Benjamin Brigant, PhD
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crisprandbeyond.bsky.social
Benjamin Brigant, PhD
@crisprandbeyond.bsky.social
400 followers 54 following 72 posts
Researcher 🔬 | CRISPR | Unraveling the link between inflammation and pathologies, Focus on Ehlers-Danlos syndrome and osteoarthritis
PhD in France, Post doc in Norway and Canada
Posts Replies Media Videos
Reposted by Benjamin Brigant, PhD
brigantlab.bsky.social
Blueprints of life! 🧬 Let's see DNA and RNA. A quick refresher on the molecules that drive our research.
Next up: the fascinating world of RNA!🔬 #AcademicSky #ScienceSky#InsideBrigantLab #RNA #DNA
DNA and RNA are two essential molecules that carry and use genetic information, but they have different roles. **DNA** is the cell's long-term blueprint, storing the genetic instructions needed to build and maintain bodies functions. **RNA** acts as the messenger, carrying and translating those instructions so cells can produce the proteins they need. #AcademicSky #ScienceSky#InsideBrigantLab #RNA #DNA
August 6, 2026 at 9:19 AM
crisprandbeyond.bsky.social
Very inspiring three days at the training school on HDR and AAV delivery — great sessions, hands-on insights, and fantastic discussions with fellow researchers. Huge thanks to the organizers for putting together such a well-run event!
brigantlab.bsky.social The Brigant Lab @brigantlab.bsky.social · Jul 24
Throwback to great days at the COSTAction #GenEHumDiTraining School on HDR & #AAV -based delivery technologies! Thanks Dr. Rajeevkumar R. Nair for the invitation, Nobel Laureates @m-bmoser.bsky.social & @edvardmoser.bsky.social for an inspiring session, @kavlintnu.bsky.social for hospitality. 🇳🇴
July 24, 2026 at 3:47 PM
crisprandbeyond.bsky.social
Happy to share our new publication!
brigantlab.bsky.social The Brigant Lab @brigantlab.bsky.social · Jul 17
🚨 New publication! We identify CD5L as a potential target in #Osteoarthritis. Lowering CD5L expression improved chondrocyte survival in vitro. Many thanks to all collaborators! 🧬📄
#AcademicSky #MedSky #SciComm#CartilageHealth#MolecularMedicine

Full text: www.oarsiopenjournal.com/article/S266...
🚨New Publication! 🚨 Our latest paper identifies CD5L as a potential target in osteoarthritis (OA). We found that CD5L levels are higher in OA patients, and reducing its expression helps chondrocytes survive in vitro. 🧬 Huge thanks to our amazing team: Kashif Rasheed, Carolina Gómez Ortega, Erlend Tande, Shiquan Sun, Xuzhao Bian, & Victor Boyartchuk. 👏 Huge thanks to our co-authors :Kashif Rasheed, Carolina Gómez Ortega, Erlend Tande, Shiquan Sun, Xuzhao Bian, & Victor Boyartchuk. 👏 🇨🇳 Special thanks to our collaborators in China, whose partnership was instrumental in strengthening the association between increased CD5L expression and the inflammatory OA endotype! 🔗 Read the full study here: https://www.oarsiopenjournal.com/article/S2665-9131(26)00107-X/fulltext #Osteoarthritis #MolecularMedicine #CartilageHealth #OpenScience
July 17, 2026 at 12:01 PM
Reposted by Benjamin Brigant, PhD
brigantlab.bsky.social
Kicking off the Training School on homology-directed repair & AAV delivery technologies at the Kavli Institute for Systems Neuroscience in Trondheim, Norway 🇳🇴 (June 24-26).
@kavlintnu.bsky.social
Kicking off the Training School on homology-directed repair & AAV delivery technologies at the Kavli Institute for Systems Neuroscience in Trondheim, Norway 🇳🇴 (June 24-26). @kavlintnu.bsky.social
June 24, 2026 at 9:44 AM
Reposted by Benjamin Brigant, PhD
brigantlab.bsky.social
Excellent lecture by Prof. Magnar Bjørås at NTNU.

A strong reminder that meaningful collaboration with patient communities is the anchor for deep research and impactful innovation.

Here: childhood dementia and rare genetic disorders.

#ScienceSky #MedicalResearch #NTNU #BrigantLab
Excellent lecture by Prof. Magnar Bjørås at NTNU. A strong reminder that meaningful collaboration with patient communities is the anchor for deep research and impactful innovation. Here: childhood dementia and rare genetic disorders. #ScienceSky #MedicalResearch #NTNU #BrigantLab
May 8, 2026 at 2:03 PM
Reposted by Benjamin Brigant, PhD
brigantlab.bsky.social
A portal to the invisible

A microscope is more than a tool—it’s a way to connect what we see to what actually happens at the cellular level.

This is where questions start to become answers.
Where we move from what is happening to how it unfolds.

#InsideBrigantLab #Microscopy #BiomedicalResearch
A portal to the invisible A microscope is more than a tool—it’s a way to connect what we see to what actually happens at the cellular level. This is where questions start to become answers. Where we move from what is happening to how it unfolds. #InsideBrigantLab #Microscopy #SciComm #BiomedicalResearch
May 5, 2026 at 6:40 PM
Reposted by Benjamin Brigant, PhD
brigantlab.bsky.social
🌟 May is EDS & HSD Awareness Month! 🦓

With @ehlersdanlos.bsky.social, we’re joining the global community to raise our voices for millions affected by Ehlers-Danlos Syndromes & Hypermobility Spectrum Disorders.
Let’s make the invisible visible. 💪✨

#EDSAwarenessMonth #HSD #ZebraStrong #BrigantLab
En caption ce message (seulement en anglais): 🌟 May is EDS & HSD Awareness Month! 🌟 Today it’s May! That means, it's Ehlers-Danlos Syndromes (EDS) and Hypermobility Spectrum Disorders (HSD) Awareness Month! 🦓 . 🌐 Every May, the EDS&HSD global community unites to raise awareness, share experiences, and drive progress for millions affected by EDS and HSD.⁠ ⁠. Let’s come together to make the invisible visible. 💪✨ . 💡 What can you do? . ✅ Learn about EDS & HSD. ✅ Share information and amplify awareness online. . No matter where you are in the world, you can take part, raise your voice, and support this incredible community.🧡✨ . . Together, we can create real change. 🌟🦓💙 . #ehlersdanlossyndromes #Zebrastrong #EDSandHSDawarenessmonth #EDSCommunity #BrigantLab
May 1, 2026 at 3:52 PM
crisprandbeyond.bsky.social
It was such a great visit ! Always happy to learn and share with colleagues and patients. I can't wait for the next edition!
brigantlab.bsky.social The Brigant Lab @brigantlab.bsky.social · Jun 13
Yesterday at #EULAR2025, we explored Ehlers-Danlos syndrome (EDS): its diagnosis, pathways, therapies, and comorbidities. Inspiring insights into this complex condition! 🦓🌍💡✨
#EULAR2025 #EDS #ehlersdanlossyndrome
#rheumaticdiseases #brigantlabonthemove #BehindBrigantLab #MedSky #AcademicSky
Yesterday at #EULAR2025, we explored Ehlers-Danlos syndrome (EDS): its diagnosis, pathways, therapies, and comorbidities. Inspiring insights into this complex condition! 🦓🌍💡✨ #EULAR2025 #EDS #ehlersdanlossyndrome #rheumaticdiseases #brigantlabonthemove #BehindBrigantLab #MedSky #AcademicSky
June 13, 2025 at 10:56 AM
Reposted by Benjamin Brigant, PhD
brigantlab.bsky.social
Hello from EULAR 2025! 🏛️✨ Ready to explore, connect, and learn in Barcelona. 🌍🔬
#EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky
Hello from EULAR 2025! 🏛️✨ Ready to explore, connect, and learn in Barcelona. 🌍🔬 #EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky
June 11, 2025 at 7:04 PM
Reposted by Benjamin Brigant, PhD
brigantlab.bsky.social
Gratulerer med dagen for 17 mai ! 🇳🇴🎊✨
May 17, 2025 at 10:36 AM
crisprandbeyond.bsky.social
Always amazed by the cells under a microscope 😍
brigantlab.bsky.social The Brigant Lab @brigantlab.bsky.social · May 13
#InsideBrigantLab How do aging cells drive joint damage?🤔
In osteoarthritis, chondrocytes lose their repair abilities and release proteins that accelerate cartilage breakdown, fueling joint degeneration. 🦴

Stay tuned for more insights ! 💡 #MedSky #AcademicSky #cellularbiology #BrigantLab
🌟 Inside Brigant Lab : The chondrocytes cells 🌟 Have you ever wondered how aging cells contribute to joint damage? Let’s dive into the science together! 🧠💡 Meet the chondrocytes, the architects of cartilage health, maintaining its structure and function. But in osteoarthritis (OA), their balance is disrupted. These cells start contributing to cartilage breakdown, driving joint degeneration. As they age, chondrocytes lose their ability to repair cartilage and produce proteins that accelerate its destruction—worsening joint damage and fueling the progression of OA. Understanding their role is key to unlocking new treatments. 🧬🦴✨ Image: Chondrocyte cells in 2D culture Want to know more? Stay tuned for more #InsideBrigantLab posts, where we’ll share insights into our research and an exclusive preview of what’s next in our scientific journey. 🔍 #CellularBiology #chondrocyteresearch #osteoarthritis #science #research #ArthritisAwarenessMonth #MolecularMedicine#sciencecommunication#lablife #brigantlab #insidebrigantlab
May 13, 2025 at 8:53 AM
crisprandbeyond.bsky.social
Lots of exciting projects in our lab !
brigantlab.bsky.social The Brigant Lab @brigantlab.bsky.social · May 6
👀 Curious about what happens at Brigant Lab?

Follow our new series: #InsideBrigantLab!

Explore our research, discoveries, and beyond. 🧬💡😃

#osteoarthritis #AcademicSky #MedSky #Science #Research #lablife #InsideBrigantLab
🌟 Welcome to InsideBrigantLab! 🌟 In this series, we’ll take you behind the scenes of our lab’s journey to advance diagnostics and develop innovative treatments for rheumatologic diseases.🔬💊📖 Our first feature focuses on Osteoarthritis (OA), the most common form of arthritis—a condition that wears down joint cartilage over time. Think of cartilage as the cushion between your joints. In OA, that cushion wears thin, leading to pain and stiffness. OA affects millions worldwide and significantly reduces quality of life. 🦴♿ Did you know that by 2050, 1 in 3 people may be living with OA? Understanding its symptoms, prevalence, and the current limitations in treatments is crucial for driving innovative research. 💡 While prevention strategies exist, effective disease-modifying treatments remain a significant unmet need—and this is where our work comes in. At BrigantLab, we’re diving deep into the molecular mechanisms of OA, with a special focus on the role of chondrocytes and connective tissues.🧬🩺 Stay tuned for more #InsideBrigantLab posts, where we’ll share insights into our work, the impact we strive to create, and an exclusive preview of what’s next in our scientific journey. Have questions or topics you’d like us to explore? Let us know! 😊 #osteoarthritis #osteoarthritisawareness #rheumaticdisease #chondrocyteresearch #molecularmedicine #research #sciencecommunication #BrigantLab #InsideBrigantLab
May 6, 2025 at 5:51 PM
crisprandbeyond.bsky.social
First official publication after the start of the brigant lab ! The first of a long series!
Thank you to all the authors and friends for this work.
brigantlab.bsky.social The Brigant Lab @brigantlab.bsky.social · May 2
Proud to be part of this new study on uremic toxins & miR-223 in CKD anemia.
🔗Check it:https://doi.org/10.1016/j.ncrna.2025.04.009

#ckd #nephrology #MedSky #AcademicSky #Science #Research #BrigantLab
🚨 Exciting Research Update! 🚨 We’re thrilled to announce the publication of an important and exciting study in Non-Coding RNA Research where BrigantLab was part ! 🎉 We reveal a strong link between uremic toxin levels and the microRNA miR-223 in chronic kidney disease (CKD)-associated anemia. We demonstrated that the uremic toxin indoxyl sulfate (IS) increases miR-223 expression in both human erythroid cell lines and primary cells. In a cohort of over 500 CKD patients, serum miR-223 levels correlated with IS and other uremic toxins, as well as with markers of endothelial dysfunction and anemia severity. 🧬 Why is this important? These findings position miR-223 as a promising biomarker for monitoring CKD-related anemia and vascular complications—opening the door to more personalized and non-invasive diagnostic strategies. 💡 A huge congratulations to Laurent Metzinger for spearheading this important work, and to all the incredible co-authors: Emma Brisot, Pierre-Marie Leprêtre, Eya Hamza, PhD, MBA, Ophelie Fourdinier, Hakim Ouled-Haddou, Gabriel Choukroun, Ziad Massy, Francis Verbeke, Valérie Metzinger-Le Meuth, and Griet Glorieux! ✨ 🔗 Read the full article here: https://doi.org/10.1016/j.ncrna.2025.04.009 [or link in bio] 📖 Stay tuned for more updates from BrigantLab ! 🚀 #ckd #chronickidneydisease #chronickidneydiseaseawareness #anemia #BiomarkerDiscovery #mir223 #uremictoxins #nephrology #Research #Researchpapers #science #lablife #brigantlab
May 2, 2025 at 7:14 PM
crisprandbeyond.bsky.social
Go to like the page if you want to follow our adventure !
brigantlab.bsky.social The Brigant Lab @brigantlab.bsky.social · Apr 25
👋🔬 Behind BrigantLab: Meet co-founder Dr. Benjamin Brigant (NTNU)! 9+ yrs in molecular bio, from France to Norway. Focus: rare genetic conditions, osteoarthritis & more. Cross-country ski lover! ❄️ Follow our science journey! ➡️ [Linktree in bio]
#AcademicSky #MedSky #lablife #BehindBrigantLab
👋🔬 "Behind the BrigantLab" series - Meet the Minds Behind BrigantLab! Today, let's spotlight Dr. Benjamin Brigant, researcher at NTNU in Trondheim, co-founder and a driving force of BrigantLab ! Currently based at the Norwegian University of Science and Technology (NTNU) in Trondheim, Benjamin brings over 9 years of expertise in molecular and cellular biology to the forefront of our research. 💡 His journey spanned studying studying microRNAs in France (UPJV), pioneering CRISPR-Cas13 RNA targeting in Canada (UoA, Alberta), and exploring CD5L in Norway (NTNU). Now, at BrigantLab, Benjamin’s work bridges his diverse experiences in inflammation and cartilage biology. His focus includes osteoarthritis, joint disorders, and rare genetic conditions like MULIBREY nanism and Ehlers-Danlos Syndrome, with a special emphasis on joint, cartilage, and inflammation abnormalities. 🧬💪 🌍 His passion for discovery is matched only by his enthusiasm for connecting ideas across disciplines—whether in the lab or at collaborative works. ✨ Fun fact: When he’s not in the lab, you might find him hitting the snow ❄️ and cross-country skiing 🎿 during the winter months! 👉 Follow us for more behind-the-scenes moments, research updates, and a peek into life at BrigantLab! 🦓 Don’t forget, you can support our latest project: https://gofund.me/15cbe96b 🔗 Visit our Linktree in bio to learn more! #BehindBrigantLab #meettheteam #brigantlab #science #research #supportscience #lablife #skiingscientists
April 25, 2025 at 5:27 PM
crisprandbeyond.bsky.social
After a few months of silence, I’m thrilled to share this promising project!

To bring it to life, we need your support!

Share it as much as possible and join us in making this project a reality!

Help us here: gofund.me/15cbe96b

#AcademicSky
April 4, 2025 at 1:08 PM
crisprandbeyond.bsky.social
🎉 Happy New Year!
Wishing everyone a successful 2025! This year is special as we officially launch our lab!

Follow the lab account for updates on research into Ehlers-Danlos syndrome (#EDS), other genetic rheumatologic conditions, and osteoarthritis. Stay tuned!

#AcademicSky #EDS #Health
brigantlab.bsky.social The Brigant Lab @brigantlab.bsky.social · Jan 6
Happy 2025! 🎉 Lab Launch!
Stay tuned for our journey! 🧪✨🚀

#PhDSky #AcademicSky #MedSky #NewBeginnings #Science #Innovation
January 8, 2025 at 10:01 AM
crisprandbeyond.bsky.social
🎉🧪 As 2024 comes to a close, let's play together and share a published paper from 2024 that inspired you or made a significant impact in your field.🌟

Together, we can create a thread of knowledge and inspiration to kick off 2025 stronger than ever! 🚀
#AcademicSky #PhDSky #MedSky
December 31, 2024 at 11:59 AM
crisprandbeyond.bsky.social
I was very lucky to see beautiful Cloud iridescence this morning all over the city!
#Cloud #Nature #Norway
December 29, 2024 at 8:36 PM
crisprandbeyond.bsky.social
🎄 Merry Christmas! 🎉 May your holidays be filled with joy and relaxation. Let's recharge and gear up for a 2025 brimming with success and grants and publications ! 🧾✨
#lab&fun #academicsky #medsky
December 24, 2024 at 7:06 PM
crisprandbeyond.bsky.social
🌟 Happy Winter Solstice and Happy Holidays! 🌟 In Trondheim, today, the sunrise was at 10:01 AM and the sunset at 2:31 PM. It's comforting to know that the days will soon start getting longer. (and don't forget your D-vitamin !) ❄️✨
#AcadelicSky
December 21, 2024 at 10:15 PM
Reposted by Benjamin Brigant, PhD
ohtwist.bsky.social
Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome and Loeys-Dietz syndrome 2017:

www.ncbi.nlm.nih.gov/pmc/articles...

#EDS #LDS #Mafran #CTD #meded #FOAMed #medicine #doctors #genetics #MedSky
Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome
Many different heritable connective tissue disorders (HCTD) have been described over the past decades. These syndromes often affect the connective tissue of various organ systems, including heart, blo...
www.ncbi.nlm.nih.gov
December 15, 2024 at 10:51 PM
crisprandbeyond.bsky.social
Do you want a nice Christmas song in your lab ?
I always love the #acapellascience work! He transforms science into amazing songs 😍
#AcademicSky #medsky #lab&fun
❄️ single cells, single cells! ❄️ #acapella #science #christmas
YouTube video by acapellascience
youtube.com
December 11, 2024 at 7:21 PM
crisprandbeyond.bsky.social
🌍🧪 Want to do something different and have fun? Try Skype a Scientist! It's an amazing chance to connect with a classroom anywhere in the world 🌎 and share your journey as a scientist. 👩‍🔬

The new 2025 volunteer form is out 🥳 Let’s inspire the next generation! 💡✨

#PhDSky #AcademicSky #MedSky
SKYPE A SCIENTIST
Skype a Scientist matches your classroom, scout troop, or library with scientists for Q&A sessions for free!
www.skypeascientist.com
December 10, 2024 at 10:27 AM
crisprandbeyond.bsky.social
Use the #lab&fun and #ScienceJokes to develop the feed:

bsky.app/profile/did:...
phdcomics.com PHD Comics @phdcomics.com · Dec 7
How long it takes...
December 7, 2024 at 6:08 PM
crisprandbeyond.bsky.social
#AcademicSky
crisprguru.bsky.social CRISPRGuru @crisprguru.bsky.social · Nov 24
In my opinion, this paper is A MUST READ for anyone who writes grant proposals.

I am sure you will agree that 'reading this entire paper was totally worth your time.'
itaiyanai.bsky.social Itai Yanai @itaiyanai.bsky.social · Nov 24

How to write a grant?
1. The application is for the reviewer, not you, the applicant.
2. Communicate in stories.
3. Make your story cohesive—leave no puzzling gaps.
4. Make your story resonate to keep the reviewer reading.
5. Accept chance and noise in peer-review.
www.pnas.org/doi/epub/10....
November 25, 2024 at 5:12 AM