Why the pseudoscience label fits synthetic mRNA technology, not its critics

Here, we applied exponential population analysis to direct RNA sequencing data from HEK293T cells and peripheral human blood to identify candidate motif patterns for pseudouridine (Ψ), inosine (I), and 5-methylcytosine (m⁵C).

A computational framework applied exponential population analysis to direct RNA sequencing data from HEK293T cells and human blood to identify candidate motif patterns for pseudouridine, inosine and

Here we show that SNORA81-guided pseudouridylation at a single 28S ribosomal RNA site, U4636, links ribosome heterogeneity to selective translation and ovarian cancer cell proliferation.

A wall of biochemistry work: cell-free autocatalytic CO₂ fixation, mRNA pseudouridine chemistry, directed evolution for precision fermentation, NOG strain engineering, DNA sequencing, and a year of st...

Dynamic ribosome heterogeneity has emerged as a potential layer of translational regulation, but whether variation in ribosomal RNA (rRNA) modification stoichiometry can selectively control the transl...

Pseudouridine is the most abundant RNA base modification due to its prevalence in tRNA and rRNA, where it serves as a key modulator of structure and function. Yet, in the widely used model organism, t...

L’industrie du marché de la pseudouridine devrait passer de 9,31 (milliards USD) en 2024 à 34,6 (milliards USD) d’ici 2032. Le TCAC (taux de croissance) du marché de la pseudouridine devrait être d’en...

Institute scholar Nicole M. Martinez and team have developed a quantitative method to examine how special enzymes called pseudouridine synthases chemically alter RNA molecules within our cells

The Pseudouridine Market is expected to grow from 500 USD Million in 2025 to 1,500 USD Million by 2035. The Pseudouridine Market CAGR (growth rate) is expected to be around 10.6% | Wiseguy Reports

Assembly of the mitochondrial ribosome (mitoribosome) is a crucial step in mitochondrial gene expression. This process facilitates mitochondrial translation, which produces essential subunits of the oxidative phosphorylation machinery—the cell’s primary energy-producing machinery. Disruptions in mitoribosome assembly can lead to severe human diseases. Given its fundamental importance, detailed structural analysis of mitoribosome assembly pathways is essential for advancing our understanding of mitochondrial function in both health and disease. In this study, we characterize twelve distinct assembly states of the mitoribosomal small subunit (mtSSU) isolated from human cells. Our findings reveal the intricate details of the final maturation stages of the mtSSU platform, decoding center, and the 3’-end of 12S rRNA. This process is governed by coordinated actions of assembly factors that ensure precise, stepwise rRNA folding and the integration of mitoribosomal proteins into the developing

The Pseudouridine Market is expected to grow from 500 USD Million in 2025 to 1,500 USD Million by 2035. The Pseudouridine Market CAGR (growth rate) is expected to be around 10.6% | Wiseguy Reports

Translational oncology · Li S, Zhong C, Zhang Y, Chen G, Zhang L, Chen J, Yang R.

We find that Dorado detected a higher number of m6A events and enabled simultaneous detection of other RNA modifications (5-methylcytosine, pseudouridine, and inosine).

In this issue of Molecular Cell, Meng et al. identify a reader for pseudouridine (Ψ) in mRNA. Ψ increases binding of SMD2, a member of the SM protein ring surrounding spliceosomal U1 and U2 snRNAs, and alters alternative splicing, revealing a new epitranscriptomic mechanism linked to splicing dysregulation in cancer through SMD2 overexpression.

Meng et al. identify SMD2 as a reader of pseudouridine (ψ) in mRNA. SMD2 colocalizes with ψ near exon-intron junctions and preferentially recognizes ψ-modified transcripts to regulate mRNA alternative splicing. SNRPD2 is highly expressed across multiple cancers, thus highlighting the therapeutic potential of targeting the ψ-SMD2 axis.