#pexophagy
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sigtrans-sttt.bsky.social
USP2 inhibition destabilizes STUB1 to suppress pathological #Pexophagy in PEX1-deficient models, restoring peroxisome abundance while mitigating metabolic abnormalities, neuro-axonal pathology, and motor dysfunction.

#STTT #OpenAccess: doi.org/10.1038/s413...
#Neurobiology #MolecularMedicine
Inhibition of USP2 suppresses pathological pexophagy and rescues PEX1-deficient peroxisome biogenesis disorder
September 27, 2026 at 6:45 AM
drbaronefg.bsky.social
🧠 Why does this matter?
Peroxisomes regulate lipid metabolism & ROS detox, and their dysfunction is linked to neurodegeneration & Zellweger spectrum disorders.

Understanding in vivo pexophagy mechanisms provides new insights into organelle homeostasis & disease.

#Autophagy #Pexophagy #Drosophila
February 6, 2025 at 7:26 PM
drbaronefg.bsky.social
📢 New Publication!
Excited to share my latest research in Open Biology! @royalsocietypublishing.org

We developed live Drosophila models to track whole organism and neuronal pexophagy - the selective autophagy of peroxisomes - in vivo.

📄 Full paper: royalsocietypublishing.org/doi/10.1098/...

🧵👇
February 6, 2025 at 7:26 PM
cbgpmadrid.bsky.social
#ResearchCBGP - Cadmium induces ROS-dependent pexophagy in Arabidopsis leaves

🇪🇸 - …
🇬🇧 - …

#somosUPM

cbgp.upm.es/index.php/es/?… cbgp.upm.es/index.php/en/?…
November 25, 2024 at 11:29 AM
flymuscles.bsky.social
Tools to study pexophagy in #Drosophila
Whole organism and tissue-specific analysis of pexophagy in Drosophila | Open Biology
Peroxisomes are essential organelles involved in critical metabolic processes in animals such as fatty acid oxidation, ether phospholipid production and reactive oxygen species detoxification. We have...
royalsocietypublishing.org
February 6, 2025 at 3:49 AM
lozanzi.bsky.social
#InterferonFriendOrFoe?! Joe Sun, Xiaoqin Wei &co show @science.org that lung macrophage peroxisomes instruct repair programs after virus infections favoring AT2 cell renewal & recovery! IFNgamma drives pexophagy, increasing mitochondrial ROS & activating inflammasomes driving KRT8 cells & fibrosis!
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae
Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...
www.science.org
March 6, 2025 at 7:48 PM
rridrobot.bsky.social
RRID:AB_2534084 from @thermofishersci.bsky.social was used by authors in their paper. We value the author's support of reproducibility. #methodsmatter #STMpublishing #STMpublishing
PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce pexophagy
doi.org
October 24, 2025 at 7:00 AM
rridrobot.bsky.social
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #reproducibility #RRID #reproducibility
Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy
doi.org
October 4, 2025 at 7:00 AM
rridrobot.bsky.social
The authors included RRIDs in their Open Biology paper! RRIDs improve reproducibility in scientific research. #accelerateopenscience #methodsmatter #reproducibility
Whole organism and tissue-specific analysis of pexophagy in Drosophila
doi.org
August 12, 2025 at 7:01 AM
josephwgordon.bsky.social
rupress.org/jcb/article-...
In vivo mapping of peroxisome dynamics and pexophagy using PO-TRG and CA-PO-TRG reporter mice
Xiong et al. present new mouse models for visualizing the selective degradation of peroxisomes (pexophagy) in living animals. The PO-TRG model reveals dist
rupress.org
February 3, 2026 at 4:06 PM
josephwgordon.bsky.social
rupress.org/jcb/article/...
PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce pexophagy | Journal of Cell Biology | Rockefeller University Press
This study uncovers and defines the peroxisomal membrane protein PEX14 as a key player in optineurin-driven pexophagy, advancing our mechanistic understand
rupress.org
November 4, 2025 at 5:02 PM
vinayshukla.bsky.social
ARP2/3 complex associates with peroxisomes to participate in pexophagy in plants
www.nature.com/articles/s41...
#plantscience
October 16, 2023 at 5:05 PM
haoyin.bsky.social
Visualize global & tissue-specific #Pexophagy in #Drosophila 🤠
Pexo-QC
Pexo-Keima
SKL signal for translocation to #Peroxisome matrix

@drbaronefg.bsky.social l #OpenBiology 2025
royalsocietypublishing.org/doi/10.1098/...

Read the excellent🧵from 1st auth Dr. Barone 👇
bsky.app/profile/drba...
February 7, 2025 at 12:53 PM
angegross.bsky.social
As my #NewPI journey is starting I re-share my latest publication: 👉We uncovered a #phosphate #metabolite sensor, binding and regulating the #autophagy Atg1/ULK1 initiation complex to regulate #pexophagy in response to
phosphate availability. nature.com/articles/s41556-024-01348-4
A metabolite sensor subunit of the Atg1/ULK complex regulates selective autophagy - Nature Cell Biology
Gross et al. show that Atg13 and Atg17 are dispensable for pexophagy during phosphate starvation in yeast. Instead, the metabolite sensor Pho81 binds the Atg1 kinase complex via Atg11 to promote Atg11...
nature.com
June 10, 2025 at 2:40 PM
biorxiv-cellbio.bsky.social
The p97-UBXD8 complex maintains peroxisome abundance by suppressing pexophagy https://www.biorxiv.org/content/10.1101/2024.09.24.614749v1
The p97-UBXD8 complex maintains peroxisome abundance by suppressing pexophagy https://www.biorxiv.org/content/10.1101/2024.09.24.614749v1
Peroxisomes are vital organelles involved in key metabolic functions in eukaryotic cells. Their sign
www.biorxiv.org
September 27, 2024 at 2:30 PM
biorxiv-cellbio.bsky.social
PEX14 acts as the interface linking optineurin to cell type-selective pexophagy https://www.biorxiv.org/content/10.1101/2024.05.31.596776v1
PEX14 acts as the interface linking optineurin to cell type-selective pexophagy https://www.biorxiv.org/content/10.1101/2024.05.31.596776v1
Peroxisome degradation, known as pexophagy, is essential for eliminating surplus and dysfunctional p
www.biorxiv.org
May 31, 2024 at 1:30 PM
biorxiv-cellbio.bsky.social
Whole organism and tissue specific analysis of pexophagy in Drosophila https://www.biorxiv.org/content/10.1101/2023.11.17.567516v1
Whole organism and tissue specific analysis of pexophagy in Drosophila https://www.biorxiv.org/content/10.1101/2023.11.17.567516v1
Peroxisomes are essential organelles involved in critical metabolic processes in animals such as fat
www.biorxiv.org
November 17, 2023 at 9:30 PM
natsansor.bsky.social
Paper alert! 🚀very happy to have been involved in this collaboration @livuni-ismib.bsky.social where we developed pexophagy reporters for use in Drosophila research. Great work from @drbaronefg.bsky.social‬

royalsocietypublishing.org/doi/10.1098/rs
February 7, 2025 at 6:27 PM
asapresearch.parkinsonsroadmap.org
Make sure to join us TODAY for the newest installment of the Mito911 webinar series. Michael Clague from the University of Liverpool will be discussing the integration of ubiquitin-dependent mitophagy and pexophagy pathways at 11 AM ET. 🧪

Reserve your spot: us06web.zoom.us/webinar/regi...
September 10, 2024 at 4:38 PM
pranea.bsky.social
Whole organism and tissue-specific analysis of pexophagy in Drosophila royalsocietypublishing.org/doi/full/10....
Whole organism and tissue-specific analysis of pexophagy in Drosophila | Open Biology
Peroxisomes are essential organelles involved in critical metabolic processes in animals such as fatty acid oxidation, ether phospholipid production and reactive oxygen species detoxification. We have generated transgenic Drosophila melanogaster models ...
royalsocietypublishing.org
February 5, 2025 at 9:34 AM
alt-text.bsky.social
Alt text retrieved
ROS AM IFNs 4-PBA 808 8 Peroxisomes Pexophagy IL-1b AT2 KRT8high AT2 renewal Mitochondria Inflammasome Chronic sequelae (PASC) Complete recovery Model of peroxisome function in macrophage-mediated alveolar regeneration after viral injury. Peroxisome activity in alveolar macrophages (AM) is essential for AT2 self-renewal and alveolar repair following viral infection. Dysfunction of macrophage peroxisomes causes excessive inflammasome activation and promotes dysplastic KRT8 transitional cell accumulation, resulting in chronic tissue sequelae post acute infection. 4-PBA treatment facilitates peroxisome biogenesis in macrophages to enhance alveolar regeneration after respiratory viral infection [figure created using BioRender.com.]
March 7, 2025 at 10:00 PM
biorxivpreprint.bsky.social
The p97-UBXD8 complex maintains peroxisome abundance by suppressing pexophagy https://www.biorxiv.org/content/10.1101/2024.09.24.614749v1
The p97-UBXD8 complex maintains peroxisome abundance by suppressing pexophagy https://www.biorxiv.org/content/10.1101/2024.09.24.614749v1
Peroxisomes are vital organelles involved in key metabolic functions in eukaryotic cells. Their sign
www.biorxiv.org
September 27, 2024 at 2:30 PM
biorxivpreprint.bsky.social
PEX14 acts as the interface linking optineurin to cell type-selective pexophagy https://www.biorxiv.org/content/10.1101/2024.05.31.596776v1
PEX14 acts as the interface linking optineurin to cell type-selective pexophagy https://www.biorxiv.org/content/10.1101/2024.05.31.596776v1
Peroxisome degradation, known as pexophagy, is essential for eliminating surplus and dysfunctional p
www.biorxiv.org
May 31, 2024 at 1:30 PM
biorxivpreprint.bsky.social
Whole organism and tissue specific analysis of pexophagy in Drosophila https://www.biorxiv.org/content/10.1101/2023.11.17.567516v1
Whole organism and tissue specific analysis of pexophagy in Drosophila https://www.biorxiv.org/content/10.1101/2023.11.17.567516v1
Peroxisomes are essential organelles involved in critical metabolic processes in animals such as fat
www.biorxiv.org
November 17, 2023 at 9:30 PM
cddpress.bsky.social
“PINK1 and STUB1 pathway orchestrates peroxisomal selective autophagy by PEX13 depletion”

Read this fascinating work highlighting how the ATM-PINK1-STUB1-ABCD3-SQSTM1 axis modulates pexophagy and peroxisomal quality control ⤵️
www.nature.com/articles/s41...
PINK1 and STUB1 pathway orchestrates peroxisomal selective autophagy by PEX13 depletion - Cell Death & Differentiation
Cell Death & Differentiation - PINK1 and STUB1 pathway orchestrates peroxisomal selective autophagy by PEX13 depletion
www.nature.com
April 8, 2026 at 8:33 AM