Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters
Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.
www.science.org
February 12, 2025 at 9:21 PM
Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
Altering metabolism programs cell identity via NAD+-dependent deacetylation
@josh-brickman.bsky.social et al show enforced OXPHOS dependence in embryonic stem cells drives deacetylation of essential transcription factors & inner-cell-mass-like gene expression
www.embopress.org/doi/full/10....
@josh-brickman.bsky.social et al show enforced OXPHOS dependence in embryonic stem cells drives deacetylation of essential transcription factors & inner-cell-mass-like gene expression
www.embopress.org/doi/full/10....
April 25, 2025 at 3:10 PM
Altering metabolism programs cell identity via NAD+-dependent deacetylation
@josh-brickman.bsky.social et al show enforced OXPHOS dependence in embryonic stem cells drives deacetylation of essential transcription factors & inner-cell-mass-like gene expression
www.embopress.org/doi/full/10....
@josh-brickman.bsky.social et al show enforced OXPHOS dependence in embryonic stem cells drives deacetylation of essential transcription factors & inner-cell-mass-like gene expression
www.embopress.org/doi/full/10....
TaHDA1-mediated #histone and non-histone #deacetylation orchestrates #drought tolerance in #wheat
onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @jipb.bsky.social @wileylifesci.bsky.social @wileyecology.bsky.social @planteditors.bsky.social @plant-sci.bsky.social @wheatpath.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @jipb.bsky.social @wileylifesci.bsky.social @wileyecology.bsky.social @planteditors.bsky.social @plant-sci.bsky.social @wheatpath.bsky.social
TaHDA1‐mediated histone and non‐histone deacetylation orchestrates drought tolerance in wheat
The histone deacetylase TaHDA1 is a key regulator linking histone and non-histone deacetylation with drought adaptation and a potential target for improving drought resilience and grain nutritional q....
onlinelibrary.wiley.com
September 17, 2026 at 12:43 PM
TaHDA1-mediated #histone and non-histone #deacetylation orchestrates #drought tolerance in #wheat
onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @jipb.bsky.social @wileylifesci.bsky.social @wileyecology.bsky.social @planteditors.bsky.social @plant-sci.bsky.social @wheatpath.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @jipb.bsky.social @wileylifesci.bsky.social @wileyecology.bsky.social @planteditors.bsky.social @plant-sci.bsky.social @wheatpath.bsky.social
Green flower coloration through AT-hook protein-mediated histone H3K27ac deacetylation in chrysanthemum (Hongfeng Huang , Jiaqi Wen , Ying Zheng , et al) doi.org/10.1093/plce... #PlantScience @aspbofficial
September 27, 2026 at 11:15 AM
Green flower coloration through AT-hook protein-mediated histone H3K27ac deacetylation in chrysanthemum (Hongfeng Huang , Jiaqi Wen , Ying Zheng , et al) doi.org/10.1093/plce... #PlantScience @aspbofficial
Our new-ish preprint: RNA Polymerase II coordinates histone deacetylation at active promoters www.biorxiv.org/content/10.1...
RNA Polymerase II coordinates histone deacetylation at active promoters
Nucleosomes at actively transcribed promoters have specific histone post-transcriptional modifications and histone variants. These features are thought to contribute to the formation and maintenance o...
www.biorxiv.org
November 15, 2024 at 1:13 PM
Our new-ish preprint: RNA Polymerase II coordinates histone deacetylation at active promoters www.biorxiv.org/content/10.1...
When your co-organiser/friend publish cool papers! Special shout out and congrats to @jxhoffman.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters
Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.
www.science.org
February 5, 2025 at 8:48 PM
When your co-organiser/friend publish cool papers! Special shout out and congrats to @jxhoffman.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
WIND1 controls cell fate transition through histone acetylation and deacetylation during somatic embryogenesis https://www.biorxiv.org/content/10.1101/2025.08.07.669221v1
August 9, 2025 at 7:03 PM
WIND1 controls cell fate transition through histone acetylation and deacetylation during somatic embryogenesis https://www.biorxiv.org/content/10.1101/2025.08.07.669221v1
Histone modifications occur independently of transcription
RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances
#chromatin #transcription #generegulation
www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances
#chromatin #transcription #generegulation
www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters
Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.
www.science.org
February 13, 2025 at 5:49 PM
Histone modifications occur independently of transcription
RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances
#chromatin #transcription #generegulation
www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances
#chromatin #transcription #generegulation
www.science.org/doi/10.1126/...
I’m back! My first new piece since my daughter was born!
This one is all about chitosan: a versatile biopolymer derived from chitin found in crustacean shells, including lobster. The structures represent 90% deacetylation. Used in everything from packaging to drug delivery #sciart
This one is all about chitosan: a versatile biopolymer derived from chitin found in crustacean shells, including lobster. The structures represent 90% deacetylation. Used in everything from packaging to drug delivery #sciart
September 8, 2026 at 3:41 PM
I’m back! My first new piece since my daughter was born!
This one is all about chitosan: a versatile biopolymer derived from chitin found in crustacean shells, including lobster. The structures represent 90% deacetylation. Used in everything from packaging to drug delivery #sciart
This one is all about chitosan: a versatile biopolymer derived from chitin found in crustacean shells, including lobster. The structures represent 90% deacetylation. Used in everything from packaging to drug delivery #sciart
WIND1 controls cell fate transition through coordinately integrating histone acetylation and deacetylation-mediated transcriptional reprogramming during somatic embryogenesis #research #MolecularPlant cell.com/molecular-pl...
March 13, 2026 at 7:22 AM
WIND1 controls cell fate transition through coordinately integrating histone acetylation and deacetylation-mediated transcriptional reprogramming during somatic embryogenesis #research #MolecularPlant cell.com/molecular-pl...
HDA19-mediated deacetylation of histone H3.3 lysine 27 and 36 regulates plant sensitivity to salt stress https://www.biorxiv.org/content/10.1101/2025.11.04.686508v1
November 5, 2025 at 7:03 PM
HDA19-mediated deacetylation of histone H3.3 lysine 27 and 36 regulates plant sensitivity to salt stress https://www.biorxiv.org/content/10.1101/2025.11.04.686508v1
Time for Charlotte Aumeier who demonstrates how kinesin motors modulate microtubule damage and allow for deacetylation enzymes to access the microtubule lumen, shaping the cellular acetylation patterns (doi.org/10.1038/s414...)
April 8, 2025 at 5:06 PM
Time for Charlotte Aumeier who demonstrates how kinesin motors modulate microtubule damage and allow for deacetylation enzymes to access the microtubule lumen, shaping the cellular acetylation patterns (doi.org/10.1038/s414...)
TaHDA1-mediated #histone and non-histone #deacetylation orchestrates #drought tolerance in #wheat
onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @jipb.bsky.social @wileylifesci.bsky.social @planteditors.bsky.social @plant-sci.bsky.social @histone-mark.bsky.social @histonelab.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @jipb.bsky.social @wileylifesci.bsky.social @planteditors.bsky.social @plant-sci.bsky.social @histone-mark.bsky.social @histonelab.bsky.social
September 9, 2026 at 11:52 AM
TaHDA1-mediated #histone and non-histone #deacetylation orchestrates #drought tolerance in #wheat
onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @jipb.bsky.social @wileylifesci.bsky.social @planteditors.bsky.social @plant-sci.bsky.social @histone-mark.bsky.social @histonelab.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience @jipb.bsky.social @wileylifesci.bsky.social @planteditors.bsky.social @plant-sci.bsky.social @histone-mark.bsky.social @histonelab.bsky.social
How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Altering metabolism programs cell identity via NAD+-dependent deacetylation | The EMBO Journal
imageimageHow alterations in cell metabolism translate into specific developmental gene programs remains a major question. This study shows that forcing OXPHOS metabolism reprograms mouse embryonic stem cells (ESCs) to a more inner cell mass (ICM)-...
www.embopress.org
April 25, 2025 at 3:26 PM
How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Macrophage SIRT6 promotes allergic airway inflammation through ATG3 deacetylation-mediated autophagy: www.mucosalimmunology.org/article/S193...
March 27, 2026 at 1:06 PM
Macrophage SIRT6 promotes allergic airway inflammation through ATG3 deacetylation-mediated autophagy: www.mucosalimmunology.org/article/S193...
MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment @natchembio.nature.com
www.nature.com/articles/s41...
see also the N&W www.nature.com/articles/s41...
www.nature.com/articles/s41...
see also the N&W www.nature.com/articles/s41...
MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment - Nature Chemical Biology
SIRT1-driven deacetylation of the MED1 subunit of the Mediator complex under stress modifies gene expression by enhancing RNA polymerase II action, promoting survival and growth of estrogen-receptor-p...
www.nature.com
October 24, 2025 at 6:56 AM
MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment @natchembio.nature.com
www.nature.com/articles/s41...
see also the N&W www.nature.com/articles/s41...
www.nature.com/articles/s41...
see also the N&W www.nature.com/articles/s41...
The miPEP171b-miR171b-SCL15/HDA19 module regulates histone deacetylation to confer cold tolerance in grapevine (Dongying Fan , Junpeng Li , Lujia Wang , et al) doi.org/10.1093/plce... #PlantScience @aspbofficial
September 28, 2026 at 12:15 AM
The miPEP171b-miR171b-SCL15/HDA19 module regulates histone deacetylation to confer cold tolerance in grapevine (Dongying Fan , Junpeng Li , Lujia Wang , et al) doi.org/10.1093/plce... #PlantScience @aspbofficial
Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation
Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing histone deacetylation.
www.science.org
December 18, 2024 at 9:59 AM
Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Exciting work! The authors conclude that condensin-mediated loop formation, Aurora B phosphorylation, and core histone deacetylation are not obligatory factors for mitotic chromosome compaction.
Our Mg2+ model is discussed as the “last model standing.”
www.cell.com/current-biol...
Our Mg2+ model is discussed as the “last model standing.”
www.cell.com/current-biol...
April 25, 2026 at 2:36 PM
Exciting work! The authors conclude that condensin-mediated loop formation, Aurora B phosphorylation, and core histone deacetylation are not obligatory factors for mitotic chromosome compaction.
Our Mg2+ model is discussed as the “last model standing.”
www.cell.com/current-biol...
Our Mg2+ model is discussed as the “last model standing.”
www.cell.com/current-biol...
What is the basis & significance of SUMO1 vs SUMO2/3 conjugation preference? Jo Morris et al find that mitotic deacetylation biases SUMO E1 SAE2 towards #SUMO1 conjugation onto NuMA to ensure faithful chromosome segregation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
August 26, 2025 at 12:49 PM
What is the basis & significance of SUMO1 vs SUMO2/3 conjugation preference? Jo Morris et al find that mitotic deacetylation biases SUMO E1 SAE2 towards #SUMO1 conjugation onto NuMA to ensure faithful chromosome segregation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
This is pretty cool! I wonder if this means Pol-2 shifts the position of the TSS in 3D space to differentially interact with #chromatin and #nucleosome remodeling enzymes
RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters
Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.
www.science.org
February 6, 2025 at 2:30 PM
This is pretty cool! I wonder if this means Pol-2 shifts the position of the TSS in 3D space to differentially interact with #chromatin and #nucleosome remodeling enzymes
RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances www.science.org/doi/10.1126/...
HDA6 regulates chloroplast biogenesis and photosynthesis in Arabidopsis through deacetylation of non-histone proteins https://www.biorxiv.org/content/10.1101/2025.10.28.685251v1
October 29, 2025 at 9:04 PM
HDA6 regulates chloroplast biogenesis and photosynthesis in Arabidopsis through deacetylation of non-histone proteins https://www.biorxiv.org/content/10.1101/2025.10.28.685251v1
Nonhistone deacetylation: a switch for crop resilience #plantscience
Nonhistone deacetylation: a switch for crop resilience
HISTONE DEACETYLASE (HDAC)-mediated nonhistone deacetylation is an evolutionarily conserved post-translational modification (PTM) essential for plant stress adaptation. Recently, two HDAC modules involved in plant responses to drought and pathogens, respectively, were functionally analyzed by Liu et al. and Zhang et al., providing evidence that biotic and abiotic stress-triggered relief of deacetylation functions as a switch for crop resilience.
dlvr.it
December 26, 2025 at 1:40 PM
Nonhistone deacetylation: a switch for crop resilience #plantscience
Here’s a cool movie showing histone H3K27ac increase upon TSA treatment (inhibits deacetylation). Here the intrabody (green; anti-H3K27ac scFv-sfGFP) translocates into the nucleus as acetylation levels there increase.
February 12, 2025 at 6:28 AM
Here’s a cool movie showing histone H3K27ac increase upon TSA treatment (inhibits deacetylation). Here the intrabody (green; anti-H3K27ac scFv-sfGFP) translocates into the nucleus as acetylation levels there increase.