The authors introduce ChronoGauge as a machine learning model which can estimate a plant’s internal circadian time using gene expression. This can be used to compare the circadian clock across differe...

OBJECTIVES: To compare relationships between the sleep-wake cycle and endogenous circadian rhythms in young and older adults and to examine correlates between evening naps and circadian rhythms in ol...

Efficient treatments to phase advance human circadian rhythms are needed to attenuate circadian misalignment and the associated negative health outcomes that accompany early morning shift work, early ...

Repressive PER2:CRY1:CK1δ complexes assembling in the cytosol enter the nucleus, where PER2 hyperphosphorylation eventually disrupts the complex, causing PER2 to relocalize to the cytoplasm, allowing ...

Circadian (~24 h) rhythms are a fundamental feature of life, and their disruption increases the risk of infectious diseases, metabolic disorders, and cancer. We previously identified circadian oscillations in intracellular potassium concentrations in cells across kingdoms. Using highly divergent eukaryotic cell types, we now show that potassium levels act to regulate the period and phase of clock gene expression rhythms, therefore establishing intracellular potassium as a bona fide regulator of cellular circadian rhythms. Intracellular potassium also regulates critical events in the cell cycle. Strikingly, we observe that manipulating potassium levels inhibits cell proliferation in a circadian phase-dependent manner. As the timing of cell division is tuned by the circadian clock, we hypothesised that potassium rhythms could mechanistically link cell proliferation rhythms to the circadian cycle. In line with this hypothesis, we find that potassium levels are not only sufficient to instr

Delayed sleep phase syndrome (DSPS) is a circadian rhythm sleep disorder that affects sleep-wake times and commonly occurs with ADHD. Learn the signs and appropriate treatments for this condition.