#posting this again if any #postdoc candidates are interested in digging deep into #TCR #Crossreactivity #Tcell functional studies in #autoimmunity and #cancer -please contact me!
Anticipating #new #funding -our lab is seeking #postdocs with #expertise in #Tcells #TCRs #crossreactivity #molecularbiology #protein #production Please #email #RT -start date flexible, end of #2025 or beginning of #2026
a cartoon of an astronaut with the words we need you written below him
ALT: a cartoon of an astronaut with the words we need you written below him
media.tenor.com
June 25, 2025 at 4:38 PM
#posting this again if any #postdoc candidates are interested in digging deep into #TCR #Crossreactivity #Tcell functional studies in #autoimmunity and #cancer -please contact me!
Throwing this out there for those doing westerns on mouse embryo lysates: ALWAYS do a secondary only blot. No matter how "clean" your primary is, your secondary can (and will) cause problems - and Murphy's law ensures the crossreactivity will be the same size as your protein of interest 1/3 🧪 🤬
January 15, 2026 at 4:24 PM
Throwing this out there for those doing westerns on mouse embryo lysates: ALWAYS do a secondary only blot. No matter how "clean" your primary is, your secondary can (and will) cause problems - and Murphy's law ensures the crossreactivity will be the same size as your protein of interest 1/3 🧪 🤬
Starting the year with a brand #NOA from #NIAID #NIH and funding from Cure All Fund -if anyone would like to join as a #postdoc in our lab, please let me know -#TCR #structure #function and #crossreactivity
January 13, 2025 at 10:04 PM
Starting the year with a brand #NOA from #NIAID #NIH and funding from Cure All Fund -if anyone would like to join as a #postdoc in our lab, please let me know -#TCR #structure #function and #crossreactivity
continuing on #TCR #Crossreactivity "recognition of structurally distinct agonist peptides is not indicative of #TCR #promiscuity, but rather #highly #specific alternative solutions to TCR engagement" www.sciencedirect.com/science/arti...
Structure of an Autoimmune T Cell Receptor Complexed with Class II Peptide-MHC: Insights into MHC Bias and Antigen Specificity
T cell receptor crossreactivity with different peptide ligands and biased recognition of MHC are coupled features of antigen recognition that are nece…
www.sciencedirect.com
November 25, 2024 at 3:27 PM
continuing on #TCR #Crossreactivity "recognition of structurally distinct agonist peptides is not indicative of #TCR #promiscuity, but rather #highly #specific alternative solutions to TCR engagement" www.sciencedirect.com/science/arti...
here in bluesky continuing on #TCR and #Crossreactivity -another great paper by Andrew McMichael -"Extent of T cell cross-reactivity presents a paradox; there is evidence that T cells are broadly cross-reactive, but other data show narrow specificities" rupress.org/jem/article-...
T Cell Cross-Reactivity and Conformational Changes during TCR Engagement | Journal of Experimental Medicine | Rockefeller University Press
rupress.org
November 21, 2024 at 5:32 PM
here in bluesky continuing on #TCR and #Crossreactivity -another great paper by Andrew McMichael -"Extent of T cell cross-reactivity presents a paradox; there is evidence that T cells are broadly cross-reactive, but other data show narrow specificities" rupress.org/jem/article-...
Our latest work featured in The Scientist! Sneha Khedkar Did a great job in summarizing the work accessibly while retaining some of the fine details. Happy reading!
www.the-scientist.com/batman-signa...
www.the-scientist.com/batman-signa...
BATMAN Signals T Cell Receptor Crossreactivity
A new AI tool that models how variations in peptides change T cell receptor binding could help design immunotherapies with fewer off-target effects.
www.the-scientist.com
July 27, 2025 at 1:05 AM
Our latest work featured in The Scientist! Sneha Khedkar Did a great job in summarizing the work accessibly while retaining some of the fine details. Happy reading!
www.the-scientist.com/batman-signa...
www.the-scientist.com/batman-signa...
Anticipating #new #funding -our lab is seeking #postdocs with #expertise in #Tcells #TCRs #crossreactivity #molecularbiology #protein #production Please #email #RT -start date flexible, end of #2025 or beginning of #2026
a cartoon of an astronaut with the words we need you written below him
ALT: a cartoon of an astronaut with the words we need you written below him
media.tenor.com
June 12, 2025 at 11:32 AM
Anticipating #new #funding -our lab is seeking #postdocs with #expertise in #Tcells #TCRs #crossreactivity #molecularbiology #protein #production Please #email #RT -start date flexible, end of #2025 or beginning of #2026
The crossreactivity will have a strong HLA component. Just like celiac disease. Having a particular HLA is a requirement, but it doesn’t mean you will get the disease. Why not is not fully understood, may be bad luck generating some TCRs even.
November 28, 2025 at 7:16 PM
The crossreactivity will have a strong HLA component. Just like celiac disease. Having a particular HLA is a requirement, but it doesn’t mean you will get the disease. Why not is not fully understood, may be bad luck generating some TCRs even.
These changes were not seen during influenza H1N1 infection.... this may be due to passive immunity (chidlren aged 5-30 months) or crossreactivity or time since infection. You would expect an immune response, involving IFN responses, it is a stronger inducer of this response.
6/7
6/7
August 3, 2025 at 11:27 AM
These changes were not seen during influenza H1N1 infection.... this may be due to passive immunity (chidlren aged 5-30 months) or crossreactivity or time since infection. You would expect an immune response, involving IFN responses, it is a stronger inducer of this response.
6/7
6/7
Continuing on #crossreactivity Structural basis for #Tcell recognition of altered peptide ligands: a single #TCR can productively recognize a large continuum of related ligands. rupress.org/jem/article-...
Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands. | Journal of Experimental Medicine | Rocke...
rupress.org
April 10, 2025 at 2:18 PM
Continuing on #crossreactivity Structural basis for #Tcell recognition of altered peptide ligands: a single #TCR can productively recognize a large continuum of related ligands. rupress.org/jem/article-...
Continuing on #TCR and #crossreactivity -an amazing paper from Singer "developmental diversion" In between, I am trying to keep my cool! Be kind to all www.nature.com/articles/ni....
Clonal deletion and the fate of autoreactive thymocytes that survive negative selection - Nature Immunology
The role of costimulation in negative selection is controversial. Singer and colleagues demonstrate that it is critical for clonal deletion and its absence results in the diversion of thymocytes to an...
www.nature.com
February 5, 2025 at 7:20 PM
Continuing on #TCR and #crossreactivity -an amazing paper from Singer "developmental diversion" In between, I am trying to keep my cool! Be kind to all www.nature.com/articles/ni....
Looking for autoimmune disease in this age group would be a big challenge. I would expect that the only cases you would see are those that arise from maternal autoantibodies that transfer across the placenta, but I guess there is the theoretical risk of a crossreactivity with self-antigen.
June 25, 2025 at 8:08 PM
Looking for autoimmune disease in this age group would be a big challenge. I would expect that the only cases you would see are those that arise from maternal autoantibodies that transfer across the placenta, but I guess there is the theoretical risk of a crossreactivity with self-antigen.
#Tcell and #crossreactivity #No #one is #naive: the significance of #heterologous #Tcell #immunity www.nature.com/articles/nri...
No one is naive: the significance of heterologous T-cell immunity - Nature Reviews Immunology
Nature Reviews Immunology - No one is naive: the significance of heterologous T-cell immunity
www.nature.com
December 5, 2024 at 3:27 PM
#Tcell and #crossreactivity #No #one is #naive: the significance of #heterologous #Tcell #immunity www.nature.com/articles/nri...
I have been silent on this issue in hand -well here it is #TCR and #crossreactivity A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides. www.sciencedirect.com/science/arti...
A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides
The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocomp…
www.sciencedirect.com
November 5, 2025 at 9:16 PM
I have been silent on this issue in hand -well here it is #TCR and #crossreactivity A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides. www.sciencedirect.com/science/arti...
There is no novel H5N1 variant, but a new strain. Currently N1H1 and H3N2 are in circulation. Because it will be new for many (there will be some crossreactivity), this can become a pandemic if it jumps from human to human. A new SC2 variant is not a major concern.
October 6, 2025 at 3:59 PM
There is no novel H5N1 variant, but a new strain. Currently N1H1 and H3N2 are in circulation. Because it will be new for many (there will be some crossreactivity), this can become a pandemic if it jumps from human to human. A new SC2 variant is not a major concern.
Continuing on #TCR #crossreactivity "how structural diversity can be presented to and accommodated by receptors of the immune system" @nd-bakerlab.bsky.social www.sciencedirect.com/science/arti...
T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility
T cell-mediated immunity requires T cell receptor (TCR) cross-reactivity, the mechanisms behind which remain incompletely elucidated. The αβ TCR A6 re…
www.sciencedirect.com
June 13, 2025 at 4:07 PM
Continuing on #TCR #crossreactivity "how structural diversity can be presented to and accommodated by receptors of the immune system" @nd-bakerlab.bsky.social www.sciencedirect.com/science/arti...
#TCR #crossreactivity "Premature #thymic #eviction is the basis for #CD8Tcell tolerance and is the mechanism responsible for the appearance in the periphery of mature CD8 T cells bearing #autoreactive #TCRs that are absent from the thymus" www.science.org/doi/10.1126/...
CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus
Thymic eviction explains CD8 T cell tolerance and why autoreactive CD8 T cells appear in the periphery but not the thymus.
www.science.org
December 2, 2024 at 5:18 PM
#TCR #crossreactivity "Premature #thymic #eviction is the basis for #CD8Tcell tolerance and is the mechanism responsible for the appearance in the periphery of mature CD8 T cells bearing #autoreactive #TCRs that are absent from the thymus" www.science.org/doi/10.1126/...
I am #obsessed with this concept of #TCR #crossreactivity and race against #pathogens in the context of #autoimmunity
November 18, 2025 at 12:30 PM
I am #obsessed with this concept of #TCR #crossreactivity and race against #pathogens in the context of #autoimmunity
It took many years to do this. Carefully assessing the small fraction of people not EBV-infected and comparing with those EBV+ (10M people). Plus a lot of molecular biology to see if there may be epitopes with crossreactivity.
med.stanford.edu/news/all-new...
med.stanford.edu/news/all-new...
Study identifies how Epstein-Barr virus triggers multiple sclerosis
A new study found that part of the Epstein-Barr virus mimics a protein made in the brain and spinal cord, leading the immune system to mistakenly attack the body's nerve cells.
med.stanford.edu
June 9, 2025 at 6:12 PM
It took many years to do this. Carefully assessing the small fraction of people not EBV-infected and comparing with those EBV+ (10M people). Plus a lot of molecular biology to see if there may be epitopes with crossreactivity.
med.stanford.edu/news/all-new...
med.stanford.edu/news/all-new...
A rare #Trichosporon inkin bloodstream infection in an #ImmunocompetentPatient highlights antigen #CrossReactivity and misidentification, stressing the need for improved #FungalDiagnostics and cautious test use.
#IDSky #ImmunoSky #MedSky #PublicHealth
Read: doi.org/10.1016/j.dc...
#IDSky #ImmunoSky #MedSky #PublicHealth
Read: doi.org/10.1016/j.dc...
March 13, 2026 at 11:40 AM
A rare #Trichosporon inkin bloodstream infection in an #ImmunocompetentPatient highlights antigen #CrossReactivity and misidentification, stressing the need for improved #FungalDiagnostics and cautious test use.
#IDSky #ImmunoSky #MedSky #PublicHealth
Read: doi.org/10.1016/j.dc...
#IDSky #ImmunoSky #MedSky #PublicHealth
Read: doi.org/10.1016/j.dc...
It is thought childhood infections with group 1 viruses (H1N1 and H2N2) promote crossreactivity againts other N1 influenza strains.
Here it is shown that antibody titers to historical and recent H5N1 strains are highest in older individuals and correlate more strongly with
2/4
Here it is shown that antibody titers to historical and recent H5N1 strains are highest in older individuals and correlate more strongly with
2/4
November 9, 2024 at 10:58 AM
It is thought childhood infections with group 1 viruses (H1N1 and H2N2) promote crossreactivity againts other N1 influenza strains.
Here it is shown that antibody titers to historical and recent H5N1 strains are highest in older individuals and correlate more strongly with
2/4
Here it is shown that antibody titers to historical and recent H5N1 strains are highest in older individuals and correlate more strongly with
2/4
have any other Canadians noticed nasal congestion from switching from bourbon to rye? I worry I may be allergic (crossreactivity with nasal allergies to grasses, perhaps?).
May 6, 2025 at 6:56 AM
have any other Canadians noticed nasal congestion from switching from bourbon to rye? I worry I may be allergic (crossreactivity with nasal allergies to grasses, perhaps?).
New viruses, H1N1, H5N1, H3N2, etc, may mean little or no immunity. If a similar strain, or one with crossreactivity, has been around before, there may be an age cohort with immunity. Most of us do not. Smaller changes (drifts) may cause epidemics. But new strains and sifts
5/10
5/10
July 20, 2024 at 6:53 PM
New viruses, H1N1, H5N1, H3N2, etc, may mean little or no immunity. If a similar strain, or one with crossreactivity, has been around before, there may be an age cohort with immunity. Most of us do not. Smaller changes (drifts) may cause epidemics. But new strains and sifts
5/10
5/10
What links dust mites, shellfish, and insect food allergies? 🦗🌬️🧪 www.news-medical.net/news/2025042... #FoodAllergy #EdibleInsects #DustMites #CrossReactivity #Allergens #Immunology #Tenerife #MolecularDiagnostics #Tropomyosin #Nutrition
What links dust mites, shellfish, and insect food allergies?
A study of 634 allergy patients in Tenerife found that 22% were sensitized to edible insects—often without ever consuming them, due to cross-reactivity with house dust mites. Tropomyosin and arginine ...
www.news-medical.net
April 24, 2025 at 2:25 AM
What links dust mites, shellfish, and insect food allergies? 🦗🌬️🧪 www.news-medical.net/news/2025042... #FoodAllergy #EdibleInsects #DustMites #CrossReactivity #Allergens #Immunology #Tenerife #MolecularDiagnostics #Tropomyosin #Nutrition
Accurate #FungalDiagnosis can be difficult when rare #pathogens mimic other infections.
This case shows how #Trichosporon inkin can be misidentified & exhibit unexpected antigen #CrossReactivity, highlighting the need for improved diagnostics. #MedSky
Read: doi.org/10.1016/j.dc...
This case shows how #Trichosporon inkin can be misidentified & exhibit unexpected antigen #CrossReactivity, highlighting the need for improved diagnostics. #MedSky
Read: doi.org/10.1016/j.dc...
July 7, 2026 at 7:52 AM
Accurate #FungalDiagnosis can be difficult when rare #pathogens mimic other infections.
This case shows how #Trichosporon inkin can be misidentified & exhibit unexpected antigen #CrossReactivity, highlighting the need for improved diagnostics. #MedSky
Read: doi.org/10.1016/j.dc...
This case shows how #Trichosporon inkin can be misidentified & exhibit unexpected antigen #CrossReactivity, highlighting the need for improved diagnostics. #MedSky
Read: doi.org/10.1016/j.dc...