Anabel Chang
@anabelcjw.bsky.social
PhD student | Infectious Disease & Cell Biology | ASTAR IDLabs & NTU
Spreading ideas, not bacteria 🦠
Spreading ideas, not bacteria 🦠
Reposted by Anabel Chang
Adaptive immunity shapes baseline physiology of M. tuberculosis in high-dose versus low-dose infection BALB/c mouse drug treatment models https://www.biorxiv.org/content/10.64898/2026.03.26.714401v1
March 27, 2026 at 4:39 AM
Adaptive immunity shapes baseline physiology of M. tuberculosis in high-dose versus low-dose infection BALB/c mouse drug treatment models https://www.biorxiv.org/content/10.64898/2026.03.26.714401v1
Reposted by Anabel Chang
Braaaains, er, genomes ... Researchers have resurrected ‘dead’ bacterial cells by replacing their defunct DNA with the working genome of another species.
go.nature.com/40Tfrio
go.nature.com/40Tfrio
Zombieland: Genome transplant brings ‘dead’ bacteria back to life
Technique that inserts the genome of one bacterial species into the ‘dead’ cells of another could open doors for synthetic biologists.
go.nature.com
March 24, 2026 at 9:36 PM
Braaaains, er, genomes ... Researchers have resurrected ‘dead’ bacterial cells by replacing their defunct DNA with the working genome of another species.
go.nature.com/40Tfrio
go.nature.com/40Tfrio
Reposted by Anabel Chang
NLRP3 acts as a direct sensor of intracellular potassium ions https://www.biorxiv.org/content/10.64898/2026.03.12.707678v1
March 12, 2026 at 1:17 PM
NLRP3 acts as a direct sensor of intracellular potassium ions https://www.biorxiv.org/content/10.64898/2026.03.12.707678v1
Reposted by Anabel Chang
Flow-sensitive K+ channels link flow to piezo1/PI3K/Akt1 pathway https://www.biorxiv.org/content/10.64898/2026.03.10.710828v1
March 13, 2026 at 12:03 AM
Flow-sensitive K+ channels link flow to piezo1/PI3K/Akt1 pathway https://www.biorxiv.org/content/10.64898/2026.03.10.710828v1
Reposted by Anabel Chang
PefA, an ALG-2-like Ca2+ sensor, regulates ESCRT and autophagy responses to mycobacterial vacuole damage https://www.biorxiv.org/content/10.64898/2026.01.30.702722v1
January 31, 2026 at 2:17 AM
PefA, an ALG-2-like Ca2+ sensor, regulates ESCRT and autophagy responses to mycobacterial vacuole damage https://www.biorxiv.org/content/10.64898/2026.01.30.702722v1
Reposted by Anabel Chang
Why do some people become severely ill from infections that leave others unscathed? 🧪
go.nature.com/4sAcsrI
go.nature.com/4sAcsrI
The infection enigma: why some people die from typically harmless germs
Nature - Millions of people worldwide carry genetic mutations that weaken their immune system.
go.nature.com
January 18, 2026 at 12:21 PM
Why do some people become severely ill from infections that leave others unscathed? 🧪
go.nature.com/4sAcsrI
go.nature.com/4sAcsrI
Reposted by Anabel Chang
People with PhDs say they spent years during their studies feeling exhausted and lost their work–life balance. Ashley Moses shares how small acts of change have helped to reset and relearn how to rest.
spklr.io/633228YX04
#PhDChat #PhDSky #AcademicSky
spklr.io/633228YX04
#PhDChat #PhDSky #AcademicSky
During the course of my PhD, I’ve been relearning how to rest
Small acts of change have helped me to reset and give myself a break.
spklr.io
January 18, 2026 at 12:36 PM
People with PhDs say they spent years during their studies feeling exhausted and lost their work–life balance. Ashley Moses shares how small acts of change have helped to reset and relearn how to rest.
spklr.io/633228YX04
#PhDChat #PhDSky #AcademicSky
spklr.io/633228YX04
#PhDChat #PhDSky #AcademicSky
Reposted by Anabel Chang
Byrd, Marmorale, Buchan et al. @uarizona.bsky.social conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
January 7, 2026 at 7:00 PM
Byrd, Marmorale, Buchan et al. @uarizona.bsky.social conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
Reposted by Anabel Chang
Mechanoresilience of lysosomes conferred by TMEM63A https://www.biorxiv.org/content/10.64898/2025.12.18.695245v1
December 19, 2025 at 1:31 PM
Mechanoresilience of lysosomes conferred by TMEM63A https://www.biorxiv.org/content/10.64898/2025.12.18.695245v1
Reposted by Anabel Chang
Regulation of STING activation by phosphoinositide and cholesterol https://www.biorxiv.org/content/10.64898/2025.12.29.696921v1
December 30, 2025 at 5:15 AM
Regulation of STING activation by phosphoinositide and cholesterol https://www.biorxiv.org/content/10.64898/2025.12.29.696921v1
Reposted by Anabel Chang
PtdIns(3,5)P2 Is an Endogenous Ligand of STING in Innate Immune Signaling https://www.biorxiv.org/content/10.64898/2025.12.29.696917v1
December 30, 2025 at 5:45 AM
PtdIns(3,5)P2 Is an Endogenous Ligand of STING in Innate Immune Signaling https://www.biorxiv.org/content/10.64898/2025.12.29.696917v1
Reposted by Anabel Chang
Metabolic Responses of Different Levels of Fitness https://www.biorxiv.org/content/10.64898/2025.12.27.696707v1
December 28, 2025 at 6:01 AM
Metabolic Responses of Different Levels of Fitness https://www.biorxiv.org/content/10.64898/2025.12.27.696707v1
Reposted by Anabel Chang
micromorph: a Python toolkit for measurement of microbial morphology https://www.biorxiv.org/content/10.64898/2025.12.05.692496v1
December 6, 2025 at 10:15 AM
micromorph: a Python toolkit for measurement of microbial morphology https://www.biorxiv.org/content/10.64898/2025.12.05.692496v1
Reposted by Anabel Chang
Spotlight: Freeman and Grinstein discuss a study from Riederer et al. (rupress.org/jcb/article/...) questioning whether TMEM175 contributes to #Parkinsons disease by serving as a pH-regulatory H⁺ channel or a K⁺ channel. rupress.org/jcb/article/...
November 26, 2025 at 6:02 PM
Spotlight: Freeman and Grinstein discuss a study from Riederer et al. (rupress.org/jcb/article/...) questioning whether TMEM175 contributes to #Parkinsons disease by serving as a pH-regulatory H⁺ channel or a K⁺ channel. rupress.org/jcb/article/...
Reposted by Anabel Chang
Studying trapped antimatter could help to explain why our world is so full of matter
go.nature.com/4pAySqA
go.nature.com/4pAySqA
Laser cooling traps more antimatter atoms than ever before
Studying trapped antimatter could help to explain why our world is so full of matter.
go.nature.com
November 28, 2025 at 10:33 AM
Studying trapped antimatter could help to explain why our world is so full of matter
go.nature.com/4pAySqA
go.nature.com/4pAySqA
Reposted by Anabel Chang
Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...
November 19, 2025 at 6:15 PM
Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...
Reposted by Anabel Chang
Direct measurements of luminal Ca²⁺ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors. New study from Belén Calvo, Sandip Patel, Teresa Alonso @uva-es.bsky.social and colleagues: rupress.org/jcb/article/...
#Technology #Physiology #CellSignaling #Organelles #Lysosomes #Endosomes
#Technology #Physiology #CellSignaling #Organelles #Lysosomes #Endosomes
November 14, 2025 at 2:45 PM
Direct measurements of luminal Ca²⁺ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors. New study from Belén Calvo, Sandip Patel, Teresa Alonso @uva-es.bsky.social and colleagues: rupress.org/jcb/article/...
#Technology #Physiology #CellSignaling #Organelles #Lysosomes #Endosomes
#Technology #Physiology #CellSignaling #Organelles #Lysosomes #Endosomes
Reposted by Anabel Chang
Watson – who won the Nobel Prize for his role in divining the structure of DNA; was instrumental in initiating and propelling the Human Genome Project; and who became notorious for his history of racist and sexist comments – has died at 97
Read the full story: go.nature.com/47NJ6wy
Read the full story: go.nature.com/47NJ6wy
November 8, 2025 at 10:24 AM
Watson – who won the Nobel Prize for his role in divining the structure of DNA; was instrumental in initiating and propelling the Human Genome Project; and who became notorious for his history of racist and sexist comments – has died at 97
Read the full story: go.nature.com/47NJ6wy
Read the full story: go.nature.com/47NJ6wy
Reposted by Anabel Chang
Lysosomal permeabilization by Group A Streptococcus releases proteins into the macrophage cytosol https://www.biorxiv.org/content/10.1101/2025.10.25.684498v1
October 26, 2025 at 1:16 AM
Lysosomal permeabilization by Group A Streptococcus releases proteins into the macrophage cytosol https://www.biorxiv.org/content/10.1101/2025.10.25.684498v1
Reposted by Anabel Chang
LLMs can mirror expert judgment but often rely on word patterns rather than reasoning. A new study introduces epistemia, the illusion of knowledge that occurs when surface plausibility replaces verification. In PNAS: https://ow.ly/ry7S50Xcv9b
October 16, 2025 at 7:00 PM
LLMs can mirror expert judgment but often rely on word patterns rather than reasoning. A new study introduces epistemia, the illusion of knowledge that occurs when surface plausibility replaces verification. In PNAS: https://ow.ly/ry7S50Xcv9b
Reposted by Anabel Chang
Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on #endosomes. New work from Kevin Swift, Iryna Pustova, Anjon Audhya and colleagues @uwmadison.bsky.social: rupress.org/jcb/article/...
#membrane #lipid
#membrane #lipid
October 15, 2025 at 2:15 PM
Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on #endosomes. New work from Kevin Swift, Iryna Pustova, Anjon Audhya and colleagues @uwmadison.bsky.social: rupress.org/jcb/article/...
#membrane #lipid
#membrane #lipid
Reposted by Anabel Chang
New study from Swift, Pustova, Audhya et al. @uwmadison.bsky.social defines the native dynamics of the ESCRT-III component Ist1 in mammalian cells, highlighting the existence of multiple, unique pools at #endosomes. rupress.org/jcb/article/...
#membrane #lipid
#membrane #lipid
October 8, 2025 at 4:01 PM
New study from Swift, Pustova, Audhya et al. @uwmadison.bsky.social defines the native dynamics of the ESCRT-III component Ist1 in mammalian cells, highlighting the existence of multiple, unique pools at #endosomes. rupress.org/jcb/article/...
#membrane #lipid
#membrane #lipid
Reposted by Anabel Chang
Here's a reminder on #InternationalCoffeeDay: It's OK to take a (coffee) break. ☕
"It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student," a #PhD student wrote in this 2019 #ScienceWorkingLife. https://scim.ag/4nvLTBb
"It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student," a #PhD student wrote in this 2019 #ScienceWorkingLife. https://scim.ag/4nvLTBb
October 1, 2025 at 4:24 PM
Here's a reminder on #InternationalCoffeeDay: It's OK to take a (coffee) break. ☕
"It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student," a #PhD student wrote in this 2019 #ScienceWorkingLife. https://scim.ag/4nvLTBb
"It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student," a #PhD student wrote in this 2019 #ScienceWorkingLife. https://scim.ag/4nvLTBb
Reposted by Anabel Chang
Duque et al @unm.edu show that a core membrane #atg8ylation & #autophagy factor ATG16L1 controls proton V-ATPase under homeostatic conditions, ensuring normo-acidification, preservation of cellular energy charge & function, & defense against #tuberculosis in murine models rupress.org/jcb/article/...
September 9, 2025 at 4:15 PM
Duque et al @unm.edu show that a core membrane #atg8ylation & #autophagy factor ATG16L1 controls proton V-ATPase under homeostatic conditions, ensuring normo-acidification, preservation of cellular energy charge & function, & defense against #tuberculosis in murine models rupress.org/jcb/article/...
Reposted by Anabel Chang
Virulence priming of Listeria monocytogenes inside replication-permissive endolysosomes https://www.biorxiv.org/content/10.1101/2025.09.02.673654v1
September 3, 2025 at 4:17 AM
Virulence priming of Listeria monocytogenes inside replication-permissive endolysosomes https://www.biorxiv.org/content/10.1101/2025.09.02.673654v1