvez notre test d'Orbitals sur Nintendo Switch 2. Shapefarm et Hidetoshi Yoshida signent une pépite coopérative au rendu cellulo vintage à ne pas manquer.

Chromatin reader inhibitors require robust cellular assays for target-engagement profiling. Recchia et al. develop modular Acyl-eCR reporters that enable scalable live-cell measurement of bromodomain inhibitor specificity and PROTAC activity, providing a versatile platform for chromatin-targeted drug discovery.

Read the full paper: A modular platform for in cellulo target engagement profiling of chromatin reader inhibitors

Artificial enzymes constructed by introducing abiological catalytic cofactors into protein scaffolds are emerging as promising biocatalysts for reactions that have no natural equivalents. However, the design of artificial enzymes for in cellulo stereoselective biosynthesis remains largely unexplored because of the numerous challenges posed by the complex cellular environment. Here, we present an efficient strategy for the intracellular assembly of artificial enzymes via covalent anchoring by incubating cells that are expressing target protein with a synthetic catalytic cofactor, in the manner of natural enzymes. The artificial enzyme is assembled efficiently via site-specific disulfide-bond formation in cells, and it catalyzes an asymmetric Mannich reaction in cellulo with excellent enantioselectivity and reactivity. Crystallographic analysis combined with computational studies provides structural and mechanistic insight into the stereoselectivity and catalytic proficiency. Overall, th

Cellulosic Fire Protection Market projected to reach USD 5.271 Billion, at a CAGR of 5.44% during 2026 to 2035, driven by Growing demand for sustainable materials enhances opportunities in the Cellulo...

AbstractDe novo nucleotide biosynthesis is directly linked to glutamine-derived nitrogen metabolism in mammalian cells. It is a fundamental process tightly tied to cellular growth, proliferation, and metabolic reprogramming, particularly in cancer cells. Direct detection and imaging of glutamine-derived nitrogen metabolism at single-cell resolution remains a challenge. The conventional liquid chromatography-mass spectrometry-based approach for detecting de novo-synthesized nucleotide studies is mostly performed on metabolites extracted from a group of cells, which makes it inherently destructive. Herein, we introduce a vibrational spectroscopy-based single-cell metabolic detection and imaging framework, “glutamine (Q)-derived nitrogen spectral tracing and imaging (QN-STIM)”. Using this strategy, we detected and mapped nitrogen flow from glutamine to de novo-synthesized nascent nucleotides at the single-cell level. First, a proof-of-concept analysis was conducted in human embryonic kidney HEK293T cells and demonstrated the feasibility of this approach in cancer cells, namely human lung carcinoma A549, human glioblastoma U87 MG, and mouse hepatoma Hepa1-6. QN-STIM technique holds immense potential to be an adjunct tool to advance our understanding of nucleotide dynamics during differentiation, stress adaptation, and immune activation, and to evaluate responses to metabolic drugs in cellulo.

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Liu and colleagues developed a robust in cellulo plasmid DNA replication system in human cells for replicating plasmid-borne AAV Rep/Cap genes during rAAV production. This new approach not only enables a 10-20 fold plasmid reduction to significantly lower manufacturing costs, but also substantially enhances rAAV potency, titer, and purity.

Série d’été, travaux d’étudiants : Alexandre Foucqueteau a apprivoisé un petit robot appelé Cellulo, qui tient dans la main et permet aux enfants aveugles ou malvoyants de se représenter leur salle, pour mieux appréhender ensuite les obstacles.