#pexophagy
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sigtrans-sttt.bsky.social
USP2 inhibition destabilizes STUB1 to suppress pathological #Pexophagy in PEX1-deficient models, restoring peroxisome abundance while mitigating metabolic abnormalities, neuro-axonal pathology, and motor dysfunction.

#STTT #OpenAccess: doi.org/10.1038/s413...
#Neurobiology #MolecularMedicine
Inhibition of USP2 suppresses pathological pexophagy and rescues PEX1-deficient peroxisome biogenesis disorder
September 27, 2026 at 6:45 AM
cddpress.bsky.social
“PINK1 and STUB1 pathway orchestrates peroxisomal selective autophagy by PEX13 depletion”

Read this fascinating work highlighting how the ATM-PINK1-STUB1-ABCD3-SQSTM1 axis modulates pexophagy and peroxisomal quality control ⤵️
www.nature.com/articles/s41...
PINK1 and STUB1 pathway orchestrates peroxisomal selective autophagy by PEX13 depletion - Cell Death & Differentiation
Cell Death & Differentiation - PINK1 and STUB1 pathway orchestrates peroxisomal selective autophagy by PEX13 depletion
www.nature.com
April 8, 2026 at 8:33 AM
jcb.org
Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab #GTPases, #mitophagy, and #pexophagy. 👉 rupress.org/jcb/collecti...
#GRC
March 17, 2026 at 3:12 PM
jcb.org
The p97 ATPase and its adaptor UBXD8 maintain #peroxisome pools by preventing #pexophagy. From Iris Montes, Malavika Raman @maliramanlab.bsky.social and colleagues: rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC
March 15, 2026 at 1:29 PM
jcb.org
PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce #pexophagy. From Hongli Li, Marc Fransen and colleagues (KU Leuven): rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC
March 14, 2026 at 2:26 PM
jcb.org
To accompany the #Autophagy #GRC, explore our recent autophagy special collection, incl. the role of ATG 9 in autophagosome formation & the regulation of lysosomal function, and the regulation of selective autophagy, incl. #mitophagy and #pexophagy 👉 rupress.org/jcb/collecti...
March 13, 2026 at 2:15 PM
jcb.org
Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab GTPases, #mitophagy, and #pexophagy. 👉 rupress.org/jcb/collecti...
February 9, 2026 at 2:30 PM
jcb.org
The p97 ATPase and its adaptor UBXD8 maintain #peroxisome pools by preventing #pexophagy. From Iris Montes, Malavika Raman @maliramanlab.bsky.social and colleagues: rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#KSAutophagy26
February 3, 2026 at 4:15 PM
josephwgordon.bsky.social
rupress.org/jcb/article-...
In vivo mapping of peroxisome dynamics and pexophagy using PO-TRG and CA-PO-TRG reporter mice
Xiong et al. present new mouse models for visualizing the selective degradation of peroxisomes (pexophagy) in living animals. The PO-TRG model reveals dist
rupress.org
February 3, 2026 at 4:06 PM
jcb.org
PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce #pexophagy. From Hongli Li, Marc Fransen and colleagues (KU Leuven): rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#KSAutophagy26
January 30, 2026 at 4:15 PM
jcb.org
Explore recent advances in #autophagy research, incl. the role of ATG 9 in autophagosome formation & the regulation of lysosomal function, and the regulation of selective autophagy, incl. #mitophagy and #pexophagy 👉 rupress.org/jcb/collecti...
@keystonesymposia.bsky.social
#KSAutophagy26
January 29, 2026 at 3:15 PM
jcb.org
#Pexophagy meets #physiology. In this Spotlight, Michael Clague @liverpooluni.bsky.social discusses recent work by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor pexophagy dynamics in vivo. rupress.org/jcb/article/...

#ProteinHomeostasis #Peroxisomes #Autophagy
January 13, 2026 at 2:30 PM
jcb.org
In vivo mapping of #peroxisome dynamics and #pexophagy using PO-TRG and CA-PO-TRG reporter mice. New study from Yue Xiong, Weihua Gao, Zelai Wu, Xiukui Gao, Qiming Sun (Zhejiang University) and colleagues: rupress.org/jcb/article/...

#Organelles #Technology
January 12, 2026 at 4:15 PM
jcb.org
Spotlight: Michael J. Clague @liverpooluni.bsky.social highlights recent work by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor #pexophagy dynamics in vivo. rupress.org/jcb/article/...

#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
January 6, 2026 at 6:01 PM
rupress.org
Spotlight: Michael J. Clague @liverpooluni.bsky.social highlights recent @jcb.org study by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor #pexophagy dynamics in vivo. rupress.org/jcb/article/...

#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
January 6, 2026 at 6:00 PM
jcb.org
Xiong, Gao, Wu et al. present new mouse models for visualizing the selective degradation of #peroxisomes (#pexophagy) in living animals. rupress.org/jcb/article/...
January 5, 2026 at 9:00 PM
cellclub.bsky.social
rupress.org/jcb/article/...
In vivo mapping of peroxisome dynamics and pexophagy using PO-TRG and CA-PO-TRG reporter mice
Xiong et al. present new mouse models for visualizing the selective degradation of peroxisomes (pexophagy) in living animals. The PO-TRG model reveals dist
rupress.org
December 28, 2025 at 8:26 AM
josephwgordon.bsky.social
rupress.org/jcb/article/...
PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce pexophagy | Journal of Cell Biology | Rockefeller University Press
This study uncovers and defines the peroxisomal membrane protein PEX14 as a key player in optineurin-driven pexophagy, advancing our mechanistic understand
rupress.org
November 4, 2025 at 5:02 PM
rridrobot.bsky.social
RRID:AB_2534084 from @thermofishersci.bsky.social was used by authors in their paper. We value the author's support of reproducibility. #methodsmatter #STMpublishing #STMpublishing
PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce pexophagy
doi.org
October 24, 2025 at 7:00 AM
jcb.org
PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce #pexophagy, say Hongli Li, Marc Fransen and colleagues (KU Leuven): rupress.org/jcb/article/...

#Biochemistry #Organelles #Autophagy #Peroxisomes
October 17, 2025 at 1:45 PM
jcb.org
Hongli Li, Marc Fransen et al. identify PEX14 as a key link between optineurin and the autophagic machinery in #pexophagy, the selective degradation of #peroxisomes. This discovery advances our understanding of #peroxisome clearance and disease. rupress.org/jcb/article/...

#Autophagy #Organelles
October 10, 2025 at 4:01 PM
rupress.org
In @jcb.org, Hongli Li, Marc Fransen et al. identify PEX14 as a key link between optineurin and the autophagic machinery in #pexophagy, the selective degradation of #peroxisomes. This discovery advances our understanding of #peroxisome clearance and disease. rupress.org/jcb/article/...

#Autophagy
October 10, 2025 at 4:01 PM
rridrobot.bsky.social
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #reproducibility #RRID #reproducibility
Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy
doi.org
October 4, 2025 at 7:00 AM
rridrobot.bsky.social
The authors included RRIDs in their Open Biology paper! RRIDs improve reproducibility in scientific research. #accelerateopenscience #methodsmatter #reproducibility
Whole organism and tissue-specific analysis of pexophagy in Drosophila
doi.org
August 12, 2025 at 7:01 AM
jcb.org
The p97 ATPase and its adaptor UBXD8 maintain #peroxisome pools by preventing #pexophagy, say Iris Montes, Malavika Raman @maliramanlab.bsky.social @tufts.edu and colleagues: rupress.org/jcb/article/...

@joshilaboratory.bsky.social
#Biochemistry #Organelles
August 5, 2025 at 2:33 PM