"A Multiome experiment is a very expensive way to find out that your hypothesis is wrong."
#devbio #collaborate #GeneRegulation #Enhancers
#devbio #collaborate #GeneRegulation #Enhancers
November 25, 2024 at 5:37 PM
"A Multiome experiment is a very expensive way to find out that your hypothesis is wrong."
#devbio #collaborate #GeneRegulation #Enhancers
#devbio #collaborate #GeneRegulation #Enhancers
Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology?
@IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-...
Pls share!
@IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-...
Pls share!
November 19, 2024 at 3:08 PM
Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology?
@IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-...
Pls share!
@IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-...
Pls share!
🧬 @danielibrahim.bsky.social, moderated by @stefanschoenfelder.bsky.social, on enhancer-promoter specificity & how promoter-proximal regions act as molecular filters.
Register: us02web.zoom.us/webinar/regi...
March 5, 4PM UK.
#Genomics #GeneRegulation
Register: us02web.zoom.us/webinar/regi...
March 5, 4PM UK.
#Genomics #GeneRegulation
February 26, 2026 at 1:37 PM
🧬 @danielibrahim.bsky.social, moderated by @stefanschoenfelder.bsky.social, on enhancer-promoter specificity & how promoter-proximal regions act as molecular filters.
Register: us02web.zoom.us/webinar/regi...
March 5, 4PM UK.
#Genomics #GeneRegulation
Register: us02web.zoom.us/webinar/regi...
March 5, 4PM UK.
#Genomics #GeneRegulation
📣 Preprint alert! We have studied the formation of pair-wise and multi-way enhancer-promoter interactions in the #3Dgenome in a lymphoid-to-myeloid transdifferentiation system and learned interesting new things about their function in #GeneRegulation. 1/10
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 22, 2024 at 11:58 AM
📣 Preprint alert! We have studied the formation of pair-wise and multi-way enhancer-promoter interactions in the #3Dgenome in a lymphoid-to-myeloid transdifferentiation system and learned interesting new things about their function in #GeneRegulation. 1/10
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Really pleased to share the *final* version of @katiegelder.bsky.social's super work, profiling the functional roles of #IDRs in CBP. Published today 🎉
🔗https://doi.org/10.1016/j.celrep.2026.117109
#IDRs #condensates #transcription #CBP #generegulation #enhancers (1/7)
🔗https://doi.org/10.1016/j.celrep.2026.117109
#IDRs #condensates #transcription #CBP #generegulation #enhancers (1/7)
Redirecting
doi.org
March 13, 2026 at 4:47 PM
Really pleased to share the *final* version of @katiegelder.bsky.social's super work, profiling the functional roles of #IDRs in CBP. Published today 🎉
🔗https://doi.org/10.1016/j.celrep.2026.117109
#IDRs #condensates #transcription #CBP #generegulation #enhancers (1/7)
🔗https://doi.org/10.1016/j.celrep.2026.117109
#IDRs #condensates #transcription #CBP #generegulation #enhancers (1/7)
Wonderful to have the last (major) part of my postdoctoral work preprinted! Huge thanks to @ioansarr.bsky.social and @tyamadat.bsky.social—it's been a blast. Grateful to be part of the inspiring, collaborative and supportive team @kaessmannlab.bsky.social! #Cerebellum rocks! #EvoDevo #GeneRegulation
March 16, 2025 at 5:45 PM
Wonderful to have the last (major) part of my postdoctoral work preprinted! Huge thanks to @ioansarr.bsky.social and @tyamadat.bsky.social—it's been a blast. Grateful to be part of the inspiring, collaborative and supportive team @kaessmannlab.bsky.social! #Cerebellum rocks! #EvoDevo #GeneRegulation
Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
www.science.org
February 7, 2025 at 10:22 AM
Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
February 26, 2025 at 7:16 AM
Incredible talk and beautiful images by @elfridedebaere.bsky.social on vision enhanceropathies.
Much food for thought. #missingheritability #generegulation #ESHG2025
Much food for thought. #missingheritability #generegulation #ESHG2025
May 25, 2025 at 4:12 PM
Incredible talk and beautiful images by @elfridedebaere.bsky.social on vision enhanceropathies.
Much food for thought. #missingheritability #generegulation #ESHG2025
Much food for thought. #missingheritability #generegulation #ESHG2025
Excited to be at @keystonesymposia.bsky.social for first time ! Looking forward to plenty of science&fun at #Epigenetics in #Development and Disease #KSEpigenetics25 keysym.us/KSEpigenetics25 #RNA #GeneReg #RNAsky #GeneRegulation
March 31, 2025 at 1:58 PM
Excited to be at @keystonesymposia.bsky.social for first time ! Looking forward to plenty of science&fun at #Epigenetics in #Development and Disease #KSEpigenetics25 keysym.us/KSEpigenetics25 #RNA #GeneReg #RNAsky #GeneRegulation
Fantastic third instalment of the Melbourne Epigenetics Club featuring talks by Lee Wong and Hamish King, and a networking reception
If you’re in Melbourne and interested in #chromatin #epigenetics or #GeneRegulation and interested in attending, visit www.eckmaslab.com/melbourne-ep... 🧪🧬
If you’re in Melbourne and interested in #chromatin #epigenetics or #GeneRegulation and interested in attending, visit www.eckmaslab.com/melbourne-ep... 🧪🧬
November 19, 2024 at 9:04 AM
Fantastic third instalment of the Melbourne Epigenetics Club featuring talks by Lee Wong and Hamish King, and a networking reception
If you’re in Melbourne and interested in #chromatin #epigenetics or #GeneRegulation and interested in attending, visit www.eckmaslab.com/melbourne-ep... 🧪🧬
If you’re in Melbourne and interested in #chromatin #epigenetics or #GeneRegulation and interested in attending, visit www.eckmaslab.com/melbourne-ep... 🧪🧬
this is important! (work from David Clark) www.biorxiv.org/content/10.1...
"..the human genome is globally accessible in living cells, unlike in isolated nuclei.... all nucleosomes in euchromatin and heterochromatin are highly dynamic in living cell...' 🧪 #chromatin #generegulation. Discussion?
"..the human genome is globally accessible in living cells, unlike in isolated nuclei.... all nucleosomes in euchromatin and heterochromatin are highly dynamic in living cell...' 🧪 #chromatin #generegulation. Discussion?
www.biorxiv.org
December 18, 2024 at 1:38 PM
this is important! (work from David Clark) www.biorxiv.org/content/10.1...
"..the human genome is globally accessible in living cells, unlike in isolated nuclei.... all nucleosomes in euchromatin and heterochromatin are highly dynamic in living cell...' 🧪 #chromatin #generegulation. Discussion?
"..the human genome is globally accessible in living cells, unlike in isolated nuclei.... all nucleosomes in euchromatin and heterochromatin are highly dynamic in living cell...' 🧪 #chromatin #generegulation. Discussion?
Finally out! We present EXTRA-seq, a new EXTended Reporter Assay to quantify endogenous enhancer-promoter communication at kb scale!
www.biorxiv.org/content/10.1...
A 🧵about what it can do:
#SynBio #DeepLearning #GeneRegulation
www.biorxiv.org/content/10.1...
A 🧵about what it can do:
#SynBio #DeepLearning #GeneRegulation
EXTRA-seq: a genome-integrated extended massively parallel reporter assay to quantify enhancer-promoter communication
Precise control of gene expression is essential for cellular function, but the mechanisms by which enhancers communicate with promoters to coordinate this process are not fully understood. While seque...
biorxiv.org
December 16, 2024 at 2:39 PM
Finally out! We present EXTRA-seq, a new EXTended Reporter Assay to quantify endogenous enhancer-promoter communication at kb scale!
www.biorxiv.org/content/10.1...
A 🧵about what it can do:
#SynBio #DeepLearning #GeneRegulation
www.biorxiv.org/content/10.1...
A 🧵about what it can do:
#SynBio #DeepLearning #GeneRegulation
#argonautes2025 day3 with amazing talks spanning widely over generegulation to evolution and parasitic interaction (via AGO).
A presentation by the Argonautes Syndrom family alliance reminded how relevant research on Argonautes and related mechanisms is
A presentation by the Argonautes Syndrom family alliance reminded how relevant research on Argonautes and related mechanisms is
August 29, 2025 at 2:20 PM
#argonautes2025 day3 with amazing talks spanning widely over generegulation to evolution and parasitic interaction (via AGO).
A presentation by the Argonautes Syndrom family alliance reminded how relevant research on Argonautes and related mechanisms is
A presentation by the Argonautes Syndrom family alliance reminded how relevant research on Argonautes and related mechanisms is
How do >1600 transcription factors (TFs) bind across hundreds of cell types? Experimentally profiling every combination isn't practically doable. But relying on DNA motifs isn't a great alternative -- they lack both sensitivity and specificity. #Genomics #GeneRegulation 👇
June 23, 2026 at 11:46 AM
How do >1600 transcription factors (TFs) bind across hundreds of cell types? Experimentally profiling every combination isn't practically doable. But relying on DNA motifs isn't a great alternative -- they lack both sensitivity and specificity. #Genomics #GeneRegulation 👇
📢 We are hiring!
👩🏾⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution
Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...
#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
👩🏾⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution
Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...
#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
October 15, 2025 at 3:00 PM
📢 We are hiring!
👩🏾⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution
Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...
#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
👩🏾⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution
Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...
#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
🗒️‼️Do not miss this exciting new #preprint from the @radaiglesiaslab.bsky.social, led by @eharo84.bsky.social: a master of building synergy ⏫- both in #enhancer research and at the lab! #DarkGenome #Transcription #GeneRegulation #Development #Genomics
Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts
Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...
www.biorxiv.org
August 11, 2025 at 4:16 PM
🗒️‼️Do not miss this exciting new #preprint from the @radaiglesiaslab.bsky.social, led by @eharo84.bsky.social: a master of building synergy ⏫- both in #enhancer research and at the lab! #DarkGenome #Transcription #GeneRegulation #Development #Genomics
📢 New preprint from the FunGen lab @svergult.bsky.social on how non-coding structural variants disrupt FOXG1 regulation during early neurodevelopment. Great teamwork from Lisa Hamerlinck and everyone in the lab! Thread below👇
www.medrxiv.org/content/10.1...
#GeneRegulation #RareDisease #Epigenomics
www.medrxiv.org/content/10.1...
#GeneRegulation #RareDisease #Epigenomics
March 13, 2025 at 4:00 PM
📢 New preprint from the FunGen lab @svergult.bsky.social on how non-coding structural variants disrupt FOXG1 regulation during early neurodevelopment. Great teamwork from Lisa Hamerlinck and everyone in the lab! Thread below👇
www.medrxiv.org/content/10.1...
#GeneRegulation #RareDisease #Epigenomics
www.medrxiv.org/content/10.1...
#GeneRegulation #RareDisease #Epigenomics
Delighted to have been able to help out with this project - congratulations Ali and the rest of the @drakesmith-lab.bsky.social - such a fascinating #genetics and #GeneRegulation story 🧪
Wonderful to see this out, a big effort led by Alexandra Preston and fun for the lab to do something new (and very very old); plus it’s only slightly iron-related! 😳😱😀 www.nature.com/articles/s41...
Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis - Nature Communications
Nprl3 controls erythroblast metabolism and is upregulated by α -globin enhancers sited within its introns. This arrangement couples metabolic and developmental control during erythropoiesis and may ex...
www.nature.com
March 27, 2025 at 8:58 PM
Delighted to have been able to help out with this project - congratulations Ali and the rest of the @drakesmith-lab.bsky.social - such a fascinating #genetics and #GeneRegulation story 🧪
Super proud of BSc honours thesis student Shahmeen for being an excellent ambassador of our lab's research program at the #OntarioBiologyDay 2025 conference! #OBD2025
@laurierbiology.bsky.social #PlantImmunity #GeneRegulation #SalicylicAcid
@laurierbiology.bsky.social #PlantImmunity #GeneRegulation #SalicylicAcid
March 22, 2025 at 9:16 PM
Super proud of BSc honours thesis student Shahmeen for being an excellent ambassador of our lab's research program at the #OntarioBiologyDay 2025 conference! #OBD2025
@laurierbiology.bsky.social #PlantImmunity #GeneRegulation #SalicylicAcid
@laurierbiology.bsky.social #PlantImmunity #GeneRegulation #SalicylicAcid
Histone modifications occur independently of transcription
RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances
#chromatin #transcription #generegulation
www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances
#chromatin #transcription #generegulation
www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters
Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.
www.science.org
February 13, 2025 at 5:49 PM
Histone modifications occur independently of transcription
RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances
#chromatin #transcription #generegulation
www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances
#chromatin #transcription #generegulation
www.science.org/doi/10.1126/...
🚀 New preprint!
We introduce K-PROB, a k-mer–based Bayesian framework that mines pangenomic promoter and expression diversity to predict cis-regulatory elements driving gene expression variation in crops 🌽🌱
🔗 biorxiv.org/content/10.1101/2025.10.27.684862v1
#Genomics #GeneRegulation #Maize #Soybean
We introduce K-PROB, a k-mer–based Bayesian framework that mines pangenomic promoter and expression diversity to predict cis-regulatory elements driving gene expression variation in crops 🌽🌱
🔗 biorxiv.org/content/10.1101/2025.10.27.684862v1
#Genomics #GeneRegulation #Maize #Soybean
Natural variation in regulatory code revealed through Bayesian analysis of plant pan-genomes and pan-transcriptomes
Understanding the genetic code of cis-regulatory elements (CREs) is essential for engineering gene expression and modulating agronomic traits in crops. In plants, CREs underlying rapid evolution of ge...
biorxiv.org
October 29, 2025 at 4:47 PM
🚀 New preprint!
We introduce K-PROB, a k-mer–based Bayesian framework that mines pangenomic promoter and expression diversity to predict cis-regulatory elements driving gene expression variation in crops 🌽🌱
🔗 biorxiv.org/content/10.1101/2025.10.27.684862v1
#Genomics #GeneRegulation #Maize #Soybean
We introduce K-PROB, a k-mer–based Bayesian framework that mines pangenomic promoter and expression diversity to predict cis-regulatory elements driving gene expression variation in crops 🌽🌱
🔗 biorxiv.org/content/10.1101/2025.10.27.684862v1
#Genomics #GeneRegulation #Maize #Soybean
I'd suggest this starter pack for #epigenetics and #generegulation:
go.bsky.app/TKp9YAn
plus see the description for another 3!
go.bsky.app/TKp9YAn
plus see the description for another 3!
November 26, 2024 at 10:25 AM
I'd suggest this starter pack for #epigenetics and #generegulation:
go.bsky.app/TKp9YAn
plus see the description for another 3!
go.bsky.app/TKp9YAn
plus see the description for another 3!
Zhijian Li ( @zhijianli.bsky.social )presents "Cell2net: A Deep Learning Framework to Decode Genotype-Specific Gene Regulatory Networks from Single-Cell Multi-Omics"
#DeepLearning #GeneRegulation #ASHG2025
#DeepLearning #GeneRegulation #ASHG2025
October 15, 2025 at 1:41 PM
Zhijian Li ( @zhijianli.bsky.social )presents "Cell2net: A Deep Learning Framework to Decode Genotype-Specific Gene Regulatory Networks from Single-Cell Multi-Omics"
#DeepLearning #GeneRegulation #ASHG2025
#DeepLearning #GeneRegulation #ASHG2025
🚨Last chance! Submit an abstract to #Fungal26 by tomorrow, December 4: buff.ly/1AMwJhf
They can cover an array of topics including #ComparativeGenomics #FunctionalGenomics #Pathogenic #GeneRegulation #CellBiology #Biochemistry #Metabolism #FungalEcology #Evo #DevelopmentalBio #PopGen and more.
They can cover an array of topics including #ComparativeGenomics #FunctionalGenomics #Pathogenic #GeneRegulation #CellBiology #Biochemistry #Metabolism #FungalEcology #Evo #DevelopmentalBio #PopGen and more.
December 3, 2025 at 2:02 PM
🚨Last chance! Submit an abstract to #Fungal26 by tomorrow, December 4: buff.ly/1AMwJhf
They can cover an array of topics including #ComparativeGenomics #FunctionalGenomics #Pathogenic #GeneRegulation #CellBiology #Biochemistry #Metabolism #FungalEcology #Evo #DevelopmentalBio #PopGen and more.
They can cover an array of topics including #ComparativeGenomics #FunctionalGenomics #Pathogenic #GeneRegulation #CellBiology #Biochemistry #Metabolism #FungalEcology #Evo #DevelopmentalBio #PopGen and more.