New in @theinnovation.bsky.social! A polymerized probucol nanoformulation with neutrophil extracellular vesicle camouflage for cerebral ischemia-reperfusion injury therapy.
This study presents the development of ROS-responsive biomimetic polyprodrug #nanoparticles.
doi.org/10.1016/j.xi...
#medicine
This study presents the development of ROS-responsive biomimetic polyprodrug #nanoparticles.
doi.org/10.1016/j.xi...
#medicine
January 18, 2025 at 4:43 AM
New in @theinnovation.bsky.social! A polymerized probucol nanoformulation with neutrophil extracellular vesicle camouflage for cerebral ischemia-reperfusion injury therapy.
This study presents the development of ROS-responsive biomimetic polyprodrug #nanoparticles.
doi.org/10.1016/j.xi...
#medicine
This study presents the development of ROS-responsive biomimetic polyprodrug #nanoparticles.
doi.org/10.1016/j.xi...
#medicine
Repurposing probucol for prevention of dementia: a nationwide cohort study #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10311061/latest
https://www.researchsquare.com/article/rs-10311061/latest
August 13, 2026 at 10:02 PM
Repurposing probucol for prevention of dementia: a nationwide cohort study #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10311061/latest
https://www.researchsquare.com/article/rs-10311061/latest
July issue now available!
#clinical #pharmacology #anxiety #ethanol #ketamine #arteries #diabete #analgesia #nebivolol #obesity #health #kidney #midazolam #pharmacokinetics #heart #inflammation #probucol #cancer #colorectal #glucagon #cocaine #SFPT
onlinelibrary.wiley.com/toc/14728206...
#clinical #pharmacology #anxiety #ethanol #ketamine #arteries #diabete #analgesia #nebivolol #obesity #health #kidney #midazolam #pharmacokinetics #heart #inflammation #probucol #cancer #colorectal #glucagon #cocaine #SFPT
onlinelibrary.wiley.com/toc/14728206...
onlinelibrary.wiley.com
July 22, 2026 at 2:23 PM
2/3 Mitochondria are like tiny powerhouses in our cells. When they get damaged, it can lead to cell death. But probucol enhances mitophagy, a process that removes these damaged parts, potentially slowing down Parkinson's progression.
February 11, 2025 at 9:35 AM
2/3 Mitochondria are like tiny powerhouses in our cells. When they get damaged, it can lead to cell death. But probucol enhances mitophagy, a process that removes these damaged parts, potentially slowing down Parkinson's progression.
1/3 Imagine a simple pill that could slow down Parkinson's! Researchers found that probucol, a cholesterol drug, can help remove damaged parts of cells called mitochondria. This could mean new hope for millions of people with Parkinson's.
February 11, 2025 at 9:35 AM
1/3 Imagine a simple pill that could slow down Parkinson's! Researchers found that probucol, a cholesterol drug, can help remove damaged parts of cells called mitochondria. This could mean new hope for millions of people with Parkinson's.
Effect of Probucol and Atorvastatin Treatment on the Self‐Care Ability of Acute Cerebral Infarction Patients: A Randomized Clinical Trial Study Br&Beh
Effect of Probucol and Atorvastatin Treatment on the Self‐Care Ability of Acute Cerebral Infarction Patients: A Randomized Clinical Trial Study
Brain and Behavior, Volume 15, Issue 5, May 2025.
dlvr.it
May 30, 2025 at 10:15 AM
Effect of Probucol and Atorvastatin Treatment on the Self‐Care Ability of Acute Cerebral Infarction Patients: A Randomized Clinical Trial Study Br&Beh
Mendelian randomization reveals probucol's preventive role in Behçet's disease via circulating metabolites
->Nature | #Health #Disease | More info from EcoSearch
->Nature | #Health #Disease | More info from EcoSearch
Mendelian randomization reveals probucol's preventive role in Behçet's disease via circulating metabolites
We accessed the expression quantitative trait loci (eQTLs) for ABCA1 related to probucol (https://go.drugbank.com/drugs/DB01599) under the identifier eqtl-a-ENSG00000165029. The eqtl-a-ENSG00000165029 dataset was obtained from the publicly available eQTLGen database (https://www.eqtlgen.org/phase1.html), which identified cis-eQTLs for 19,938 genes through a large-scale meta-analysis...
www.nature.com
March 21, 2025 at 7:02 AM
Now available:
Probucol Exerts Anticancer Effects on SW480 Human Colorectal Cancer Cells via Modulation of Apoptosis- and Angiogenesis-Related Proteins
#clinical #pharmacology #cancer #colorectal #apoptosis #angiogenesis #probucol #SW480 #DrugRepositioning
onlinelibrary.wiley.com/doi/10.1111/...
Probucol Exerts Anticancer Effects on SW480 Human Colorectal Cancer Cells via Modulation of Apoptosis- and Angiogenesis-Related Proteins
#clinical #pharmacology #cancer #colorectal #apoptosis #angiogenesis #probucol #SW480 #DrugRepositioning
onlinelibrary.wiley.com/doi/10.1111/...
Probucol Exerts Anticancer Effects on SW480 Human Colorectal Cancer Cells via Modulation of Apoptosis‐ and Angiogenesis‐Related Proteins
Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide, highlighting the need for novel therapeutic agents with multitarget anticancer activity. Probucol is a pheno...
onlinelibrary.wiley.com
June 29, 2026 at 8:53 AM
Now available:
Probucol Exerts Anticancer Effects on SW480 Human Colorectal Cancer Cells via Modulation of Apoptosis- and Angiogenesis-Related Proteins
#clinical #pharmacology #cancer #colorectal #apoptosis #angiogenesis #probucol #SW480 #DrugRepositioning
onlinelibrary.wiley.com/doi/10.1111/...
Probucol Exerts Anticancer Effects on SW480 Human Colorectal Cancer Cells via Modulation of Apoptosis- and Angiogenesis-Related Proteins
#clinical #pharmacology #cancer #colorectal #apoptosis #angiogenesis #probucol #SW480 #DrugRepositioning
onlinelibrary.wiley.com/doi/10.1111/...
Repurposing probucol for prevention of dementia: Evidence from a nationwide cohort study https://www.medrxiv.org/content/10.1101/2025.11.17.25340427v1
November 20, 2025 at 1:26 AM
Repurposing probucol for prevention of dementia: Evidence from a nationwide cohort study https://www.medrxiv.org/content/10.1101/2025.11.17.25340427v1
Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice https://www.biorxiv.org/content/10.1101/2024.11.05.622070v1
Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice https://www.biorxiv.org/content/10.1101/2024.11.05.622070v1
Abstract Background and aims Chronically elevated levels of circulating lipoprotein-amyloid-beta (Ab
www.biorxiv.org
November 6, 2024 at 5:16 AM
Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice https://www.biorxiv.org/content/10.1101/2024.11.05.622070v1
Probucol mitigates high-fat diet-induced cognitive and social impairments through disruption of redox-inflammation association https://www.biorxiv.org/content/10.1101/2023.09.05.556289v1
Probucol mitigates high-fat diet-induced cognitive and social impairments through disruption of redox-inflammation association https://www.biorxiv.org/content/10.1101/2023.09.05.556289v1
Obesity and its detrimental metabolic consequences are commonly recognized as risk factors for impai
www.biorxiv.org
September 6, 2023 at 12:45 AM
Probucol mitigates high-fat diet-induced cognitive and social impairments through disruption of redox-inflammation association https://www.biorxiv.org/content/10.1101/2023.09.05.556289v1
Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice https://www.biorxiv.org/content/10.1101/2024.11.05.622070v1
Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice https://www.biorxiv.org/content/10.1101/2024.11.05.622070v1
Abstract Background and aims Chronically elevated levels of circulating lipoprotein-amyloid-beta (Ab
www.biorxiv.org
November 6, 2024 at 5:16 AM
Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice https://www.biorxiv.org/content/10.1101/2024.11.05.622070v1
Repurposing probucol for prevention of dementia: Evidence from a nationwide cohort study #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.11.17.25340427v1
http://medrxiv.org/cgi/content/short/2025.11.17.25340427v1
November 20, 2025 at 8:02 AM
Repurposing probucol for prevention of dementia: Evidence from a nationwide cohort study #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.11.17.25340427v1
http://medrxiv.org/cgi/content/short/2025.11.17.25340427v1
Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice #neurodegeneration
http://biorxiv.org/cgi/content/short/2024.11.05.622070v1
http://biorxiv.org/cgi/content/short/2024.11.05.622070v1
November 6, 2024 at 9:01 AM
Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice #neurodegeneration
http://biorxiv.org/cgi/content/short/2024.11.05.622070v1
http://biorxiv.org/cgi/content/short/2024.11.05.622070v1