For #FluorescenceFriday, microtubules are shown in this massive oligodendrocyte from a primary hippocampal culture 🔬 #Microscopy #Neuroscience
February 21, 2025 at 8:29 PM
For #FluorescenceFriday, microtubules are shown in this massive oligodendrocyte from a primary hippocampal culture 🔬 #Microscopy #Neuroscience
New preprint from the lab 🎉: γ-tubulin is a novel target of the tubulin autoregulation pathway! Previously thought to exclusively target α- and β-tubulin mRNAs, we show that the TTC5–SCAPER–CNOT11 axis also degrades γ-tubulin mRNA, expanding the scope of this fundamental regulatory mechanism.
January 10, 2026 at 11:17 AM
New preprint from the lab 🎉: γ-tubulin is a novel target of the tubulin autoregulation pathway! Previously thought to exclusively target α- and β-tubulin mRNAs, we show that the TTC5–SCAPER–CNOT11 axis also degrades γ-tubulin mRNA, expanding the scope of this fundamental regulatory mechanism.
For #FluorescenceFriday, microtubule networks are shown in two adipocytes 🔬 #CellBiology #Microscopy
September 5, 2025 at 6:39 PM
For #FluorescenceFriday, microtubule networks are shown in two adipocytes 🔬 #CellBiology #Microscopy
🔬 Cryo-EM Reveals the Molecular Machinery of Tubulin Assembly
In a recent study from @ucdavis.bsky.social, #cryoEM and #CryoSPARC were used to uncover the molecular mechanism underlying α/β-tubulin biogenesis!
Read more on the latest CyoSPARC blog 👉 cryosparc.com/blog/tubulin
In a recent study from @ucdavis.bsky.social, #cryoEM and #CryoSPARC were used to uncover the molecular mechanism underlying α/β-tubulin biogenesis!
Read more on the latest CyoSPARC blog 👉 cryosparc.com/blog/tubulin
July 30, 2026 at 12:30 PM
🔬 Cryo-EM Reveals the Molecular Machinery of Tubulin Assembly
In a recent study from @ucdavis.bsky.social, #cryoEM and #CryoSPARC were used to uncover the molecular mechanism underlying α/β-tubulin biogenesis!
Read more on the latest CyoSPARC blog 👉 cryosparc.com/blog/tubulin
In a recent study from @ucdavis.bsky.social, #cryoEM and #CryoSPARC were used to uncover the molecular mechanism underlying α/β-tubulin biogenesis!
Read more on the latest CyoSPARC blog 👉 cryosparc.com/blog/tubulin
αチューブリンとビメンチンを染めたHeLa細胞です。Immunofluorescence of α-Tubulin & Vimentin in HeLa cells.
🧡anti-α-Tubulin (proteinteck, 11224-1-AP)
🩵anti-Vimentin (SigmaAldrich, V6630)
💙Nucleus (Hoechst)
🔬KEYENCE, BZ-XLC1
Image size: approx. 130μm × 100μm
#PositiveControlSharing #Microscopy #αTubulin #Vimentin #ポジコン共有
🧡anti-α-Tubulin (proteinteck, 11224-1-AP)
🩵anti-Vimentin (SigmaAldrich, V6630)
💙Nucleus (Hoechst)
🔬KEYENCE, BZ-XLC1
Image size: approx. 130μm × 100μm
#PositiveControlSharing #Microscopy #αTubulin #Vimentin #ポジコン共有
June 23, 2026 at 6:03 PM
αチューブリンとビメンチンを染めたHeLa細胞です。Immunofluorescence of α-Tubulin & Vimentin in HeLa cells.
🧡anti-α-Tubulin (proteinteck, 11224-1-AP)
🩵anti-Vimentin (SigmaAldrich, V6630)
💙Nucleus (Hoechst)
🔬KEYENCE, BZ-XLC1
Image size: approx. 130μm × 100μm
#PositiveControlSharing #Microscopy #αTubulin #Vimentin #ポジコン共有
🧡anti-α-Tubulin (proteinteck, 11224-1-AP)
🩵anti-Vimentin (SigmaAldrich, V6630)
💙Nucleus (Hoechst)
🔬KEYENCE, BZ-XLC1
Image size: approx. 130μm × 100μm
#PositiveControlSharing #Microscopy #αTubulin #Vimentin #ポジコン共有
✨#FluorescenceFriday brings you a glowing Berghia stephanieae juvenile! This stunning sea slug is lit up with Anti-α-Tubulin 🟢, revealing the dense network of cilia that help it glide across surfaces. 🐌💫 Image taken by @Luiza-O-Saad.bsky.social
#Microscopy #DevBio
#Microscopy #DevBio
June 6, 2025 at 1:01 PM
✨#FluorescenceFriday brings you a glowing Berghia stephanieae juvenile! This stunning sea slug is lit up with Anti-α-Tubulin 🟢, revealing the dense network of cilia that help it glide across surfaces. 🐌💫 Image taken by @Luiza-O-Saad.bsky.social
#Microscopy #DevBio
#Microscopy #DevBio
🍃 🧪 Regulation of γ-Tubulin by α,β-Tubulin Levels
Results in control of microtubule nucleation during division
Results in control of microtubule nucleation during division
Tubulin controls the number of microtubules!
January 10, 2026 at 11:47 AM
🍃 🧪 Regulation of γ-Tubulin by α,β-Tubulin Levels
Results in control of microtubule nucleation during division
Results in control of microtubule nucleation during division
#Microtubule #SkeletalMuscle
TUBB6, β6V tubulin
⏫in muscle regeneration/dystrophy/myositis
TUBB6 overexpression➡️WT FDB muscle
⏫tubulin detyrosination + total α-tubulin
shRNA Tubb6➡️mdx FDB muscle
normalize cortical microtubule
#MyoTwitter
#HumMolGenet 2019
academic.oup.com/hmg/article/...
TUBB6, β6V tubulin
⏫in muscle regeneration/dystrophy/myositis
TUBB6 overexpression➡️WT FDB muscle
⏫tubulin detyrosination + total α-tubulin
shRNA Tubb6➡️mdx FDB muscle
normalize cortical microtubule
#MyoTwitter
#HumMolGenet 2019
academic.oup.com/hmg/article/...
March 16, 2025 at 11:09 AM
#Microtubule #SkeletalMuscle
TUBB6, β6V tubulin
⏫in muscle regeneration/dystrophy/myositis
TUBB6 overexpression➡️WT FDB muscle
⏫tubulin detyrosination + total α-tubulin
shRNA Tubb6➡️mdx FDB muscle
normalize cortical microtubule
#MyoTwitter
#HumMolGenet 2019
academic.oup.com/hmg/article/...
TUBB6, β6V tubulin
⏫in muscle regeneration/dystrophy/myositis
TUBB6 overexpression➡️WT FDB muscle
⏫tubulin detyrosination + total α-tubulin
shRNA Tubb6➡️mdx FDB muscle
normalize cortical microtubule
#MyoTwitter
#HumMolGenet 2019
academic.oup.com/hmg/article/...
Tubulin arginylation regulates #microtubule dynamics. New study from MacTaggart, @annakashina.bsky.social and colleagues identifies an ATE1-dependent #arginylation site at E77 of α-tubulin and show that this modification regulates the binding of MAP1S to #microtubules. https://buff.ly/4jqLqhT
January 24, 2025 at 5:58 PM
Tubulin arginylation regulates #microtubule dynamics. New study from MacTaggart, @annakashina.bsky.social and colleagues identifies an ATE1-dependent #arginylation site at E77 of α-tubulin and show that this modification regulates the binding of MAP1S to #microtubules. https://buff.ly/4jqLqhT
Thinking about the role of tubulin acetylation in cell physiology? Look no further 🙌 check out the review Lisa Donker and I wrote on this puzzling microtubule PTM 👇
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Rethinking tubulin acetylation: From regulation to cellular adaptation
Ever since its discovery, acetylation of α-tubulin on lysine 40 (K40) has been associated with the presence of long-lived, stable microtubules. Indeed…
www.sciencedirect.com
April 14, 2025 at 11:17 AM
Thinking about the role of tubulin acetylation in cell physiology? Look no further 🙌 check out the review Lisa Donker and I wrote on this puzzling microtubule PTM 👇
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Learn more about the clinical relevance of the tubulin code in our comprehensive review, recently published in Cancer and Metastasis Reviews.
#Cancer #Tubulin
link.springer.com/article/10.1...
#Cancer #Tubulin
link.springer.com/article/10.1...
Prognostic, diagnostic and therapeutic value of the cancer tubulin code - Cancer and Metastasis Reviews
Microtubules are essential cytoskeleton polymers composed of α/β-tubulin heterodimers that play a central role in the regulation of various cellular processes, including cell division, cell shape, cel...
link.springer.com
August 11, 2026 at 4:47 PM
Learn more about the clinical relevance of the tubulin code in our comprehensive review, recently published in Cancer and Metastasis Reviews.
#Cancer #Tubulin
link.springer.com/article/10.1...
#Cancer #Tubulin
link.springer.com/article/10.1...
Indirect immunostaining of rat hippocampus neurons with
β-Actin (red), Giantin (green) and α-Tubulin (blue). Nuclei have been visualized by DAPI staining (cyan).
#FluorescenceFriday
#neuroscience
#CellBiology
β-Actin (red), Giantin (green) and α-Tubulin (blue). Nuclei have been visualized by DAPI staining (cyan).
#FluorescenceFriday
#neuroscience
#CellBiology
February 7, 2025 at 2:57 PM
Indirect immunostaining of rat hippocampus neurons with
β-Actin (red), Giantin (green) and α-Tubulin (blue). Nuclei have been visualized by DAPI staining (cyan).
#FluorescenceFriday
#neuroscience
#CellBiology
β-Actin (red), Giantin (green) and α-Tubulin (blue). Nuclei have been visualized by DAPI staining (cyan).
#FluorescenceFriday
#neuroscience
#CellBiology
This ‘fundamental’ study shows that the α-tubulin tail is exposed more or less depending on the microtubule lattice state, influencing how microtubules interact with binding proteins and undergo chemical modifications.
🔗 buff.ly/dLncjnM
🔗 buff.ly/dLncjnM
February 20, 2026 at 9:03 PM
This ‘fundamental’ study shows that the α-tubulin tail is exposed more or less depending on the microtubule lattice state, influencing how microtubules interact with binding proteins and undergo chemical modifications.
🔗 buff.ly/dLncjnM
🔗 buff.ly/dLncjnM
In this Opinion article, Yu-Ming Lu discusses multiple important studies on microtubule acetylation with the aim of clarifying the actual role of α-tubulin K40 acetylation, a major tubulin post-translational modification.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
July 22, 2025 at 8:43 AM
In this Opinion article, Yu-Ming Lu discusses multiple important studies on microtubule acetylation with the aim of clarifying the actual role of α-tubulin K40 acetylation, a major tubulin post-translational modification.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
The metallopeptidase MATCAP1 preferentially binds microtubules with an expanded tubulin conformation to generate detyrosinated and ΔC2 α-tubulin
@kjverhey1.bsky.social, Puck Ohi and collaborators
link.springer.com/article/10.1...
@kjverhey1.bsky.social, Puck Ohi and collaborators
link.springer.com/article/10.1...
MATCAP1 preferentially binds an expanded tubulin conformation to generate detyrosinated and ΔC2 α-tubulin - The EMBO Journal
Microtubules are cytoskeletal filaments with critical roles in cell division, cell motility, intracellular trafficking, and cilium function. In cells, subsets of microtubules are selectively marked by...
link.springer.com
April 14, 2026 at 12:07 PM
The metallopeptidase MATCAP1 preferentially binds microtubules with an expanded tubulin conformation to generate detyrosinated and ΔC2 α-tubulin
@kjverhey1.bsky.social, Puck Ohi and collaborators
link.springer.com/article/10.1...
@kjverhey1.bsky.social, Puck Ohi and collaborators
link.springer.com/article/10.1...
Microtubule lattice conformation and integrity regulate α-tubulin acetylation https://www.biorxiv.org/content/10.1101/2025.09.09.675099v1
September 10, 2025 at 11:30 AM
Microtubule lattice conformation and integrity regulate α-tubulin acetylation https://www.biorxiv.org/content/10.1101/2025.09.09.675099v1
What does a fruit fly dosage compensation complex have to do with human brain development? More than one expected.
Stunning paper by the lab of @asifa-akhtar.bsky.social in Science Advances: »Stage-specific epigenetic priming amplifies gene activation during lineage commitment« (1/6)
Stunning paper by the lab of @asifa-akhtar.bsky.social in Science Advances: »Stage-specific epigenetic priming amplifies gene activation during lineage commitment« (1/6)
March 27, 2026 at 7:37 PM
What does a fruit fly dosage compensation complex have to do with human brain development? More than one expected.
Stunning paper by the lab of @asifa-akhtar.bsky.social in Science Advances: »Stage-specific epigenetic priming amplifies gene activation during lineage commitment« (1/6)
Stunning paper by the lab of @asifa-akhtar.bsky.social in Science Advances: »Stage-specific epigenetic priming amplifies gene activation during lineage commitment« (1/6)
A unified mechanism for tubulin cofactors catalyzing α/β-tubulin biogenesis and degradation pubmed.ncbi.nlm.nih.gov/42102195/ #cryoem
May 9, 2026 at 9:42 PM
A unified mechanism for tubulin cofactors catalyzing α/β-tubulin biogenesis and degradation pubmed.ncbi.nlm.nih.gov/42102195/ #cryoem
A new paper in PNAS identifies tumabulin-2 as a #molecularglue targeting the tripartite interface of α-tubulin, β-tubulin, & RB3 to elicit a novel mechanism of microtubule disruption via stabilization of a polymer-incompatible complex & sequestration of tubulin dimers!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
March 14, 2025 at 5:22 PM
A new paper in PNAS identifies tumabulin-2 as a #molecularglue targeting the tripartite interface of α-tubulin, β-tubulin, & RB3 to elicit a novel mechanism of microtubule disruption via stabilization of a polymer-incompatible complex & sequestration of tubulin dimers!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Let's start this Thursday having some fun with #June 's Image of the Month!
🎮 This composition is not our beloved Tetris but centriole images obtained with acetylated α-tubulin staining.
Thanks Marcos Fariña and Júlia Mestres from @luderslab.bsky.social!
#ImageOfTheMonth #CancerResearch
🎮 This composition is not our beloved Tetris but centriole images obtained with acetylated α-tubulin staining.
Thanks Marcos Fariña and Júlia Mestres from @luderslab.bsky.social!
#ImageOfTheMonth #CancerResearch
June 5, 2025 at 9:36 AM
Let's start this Thursday having some fun with #June 's Image of the Month!
🎮 This composition is not our beloved Tetris but centriole images obtained with acetylated α-tubulin staining.
Thanks Marcos Fariña and Júlia Mestres from @luderslab.bsky.social!
#ImageOfTheMonth #CancerResearch
🎮 This composition is not our beloved Tetris but centriole images obtained with acetylated α-tubulin staining.
Thanks Marcos Fariña and Júlia Mestres from @luderslab.bsky.social!
#ImageOfTheMonth #CancerResearch
The cryoEM structure of blood cell-specific tubulin is out! @cryoempapers.bsky.social @pdbeurope.bsky.social @actacrystd.iucr.org
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Structure of blood cell-specific tubulin and demonstration of dimer spacing compaction in a single protofilament
Microtubule (MT) function plasticity originates from its composition of α− and β−tubulin isotypes and the post-translational modifications of both sub…
www.sciencedirect.com
January 3, 2025 at 1:50 AM
The cryoEM structure of blood cell-specific tubulin is out! @cryoempapers.bsky.social @pdbeurope.bsky.social @actacrystd.iucr.org
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
🔬We study the dorsal root ganglion (DRG), which is a cluster of cells located just outside of the spinal cord. The DRG routes pain signals from the periphery to the central nervous system.
#FluorescenceFriday #sciart #neuroart
#FluorescenceFriday #sciart #neuroart
March 14, 2025 at 5:27 PM
🔬We study the dorsal root ganglion (DRG), which is a cluster of cells located just outside of the spinal cord. The DRG routes pain signals from the periphery to the central nervous system.
#FluorescenceFriday #sciart #neuroart
#FluorescenceFriday #sciart #neuroart
#Microtubule #SmoothMuscleCell Contractility
MT support #SarcoplasmicReticulum - #PlasmaMembrance contact
RyR2 channel clusters on tubulin filaments
Nocodazole
⏫Ca2+ spark spread
⏬RyR2-BKα co-localization
⏫myogenic tone
@vesselman.bsky.social #SciSignal 2017
www.science.org/doi/10.1126/...
MT support #SarcoplasmicReticulum - #PlasmaMembrance contact
RyR2 channel clusters on tubulin filaments
Nocodazole
⏫Ca2+ spark spread
⏬RyR2-BKα co-localization
⏫myogenic tone
@vesselman.bsky.social #SciSignal 2017
www.science.org/doi/10.1126/...
February 22, 2025 at 12:26 PM
#Microtubule #SmoothMuscleCell Contractility
MT support #SarcoplasmicReticulum - #PlasmaMembrance contact
RyR2 channel clusters on tubulin filaments
Nocodazole
⏫Ca2+ spark spread
⏬RyR2-BKα co-localization
⏫myogenic tone
@vesselman.bsky.social #SciSignal 2017
www.science.org/doi/10.1126/...
MT support #SarcoplasmicReticulum - #PlasmaMembrance contact
RyR2 channel clusters on tubulin filaments
Nocodazole
⏫Ca2+ spark spread
⏬RyR2-BKα co-localization
⏫myogenic tone
@vesselman.bsky.social #SciSignal 2017
www.science.org/doi/10.1126/...
If you like sproinger and microtubule, behold NOMPC/TRPN, sensor of gentle touch in flies and fish! Cell deformation and microtubule movements are thought to compress the spring-like ankyrin repeats and in turn gate the channel.
December 25, 2025 at 9:42 AM
If you like sproinger and microtubule, behold NOMPC/TRPN, sensor of gentle touch in flies and fish! Cell deformation and microtubule movements are thought to compress the spring-like ankyrin repeats and in turn gate the channel.
