MARCH7 prevents ferroptosis by regulating intracellular iron release and extracellular iron uptake. A small molecule stabilizer, EmodAn, offers robust cardioprotection, highlighting MARCH7 as a promising target for treating ferroptosis-related diseases.

Abstract. Endocrine therapy (ET) is the standard of care for estrogen receptor-positive (ER+) breast cancer. Point mutations in the ligand-binding domain of the gene encoding the estrogen receptor (ES...

Researchers have discovered a protective mechanism in nerve cells that offers new targets for future therapies—especially for dementia.

Cell Death & Disease - Genetic mutations governing ferroptosis sensitivity and resistance: a precision approach to cancer therapy

The brain offers a unique environment for cancer, with limited access to nutrients and highly regulated immune surveillance. Here we explore the role of ferroptosis, a form of metabolically regulated cell death driven by iron-mediated lipid peroxidation, in shaping immune-cell composition and function in glial tumours. We review the complex metabolic crosstalk between cell populations regulating ferroptosis in the glioma milieu. Ferroptosis induces polarization of resident microglia and controls the cytotoxic roles of CD8+ T cells and the immunosuppressive effects of regulatory T cells. We discuss recently uncovered mechanisms of ferroptosis-driven immune evasion and the impact on tumour evolution. Additionally, we analyse mechanisms of synergy in combinations incorporating ferroptosis-inducing agents and immunotherapies, including immune checkpoint blockade and adoptive cell therapies, which aim to induce effective immune responses and durable control in gliomas. This Review discusses

Walker and colleagues show that hippocampal neural precursor cells are especially vulnerable to ferroptosis-related stress. Modulating this pathway alters adult neurogenesis and spatial learning and m...

Adult hippocampal neurogenesis declines with age, but the stress pathways that shape neural precursor cell (NPC) survival and lineage progression rema…

New research shows that ferroptosis, a form of cell death, occurs in severe COVID-19 patient lungs. Stopping it improves outcomes.

A new study published in IOP Publishing’s Nanotechnology offers new hope for less harmful breast cancer therapy by combining two powerful, non-invasive cancer treatments. Researchers are exploring a potential new approach to treating breast cancer, merging photodynamic therapy (PDT), which uses light-activated drugs to destroy cancer cells, with ferroptosis, a method of killing cancer cells […] The post Dual-action Therapy Shows Promise in Breast Cancer Care appeared first on IOP Publishing.

Colorectal cancer (CRC) is a third leading cause of death and is often recognised by a higher mutation burden. The standard clinical regimen for CRC chiefly focuses on targeting a single-cell death mechanism, which encounters constraints such as resistance, chronic toxicity, and suboptimal efficacy. Thus, triggering a hybrid cell death mechanism that acts through distinct pathways offers a promising avenue in CRC management. The present investigation explores the combined therapy of Sorafenib (SOR) and Atorvastatin (ATST) to induce a dual cell death mechanism, specifically ferroptosis and classic apoptosis, in colon cancer cells. The combination of ATST + SOR at a 1:1 ratio showed a combination index value of < 1 and a dose reduction index > 1 in HT29, HCT116, CT26, and SW480 cell lines. In-vitro studies with a synergistic combination of ATST + SOR showed amplified levels of MDA, ROS, and membrane depolarisation, while diminishing a

Signal Transduction and Targeted Therapy - Ferroptosis modulation enhances astrocyte-to-neuron conversion induced by a novel chemical cocktail in the hemorrhagic brain

Published in European journal of medical research

Key PointsIntegrated single-cell spatial transcriptomics and metabolomics identified cholesterol reprogramming as a driver of ferroptosis in proximal...

By establishing an iron overload-induced hepatic ferroptosis model, scientists from Japan have identified iFerroptosis—an integrated gene signature for ferroptosis. They evaluated the associated genes in both mice and human liver injury systems, validating the potential use of iFerroptosis as a biomarker. By highlighting the role of ferroptosis in liver injuries, this study offers insights into unique therapeutic targets.

Ferroptosis, a novel form of programmed cell death, offers promising therapeutic potential for drug-resistant glioblastoma multiforme. This review investigates key molecular mediators and emerging strategies targeting ferroptosis, suggesting that its integration with current therapies could improve outcomes for patients with this aggressive brain tumor.