Can AI revolutionize protein engineering and enzyme design? 🧬🤖 Explore smarter enzyme development, innovative biocatalysis, and sustainable solutions at BCBTC🌱

📅 March 25–26, 2027 | Singapore

Join to learn!

#BCBTC2027 #Biocatalysis #ProteinEngineering #EnzymeDesign #AI #Biotechnology

🚀 Big news from #Hephaistos ⚙️ The #ETH startup
is launching its first industrial pilot with #SpiroChem, bringing de novo designed enzymes from the lab into real-world chemical synthesis > tinyurl.com/ynyja5nk
@ethz.ch #ETHstartup #Biotech #Biocatalysis #EnzymeDesign

Biomatter Raises €6.5M to Revolutionize #EnzymeDesign with #GenerativeAI: With fresh funding, Biomatter aims to revolutionize enzyme creation using its Intelligent Architecture™ platform, enabling rapid innovation across multiple industries. #synbio

✨Millions of years of evolution unlocked! Scientists are now *designing* optimal enzymes from scratch!🤯 A new era for biology & chemistry!🔬 #EnzymeDesign

Source: https://phys.org/news/2025-05-enzymes-universal-optimal-enzyme.html

Why borrow from nature when you can build better? Scientists just created enzymes from scratch — unlocking cleaner, smarter chemistry. #EnzymeDesign #GreenChemistry #SyntheticBiology

📣We offer a #PhDposition in #MachineLearning for #EnzymeDesign in Mehdi Davari's group. Funded within the Priority Programme SPP2363 “Molecular Machine Learning” by @dfg.de.

🔗All information: www.ipb-halle.de/en/career/jo...

📅Apply now!

#Bioinformatics
#Chemoinformatics
#Joboffer
#Scijobs

Done for today
#teaching #biomoleculardesign #enzymedesign #pymol

Who can guess the enzyme?

Keynote by Don Hilvert 🧪 Mastering enzyme design and evolution — from mechanistic insights to de novo biocatalysts. A true pioneer in protein engineering! #CSSB25 #EnzymeDesign #ProteinEngineering

In collaboration with @birtehoecker.bsky.social, we’ve unlocked enzymatic activity in a minimal de novo TIM barrel by designing a custom lid for catalysis! 🧵👇
#ProteinDesign #EnzymeDesign

Customizing the Structure of a Minimal TIM Barrel to Create a De Novo Enzyme
www.biorxiv.org/content/10.1...

Together, our findings reveal how distal mutations sculpt enzyme function by reshaping the catalytic cycle for more efficient catalysis.

What does this mean for enzyme design? Find out in our preprint: www.biorxiv.org/content/10.1...
#Enzymology #Biophysics #Catalysis #EnzymeDesign

Happy to announce our latest article on #enzymedesign, in collaboration with Mike Thompson's group! Check it out in JACS:

Design of Efficient Artificial Enzymes Using Crystallographically Enhanced Conformational Sampling

pubs.acs.org/doi/full/10....

🚨Out now in Angewandte Chemie:

AI.zymes - A modular platform for evolutionary enzyme design.

AI.zymes integrates established and emerging bioengineering tools into a coherent pipeline for #enzymedesign.

📄Paper: doi.org/10.1002/anie...
💻GitHub: github.com/bunzela/AIzy...

Ammonia is key to fertilizers and essential to feed the world.🌍Its industrial production consumes ~2% of the global energy.
In this fully funded PhD project, you'll combine #enzymedesign and #directedevolution to turn nitrogen into ammonia.💡🌱

AI.zymes was developed primarily by Master students at
ETH Zurich and U Bristol!

Thanks to Lucas, Jannik, Abbie, Vivienne, Moor, Tudor, and Adrian for advancing #enzymedesign and bringing AI.zymes to life!🎉

🚨Preprint Alert!🚨

#ProteinDesign is advancing rapidly—wouldn't it be great to seamlessly combine design tools to achieve more than what each can do alone?🤔

Here, we introduce AI.zymes: A modular platform for evolutionary #EnzymeDesign.♻️🖥️

biorxiv.org/content/10.1...
1/🧵

AI-designed enzymes are here! A trio of diffusion models—RFdiffusion2, RFdiffusion3 & Riff-Diff—are solving long-standing challenges in enzyme design, enabling new reactions never seen in nature. The age of programmable chemistry begins. 🔍⚗️🧬
#AIforScience #EnzymeDesign
cen.acs.org/physical-che...