"These findings identify inflammation as the major driver of post-COVID neurological sequelae and suggest early immunomodulation as an effective intervention."
From #LongCovid experimental model w/ combined treatment of antivirals + anti-inflammatory drugs
www.pnas.org/doi/10.1073/...
From #LongCovid experimental model w/ combined treatment of antivirals + anti-inflammatory drugs
www.pnas.org/doi/10.1073/...
January 8, 2026 at 1:28 AM
"These findings identify inflammation as the major driver of post-COVID neurological sequelae and suggest early immunomodulation as an effective intervention."
From #LongCovid experimental model w/ combined treatment of antivirals + anti-inflammatory drugs
www.pnas.org/doi/10.1073/...
From #LongCovid experimental model w/ combined treatment of antivirals + anti-inflammatory drugs
www.pnas.org/doi/10.1073/...
Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality www.science.org/doi/10.1126/...
Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality
Preventing measles prevents immune memory damage and nonspecifically safeguards against many childhood infections.
www.science.org
March 4, 2025 at 4:14 PM
Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality www.science.org/doi/10.1126/...
More adjunctive immunomodulation for an infectious disease!
Here it's dupilumab (IL-4/13 blockade) in coccidioidomycosis.
Case series only, but not overtly harmful and maybe even helpful.
#IDSky #immunosky
academic.oup.com/cid/advance-...
Here it's dupilumab (IL-4/13 blockade) in coccidioidomycosis.
Case series only, but not overtly harmful and maybe even helpful.
#IDSky #immunosky
academic.oup.com/cid/advance-...
Immunomodulation in the Treatment of Disseminated Coccidioidomycosis
Severe coccidioidomycosis carries high mortality despite antifungals. We treated 18 refractory cases with immune modulation, including augmentation of Type
academic.oup.com
March 5, 2026 at 7:38 AM
More adjunctive immunomodulation for an infectious disease!
Here it's dupilumab (IL-4/13 blockade) in coccidioidomycosis.
Case series only, but not overtly harmful and maybe even helpful.
#IDSky #immunosky
academic.oup.com/cid/advance-...
Here it's dupilumab (IL-4/13 blockade) in coccidioidomycosis.
Case series only, but not overtly harmful and maybe even helpful.
#IDSky #immunosky
academic.oup.com/cid/advance-...
Congratulations to Jana Ordon and all coauthors!!! Our new study is published in @natureplants.bsky.social
"Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota" (0/n)
rdcu.be/eauzt
"Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota" (0/n)
rdcu.be/eauzt
Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota
Nature Plants - The authors show that immunosuppression is highly conserved in the bacterial order Xanthomonadales. This feature, which preceded their specialization as host-adapted pathogens,...
rdcu.be
February 20, 2025 at 9:44 AM
Congratulations to Jana Ordon and all coauthors!!! Our new study is published in @natureplants.bsky.social
"Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota" (0/n)
rdcu.be/eauzt
"Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota" (0/n)
rdcu.be/eauzt
Bacterial Superantigen-Mediated Toxic Shock: Hyperinflammatory Trajectories and Extracorporeal Immunomodulation in Streptococcal Toxic Shock Syndrome
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
September 26, 2026 at 1:14 PM
Bacterial Superantigen-Mediated Toxic Shock: Hyperinflammatory Trajectories and Extracorporeal Immunomodulation in Streptococcal Toxic Shock Syndrome
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
News Release 11-Feb-2026
Vanderbilt Health to lead expanded multisite study of immunomodulation in long COVID
www.eurekalert.org/news-release...
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary symptoms of #LongCOVID (REVERSE-LC)
Vanderbilt Health to lead expanded multisite study of immunomodulation in long COVID
www.eurekalert.org/news-release...
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary symptoms of #LongCOVID (REVERSE-LC)
February 13, 2026 at 7:25 PM
News Release 11-Feb-2026
Vanderbilt Health to lead expanded multisite study of immunomodulation in long COVID
www.eurekalert.org/news-release...
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary symptoms of #LongCOVID (REVERSE-LC)
Vanderbilt Health to lead expanded multisite study of immunomodulation in long COVID
www.eurekalert.org/news-release...
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary symptoms of #LongCOVID (REVERSE-LC)
I'm thrilled to announce that I'm launching the Biomaterial Research for Immunomodulation, Drug delivery, and Genetic Engineering (BRIDGE) lab in January 2026 as an Assistant Professor in the Department of Bioengineering at the University of Oregon! @uoknightcampus.bsky.social
April 7, 2025 at 2:41 PM
I'm thrilled to announce that I'm launching the Biomaterial Research for Immunomodulation, Drug delivery, and Genetic Engineering (BRIDGE) lab in January 2026 as an Assistant Professor in the Department of Bioengineering at the University of Oregon! @uoknightcampus.bsky.social
protest and we remind these wannabe autocrats that this is a nation of laws and democratic process. In the meantime, on the clinical and scientific side of #LongCOVID and complex chronic illness, we keep learning new tricks and running new trials: immunomodulation drugs, combo 5/
March 15, 2025 at 9:56 PM
protest and we remind these wannabe autocrats that this is a nation of laws and democratic process. In the meantime, on the clinical and scientific side of #LongCOVID and complex chronic illness, we keep learning new tricks and running new trials: immunomodulation drugs, combo 5/
7/5/24, UniteToFight: Prof. E. Wesley Ely: Immunomodulation in Long Covid (Day 1, Block 4)
"...we were able to receive a fourth percentile score from NIH that will now fund the trial...the 550 patients enrolled in this trial will be reimbursed.."
www.youtube.com/watch?v=H9jj...
"...we were able to receive a fourth percentile score from NIH that will now fund the trial...the 550 patients enrolled in this trial will be reimbursed.."
www.youtube.com/watch?v=H9jj...
Prof. E. Wesley Ely: Immunomodulation in Long Covid (Day 1, Block 4)
YouTube video by UniteToFight
www.youtube.com
November 17, 2024 at 12:36 AM
7/5/24, UniteToFight: Prof. E. Wesley Ely: Immunomodulation in Long Covid (Day 1, Block 4)
"...we were able to receive a fourth percentile score from NIH that will now fund the trial...the 550 patients enrolled in this trial will be reimbursed.."
www.youtube.com/watch?v=H9jj...
"...we were able to receive a fourth percentile score from NIH that will now fund the trial...the 550 patients enrolled in this trial will be reimbursed.."
www.youtube.com/watch?v=H9jj...
Immunomodulation in the Treatment of Disseminated Coccidioidomycosis
✅ Just Accepted
🔗 https://bit.ly/4t2DY0E
✅ Just Accepted
🔗 https://bit.ly/4t2DY0E
March 22, 2026 at 12:55 PM
Immunomodulation in the Treatment of Disseminated Coccidioidomycosis
✅ Just Accepted
🔗 https://bit.ly/4t2DY0E
✅ Just Accepted
🔗 https://bit.ly/4t2DY0E
Inducing bacterial calcification for systematic treatment and immunomodulation against methicillin-resistant Staphylococcus aureus go.nature.com/3UaGItg
Inducing bacterial calcification for systematic treatment and immunomodulation against methicillin-resistant Staphylococcus aureus - Nature Biotechnology
An antibody–polysialic acid conjugate induces calcification on the surface of methicillin-resistant Staphylococcus aureus and boosts immunogenicity in mice.
go.nature.com
July 15, 2025 at 3:39 PM
Inducing bacterial calcification for systematic treatment and immunomodulation against methicillin-resistant Staphylococcus aureus go.nature.com/3UaGItg
Adjunctive immunomodulation to improve outcomes from a respiratory infection! 👀 👇
#IDSky #mycoplasma
#IDSky #mycoplasma
Adjunctive corticosteroids may have a role in M. pneumoniae CAP 🫁- In a multicentre RCT among 70 hospitalised adults, oral betamethasone significantly shortened time to resolution of hypoxaemia vs standard care. Presented at #ESCMIDGlobal2026
👇
www.thelancet.com/journals/lan...
👇
www.thelancet.com/journals/lan...
April 22, 2026 at 7:12 AM
Adjunctive immunomodulation to improve outcomes from a respiratory infection! 👀 👇
#IDSky #mycoplasma
#IDSky #mycoplasma
Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota www.nature.com/articles/s41...
Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota - Nature Plants
The authors show that immunosuppression is highly conserved in the bacterial order Xanthomonadales. This feature, which preceded their specialization as host-adapted pathogens, probably contributes to...
www.nature.com
February 19, 2025 at 1:33 PM
Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota www.nature.com/articles/s41...
#UniteToFight2024
Prof. Dr. Wes Ely's talk on immunomodulation in #LongCovid and the REVERSE-LC clinical trial is now available with 🇬🇧 subtitles: youtu.be/H9jj7Hs_FJU @weselymd.bsky.social
You can use YouTube's auto-translation for subtitles in many other languages.
Prof. Dr. Wes Ely's talk on immunomodulation in #LongCovid and the REVERSE-LC clinical trial is now available with 🇬🇧 subtitles: youtu.be/H9jj7Hs_FJU @weselymd.bsky.social
You can use YouTube's auto-translation for subtitles in many other languages.
Prof. E. Wesley Ely: Immunomodulation in Long Covid (Day 1, Block 4)
YouTube video by UniteToFight
youtu.be
November 21, 2024 at 1:09 PM
#UniteToFight2024
Prof. Dr. Wes Ely's talk on immunomodulation in #LongCovid and the REVERSE-LC clinical trial is now available with 🇬🇧 subtitles: youtu.be/H9jj7Hs_FJU @weselymd.bsky.social
You can use YouTube's auto-translation for subtitles in many other languages.
Prof. Dr. Wes Ely's talk on immunomodulation in #LongCovid and the REVERSE-LC clinical trial is now available with 🇬🇧 subtitles: youtu.be/H9jj7Hs_FJU @weselymd.bsky.social
You can use YouTube's auto-translation for subtitles in many other languages.
Nasal Spray Immunomodulation: A Novel Approach to Treating TBI
www.emjreviews.com/neurology/ne...
www.emjreviews.com/neurology/ne...
Nasal Spray Immunomodulation: A Novel Approach to Treating TBI
Nasal anti-CD3 spray reduces traumatic brain injury in mice, a potential breakthrough for TBI treatment. Read now.
www.emjreviews.com
March 19, 2025 at 10:54 AM
Nasal Spray Immunomodulation: A Novel Approach to Treating TBI
www.emjreviews.com/neurology/ne...
www.emjreviews.com/neurology/ne...
Fungal extracellular vesicles mediate conserved cross-species communication and immunomodulation
-in #mBio
journals.asm.org/doi/10.1128/...
-in #mBio
journals.asm.org/doi/10.1128/...
Fungal extracellular vesicles mediate conserved cross-species communication and immunomodulation | mBio
Currently, no vaccines exist to prevent fungal infections, underscoring the need for
new therapies. As fungal diseases increase globally, understanding fungal biology
is essential to identifying treat...
journals.asm.org
January 31, 2026 at 6:24 PM
Fungal extracellular vesicles mediate conserved cross-species communication and immunomodulation
-in #mBio
journals.asm.org/doi/10.1128/...
-in #mBio
journals.asm.org/doi/10.1128/...
#CovidIsNotOver
The Intrinsic Severity of SARS Cov 2
It's all about immunomodulation
AJ LEONARDI
One of the most serious errors in assessment of SARS Cov 2 came down to misappraisals of how it causes illness.
The Intrinsic Severity of SARS Cov 2
It's all about immunomodulation
AJ LEONARDI
One of the most serious errors in assessment of SARS Cov 2 came down to misappraisals of how it causes illness.
The Intrinsic Severity of SARS Cov 2
It's all about immunomodulation
www.easychair.info
February 8, 2024 at 9:02 PM
#CovidIsNotOver
The Intrinsic Severity of SARS Cov 2
It's all about immunomodulation
AJ LEONARDI
One of the most serious errors in assessment of SARS Cov 2 came down to misappraisals of how it causes illness.
The Intrinsic Severity of SARS Cov 2
It's all about immunomodulation
AJ LEONARDI
One of the most serious errors in assessment of SARS Cov 2 came down to misappraisals of how it causes illness.
Has anyone seen any updates on the REVERSE LC trial evaluating Baricitinib in pwLC? Thanks!
news.vumc.org/2024/02/22/n...
news.vumc.org/2024/02/22/n...
NIH-funded trial to determine if immunomodulation can improve brain and cardiovascular dysfunction in Long COVID
Vanderbilt University Medical Center is working with scientists around the U.S. to launch the first Phase III, multicenter, placebo-controlled trial to determine the effect of immunomodulation on Long...
news.vumc.org
January 5, 2025 at 10:48 PM
Has anyone seen any updates on the REVERSE LC trial evaluating Baricitinib in pwLC? Thanks!
news.vumc.org/2024/02/22/n...
news.vumc.org/2024/02/22/n...
Donor bone marrow combined with recipient regulatory T cells induces chimerism and immunomodulation without irradiation in kidney transplantation
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
June 17, 2026 at 11:01 PM
Donor bone marrow combined with recipient regulatory T cells induces chimerism and immunomodulation without irradiation in kidney transplantation
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Check out our latest issue in The Innovation Reviews! Volume 1, Issue 1 is now online!
www.the-innovation.org/the-innovati...
#RocketRecovery #lunardrilling #immunomodulation #boneregeneration #ExtremeHeat #poweroutage #ammoniaexposure #FoundationModels #computationalneuroethology
www.the-innovation.org/the-innovati...
#RocketRecovery #lunardrilling #immunomodulation #boneregeneration #ExtremeHeat #poweroutage #ammoniaexposure #FoundationModels #computationalneuroethology
September 29, 2026 at 3:26 AM
Check out our latest issue in The Innovation Reviews! Volume 1, Issue 1 is now online!
www.the-innovation.org/the-innovati...
#RocketRecovery #lunardrilling #immunomodulation #boneregeneration #ExtremeHeat #poweroutage #ammoniaexposure #FoundationModels #computationalneuroethology
www.the-innovation.org/the-innovati...
#RocketRecovery #lunardrilling #immunomodulation #boneregeneration #ExtremeHeat #poweroutage #ammoniaexposure #FoundationModels #computationalneuroethology
Excited to share our new paper: ‘Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation’ led by Callum Nattress in collab. with Jonathan Fisher lab (1/13)
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
October 14, 2025 at 5:07 PM
Excited to share our new paper: ‘Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation’ led by Callum Nattress in collab. with Jonathan Fisher lab (1/13)
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Our new review is out! We examine the JAK/STAT pathway as a therapeutic target in chronic viral infections, including HIV, hepatitis viruses, SARS-CoV-2 & herpesviruses and the balance between reducing harmful inflammation while preserving antiviral immunity.
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
Frontiers | Targeting the JAK/STAT pathway in chronic viral infections: opportunities and challenges for immunomodulation
The discovery of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway as a key regulator of immune function and inflammation ...
www.frontiersin.org
August 21, 2026 at 11:20 AM
Our new review is out! We examine the JAK/STAT pathway as a therapeutic target in chronic viral infections, including HIV, hepatitis viruses, SARS-CoV-2 & herpesviruses and the balance between reducing harmful inflammation while preserving antiviral immunity.
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
12 weeks of kimchi dietary intervention enhanced antigen presentation and remodeled CD4+ T cells without broad systemic activation, providing single-cell evidence of kimchi-induced dietary immunomodulation in humans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 18, 2025 at 5:48 PM
12 weeks of kimchi dietary intervention enhanced antigen presentation and remodeled CD4+ T cells without broad systemic activation, providing single-cell evidence of kimchi-induced dietary immunomodulation in humans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New Spotlight alert! The bite that binds: #mosquito #saliva mediates #TLR2-driven #flavivirus infection, authored by Laura Willen & Fabiano Oliveira, highlighting Y. Matsuura, T. Okamoto & colleagues’ @cp-cellreports.bsky.social article. #immunomodulation
authors.elsevier.com/a/1llns5Eb1x...
authors.elsevier.com/a/1llns5Eb1x...
September 15, 2025 at 11:50 AM
New Spotlight alert! The bite that binds: #mosquito #saliva mediates #TLR2-driven #flavivirus infection, authored by Laura Willen & Fabiano Oliveira, highlighting Y. Matsuura, T. Okamoto & colleagues’ @cp-cellreports.bsky.social article. #immunomodulation
authors.elsevier.com/a/1llns5Eb1x...
authors.elsevier.com/a/1llns5Eb1x...
two years after the thread was written but tangentially I'm starting to wonder how much of this is from the act of pregnancy requiring some level of immunomodulation of the pathways that affect these autoimmune illnesses to not just reject the fetus like a transplanted organ
July 6, 2025 at 6:09 PM
two years after the thread was written but tangentially I'm starting to wonder how much of this is from the act of pregnancy requiring some level of immunomodulation of the pathways that affect these autoimmune illnesses to not just reject the fetus like a transplanted organ