In Nature - Paediatric Research
🧪Protein analysis of blood vessels
⬆️ proinflammatory and blood vessel inflammation
🥳#LongCovid was able to be identified with an accuracy of 93%
Great to see some decent research for #longcovidkids
Paper 👇
https://buff.ly/3WxYyIk
🧪Protein analysis of blood vessels
⬆️ proinflammatory and blood vessel inflammation
🥳#LongCovid was able to be identified with an accuracy of 93%
Great to see some decent research for #longcovidkids
Paper 👇
https://buff.ly/3WxYyIk
January 25, 2025 at 10:33 AM
In Nature - Paediatric Research
🧪Protein analysis of blood vessels
⬆️ proinflammatory and blood vessel inflammation
🥳#LongCovid was able to be identified with an accuracy of 93%
Great to see some decent research for #longcovidkids
Paper 👇
https://buff.ly/3WxYyIk
🧪Protein analysis of blood vessels
⬆️ proinflammatory and blood vessel inflammation
🥳#LongCovid was able to be identified with an accuracy of 93%
Great to see some decent research for #longcovidkids
Paper 👇
https://buff.ly/3WxYyIk
Neutrophil-chemoattractant CXCL5 induces lung barrier permeability in acute lung injury https://www.biorxiv.org/content/10.1101/2024.11.25.625215v1
Neutrophil-chemoattractant CXCL5 induces lung barrier permeability in acute lung injury https://www.biorxiv.org/content/10.1101/2024.11.25.625215v1
Rationale: Acute lung injury is frequently caused by pneumonia, and severity correlates with inflamm
www.biorxiv.org
November 27, 2024 at 1:24 AM
Neutrophil-chemoattractant CXCL5 induces lung barrier permeability in acute lung injury https://www.biorxiv.org/content/10.1101/2024.11.25.625215v1
New Journal for ImmunoTherapy of Cancer (JITC) article: Depletion of tumor-derived CXCL5 improves T cell infiltration and anti-PD-1 therapy response in an obese model of pancreatic cancer bit.ly/4bZUKWM
@bailey-bye.bsky.social @mruckert.bsky.social
#JITC #MedSky #OncSky #pancreatic #therapy
@bailey-bye.bsky.social @mruckert.bsky.social
#JITC #MedSky #OncSky #pancreatic #therapy
March 27, 2025 at 4:18 PM
New Journal for ImmunoTherapy of Cancer (JITC) article: Depletion of tumor-derived CXCL5 improves T cell infiltration and anti-PD-1 therapy response in an obese model of pancreatic cancer bit.ly/4bZUKWM
@bailey-bye.bsky.social @mruckert.bsky.social
#JITC #MedSky #OncSky #pancreatic #therapy
@bailey-bye.bsky.social @mruckert.bsky.social
#JITC #MedSky #OncSky #pancreatic #therapy
Played a small part in this cool study @jem.org.
Identifies myofibroblasts as sources of tissue damaging enzymes (MMP1) in TB granuloma, probably responding to cytokine cues from nearby macrophages.
Question now is: can we target therapeutically to prevent post-TB lung damage?
#TBSky #IDSky
Identifies myofibroblasts as sources of tissue damaging enzymes (MMP1) in TB granuloma, probably responding to cytokine cues from nearby macrophages.
Question now is: can we target therapeutically to prevent post-TB lung damage?
#TBSky #IDSky
Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology
Single-cell and spatial transcriptomics of human TB lung tissues from individuals in South Africa revealed that MMP1+CXCL5+ fibroblasts and SPP1+ macrophag
rupress.org
March 4, 2026 at 11:13 PM
Osteoblasts exert a pro-tumorigenic effect on breast cancer spheroids through CXCL5/CXCR2 signalling in two-dimensional and three-dimensional bone mimetic cultures url: royalsocietypublishing.org/rsif/article...
Osteoblasts exert a pro-tumorigenic effect on breast cancer spheroids through CXCL5/CXCR2 signalling in two-dimensional and three-dimensional bone mimetic cultures
Abstract. Bone provides a favourable niche for breast cancer colonization and metastatic progression. Breast cancer cells are attracted to the bone microen
royalsocietypublishing.org
February 23, 2026 at 3:35 AM
Osteoblasts exert a pro-tumorigenic effect on breast cancer spheroids through CXCL5/CXCR2 signalling in two-dimensional and three-dimensional bone mimetic cultures url: royalsocietypublishing.org/rsif/article...
In a new study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/...
#InfectiousDisease
#InfectiousDisease
January 7, 2026 at 2:30 PM
In a new study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/...
#InfectiousDisease
#InfectiousDisease
Yun Xue et al. show that a TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition. rupress.org/jem/article/...
📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25
📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25
March 14, 2025 at 5:15 PM
Yun Xue et al. show that a TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition. rupress.org/jem/article/...
📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25
📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25
Excited to share the latest preprint from the #Nicholaslab my MDPhD student Zena did fantastic work describing a novel niche of macrophages that regulate reproductive hormones. #PitMacs
www.biorxiv.org/content/10.6...
Hoping to find an official home for the with work soon!
@aai.org #immunology
www.biorxiv.org/content/10.6...
Hoping to find an official home for the with work soon!
@aai.org #immunology
Endocrine-Adapted Pituitary Macrophages Regulate Gonadotropin Secretion through CXCL5-CXCR2-MAPK Signaling
Chronic inflammation disrupts hormonal balance in the Hypothalamic-Pituitary-Gonadal (HPG) axis, contributing to reproductive disorders. While immune cells in the hypothalamus and ovaries have been ex...
www.biorxiv.org
August 18, 2026 at 3:58 PM
Excited to share the latest preprint from the #Nicholaslab my MDPhD student Zena did fantastic work describing a novel niche of macrophages that regulate reproductive hormones. #PitMacs
www.biorxiv.org/content/10.6...
Hoping to find an official home for the with work soon!
@aai.org #immunology
www.biorxiv.org/content/10.6...
Hoping to find an official home for the with work soon!
@aai.org #immunology
A multitarget strategy may help address #TNBC heterogeneity.
Opti-hTIF1γ suppresses β-catenin, TGFβ and STAT3 signaling while downregulating CD47 and CXCL5, enhancing #macrophage phagocytosis and #antitumoractivity.
#TumorMicroenvironment #CancerBiology
#STTT #OpenAccess: doi.org/10.1038/s413...
Opti-hTIF1γ suppresses β-catenin, TGFβ and STAT3 signaling while downregulating CD47 and CXCL5, enhancing #macrophage phagocytosis and #antitumoractivity.
#TumorMicroenvironment #CancerBiology
#STTT #OpenAccess: doi.org/10.1038/s413...
October 1, 2026 at 7:42 AM
A multitarget strategy may help address #TNBC heterogeneity.
Opti-hTIF1γ suppresses β-catenin, TGFβ and STAT3 signaling while downregulating CD47 and CXCL5, enhancing #macrophage phagocytosis and #antitumoractivity.
#TumorMicroenvironment #CancerBiology
#STTT #OpenAccess: doi.org/10.1038/s413...
Opti-hTIF1γ suppresses β-catenin, TGFβ and STAT3 signaling while downregulating CD47 and CXCL5, enhancing #macrophage phagocytosis and #antitumoractivity.
#TumorMicroenvironment #CancerBiology
#STTT #OpenAccess: doi.org/10.1038/s413...
Dr. Alec Kimmelman, Dean at @nyugrossman gives a fantastic presentation about metabolic dependencies in pancreatic cancer. He spoke about a relevant loss of PHGDH in PDAC leading to CXCL5 production by tumor cells. CXCL5 acts on hepatocytes or nerves to increase PHGDH & serine.
April 4, 2025 at 10:43 PM
Dr. Alec Kimmelman, Dean at @nyugrossman gives a fantastic presentation about metabolic dependencies in pancreatic cancer. He spoke about a relevant loss of PHGDH in PDAC leading to CXCL5 production by tumor cells. CXCL5 acts on hepatocytes or nerves to increase PHGDH & serine.
Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
October 22, 2025 at 1:28 PM
Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
A new study of blood samples from 112 children found a molecular signature for long COVID, which could lead to a routine blood test for it.
scitechdaily.com/revolutionar...
scitechdaily.com/revolutionar...
January 24, 2025 at 12:38 PM
A new study of blood samples from 112 children found a molecular signature for long COVID, which could lead to a routine blood test for it.
scitechdaily.com/revolutionar...
scitechdaily.com/revolutionar...
New paper from the Nouailles Lab! 🧬
@mucosalimmunol.bsky.social
Co–first authors Sarah Berger, @cgokeri.bsky.social & Peter Pennitz show that CXCL5 not only attracts neutrophils but also weakens the lung barrier in pneumonia.
Read it here: doi.org/10.1016/j.mu...
#LungInjury #Pneumonia #CXCL5
@mucosalimmunol.bsky.social
Co–first authors Sarah Berger, @cgokeri.bsky.social & Peter Pennitz show that CXCL5 not only attracts neutrophils but also weakens the lung barrier in pneumonia.
Read it here: doi.org/10.1016/j.mu...
#LungInjury #Pneumonia #CXCL5
Redirecting
doi.org
October 17, 2025 at 11:52 AM
New paper from the Nouailles Lab! 🧬
@mucosalimmunol.bsky.social
Co–first authors Sarah Berger, @cgokeri.bsky.social & Peter Pennitz show that CXCL5 not only attracts neutrophils but also weakens the lung barrier in pneumonia.
Read it here: doi.org/10.1016/j.mu...
#LungInjury #Pneumonia #CXCL5
@mucosalimmunol.bsky.social
Co–first authors Sarah Berger, @cgokeri.bsky.social & Peter Pennitz show that CXCL5 not only attracts neutrophils but also weakens the lung barrier in pneumonia.
Read it here: doi.org/10.1016/j.mu...
#LungInjury #Pneumonia #CXCL5
And on insights on the role of CXCL5 during acute lung infection in her recent preprint
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Neutrophil-chemoattractant CXCL5 induces lung barrier permeability in acute lung injury
Rationale Acute lung injury is frequently caused by pneumonia, and severity correlates with inflammatory cell recruitment and lung barrier failure. Deciphering drug-targetable pathways is of clinical ...
www.biorxiv.org
September 25, 2025 at 9:09 AM
And on insights on the role of CXCL5 during acute lung infection in her recent preprint
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Intestinal Epithelial C/EBPβ Deficiency Impairs Colitis-Associated Tumorigenesis by Disrupting CXCL1 /CXCL2/CXCL5-CXCR2-Mediated Neutrophil Infiltration https://www.biorxiv.org/content/10.1101/2025.06.25.661448v1
June 28, 2025 at 1:48 AM
Intestinal Epithelial C/EBPβ Deficiency Impairs Colitis-Associated Tumorigenesis by Disrupting CXCL1 /CXCL2/CXCL5-CXCR2-Mediated Neutrophil Infiltration https://www.biorxiv.org/content/10.1101/2025.06.25.661448v1
Neutrophil-chemoattractant CXCL5 induces lung barrier permeability in acute lung injury https://www.biorxiv.org/content/10.1101/2024.11.25.625215v1
Neutrophil-chemoattractant CXCL5 induces lung barrier permeability in acute lung injury https://www.biorxiv.org/content/10.1101/2024.11.25.625215v1
Rationale: Acute lung injury is frequently caused by pneumonia, and severity correlates with inflamm
www.biorxiv.org
November 27, 2024 at 1:24 AM
Neutrophil-chemoattractant CXCL5 induces lung barrier permeability in acute lung injury https://www.biorxiv.org/content/10.1101/2024.11.25.625215v1
Osteoblasts exert a pro-tumorigenic effect on breast cancer spheroids through CXCL5/CXCR2 signalling in two-dimensional and three-dimensional bone mimetic cultures url: royalsocietypublishing.org/rsif/article...
Osteoblasts exert a pro-tumorigenic effect on breast cancer spheroids through CXCL5/CXCR2 signalling in two-dimensional and three-dimensional bone mimetic cultures
Abstract. Bone provides a favourable niche for breast cancer colonization and metastatic progression. Breast cancer cells are attracted to the bone microen
royalsocietypublishing.org
February 25, 2026 at 2:47 PM
Osteoblasts exert a pro-tumorigenic effect on breast cancer spheroids through CXCL5/CXCR2 signalling in two-dimensional and three-dimensional bone mimetic cultures url: royalsocietypublishing.org/rsif/article...
From Spain:
Transcriptomic Profiling of Endothelial Progenitor Cells in Post-COVID-19 Patients: Insights at 3 and 6-Months Post-Infection
www.sciencedirect.com/science/arti...
"Minimal changes between 3 & 6 months suggest sustained endothelial damage"
From Science for ME update
#LongCovid #PASC
Transcriptomic Profiling of Endothelial Progenitor Cells in Post-COVID-19 Patients: Insights at 3 and 6-Months Post-Infection
www.sciencedirect.com/science/arti...
"Minimal changes between 3 & 6 months suggest sustained endothelial damage"
From Science for ME update
#LongCovid #PASC
![Transcriptomic Profiling of Endothelial Progenitor Cells in Post-COVID-19 Patients: Insights at 3 and 6-Months Post-Infection — Poyatos et al.
"Transcriptomic profiling identified differentially expressed genes (DEGs) associated with endothelial homeostasis, inflammation, oxidative stress, and thrombosis. Post-COVID [Endothelial Progenitor Cells] showed downregulation of NOS3, KLF2, ANGPT1, PIK3R3, GBX2, GDF6, SMAD6, SRC, and TGFB1, and upregulation of CASP1, CXCL5, IL12A, SOD2, TIMP3, and TLR2."](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:43rudsv62fuwsmnk7oppgtdy/bafkreicslwnlf62h2t4cclhri3ptl3ruaaa4brpwpllib76hy2pzha5q2i)
October 20, 2025 at 2:12 AM
From Spain:
Transcriptomic Profiling of Endothelial Progenitor Cells in Post-COVID-19 Patients: Insights at 3 and 6-Months Post-Infection
www.sciencedirect.com/science/arti...
"Minimal changes between 3 & 6 months suggest sustained endothelial damage"
From Science for ME update
#LongCovid #PASC
Transcriptomic Profiling of Endothelial Progenitor Cells in Post-COVID-19 Patients: Insights at 3 and 6-Months Post-Infection
www.sciencedirect.com/science/arti...
"Minimal changes between 3 & 6 months suggest sustained endothelial damage"
From Science for ME update
#LongCovid #PASC
New Journal for ImmunoTherapy of Cancer (JITC) article: METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation bit.ly/42CZFIT
#JITC #research #MedSky #OncSky
#JITC #research #MedSky #OncSky
April 23, 2025 at 2:08 PM
New Journal for ImmunoTherapy of Cancer (JITC) article: METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation bit.ly/42CZFIT
#JITC #research #MedSky #OncSky
#JITC #research #MedSky #OncSky
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #ReproducibleResearch #OpenScience #accelerateopenscience
Cancer-intrinsic Cxcl5 orchestrates a global metabolic reprogramming for resistance to oxidative cell death in 3D
doi.org
August 12, 2025 at 7:00 AM
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #ReproducibleResearch #OpenScience #accelerateopenscience
We implanted the Gli2CA line in immune competent mice which demonstrated more rapid tumor growth than the control, more MDSCs and fewer CD8+ T cells. CXCR2 (neutrophil-recruiting) chemokines were also up with Gli2 activation, consistent with Wnt5a-CXCL2/CXCL5 link.
February 24, 2025 at 7:00 PM
We implanted the Gli2CA line in immune competent mice which demonstrated more rapid tumor growth than the control, more MDSCs and fewer CD8+ T cells. CXCR2 (neutrophil-recruiting) chemokines were also up with Gli2 activation, consistent with Wnt5a-CXCL2/CXCL5 link.
Meta-analysis finds that olfactory dysfunction in chronic rhinosinusitis with nasal polyps correlates with Type 2 cytokines (IL-5, IL-6, IL-13, IgE), while polyp-free cases show only weak non-Type-2 links (IL-8, CXCL5)—highlighting distinct local immune fingerprints for smell loss.
🔗 ino.to/OOnoJKD
🔗 ino.to/OOnoJKD
Correlation of Local Nasal Biomarkers and Olfactory Dysfunction in Chronic Rhinosinusitis: A Systematic Review and Meta‐Analysis
Background To systematically evaluate the local biomarkers correlated with olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). Methods A systematic review was conducted in CINAHL, Cochrane ...
ino.to
July 28, 2026 at 4:05 AM
Meta-analysis finds that olfactory dysfunction in chronic rhinosinusitis with nasal polyps correlates with Type 2 cytokines (IL-5, IL-6, IL-13, IgE), while polyp-free cases show only weak non-Type-2 links (IL-8, CXCL5)—highlighting distinct local immune fingerprints for smell loss.
🔗 ino.to/OOnoJKD
🔗 ino.to/OOnoJKD
A paper using RRID:AB_10853339 from @thermofishersci.bsky.social was just published in Journal for ImmunoTherapy of Cancer. Thanks for making your methods matter! #methodsmatter #ReproducibleResearch #STMpublishing
METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation
doi.org
April 21, 2025 at 7:01 AM
A paper using RRID:AB_10853339 from @thermofishersci.bsky.social was just published in Journal for ImmunoTherapy of Cancer. Thanks for making your methods matter! #methodsmatter #ReproducibleResearch #STMpublishing
RRID:Addgene_8455, was just reported to be used in "Depletion of tumor-derived CXCL5 improves T cell infiltration and anti-PD-1 therapy response in an obese model of pancreatic cancer". RRIDs like this improve reproducibility in scientific research. #RRID #ReproducibleResearch
doi.org
April 12, 2025 at 7:00 AM
RRID:Addgene_8455, was just reported to be used in "Depletion of tumor-derived CXCL5 improves T cell infiltration and anti-PD-1 therapy response in an obese model of pancreatic cancer". RRIDs like this improve reproducibility in scientific research. #RRID #ReproducibleResearch