Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis
Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis
Exploiting ORFeome libraries with different C-terminal architectures, Grant et al. perform comparative stability profiling to identify a conditionally regulated C-degron pathway governed by the CTLHMuskelin E3 ligase complex. Its substrate AAMP is the human ortholog of yeast Sqt1 and acts similarly as a uL16 chaperone, connecting nutrient status to control of ribosome biogenesis.
dlvr.it
November 9, 2026 at 4:19 PM
Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis
New from us. We show proof-of-concept that protein biogenesis intermediates contain druggable pockets, and create a platform for binder discovery. This new approach could dramatically expand druggable space and be useful for the most challenging targets. 1/2 www.biorxiv.org/content/10.6...
Selective binders of a cotranslational folding intermediate
Drug discovery efforts typically target mature, folded proteins, primarily to inhibit their function or induce their degradation. An alternative strategy would be to target incompletely folded states ...
www.biorxiv.org
November 9, 2026 at 4:37 PM
New from us. We show proof-of-concept that protein biogenesis intermediates contain druggable pockets, and create a platform for binder discovery. This new approach could dramatically expand druggable space and be useful for the most challenging targets. 1/2 www.biorxiv.org/content/10.6...
queen’s domain: It Has The Juice
im only three hours in but it’s the best Metroid Prime since Metroid Prime
wish I loved the combat flow more but I respect why it’s the way it is. surprised it surpasses the hype!
youtu.be/FdQySmFfZlU?...
im only three hours in but it’s the best Metroid Prime since Metroid Prime
wish I loved the combat flow more but I respect why it’s the way it is. surprised it surpasses the hype!
youtu.be/FdQySmFfZlU?...
Queen's Domain | PC & Console Launch Trailer
YouTube video by Biogenesis
youtu.be
November 7, 2026 at 6:58 PM
queen’s domain: It Has The Juice
im only three hours in but it’s the best Metroid Prime since Metroid Prime
wish I loved the combat flow more but I respect why it’s the way it is. surprised it surpasses the hype!
youtu.be/FdQySmFfZlU?...
im only three hours in but it’s the best Metroid Prime since Metroid Prime
wish I loved the combat flow more but I respect why it’s the way it is. surprised it surpasses the hype!
youtu.be/FdQySmFfZlU?...
I gotta say, the game director’s signature on the fourms is pretty great
It’s changed to match the next dlc but for biogenesis it was
“Adding meat to our spaceship of Theseus”
And if that’s not the stellaris devs, what is?
It’s changed to match the next dlc but for biogenesis it was
“Adding meat to our spaceship of Theseus”
And if that’s not the stellaris devs, what is?
November 10, 2026 at 3:52 AM
I gotta say, the game director’s signature on the fourms is pretty great
It’s changed to match the next dlc but for biogenesis it was
“Adding meat to our spaceship of Theseus”
And if that’s not the stellaris devs, what is?
It’s changed to match the next dlc but for biogenesis it was
“Adding meat to our spaceship of Theseus”
And if that’s not the stellaris devs, what is?
🧪 Elucidating molecular mechanisms of chloroplast biogenesis and operation: protein translocation and regulation by the ubiquitin-proteasome system - with @pauljarvislab.bsky.social
On the biogenesis of chloroplasts (plastids) in plants, eg import of proteins and proteolysis
On the biogenesis of chloroplasts (plastids) in plants, eg import of proteins and proteolysis
Elucidating molecular mechanisms of chloroplast biogenesis and operation: protein translocation and regulation by the ubiquitin-proteasome system at University of Oxford on FindAPhD.com
PhD Project - Elucidating molecular mechanisms of chloroplast biogenesis and operation: protein translocation and regulation by the ubiquitin-proteasome system at University of Oxford, listed on FindAPhD.com
bit.ly
November 5, 2026 at 10:32 AM
🧪 Elucidating molecular mechanisms of chloroplast biogenesis and operation: protein translocation and regulation by the ubiquitin-proteasome system - with @pauljarvislab.bsky.social
On the biogenesis of chloroplasts (plastids) in plants, eg import of proteins and proteolysis
On the biogenesis of chloroplasts (plastids) in plants, eg import of proteins and proteolysis
Combining these data, we determine a LOF mechanism for each variant/position. From this we can say which positions primarily govern receptor biogenesis vs those that have signaling-specific effects.
November 10, 2026 at 8:01 PM
Combining these data, we determine a LOF mechanism for each variant/position. From this we can say which positions primarily govern receptor biogenesis vs those that have signaling-specific effects.
🩸 #Zinc ions, migrasomes & platelet function!
Zinc ions inhibit #migrasome #biogenesis, lower #cholesterol and #sphingomyelin levels, and reduce platelet #aggregation, revealing a link between trace #elements and #hemostasis.
www.oaepublish.com/articles/evc...
@luismsilva.bsky.social
Zinc ions inhibit #migrasome #biogenesis, lower #cholesterol and #sphingomyelin levels, and reduce platelet #aggregation, revealing a link between trace #elements and #hemostasis.
www.oaepublish.com/articles/evc...
@luismsilva.bsky.social
November 10, 2026 at 6:44 AM
🩸 #Zinc ions, migrasomes & platelet function!
Zinc ions inhibit #migrasome #biogenesis, lower #cholesterol and #sphingomyelin levels, and reduce platelet #aggregation, revealing a link between trace #elements and #hemostasis.
www.oaepublish.com/articles/evc...
@luismsilva.bsky.social
Zinc ions inhibit #migrasome #biogenesis, lower #cholesterol and #sphingomyelin levels, and reduce platelet #aggregation, revealing a link between trace #elements and #hemostasis.
www.oaepublish.com/articles/evc...
@luismsilva.bsky.social
Watched the launch trailer for Queen's Domain and like 90% of it I haven't even seen yet, and I've put in 12 hours on it already. This game is bananas. www.youtube.com/watch?v=FdQy...
Queen's Domain | PC & Console Launch Trailer
YouTube video by Biogenesis
www.youtube.com
November 7, 2026 at 5:34 PM
Watched the launch trailer for Queen's Domain and like 90% of it I haven't even seen yet, and I've put in 12 hours on it already. This game is bananas. www.youtube.com/watch?v=FdQy...
Combining the information from these 3 DMS, we can assign a LOF mechanism to each variant/position. Ultimately we can determine which are essential for receptor biogenesis and which have signaling-specific effects
November 10, 2026 at 7:25 PM
Combining the information from these 3 DMS, we can assign a LOF mechanism to each variant/position. Ultimately we can determine which are essential for receptor biogenesis and which have signaling-specific effects
RESEARCH PAPER: mTOR inactivation governs adaptive survival to ribosome biogenesis deficiency
By Fan et al. and Marikki Laiho
➡️ https://genesdev.cshlp.org/content/40/21-22/1855.abstract
Johns Hopkins University
#cancer #ribosome #translation #mTOR
By Fan et al. and Marikki Laiho
➡️ https://genesdev.cshlp.org/content/40/21-22/1855.abstract
Johns Hopkins University
#cancer #ribosome #translation #mTOR
November 5, 2026 at 7:00 PM
RESEARCH PAPER: mTOR inactivation governs adaptive survival to ribosome biogenesis deficiency
By Fan et al. and Marikki Laiho
➡️ https://genesdev.cshlp.org/content/40/21-22/1855.abstract
Johns Hopkins University
#cancer #ribosome #translation #mTOR
By Fan et al. and Marikki Laiho
➡️ https://genesdev.cshlp.org/content/40/21-22/1855.abstract
Johns Hopkins University
#cancer #ribosome #translation #mTOR
Host-Derived Lipids Sustain Membrane Biogenesis in an Obligate Endosymbiont https://www.biorxiv.org/content/10.64898/2026.11.04.764378v1
November 6, 2026 at 11:32 AM
Host-Derived Lipids Sustain Membrane Biogenesis in an Obligate Endosymbiont https://www.biorxiv.org/content/10.64898/2026.11.04.764378v1
Host-Derived Lipids Sustain Membrane Biogenesis in an Obligate Endosymbiont https://www.biorxiv.org/content/10.64898/2026.11.04.764378v1
November 6, 2026 at 11:32 AM
Host-Derived Lipids Sustain Membrane Biogenesis in an Obligate Endosymbiont https://www.biorxiv.org/content/10.64898/2026.11.04.764378v1
✨Highly Cited Paper
#Exosomes in #PrecisionOncology and Beyond: From Bench to Bedside in Diagnostics and Therapeutics
👥by Emile Youssef, Dannelle Palmer et al.
📈Citations: 76
Full text➡️ www.mdpi.com/2072-6694/17...
#ExtracellularVesicles
#Exosomes in #PrecisionOncology and Beyond: From Bench to Bedside in Diagnostics and Therapeutics
👥by Emile Youssef, Dannelle Palmer et al.
📈Citations: 76
Full text➡️ www.mdpi.com/2072-6694/17...
#ExtracellularVesicles
November 11, 2026 at 9:11 AM
✨Highly Cited Paper
#Exosomes in #PrecisionOncology and Beyond: From Bench to Bedside in Diagnostics and Therapeutics
👥by Emile Youssef, Dannelle Palmer et al.
📈Citations: 76
Full text➡️ www.mdpi.com/2072-6694/17...
#ExtracellularVesicles
#Exosomes in #PrecisionOncology and Beyond: From Bench to Bedside in Diagnostics and Therapeutics
👥by Emile Youssef, Dannelle Palmer et al.
📈Citations: 76
Full text➡️ www.mdpi.com/2072-6694/17...
#ExtracellularVesicles
Hong Kong Baptist University researchers review how extracellular vesicles use surface proteins to target tissues, influence inflammation, immune responses, and cancer spread.
These signals could enable better biomarkers and targeted therapies.
www.oaepublish.com/articles/evc...
These signals could enable better biomarkers and targeted therapies.
www.oaepublish.com/articles/evc...
Extracellular vesicle surface proteins in tissue recognition, organotropism, biomarkers, and therapeutic engineering
Extracellular vesicles (EVs), including exosomes, carry donor-cell-derived molecular features that influence their interactions with recipient cells. This review links EV biogenesis and the assembly o...
www.oaepublish.com
November 9, 2026 at 1:37 PM
Hong Kong Baptist University researchers review how extracellular vesicles use surface proteins to target tissues, influence inflammation, immune responses, and cancer spread.
These signals could enable better biomarkers and targeted therapies.
www.oaepublish.com/articles/evc...
These signals could enable better biomarkers and targeted therapies.
www.oaepublish.com/articles/evc...
Anionic lipids stabilize etioplast prolamellar bodies and facilitate thylakoid biogenesis during etioplast-to-chloroplast differentiation https://www.biorxiv.org/content/10.64898/2026.10.31.763292v1
November 4, 2026 at 10:02 AM
Anionic lipids stabilize etioplast prolamellar bodies and facilitate thylakoid biogenesis during etioplast-to-chloroplast differentiation https://www.biorxiv.org/content/10.64898/2026.10.31.763292v1
RRID:AB_3073913 from @proteintech.bsky.social was used by authors in their Cell Reports paper. We value the author's support of reproducibility. #methodsmatter #BetterScience #OpenResearch
Mesothelin-induced lysosomal biogenesis sustains neutrophil longevity to drive brain metastasis
Read the full paper: Mesothelin-induced lysosomal biogenesis sustains neutrophil longevity to drive brain metastasis
doi.org
November 6, 2026 at 8:00 AM
RRID:AB_3073913 from @proteintech.bsky.social was used by authors in their Cell Reports paper. We value the author's support of reproducibility. #methodsmatter #BetterScience #OpenResearch
Small Nucleolar RNAs, Big Impact: Biogenesis, Mechanisms, and Roles in Health and Disease
American journal of physiology. Cell physiology · Natarajaseenivasan et al.
doi.org/10.1152/ajpcell.90164.2026
#RNAsky #RNAmods
American journal of physiology. Cell physiology · Natarajaseenivasan et al.
doi.org/10.1152/ajpcell.90164.2026
#RNAsky #RNAmods
Small Nucleolar RNAs, Big Impact: Biogenesis, Mechanisms, and Roles in Health and Disease
American journal of physiology. Cell physiology · Natarajaseenivasan SM, Rai AK, Pierre N, Joseph ME, Lam M, Sharma P, Garikipati VNS.
doi.org
November 4, 2026 at 8:24 PM
Small Nucleolar RNAs, Big Impact: Biogenesis, Mechanisms, and Roles in Health and Disease
American journal of physiology. Cell physiology · Natarajaseenivasan et al.
doi.org/10.1152/ajpcell.90164.2026
#RNAsky #RNAmods
American journal of physiology. Cell physiology · Natarajaseenivasan et al.
doi.org/10.1152/ajpcell.90164.2026
#RNAsky #RNAmods
Queen's Domain | Release Date & Console Reveal Trailer
YouTube video by Biogenesis
youtu.be
November 3, 2026 at 11:06 PM
CRV Science Wiki
🧬 Nucleolus — The nucleolus is the largest subnuclear body in eukaryotic cells and the primary site of ribosome biogenesis—where ribosomal RNA (rRNA) is transcribed from tandem arrays of ribosomal DNA (rDNA), chemically modified, cleaved, an…
https://crvscience.com/wiki/nucleolus
🧬 Nucleolus — The nucleolus is the largest subnuclear body in eukaryotic cells and the primary site of ribosome biogenesis—where ribosomal RNA (rRNA) is transcribed from tandem arrays of ribosomal DNA (rDNA), chemically modified, cleaved, an…
https://crvscience.com/wiki/nucleolus
CRV Science Wiki
🧬 Nucleolus — The nucleolus is the largest subnuclear body in eukaryotic cells and the primary site of ribosome biogenesis—where ribosomal RNA (rRNA) is transcribed from tandem arrays of ribosomal DNA (rDNA), chemically modified, cleaved, and assembled with ~80 ribosomal proteins…
crvscience.com
November 7, 2026 at 9:39 PM
CRV Science Wiki
🧬 Nucleolus — The nucleolus is the largest subnuclear body in eukaryotic cells and the primary site of ribosome biogenesis—where ribosomal RNA (rRNA) is transcribed from tandem arrays of ribosomal DNA (rDNA), chemically modified, cleaved, an…
https://crvscience.com/wiki/nucleolus
🧬 Nucleolus — The nucleolus is the largest subnuclear body in eukaryotic cells and the primary site of ribosome biogenesis—where ribosomal RNA (rRNA) is transcribed from tandem arrays of ribosomal DNA (rDNA), chemically modified, cleaved, an…
https://crvscience.com/wiki/nucleolus
The Dietary Polyphenol Epigallocatechin Gallate Delays Biological Aging by Activating Peroxisome Biogenesis and Peroxisomal Fatty Acid β-Oxidation
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
The Dietary Polyphenol Epigallocatechin Gallate Delays Biological Aging by Activating Peroxisome Biogenesis and Peroxisomal Fatty Acid β‐Oxidation
Dietary EGCG intake was associated with slower biological aging, lower mortality risk, and longer residual life expectancy in humans. Mechanistic studies in C. elegans and AML12 hepatocytes support p...
onlinelibrary.wiley.com
November 4, 2026 at 11:58 PM
The Dietary Polyphenol Epigallocatechin Gallate Delays Biological Aging by Activating Peroxisome Biogenesis and Peroxisomal Fatty Acid β-Oxidation
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Anionic lipids stabilize etioplast prolamellar bodies and facilitate thylakoid biogenesis during etioplast-to-chloroplast differentiation www.biorxiv.org/content/10.64898/2026.10.31.763292v1
November 5, 2026 at 7:45 PM
Anionic lipids stabilize etioplast prolamellar bodies and facilitate thylakoid biogenesis during etioplast-to-chloroplast differentiation www.biorxiv.org/content/10.64898/2026.10.31.763292v1
(🧵 1/4) On the cover of our #LatestIssue: The liverwort Marchantia polymorpha reproduces asexually through clonal propagules called gemmae. Gemma formation is controlled by a developmental program that balances auxin levels and restricts gemma-cell identity...
November 5, 2026 at 3:08 PM
(🧵 1/4) On the cover of our #LatestIssue: The liverwort Marchantia polymorpha reproduces asexually through clonal propagules called gemmae. Gemma formation is controlled by a developmental program that balances auxin levels and restricts gemma-cell identity...
Anionic lipids stabilize etioplast prolamellar bodies and facilitate thylakoid biogenesis during etioplast-to-chloroplast differentiation www.biorxiv.org/content/10.6...
Anionic lipids stabilize etioplast prolamellar bodies and facilitate thylakoid biogenesis during etioplast-to-chloroplast differentiation
Etioplasts of dark-grown angiosperm seedlings contain prolamellar bodies (PLBs), lattice-like membranes that are quickly transformed into thylakoids upon illumination. Phosphatidylglycerol (PG) and su...
www.biorxiv.org
November 5, 2026 at 2:55 PM
Anionic lipids stabilize etioplast prolamellar bodies and facilitate thylakoid biogenesis during etioplast-to-chloroplast differentiation www.biorxiv.org/content/10.6...