I'm looking forward to reading this exciting new paper on circRNAs and herpesvirus infection! Congrats
@sarahdremel.bsky.social!
@sarahdremel.bsky.social!
Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection - PubMed
To globally profile circRNAs, we employ RNA-Sequencing paired with chimeric junction analysis for alpha-, beta-, and gamma-herpesvirus infection. We find circRNAs are, as a population, resistant to ho...
pubmed.ncbi.nlm.nih.gov
January 27, 2024 at 4:13 PM
I'm looking forward to reading this exciting new paper on circRNAs and herpesvirus infection! Congrats
@sarahdremel.bsky.social!
@sarahdremel.bsky.social!
Super excited our paper on circRNA stability in the brain and their use as life experience markers is out! @inespatop.bsky.social www.cell.com/cell-reports...
Circular RNAs exhibit exceptional stability in the aging brain and serve as reliable age and experience indicators
Kirio et al. demonstrate that circRNAs steadily accumulate in the aging fly brain due to their exceptional stability. Temperature exposure (29°C) further elevates select circRNAs, which remain high weeks later, underscoring their potential as markers of both age and past experiences.
www.cell.com
April 9, 2025 at 4:23 PM
Super excited our paper on circRNA stability in the brain and their use as life experience markers is out! @inespatop.bsky.social www.cell.com/cell-reports...
How do neurons deal with fitting large regulatory proteins into small spaces to control plasticity and memory? By generating micropeptides via local translation of circRNAs, of course! Here’s to shedding new light on the ‘dark’ proteome in the brain.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Local translation of circular RNAs is required for synaptic activity and memory
Circular RNAs (circRNAs) are enriched in synapses and implicated in cognitive processes, and recent studies have shown that circRNAs can encode micropeptides, which suggests that there may be novel sy...
www.biorxiv.org
September 20, 2025 at 1:11 AM
How do neurons deal with fitting large regulatory proteins into small spaces to control plasticity and memory? By generating micropeptides via local translation of circRNAs, of course! Here’s to shedding new light on the ‘dark’ proteome in the brain.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Thinking about using Cas13 to screen for functional circRNAs?
Think again!
Thread coming soon
Think again!
Thread coming soon
Junction-targeting designs limit the application of CRISPR-Cas13d in circular RNA perturbation studies url: academic.oup.com/nar/article/...
Junction-targeting designs limit the application of CRISPR-Cas13d in circular RNA perturbation studies
Abstract. Circular RNAs (circRNAs) are RNA molecules formed through the backsplicing of linear exons. Several thousand have been identified, yet relatively
academic.oup.com
January 10, 2026 at 1:43 AM
Thinking about using Cas13 to screen for functional circRNAs?
Think again!
Thread coming soon
Think again!
Thread coming soon
Pesquisa da Escola de Educação Física e Esporte da USP mostra que o treino aeróbico regula a expressão de RNAs circulares e auxilia na recuperação do coração após um infarto
Exercício físico atua na regulação genética para proteger coração infartado
Resultados fornecem evidências inéditas do envolvimento dos circRNAs como chaves reguladoras na resposta do coração ao exercício aeróbico após o infarto
jornal.usp.br
June 2, 2026 at 3:21 PM
Pesquisa da Escola de Educação Física e Esporte da USP mostra que o treino aeróbico regula a expressão de RNAs circulares e auxilia na recuperação do coração após um infarto
Functions & application of circRNAs in #VascularAging & aging-related vascular diseases
miR sponge
Linear mRNA translation
Interact with epigenetic/transcriptional machinery
Form R-loop on host gene
Protein-coding
#JNanobiotech 2025
jnanobiotechnology.biomedcentral.com/articles/10....
miR sponge
Linear mRNA translation
Interact with epigenetic/transcriptional machinery
Form R-loop on host gene
Protein-coding
#JNanobiotech 2025
jnanobiotechnology.biomedcentral.com/articles/10....
March 30, 2025 at 12:16 PM
Functions & application of circRNAs in #VascularAging & aging-related vascular diseases
miR sponge
Linear mRNA translation
Interact with epigenetic/transcriptional machinery
Form R-loop on host gene
Protein-coding
#JNanobiotech 2025
jnanobiotechnology.biomedcentral.com/articles/10....
miR sponge
Linear mRNA translation
Interact with epigenetic/transcriptional machinery
Form R-loop on host gene
Protein-coding
#JNanobiotech 2025
jnanobiotechnology.biomedcentral.com/articles/10....
🚨 1/5 Check out the 2nd preprint from our lab on how IRES-mediated translation of synthetic circRNAs is employed in cells and in cell-free translation extracts, a highly collaborative effort with @immagina.bsky.social & the labs of @andershlund.bsky.social and CK Chen www.biorxiv.org/content/10.6...
May 26, 2026 at 4:15 PM
🚨 1/5 Check out the 2nd preprint from our lab on how IRES-mediated translation of synthetic circRNAs is employed in cells and in cell-free translation extracts, a highly collaborative effort with @immagina.bsky.social & the labs of @andershlund.bsky.social and CK Chen www.biorxiv.org/content/10.6...
this is amazing
they show some compelling evidence for 3' to 5' translation
#RNASky #RNABiology 🧪
www.biorxiv.org/content/10.6...
they show some compelling evidence for 3' to 5' translation
#RNASky #RNABiology 🧪
www.biorxiv.org/content/10.6...
3' to 5' Translation of Circular RNAs?
For decades, the 5' to 3' direction of translation has been a central dogma of molecular biology. Here we present evidence that eukaryotic circular RNAs (circRNAs) can serve as templates for 3' to 5' ...
www.biorxiv.org
December 10, 2025 at 6:07 AM
this is amazing
they show some compelling evidence for 3' to 5' translation
#RNASky #RNABiology 🧪
www.biorxiv.org/content/10.6...
they show some compelling evidence for 3' to 5' translation
#RNASky #RNABiology 🧪
www.biorxiv.org/content/10.6...
How can we identify circRNAs that might be functional?
Together with @jengreitz.bsky.social, Howard Chang, and team, we found that answering this question is much more challenging than previously thought!
academic.oup.com/nar/article/...
See thread below:
Together with @jengreitz.bsky.social, Howard Chang, and team, we found that answering this question is much more challenging than previously thought!
academic.oup.com/nar/article/...
See thread below:
Junction-targeting designs limit the application of CRISPR-Cas13d in circular RNA perturbation studies
Abstract. Circular RNAs (circRNAs) are RNA molecules formed through the backsplicing of linear exons. Several thousand have been identified, yet relatively
academic.oup.com
January 17, 2026 at 2:38 AM
How can we identify circRNAs that might be functional?
Together with @jengreitz.bsky.social, Howard Chang, and team, we found that answering this question is much more challenging than previously thought!
academic.oup.com/nar/article/...
See thread below:
Together with @jengreitz.bsky.social, Howard Chang, and team, we found that answering this question is much more challenging than previously thought!
academic.oup.com/nar/article/...
See thread below:
🧪 Once seen as splicing errors, circular RNAs (circRNAs) are now key biomarkers and therapeutic targets in cancer and Alzheimer's.
New methods like RNase R processing and SPLASH2 software improve detection, though challenges in quantifying and studying circRNA functions remain. 🧬🖥️
New methods like RNase R processing and SPLASH2 software improve detection, though challenges in quantifying and studying circRNA functions remain. 🧬🖥️
Circular logic: understanding RNA’s strangest form yet
Circular RNAs are prevalent, mysterious and fascinating, but their study requires great care.
www.nature.com
November 14, 2024 at 4:31 PM
🧪 Once seen as splicing errors, circular RNAs (circRNAs) are now key biomarkers and therapeutic targets in cancer and Alzheimer's.
New methods like RNase R processing and SPLASH2 software improve detection, though challenges in quantifying and studying circRNA functions remain. 🧬🖥️
New methods like RNase R processing and SPLASH2 software improve detection, though challenges in quantifying and studying circRNA functions remain. 🧬🖥️
Lysosomes join the circular RNA decay machinery
Lysosomes join the circular RNA decay machinery
Circular RNAs (circRNAs) are covalently closed, stable RNA molecules with broad physiological functions. Precise regulation of circRNA turnover is essential for cellular homeostasis. A recent study by Deng et al. uncovers an evolutionarily conserved mechanism in which RNAseK and the lysosome act synergistically to degrade circRNAs across metazoans.
dlvr.it
July 31, 2026 at 12:02 PM
Lysosomes join the circular RNA decay machinery
New Resource Article:
Joseph Ziegelbauer @drjz.bsky.social and colleagues profile cis- and trans-acting elements of viral circRNAs and identify noncanonical mechanisms underlying back-splicing - utilizing their custom-built “CHARLIE” pipeline
www.embopress.org/doi/full/10....
Joseph Ziegelbauer @drjz.bsky.social and colleagues profile cis- and trans-acting elements of viral circRNAs and identify noncanonical mechanisms underlying back-splicing - utilizing their custom-built “CHARLIE” pipeline
www.embopress.org/doi/full/10....
March 3, 2025 at 5:32 PM
New Resource Article:
Joseph Ziegelbauer @drjz.bsky.social and colleagues profile cis- and trans-acting elements of viral circRNAs and identify noncanonical mechanisms underlying back-splicing - utilizing their custom-built “CHARLIE” pipeline
www.embopress.org/doi/full/10....
Joseph Ziegelbauer @drjz.bsky.social and colleagues profile cis- and trans-acting elements of viral circRNAs and identify noncanonical mechanisms underlying back-splicing - utilizing their custom-built “CHARLIE” pipeline
www.embopress.org/doi/full/10....
EMBO practical workshop dedicated to circular RNAs to be held from May 31 to June 6, 2025 at the University of Trento, Italy.
INFO & REGISTRATION: meetings.embo.org/event/25-cir...
DEADLINE: February 1, 2025
INFO & REGISTRATION: meetings.embo.org/event/25-cir...
DEADLINE: February 1, 2025
gROUNDbreaking approaches for advancing circRNA research: detection, function, therapeutics
Circular RNAs (CircRNAs) are a rediscovered class of RNA species that originate from back-splicing events, which have been reported across all domains of life. Many circRNAs are stable, abundant and …
meetings.embo.org
January 18, 2025 at 9:37 PM
EMBO practical workshop dedicated to circular RNAs to be held from May 31 to June 6, 2025 at the University of Trento, Italy.
INFO & REGISTRATION: meetings.embo.org/event/25-cir...
DEADLINE: February 1, 2025
INFO & REGISTRATION: meetings.embo.org/event/25-cir...
DEADLINE: February 1, 2025
circRNAs as tools for gene silencing, similar to microRNA-mediated gene silencing. Do we also need circRNA target prediction software? Circular RNAs trigger nonsense-mediated mRNA decay: Molecular Cell
Circular RNAs trigger nonsense-mediated mRNA decay
Boo and Shin et al. uncover that the EJC deposited onto circRNAs after back-splicing is spatially located near the 3′ UTR of mRNA through circRNA-mRNA interaction. The EJC on circRNA triggers NMD of the mRNA. Mechanistic studies reveal the roles of circNMD in apoptosis and its therapeutic potential for mRNA downregulation.
www.cell.com
December 12, 2024 at 2:30 PM
circRNAs as tools for gene silencing, similar to microRNA-mediated gene silencing. Do we also need circRNA target prediction software? Circular RNAs trigger nonsense-mediated mRNA decay: Molecular Cell
Online Now: Degradation of circular RNA by the ribonuclease DIS3
Degradation of circular RNA by the ribonuclease DIS3
Tao et al. uncover a DIS3-mediated circRNA degradation pathway, which occurs in the cytoplasm and is independent of the RNA exosome complex. DIS3 recognizes circRNAs containing U-rich motifs and requires its endonucleolytic activity for degradation.…
dlvr.it
February 17, 2025 at 4:19 PM
Online Now: Degradation of circular RNA by the ribonuclease DIS3
Tested in large cohorts, a predictive model including 34 blood circular RNAs predicts progression to symptomatic Alzheimer’s disease, outperforming pTau217 and amyloid-PET, according to a paper in Nature Medicine. go.nature.com/3QGdpAV #medsky 🧪
July 7, 2026 at 7:38 PM
Tested in large cohorts, a predictive model including 34 blood circular RNAs predicts progression to symptomatic Alzheimer’s disease, outperforming pTau217 and amyloid-PET, according to a paper in Nature Medicine. go.nature.com/3QGdpAV #medsky 🧪
The authors included RRIDs in their in Leukemia paper! We value the author's support of reproducibility. #RRID #ReproducibleResearch #OpenResearch
Systematic profiling of AGO2-associated circRNAs and functional investigation reveal circN4BP2L2 as a survival-promoting regulator in T-ALL - Leukemia
Read the full paper: Systematic profiling of AGO2-associated circRNAs and functional investigation reveal circN4BP2L2 as a survival-promoting regulator in T-ALL
doi.org
October 1, 2026 at 7:01 AM
The authors included RRIDs in their in Leukemia paper! We value the author's support of reproducibility. #RRID #ReproducibleResearch #OpenResearch
Showing the last circRNAs we could spot
July 10, 2025 at 8:50 AM
Showing the last circRNAs we could spot
This comprehensive review elucidates the biogenesis of Circular RNAs (#circRNAs) and the pathophysiology of #HepatitisBVirus (HBV)-induced #HepatocellularCarcinoma (HCC) and comprehensively analyzes the applications of circRNAs in oncology and therapeutics. #medsky
#OpenAccess: buff.ly/9BHjb4Q
#OpenAccess: buff.ly/9BHjb4Q
March 28, 2025 at 1:04 PM
This comprehensive review elucidates the biogenesis of Circular RNAs (#circRNAs) and the pathophysiology of #HepatitisBVirus (HBV)-induced #HepatocellularCarcinoma (HCC) and comprehensively analyzes the applications of circRNAs in oncology and therapeutics. #medsky
#OpenAccess: buff.ly/9BHjb4Q
#OpenAccess: buff.ly/9BHjb4Q
Cytoplasmic DIS3 is an exosome-independent endoribonuclease with catalytic activity toward circular RNAs
Cytoplasmic DIS3 is an exosome-independent endoribonuclease with catalytic activity toward circular RNAs
CircRNAs are generated during splicing, but their specific degradation pathways are poorly understood. Latini et al. identify and biochemically characterize the exo- and endoribonuclease DIS3 as a candidate for cytoplasmic circRNA degradation. DIS3 uses its catalytic PIN domain to cleave circRNAs and functions in the cytoplasm independently of the exosome.
dlvr.it
June 1, 2025 at 2:38 PM
Cytoplasmic DIS3 is an exosome-independent endoribonuclease with catalytic activity toward circular RNAs
"Emerging evidence indicates that circRNAs play pivotal regulatory roles in the aging process."
CircAge encompasses 803 aging-related samples from 7 species and 24 tissue types.
CircAge is publicly available at circage.kiz.ac.cn.
#aging #circRNAs
academic.oup.com/gpb/advance-...
CircAge encompasses 803 aging-related samples from 7 species and 24 tissue types.
CircAge is publicly available at circage.kiz.ac.cn.
#aging #circRNAs
academic.oup.com/gpb/advance-...
watermark.silverchair.com
June 2, 2025 at 2:12 PM
"Emerging evidence indicates that circRNAs play pivotal regulatory roles in the aging process."
CircAge encompasses 803 aging-related samples from 7 species and 24 tissue types.
CircAge is publicly available at circage.kiz.ac.cn.
#aging #circRNAs
academic.oup.com/gpb/advance-...
CircAge encompasses 803 aging-related samples from 7 species and 24 tissue types.
CircAge is publicly available at circage.kiz.ac.cn.
#aging #circRNAs
academic.oup.com/gpb/advance-...
I am glad to share that our study on RNA-protein interactions in the brain affected by myelin deficiency has been published in the latest
Cell Reports issue.
😊🤠
Except for insights into RBPs, you will find there also something about circRNAs (of course!) :)
www.cell.com/cell-reports...
Cell Reports issue.
😊🤠
Except for insights into RBPs, you will find there also something about circRNAs (of course!) :)
www.cell.com/cell-reports...
Interrogation of RNA-bound proteome with XRNAX illuminates molecular alterations in the mouse brain affected with dysmyelination
Myelin deficiency in the central nervous system leads to severe neurological dysfunctions.
Sztachera et al. probe RNA-protein interactions in the myelin-deficient mouse brain
in a high-throughput mann...
www.cell.com
January 31, 2025 at 1:43 PM
I am glad to share that our study on RNA-protein interactions in the brain affected by myelin deficiency has been published in the latest
Cell Reports issue.
😊🤠
Except for insights into RBPs, you will find there also something about circRNAs (of course!) :)
www.cell.com/cell-reports...
Cell Reports issue.
😊🤠
Except for insights into RBPs, you will find there also something about circRNAs (of course!) :)
www.cell.com/cell-reports...
I would have to say circRNAs, never ending possibilities (since they have no ends)
March 2, 2025 at 1:26 AM
I would have to say circRNAs, never ending possibilities (since they have no ends)
Circular RNAs exhibit exceptional stability in the aging brain and serve as reliable age and experience indicators
Circular RNAs exhibit exceptional stability in the aging brain and serve as reliable age and experience indicators
Kirio et al. demonstrate that circRNAs steadily accumulate in the aging fly brain due to their exceptional stability. Temperature exposure (29°C) further elevates select circRNAs, which remain high weeks later, underscoring their potential as markers of both age and past experiences.
dlvr.it
April 5, 2025 at 2:38 PM
Circular RNAs exhibit exceptional stability in the aging brain and serve as reliable age and experience indicators