Enzymatic halogenation of C–H bonds is a promising approach to synthesize chlorine-containing compounds. However, few halogenases chlorinate C(sp3)–H bonds of molecules lacking a carrier protein, and ...

Direct regioselective C-3 halogenation of pyridines is achieved using ether solvents, and interactions between the pyridine substrate, ether solvent and haleniums play a dominant role in the reactivit...

Flavin-dependent halogenases (FDHs) provide a biocatalytic approach for the site-selective halogenation of aromatic compounds, but their use in late-stage functionalization of peptides has remained li...

Radical processes can be leveraged to impart meta selectivity in pyridine functionalization, offering a valuable approach for the late-stage functionalization of bioactive molecules.

Halogenation of natural products can improve their bioactivity, pharmacokinetics, and commercial value, yet sustainable production of halogenated smal…

In this study meta-selective single-step bromination and chlorination reactions of pyridines and their derivatives are developed, with pyridinium radical cations as the key intermediates. A spin-densi...

Nature Reviews Materials, Published online: 21 May 2025; doi:10.1038/s41578-025-00804-3Organic solar cells that use halogenated building blocks now boast power conversion efficiencies beyond 20%, albeit at the expense of increased synthetic complexity. This Perspective explores trade-offs among efficiency, scalability and cost–effectiveness in halogenated organic solar cells.

Despite their intriguing native metalloenzymology, naturally occurring copper enzymes remain largely underexploited for new-to-nature biocatalytic reactions. Herein, we report the systematic investigation and reprogramming of natural copper enzymes to catalyze unnatural free radical (pseudo)halogenation reaction in a highly enantioselective fashion. Evaluating Cu enzymes in the decarboxylative azidation of redox-active esters revealed activity across multiple Cu enzyme families, with type III b…

Halogenation of ligands intensely modulates the redox and photophysical properties of transition-metal complexes, yet fully halogenated systems remain largely unexplored. Here we report the synthesis ...

Inspired by natural cryptic halogenation in C,C-bond formation, this study developed a synthetic approach combining biocatalytic bromination with transition-metal-catalyzed cross-coupling. Using the c...

Vanadium-dependent haloperoxidases (VHPOs) are versatile enzymes that catalyze oxidation of halides followed by halogenation of electron-rich substrates, but the factors dictating substrate and haloge...

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Carbon–hydrogen (C–H) bonds are the foundation of essentially every organic molecule, making them an ideal place to do chemical synthesis. The key challenge is achieving selectivity for one particular C(sp3)−H bond1–3. In recent years, metalloenzymes have been found to perform C(sp3)−H bond functionalization4,5. Despite substantial progresses in the past two decades6,7, enzymatic halogenation and pseudohalogenation of unactivated C(sp3)−H—providing a functional handle for further modification—have been achieved with only non-haem iron/α-ketoglutarate-dependent halogenases, and are therefore limited by the chemistry possible with these enzymes8. Here we report the discovery and characterization of a previously unknown halogenase ApnU, part of a protein family containing domain of unknown function 3328 (DUF3328). ApnU uses copper in its active site to catalyse iterative chlorinations on multiple unactivated C(sp3)−H bonds. By taking advantage of the softer copper centre, we demonstrate t

#LCSOJournalClub 207.1 (Highlighted in picture) a simple selective C3-halogenation of pyridines developed by Ning Jiao, Song Song and co-workers from Peking University in Nat. Synth. https://lnkd.in/e...