Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...
Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
www.nature.com
November 28, 2025 at 4:43 PM
Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...
Introns have a hidden regulatory role! 🧬🎉
Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression
nature.com/articles/s41...
Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression
nature.com/articles/s41...
July 8, 2026 at 4:17 PM
Introns have a hidden regulatory role! 🧬🎉
Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression
nature.com/articles/s41...
Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression
nature.com/articles/s41...
Always warms the heart to see the spliceosomal active site! Lovely work.
Very happy to share the first paper from our lab, out now in Nature Communications!🎉🥳
Structural basis of step II Spliced Leader RNA trans-splicing in trypanosomatid parasites 🧬🔬
🔗 www.nature.com/articles/s41...
@natcomms.nature.com @universitedeliege.bsky.social @rockefeller.edu #cryoEM #cryo-EM
Structural basis of step II Spliced Leader RNA trans-splicing in trypanosomatid parasites 🧬🔬
🔗 www.nature.com/articles/s41...
@natcomms.nature.com @universitedeliege.bsky.social @rockefeller.edu #cryoEM #cryo-EM
September 24, 2026 at 3:18 PM
Always warms the heart to see the spliceosomal active site! Lovely work.
Interesting.
Full deletion of all introns in yeast was actually my project in the Staley lab, *20 years ago*. I actually found a bunch of phenotypes. We did this in collaboration with the Guthrie lab.
www.cell.com/cell/abstrac...
Full deletion of all introns in yeast was actually my project in the Staley lab, *20 years ago*. I actually found a bunch of phenotypes. We did this in collaboration with the Guthrie lab.
www.cell.com/cell/abstrac...
A spliceosome-independent eukaryote generated by complete intron removal
Elimination of all spliceosomal introns reveals a spliceosome-independent eukaryote.
www.cell.com
July 15, 2026 at 4:28 PM
Interesting.
Full deletion of all introns in yeast was actually my project in the Staley lab, *20 years ago*. I actually found a bunch of phenotypes. We did this in collaboration with the Guthrie lab.
www.cell.com/cell/abstrac...
Full deletion of all introns in yeast was actually my project in the Staley lab, *20 years ago*. I actually found a bunch of phenotypes. We did this in collaboration with the Guthrie lab.
www.cell.com/cell/abstrac...
www.nature.com/articles/s41...
Thrilled to share our new study! We show that mirusviruses include lineages packed with spliceosomal introns and likely replicating in the nucleus of unicellular eukaryotes—a sharp contrast to most large and giant eukaryotic viruses that replicate in the cytoplasm.
Thrilled to share our new study! We show that mirusviruses include lineages packed with spliceosomal introns and likely replicating in the nucleus of unicellular eukaryotes—a sharp contrast to most large and giant eukaryotic viruses that replicate in the cytoplasm.
Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
www.nature.com
November 28, 2025 at 1:21 PM
www.nature.com/articles/s41...
Thrilled to share our new study! We show that mirusviruses include lineages packed with spliceosomal introns and likely replicating in the nucleus of unicellular eukaryotes—a sharp contrast to most large and giant eukaryotic viruses that replicate in the cytoplasm.
Thrilled to share our new study! We show that mirusviruses include lineages packed with spliceosomal introns and likely replicating in the nucleus of unicellular eukaryotes—a sharp contrast to most large and giant eukaryotic viruses that replicate in the cytoplasm.
Transposable elements are a major driver of intron gain in eukaryotes, and are capable of transmission between diverse species #HGT #evolution - www.pnas.org/doi/10.1073/...
Horizontal transmission of functionally diverse transposons is a major source of new introns | PNAS
Since the discovery of spliceosomal introns in eukaryotic genomes, the proximate molecular
and evolutionary processes that generate new introns hav...
www.pnas.org
May 26, 2025 at 5:03 AM
Transposable elements are a major driver of intron gain in eukaryotes, and are capable of transmission between diverse species #HGT #evolution - www.pnas.org/doi/10.1073/...
The conserved spliceosomal protein AtSF3B2 controls the floral transition by regulating transcription and splicing in Arabidopsis (Zhou Zhou , Xuan-Ru Yin , Yu-Yi Wang , Jing-Jing Ren , et al) doi.org/10.1093/plce... #PlantScience @aspbofficial
The conserved spliceosomal protein AtSF3B2 controls the floral transition by regulating transcription and splicing in Arabidopsis
A spliceosomal protein controls flowering time by coordinating gene transcription and RNA splicing of key flowering regulators through interactions with pr
doi.org
July 8, 2026 at 12:42 PM
The conserved spliceosomal protein AtSF3B2 controls the floral transition by regulating transcription and splicing in Arabidopsis (Zhou Zhou , Xuan-Ru Yin , Yu-Yi Wang , Jing-Jing Ren , et al) doi.org/10.1093/plce... #PlantScience @aspbofficial
Intron-rich viruses - WOW!
rdcu.be/eSfG2
rdcu.be/eSfG2
Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
www.nature.com
November 28, 2025 at 1:15 PM
Intron-rich viruses - WOW!
rdcu.be/eSfG2
rdcu.be/eSfG2
Group II Introns in Archaeal Genomes and the Evolutionary Origin of Eukaryotic Spliceosomal Introns https://www.biorxiv.org/content/10.1101/2024.12.10.627823v1
December 15, 2024 at 3:32 AM
Group II Introns in Archaeal Genomes and the Evolutionary Origin of Eukaryotic Spliceosomal Introns https://www.biorxiv.org/content/10.1101/2024.12.10.627823v1
Polyamine-dependent metabolic shielding regulates alternative splicing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Polyamine-dependent metabolic shielding regulates alternative splicing - Nature
Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.
www.nature.com
January 16, 2026 at 7:46 AM
Polyamine-dependent metabolic shielding regulates alternative splicing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nature research paper: Polyamine-dependent metabolic shielding regulates alternative splicing
go.nature.com/49kxV0m
go.nature.com/49kxV0m
Polyamine-dependent metabolic shielding regulates alternative splicing - Nature
Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.
go.nature.com
January 14, 2026 at 5:58 PM
Nature research paper: Polyamine-dependent metabolic shielding regulates alternative splicing
go.nature.com/49kxV0m
go.nature.com/49kxV0m
Group II Introns in Archaeal Genomes and the Evolutionary Origin of Eukaryotic Spliceosomal Introns https://www.biorxiv.org/content/10.1101/2024.12.10.627823v1
December 15, 2024 at 3:32 AM
Group II Introns in Archaeal Genomes and the Evolutionary Origin of Eukaryotic Spliceosomal Introns https://www.biorxiv.org/content/10.1101/2024.12.10.627823v1
#NewResearch
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
#MicroSky 🦠
www.nature.com/articles/s41...
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
#MicroSky 🦠
www.nature.com/articles/s41...
Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
www.nature.com
November 28, 2025 at 1:17 PM
#NewResearch
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
#MicroSky 🦠
www.nature.com/articles/s41...
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
#MicroSky 🦠
www.nature.com/articles/s41...
Yeast (S. cerevisiae) can survive despite all 300 spliceosomal introns being engineered out. Marketing opportunity for "made with 0% intron yeast" beer right there.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
A spliceosome-independent eukaryote generated by complete intron removal
Elimination of all spliceosomal introns reveals a spliceosome-independent eukaryote.
www.cell.com
July 18, 2026 at 6:40 AM
Yeast (S. cerevisiae) can survive despite all 300 spliceosomal introns being engineered out. Marketing opportunity for "made with 0% intron yeast" beer right there.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Group II Introns in Archaeal Genomes and the Evolutionary Origin of Eukaryotic Spliceosomal Introns http://biorxiv.org/cgi/content/short/2024.12.10.627823v1
December 15, 2024 at 11:03 PM
Group II Introns in Archaeal Genomes and the Evolutionary Origin of Eukaryotic Spliceosomal Introns http://biorxiv.org/cgi/content/short/2024.12.10.627823v1
Very happy to share the peer-reviewed version of our work on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4, published in @natsmb.nature.com!
rdcu.be/ezGqT
Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu
rdcu.be/ezGqT
Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu
Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4
Nature Structural & Molecular Biology - Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode...
rdcu.be
August 7, 2025 at 10:37 AM
Very happy to share the peer-reviewed version of our work on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4, published in @natsmb.nature.com!
rdcu.be/ezGqT
Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu
rdcu.be/ezGqT
Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu
📣 New preprint: “Guidance for clinical variant classification in genes for spliceosomal small nuclear RNAs”
www.medrxiv.org/content/10.6...
snRNAs are increasingly recognised as major players in rare disorders (RNUopathies), yet interpreting variants in these genes is a major challenge.
🧵 1/7
www.medrxiv.org/content/10.6...
snRNAs are increasingly recognised as major players in rare disorders (RNUopathies), yet interpreting variants in these genes is a major challenge.
🧵 1/7
Guidance for clinical variant classification in genes for spliceosomal small nuclear RNAs
Background: Small nuclear RNAs (snRNAs) are RNA components of the major and minor spliceosomes that play a core role in splice-site recognition and control of the splicing process. Variants in genes t...
www.medrxiv.org
August 5, 2026 at 11:12 AM
📣 New preprint: “Guidance for clinical variant classification in genes for spliceosomal small nuclear RNAs”
www.medrxiv.org/content/10.6...
snRNAs are increasingly recognised as major players in rare disorders (RNUopathies), yet interpreting variants in these genes is a major challenge.
🧵 1/7
www.medrxiv.org/content/10.6...
snRNAs are increasingly recognised as major players in rare disorders (RNUopathies), yet interpreting variants in these genes is a major challenge.
🧵 1/7
Dynamic interaction of spliceosomal snRNPs with coilin explains Cajal body characteristics. New study from Davide Basello, David Staněk and colleagues @imgprague.bsky.social: rupress.org/jcb/article/...
#Biophysics #Organelles
#Biophysics #Organelles
July 2, 2025 at 2:28 PM
Dynamic interaction of spliceosomal snRNPs with coilin explains Cajal body characteristics. New study from Davide Basello, David Staněk and colleagues @imgprague.bsky.social: rupress.org/jcb/article/...
#Biophysics #Organelles
#Biophysics #Organelles
Well I like it! For the human spliceosomal RNA fans -- secondary structures & interactions mined from PDB & indicated by arcs between snRNA nucleotides which are plotted around the circle. Evolutionary conservation is from Rfam seed alignments and phyloP scores.
August 28, 2026 at 6:47 AM
Well I like it! For the human spliceosomal RNA fans -- secondary structures & interactions mined from PDB & indicated by arcs between snRNA nucleotides which are plotted around the circle. Evolutionary conservation is from Rfam seed alignments and phyloP scores.
Retinitis pigmentosa retinal degeneration caused by mutations that affect spliceosomal RNAs
🧬 Major breakthrough: IOB researchers identify new genetic cause of inherited blindness in overlooked RNA genes. The discovery solves decades-old diagnostic mystery and opens new pathways for many patients worldwide.
➡️ www.nature.com/articles/s41...
#AcademicBlueSky #Genetics #VisionResearch #IRDs
➡️ www.nature.com/articles/s41...
#AcademicBlueSky #Genetics #VisionResearch #IRDs
January 12, 2026 at 8:18 PM
Retinitis pigmentosa retinal degeneration caused by mutations that affect spliceosomal RNAs
Major spliceosomal RNA secondary structures, interactions (PDB), evolutionary conservation (PhyloP & Rfam SEEDs), and disease associations (D’Souza et al 2026). All in one monstrously busy plot. 😁
August 31, 2026 at 10:20 PM
Major spliceosomal RNA secondary structures, interactions (PDB), evolutionary conservation (PhyloP & Rfam SEEDs), and disease associations (D’Souza et al 2026). All in one monstrously busy plot. 😁