True every day—but for godsake, he looks like 10 pounds of shite in a five-pound sack.
Thick orange greasepaint. Flopsweat. Ill-fitting fatsuit. Hyperreactive, short-fused, Tiny Hands Syndrome.
Sputtering with inarticulate rage.
Godspeed his end.
Thick orange greasepaint. Flopsweat. Ill-fitting fatsuit. Hyperreactive, short-fused, Tiny Hands Syndrome.
Sputtering with inarticulate rage.
Godspeed his end.
October 31, 2026 at 1:17 AM
True every day—but for godsake, he looks like 10 pounds of shite in a five-pound sack.
Thick orange greasepaint. Flopsweat. Ill-fitting fatsuit. Hyperreactive, short-fused, Tiny Hands Syndrome.
Sputtering with inarticulate rage.
Godspeed his end.
Thick orange greasepaint. Flopsweat. Ill-fitting fatsuit. Hyperreactive, short-fused, Tiny Hands Syndrome.
Sputtering with inarticulate rage.
Godspeed his end.
PHP est l'acronyme de PHP Hyperreactive Psychodrama.
October 21, 2026 at 2:28 PM
PHP est l'acronyme de PHP Hyperreactive Psychodrama.
How about, instead, spending time, money and effort into figuring out *why* they want to rape, so we can stop rapes *before* they ever happen? Proactive instead of hyperreactive?
September 30, 2026 at 12:25 AM
How about, instead, spending time, money and effort into figuring out *why* they want to rape, so we can stop rapes *before* they ever happen? Proactive instead of hyperreactive?
Brain organoids reveal new clues for childhood epilepsy treatments
->News-Medical | More on "Brain organoids for epilepsy treatment" at BigEarthData.ai
->News-Medical | More on "Brain organoids for epilepsy treatment" at BigEarthData.ai
Brain organoids reveal new clues for childhood epilepsy treatments
Tiny, year-old human brain organoids that mimic the brain of a newborn are providing new clues to potential treatments for a leading genetic cause of childhood epilepsy that typically manifests as the brain matures shortly after birth. A new study by UC Berkeley researchers points to hyperreactive astrocytes as one of the primary drivers of the inflammation that can cause seizures and highlights possible therapies that could tamp down the inflammation. Astrocytes are one of three main types of glial cells in the brain and help to support and facilitate the transmission of signals through neurons. Human brain organoids - balls of brain tissue several millimeters across floating in a nutrient liquid - contain only a few types of brain cells and are far from a real brain. But, unlike the flat layer of cells in a traditional cell culture, organoids develop and behave much like cells inside a living brain. The inherited disorder, called tuberous sclerosis complex, is characterized by potato-shaped lesions in the brain that cause severe seizures often resistant to common antiseizure medications. The disease is also accompanied by debilitating symptoms in other parts of the body, including the heart, skin and kidneys. The specific genetic cause...
www.news-medical.net
September 24, 2026 at 4:00 AM
Growing up, I wasn't really allowed to think for myself or voice opinions which differed too drastically from those of my egotistical, abusive parents.
If you can't relate to that experience, you should probably just be grateful you weren't also raised by emotionally immature, hyperreactive idjits.
If you can't relate to that experience, you should probably just be grateful you weren't also raised by emotionally immature, hyperreactive idjits.
September 14, 2026 at 3:18 PM
Growing up, I wasn't really allowed to think for myself or voice opinions which differed too drastically from those of my egotistical, abusive parents.
If you can't relate to that experience, you should probably just be grateful you weren't also raised by emotionally immature, hyperreactive idjits.
If you can't relate to that experience, you should probably just be grateful you weren't also raised by emotionally immature, hyperreactive idjits.
(It also happens if I'm standing too long or sitting down for too long.)
Turns out I'm not dying, it's a genetically hyperreactive blood pressure thing.
I mean ...I am dying, just no faster than anyone else. Hopefully.
Anyway, cosmetics mastery: achieved.
Turns out I'm not dying, it's a genetically hyperreactive blood pressure thing.
I mean ...I am dying, just no faster than anyone else. Hopefully.
Anyway, cosmetics mastery: achieved.
September 1, 2026 at 11:51 PM
(It also happens if I'm standing too long or sitting down for too long.)
Turns out I'm not dying, it's a genetically hyperreactive blood pressure thing.
I mean ...I am dying, just no faster than anyone else. Hopefully.
Anyway, cosmetics mastery: achieved.
Turns out I'm not dying, it's a genetically hyperreactive blood pressure thing.
I mean ...I am dying, just no faster than anyone else. Hopefully.
Anyway, cosmetics mastery: achieved.
i am PISSING you off with my hyperreactive attack patterns and im jumping around you and shit while tossing my projectiles that piss you off
August 28, 2026 at 5:11 PM
i am PISSING you off with my hyperreactive attack patterns and im jumping around you and shit while tossing my projectiles that piss you off
HYPERREACTIVE BRAIN NETWORK MAY BE CAUSE OF CHRONIC PAIN IN FIBROMYALGIA
Hypersensitivity in #fibromyalgia isn't the same things as being "too sensitive" in the way people usually mean when they throw that phrase around.
@FibromyalgiaDiary #MySeveralWorlds
#FibromyalgiaAwareness
#ChronicPain
Hypersensitivity in #fibromyalgia isn't the same things as being "too sensitive" in the way people usually mean when they throw that phrase around.
@FibromyalgiaDiary #MySeveralWorlds
#FibromyalgiaAwareness
#ChronicPain
August 12, 2026 at 2:39 PM
HYPERREACTIVE BRAIN NETWORK MAY BE CAUSE OF CHRONIC PAIN IN FIBROMYALGIA
Hypersensitivity in #fibromyalgia isn't the same things as being "too sensitive" in the way people usually mean when they throw that phrase around.
@FibromyalgiaDiary #MySeveralWorlds
#FibromyalgiaAwareness
#ChronicPain
Hypersensitivity in #fibromyalgia isn't the same things as being "too sensitive" in the way people usually mean when they throw that phrase around.
@FibromyalgiaDiary #MySeveralWorlds
#FibromyalgiaAwareness
#ChronicPain
This is a super interesting (IMO) study on how T cells can repress out of control B cell responses, particularly relevant to autoimmunity and lymphomagenesis #Immunosky #lymphomasky
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis
Aberrant immune signal strength in B cells is associated with autoimmune diseases
and lymphoma. Diehl et al. show that hyperreactive B cells trigger cytotoxic T cell-mediated
elimination. Less reactiv...
www.cell.com
January 16, 2025 at 7:24 PM
This is a super interesting (IMO) study on how T cells can repress out of control B cell responses, particularly relevant to autoimmunity and lymphomagenesis #Immunosky #lymphomasky
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
“Look all we did was feed the bigoted predispositions of the hyperreactive and ignorant Volk for 25 years to tell them that there was a pan-Islamic murder conspiracy against them, no idea how this happened, must have been the factories closing and university DEI”
June 3, 2026 at 3:28 AM
“Look all we did was feed the bigoted predispositions of the hyperreactive and ignorant Volk for 25 years to tell them that there was a pan-Islamic murder conspiracy against them, no idea how this happened, must have been the factories closing and university DEI”
Yeah this is the kind of hyperreactive mindset that I am talking about. Assuming people who are struggling hate you and everyone who looks like you isn't healthy.
December 13, 2024 at 3:41 AM
Yeah this is the kind of hyperreactive mindset that I am talking about. Assuming people who are struggling hate you and everyone who looks like you isn't healthy.
More on Zofran & why it helps: Zofran (ondansetron) blocks 5-HT3 serotonin receptors that trigger nausea, vagal overstimulation & sensory crashes. For those with Long COVID, POTS, or MCAS, and especially with COMT or serotonin-related gene variants,this can calm a hyperreactive nervous system
April 20, 2025 at 9:18 PM
More on Zofran & why it helps: Zofran (ondansetron) blocks 5-HT3 serotonin receptors that trigger nausea, vagal overstimulation & sensory crashes. For those with Long COVID, POTS, or MCAS, and especially with COMT or serotonin-related gene variants,this can calm a hyperreactive nervous system
wip of an adorable comission I'm working on :)
Sorry for the radio silence, I have developed hyperreactive airways (it's possible it's asthma, but needs testing to know if it's going to be the chronic deal or not). It's very chaotic to pinpoint what has been going on but I'm feeling better now!
Sorry for the radio silence, I have developed hyperreactive airways (it's possible it's asthma, but needs testing to know if it's going to be the chronic deal or not). It's very chaotic to pinpoint what has been going on but I'm feeling better now!
August 1, 2026 at 11:50 AM
wip of an adorable comission I'm working on :)
Sorry for the radio silence, I have developed hyperreactive airways (it's possible it's asthma, but needs testing to know if it's going to be the chronic deal or not). It's very chaotic to pinpoint what has been going on but I'm feeling better now!
Sorry for the radio silence, I have developed hyperreactive airways (it's possible it's asthma, but needs testing to know if it's going to be the chronic deal or not). It's very chaotic to pinpoint what has been going on but I'm feeling better now!
Huda's logic is illogical. And Chris has checked out. "I don't have any thoughts."
It's clear that Huda has a deep history of trauma and she's stuck in a very hyperreactive place. She needs to feel safe within herself before she can be in a relationship with ANYONE. #LoveIslanduSA
It's clear that Huda has a deep history of trauma and she's stuck in a very hyperreactive place. She needs to feel safe within herself before she can be in a relationship with ANYONE. #LoveIslanduSA
July 11, 2025 at 12:50 AM
Huda's logic is illogical. And Chris has checked out. "I don't have any thoughts."
It's clear that Huda has a deep history of trauma and she's stuck in a very hyperreactive place. She needs to feel safe within herself before she can be in a relationship with ANYONE. #LoveIslanduSA
It's clear that Huda has a deep history of trauma and she's stuck in a very hyperreactive place. She needs to feel safe within herself before she can be in a relationship with ANYONE. #LoveIslanduSA
From my experience, she doesn't have to talk about it. It's the way she's acting. It's very hyperreactive, and I don't think it's because she's an asshole. Also, if you have it that easy, you don't have to talk about it as much as she has. Of course, I could be wrong. Either way, she could use help
February 6, 2025 at 4:15 AM
From my experience, she doesn't have to talk about it. It's the way she's acting. It's very hyperreactive, and I don't think it's because she's an asshole. Also, if you have it that easy, you don't have to talk about it as much as she has. Of course, I could be wrong. Either way, she could use help
-Chronic low-grade peripheral inflammation triggers the activation of microglia (the brain's resident immune cells). These cells can become "primed" or hyperreactive, leading to an exaggerated release of central cytokines that causes persistent neuroinflammation.
March 15, 2026 at 7:20 AM
-Chronic low-grade peripheral inflammation triggers the activation of microglia (the brain's resident immune cells). These cells can become "primed" or hyperreactive, leading to an exaggerated release of central cytokines that causes persistent neuroinflammation.
There of BclxLtg-A20wt/− B cells and/or that A20-haploinsufficient BclxLtg B cells are better at generating and/or receiving T cell help. @cellpress.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis
Aberrant immune signal strength in B cells is associated with autoimmune diseases and lymphoma. Diehl et al. show that hyperreactive B cells trigger cytotoxic T cell-mediated elimination. Less reactive B cells escape this tolerance mechanism, revealing a narrow reactivity window for the emergence of autoimmunity.
www.cell.com
December 29, 2024 at 12:48 PM
There of BclxLtg-A20wt/− B cells and/or that A20-haploinsufficient BclxLtg B cells are better at generating and/or receiving T cell help. @cellpress.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
🧪 Hyperreactive B cells induce cytotoxic T cells and stem-like Tpex cells
🧪 Lack of T cells reveals B cell-intrinsic lymphoproliferative and oncogenic potentials
results implied that either T cells restrain the autoreactivity of BclxLtg-A20−/− B cells more than
🧪 Lack of T cells reveals B cell-intrinsic lymphoproliferative and oncogenic potentials
results implied that either T cells restrain the autoreactivity of BclxLtg-A20−/− B cells more than
December 29, 2024 at 12:46 PM
🧪 Hyperreactive B cells induce cytotoxic T cells and stem-like Tpex cells
🧪 Lack of T cells reveals B cell-intrinsic lymphoproliferative and oncogenic potentials
results implied that either T cells restrain the autoreactivity of BclxLtg-A20−/− B cells more than
🧪 Lack of T cells reveals B cell-intrinsic lymphoproliferative and oncogenic potentials
results implied that either T cells restrain the autoreactivity of BclxLtg-A20−/− B cells more than
This steadily increases the likelihood of dx esp when somatic mutations & germline variants affect the same gene or pathway.
🧪 Mildly hyperreactive B cells (B-A20+/−) drive lethal F sex-biased autoimmunity
🧪 Strong hyperreactivity (B-A20−/− with BAFF, BCLxL, or NIK gain) causes mild disorders
🧪 Mildly hyperreactive B cells (B-A20+/−) drive lethal F sex-biased autoimmunity
🧪 Strong hyperreactivity (B-A20−/− with BAFF, BCLxL, or NIK gain) causes mild disorders
December 29, 2024 at 12:44 PM
This steadily increases the likelihood of dx esp when somatic mutations & germline variants affect the same gene or pathway.
🧪 Mildly hyperreactive B cells (B-A20+/−) drive lethal F sex-biased autoimmunity
🧪 Strong hyperreactivity (B-A20−/− with BAFF, BCLxL, or NIK gain) causes mild disorders
🧪 Mildly hyperreactive B cells (B-A20+/−) drive lethal F sex-biased autoimmunity
🧪 Strong hyperreactivity (B-A20−/− with BAFF, BCLxL, or NIK gain) causes mild disorders
Super duper nauseous today. I cannot wait for my Cosentyx to get here tomorrow.
I hate having a psycho hyperreactive immune system. It thinks my internal stuffs are the enemy. I assure you, Mr. HLA-B27 gene, I am not your enemy.
I hate having a psycho hyperreactive immune system. It thinks my internal stuffs are the enemy. I assure you, Mr. HLA-B27 gene, I am not your enemy.
two drag queens are having a conversation and one of them is asking the other if she has do you have
ALT: two drag queens are having a conversation and one of them is asking the other if she has do you have
media.tenor.com
October 1, 2025 at 8:17 PM
Super duper nauseous today. I cannot wait for my Cosentyx to get here tomorrow.
I hate having a psycho hyperreactive immune system. It thinks my internal stuffs are the enemy. I assure you, Mr. HLA-B27 gene, I am not your enemy.
I hate having a psycho hyperreactive immune system. It thinks my internal stuffs are the enemy. I assure you, Mr. HLA-B27 gene, I am not your enemy.