We have a great PhD program across many disciplines, including #proteinengineering, #directedevolution, #machinelearning, #biocatalysis, #enzymes, and much more.
We’re looking for talented, driven graduate students to join our growing Chemical Engineering Ph.D. program at @caltech.edu !
⏰ Applications are due December 1, 2024.
➡️ Apply Here: www.applyweb.com/caltgapp/ind...
⏰ Applications are due December 1, 2024.
➡️ Apply Here: www.applyweb.com/caltgapp/ind...
November 27, 2024 at 6:47 PM
We have a great PhD program across many disciplines, including #proteinengineering, #directedevolution, #machinelearning, #biocatalysis, #enzymes, and much more.
🧠🦋💫Please share! Ambitious young scientist? Multiple
@ERC_Research #postdoc #opportunities in #RNA #DirectedEvolution #GenomeEditing #FitnessLandscapes #Bioengineering #MachineLearning at @GOLDLab_UCD. Full details here: www.gold-lab.org/we-are-hiring
@ERC_Research #postdoc #opportunities in #RNA #DirectedEvolution #GenomeEditing #FitnessLandscapes #Bioengineering #MachineLearning at @GOLDLab_UCD. Full details here: www.gold-lab.org/we-are-hiring
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www.gold-lab.org
September 22, 2026 at 2:44 PM
🧠🦋💫Please share! Ambitious young scientist? Multiple
@ERC_Research #postdoc #opportunities in #RNA #DirectedEvolution #GenomeEditing #FitnessLandscapes #Bioengineering #MachineLearning at @GOLDLab_UCD. Full details here: www.gold-lab.org/we-are-hiring
@ERC_Research #postdoc #opportunities in #RNA #DirectedEvolution #GenomeEditing #FitnessLandscapes #Bioengineering #MachineLearning at @GOLDLab_UCD. Full details here: www.gold-lab.org/we-are-hiring
Our new paper on AI-generated TrpBs with @anima-anandkumar.bsky.social. GenSLM generated very useful promiscuous TrpB #enzymes, bypassing a lot of #directedevolution! great work by the whole team, especially Theophile Lambert. www.biorxiv.org/content/10.1...
www.biorxiv.org
September 4, 2025 at 2:58 PM
Our new paper on AI-generated TrpBs with @anima-anandkumar.bsky.social. GenSLM generated very useful promiscuous TrpB #enzymes, bypassing a lot of #directedevolution! great work by the whole team, especially Theophile Lambert. www.biorxiv.org/content/10.1...
New paper from our lab @elife.bsky.social . We show how #DirectedEvolution reshaped #CRISPR for expanding DNA recongition.
This is work by Kazi Hossain, an incredibly talented student visiting my lab from the Czub lab, now in Orozco's lab & Lukasz Nierzwicki.
doi.org/10.7554/eLif...
This is work by Kazi Hossain, an incredibly talented student visiting my lab from the Czub lab, now in Orozco's lab & Lukasz Nierzwicki.
doi.org/10.7554/eLif...
February 11, 2025 at 8:22 AM
New paper from our lab @elife.bsky.social . We show how #DirectedEvolution reshaped #CRISPR for expanding DNA recongition.
This is work by Kazi Hossain, an incredibly talented student visiting my lab from the Czub lab, now in Orozco's lab & Lukasz Nierzwicki.
doi.org/10.7554/eLif...
This is work by Kazi Hossain, an incredibly talented student visiting my lab from the Czub lab, now in Orozco's lab & Lukasz Nierzwicki.
doi.org/10.7554/eLif...
This is a very good, succinct description of the problem! I gave it to my group to read. #directedevolution #enzymes #AI4proteins
November 26, 2024 at 12:37 AM
This is a very good, succinct description of the problem! I gave it to my group to read. #directedevolution #enzymes #AI4proteins
Check out our new review we wrote with @shaunmckinnie.bsky.social @robbieshepherd.bsky.social pubs.rsc.org/en/content/a... looking at the interface of MS for screening large mutant libraries like those associated with #directedevolution @ucscscicomm.bsky.social
‘Need for speed: high throughput’ – mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes
Covering: 2015 to 2024Mass spectrometry (MS)-based methods have been implemented extensively for enzyme engineering due to their label-free nature, making them suitable for screening a wide range of b...
pubs.rsc.org
March 3, 2025 at 5:24 PM
Check out our new review we wrote with @shaunmckinnie.bsky.social @robbieshepherd.bsky.social pubs.rsc.org/en/content/a... looking at the interface of MS for screening large mutant libraries like those associated with #directedevolution @ucscscicomm.bsky.social
🌍 Exciting news! This summer, my group joins @mpimicrobiomarburg.bsky.social l to create photoenzymes for solar energy conversion & carbon capture. With #ProteinDesign 🖥️ & #DirectedEvolution 🧬, we’ll push enzyme design to new limits for a sustainable future!
#Hiring www.mpg.de/24336572/phd...
#Hiring www.mpg.de/24336572/phd...
Three PhD positions | Computational protein design
Three PhD postiions in computational protein design
www.mpg.de
March 16, 2025 at 7:39 AM
🌍 Exciting news! This summer, my group joins @mpimicrobiomarburg.bsky.social l to create photoenzymes for solar energy conversion & carbon capture. With #ProteinDesign 🖥️ & #DirectedEvolution 🧬, we’ll push enzyme design to new limits for a sustainable future!
#Hiring www.mpg.de/24336572/phd...
#Hiring www.mpg.de/24336572/phd...
Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
Research Position (PhD) in organic chemistry and b...
<div style="text-align: justify;">The research group „Organic Chemistry and&nb...
uni-bielefeld.hr4you.org
June 27, 2025 at 9:13 PM
Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
📅July 7-11
The 2025 Onassis Lectures in Biology and Chemistry will be held @forth-ite.bsky.social, Heraklion, Crete. This year’s Lectures are devoted to the advances, challenges, and future prospects of #Re-engineeringBiology through #DirectedEvolution and #Synthetic cellular pathways.
The 2025 Onassis Lectures in Biology and Chemistry will be held @forth-ite.bsky.social, Heraklion, Crete. This year’s Lectures are devoted to the advances, challenges, and future prospects of #Re-engineeringBiology through #DirectedEvolution and #Synthetic cellular pathways.
July 2, 2025 at 8:14 AM
📅July 7-11
The 2025 Onassis Lectures in Biology and Chemistry will be held @forth-ite.bsky.social, Heraklion, Crete. This year’s Lectures are devoted to the advances, challenges, and future prospects of #Re-engineeringBiology through #DirectedEvolution and #Synthetic cellular pathways.
The 2025 Onassis Lectures in Biology and Chemistry will be held @forth-ite.bsky.social, Heraklion, Crete. This year’s Lectures are devoted to the advances, challenges, and future prospects of #Re-engineeringBiology through #DirectedEvolution and #Synthetic cellular pathways.
Chen Liang and Li Dali's teams engineered smACGmax, a tri-base editor fusing deaminases and glycosylases inside Cas9 to achieve up to 41% simultaneous A, C, and G editing for multi-residue saturation screening. 🧬🤖 #BaseEditing #CRISPR #NatureComms2026 #TriBaseEditor #DirectedEvolution #Genomics
July 31, 2026 at 7:37 AM
Chen Liang and Li Dali's teams engineered smACGmax, a tri-base editor fusing deaminases and glycosylases inside Cas9 to achieve up to 41% simultaneous A, C, and G editing for multi-residue saturation screening. 🧬🤖 #BaseEditing #CRISPR #NatureComms2026 #TriBaseEditor #DirectedEvolution #Genomics
Very relevant to #DirectedEvolution and what transition vs. transversion mutations do if they happen at the 2nd base.
TIL when you sort the codon wheel by the second base the quadrants align with the properties of the amino acids being coded for and also it looks like the mystic sigil of the coven of the four bases
journals.asm.org/doi/pdf/10.1...
journals.asm.org/doi/pdf/10.1...
February 15, 2025 at 5:43 PM
Very relevant to #DirectedEvolution and what transition vs. transversion mutations do if they happen at the 2nd base.
📄🌿 PSRW summary
In planta directed evolution: Turning a single leaf into a laboratory of quasi-infinite variants
🔗 plantae.org/in-planta-di...
#PlantaePSRW #PlantScience #DirectedEvolution
In planta directed evolution: Turning a single leaf into a laboratory of quasi-infinite variants
🔗 plantae.org/in-planta-di...
#PlantaePSRW #PlantScience #DirectedEvolution
In planta directed evolution: Turning a single leaf into a laboratory of quasi-infinite variants | Plantae
Directed evolution aims to identify variants of a gene of interest (GOI) with improved or novel functions by accelerating mutation and selection under experimental conditions. However…
plantae.org
January 28, 2026 at 3:00 PM
📄🌿 PSRW summary
In planta directed evolution: Turning a single leaf into a laboratory of quasi-infinite variants
🔗 plantae.org/in-planta-di...
#PlantaePSRW #PlantScience #DirectedEvolution
In planta directed evolution: Turning a single leaf into a laboratory of quasi-infinite variants
🔗 plantae.org/in-planta-di...
#PlantaePSRW #PlantScience #DirectedEvolution
Yeah, like this!
February 24, 2025 at 10:29 PM
Yeah, like this!
Researchers engineered A&GBE and the QBMM hypermutator (dTAGBE+AID) to achieve concurrent, balanced four-base (A, T, G, C) mutagenesis across a ~100 bp window in mammalian cells. 🧬🤖 #BaseEditing #NatComms2026 #GenomeEditing #DirectedEvolution #Hypermutator #MAP2K1
August 31, 2026 at 8:37 AM
Researchers engineered A&GBE and the QBMM hypermutator (dTAGBE+AID) to achieve concurrent, balanced four-base (A, T, G, C) mutagenesis across a ~100 bp window in mammalian cells. 🧬🤖 #BaseEditing #NatComms2026 #GenomeEditing #DirectedEvolution #Hypermutator #MAP2K1
✨Scientists are *evolving* genes in the lab! 🧬 Mimicking nature's power to create & refine proteins.🤯 What will they engineer next? #DirectedEvolution
Source: https://phys.org/news/2025-10-rapid-scalable-platform-enables-evolution.html
Source: https://phys.org/news/2025-10-rapid-scalable-platform-enables-evolution.html
Rapid and scalable platform enables directed evolution in plant cells
Directed evolution is a laboratory technique that mimics natural selection and allows scientists to evolve genes and the proteins they encode. Traditionally, this technique has been used in microbes, mammalian cells, or in test tubes.
phys.org
October 4, 2025 at 5:52 AM
✨Scientists are *evolving* genes in the lab! 🧬 Mimicking nature's power to create & refine proteins.🤯 What will they engineer next? #DirectedEvolution
Source: https://phys.org/news/2025-10-rapid-scalable-platform-enables-evolution.html
Source: https://phys.org/news/2025-10-rapid-scalable-platform-enables-evolution.html
Recent Advances in Cytochrome P450 Engineering
📢 Biocatalysis and Biotransformation Congress 2026
🗓️ October 21–22, 2026
📍 San Francisco, California, USA
🏢 Organized by Sciinov Group
#Biocatalysis #Biotransformation #CytochromeP450
#EnzymeEngineering #DirectedEvolution #GreenChemistry
📢 Biocatalysis and Biotransformation Congress 2026
🗓️ October 21–22, 2026
📍 San Francisco, California, USA
🏢 Organized by Sciinov Group
#Biocatalysis #Biotransformation #CytochromeP450
#EnzymeEngineering #DirectedEvolution #GreenChemistry
March 23, 2026 at 4:01 AM
Recent Advances in Cytochrome P450 Engineering
📢 Biocatalysis and Biotransformation Congress 2026
🗓️ October 21–22, 2026
📍 San Francisco, California, USA
🏢 Organized by Sciinov Group
#Biocatalysis #Biotransformation #CytochromeP450
#EnzymeEngineering #DirectedEvolution #GreenChemistry
📢 Biocatalysis and Biotransformation Congress 2026
🗓️ October 21–22, 2026
📍 San Francisco, California, USA
🏢 Organized by Sciinov Group
#Biocatalysis #Biotransformation #CytochromeP450
#EnzymeEngineering #DirectedEvolution #GreenChemistry
🔥Hot Off the Press | GRAPE: #DirectedEvolution in #Plants
A #Science study shows GRAPE enables fast, versatile directed evolution in planta. Evolved NLR NRC3 escapes nematode inhibition; rice NLR Pikm-1 recognizes 6 AVR-Pik alleles. Boosts plant breeding.
ow.ly/ZlMQ50XyUek
A #Science study shows GRAPE enables fast, versatile directed evolution in planta. Evolved NLR NRC3 escapes nematode inhibition; rice NLR Pikm-1 recognizes 6 AVR-Pik alleles. Boosts plant breeding.
ow.ly/ZlMQ50XyUek
December 1, 2025 at 4:00 PM
🔥Hot Off the Press | GRAPE: #DirectedEvolution in #Plants
A #Science study shows GRAPE enables fast, versatile directed evolution in planta. Evolved NLR NRC3 escapes nematode inhibition; rice NLR Pikm-1 recognizes 6 AVR-Pik alleles. Boosts plant breeding.
ow.ly/ZlMQ50XyUek
A #Science study shows GRAPE enables fast, versatile directed evolution in planta. Evolved NLR NRC3 escapes nematode inhibition; rice NLR Pikm-1 recognizes 6 AVR-Pik alleles. Boosts plant breeding.
ow.ly/ZlMQ50XyUek
GRAPE is a new platform for in planta directed evolution. For this, it uses geminivirus rolling circle replication achieving high-throughput selection for desired gene activities.🌱
doi.org/10.1126/scie...
#iGEM2026#SynBio#directedevolution
doi.org/10.1126/scie...
#iGEM2026#SynBio#directedevolution
Engineered geminivirus replicons enable rapid in planta directed evolution
Directed evolution can rapidly generate genetic variants with new and enhanced properties, yet efficient platforms for performing such evolution directly in plant cells have been lacking. We developed...
doi.org
October 27, 2025 at 12:49 PM
GRAPE is a new platform for in planta directed evolution. For this, it uses geminivirus rolling circle replication achieving high-throughput selection for desired gene activities.🌱
doi.org/10.1126/scie...
#iGEM2026#SynBio#directedevolution
doi.org/10.1126/scie...
#iGEM2026#SynBio#directedevolution
Ammonia is key to fertilizers and essential to feed the world.🌍Its industrial production consumes ~2% of the global energy.
In this fully funded PhD project, you'll combine #enzymedesign and #directedevolution to turn nitrogen into ammonia.💡🌱
In this fully funded PhD project, you'll combine #enzymedesign and #directedevolution to turn nitrogen into ammonia.💡🌱
March 25, 2025 at 8:52 AM
Ammonia is key to fertilizers and essential to feed the world.🌍Its industrial production consumes ~2% of the global energy.
In this fully funded PhD project, you'll combine #enzymedesign and #directedevolution to turn nitrogen into ammonia.💡🌱
In this fully funded PhD project, you'll combine #enzymedesign and #directedevolution to turn nitrogen into ammonia.💡🌱
A huge thanks to my past and present group members, mentors, and collaborators who have supported this journey!
#Biocatalysis #EnzymeEngineering #Photoenzymes #SustainableChemistry #DirectedEvolution #ComputationalBiology #ProteinDesign #Hiring #PhDPositions
#Biocatalysis #EnzymeEngineering #Photoenzymes #SustainableChemistry #DirectedEvolution #ComputationalBiology #ProteinDesign #Hiring #PhDPositions
March 16, 2025 at 7:39 AM
A huge thanks to my past and present group members, mentors, and collaborators who have supported this journey!
#Biocatalysis #EnzymeEngineering #Photoenzymes #SustainableChemistry #DirectedEvolution #ComputationalBiology #ProteinDesign #Hiring #PhDPositions
#Biocatalysis #EnzymeEngineering #Photoenzymes #SustainableChemistry #DirectedEvolution #ComputationalBiology #ProteinDesign #Hiring #PhDPositions