Happy to announce that the final version of our paper on #endothelial cell #migration #mechanobiology, #angiogenesis, #hydrostaticpressure is out on @elife.bsky.social doi.org/10.7554/eLif... !! In our revised paper, we show that disrupted osmotic gradient and water inflow impair tip cell migration!

#SmoothMuscleCell #Piezo1 #Hypertension

#HydrostaticPressure➡️
⏫GPR146➡️
⏫SMC synthetic phenotype
⏫cAMP-CREB-Piezo1➡️⏫Syst/Diastolic Blood Pressure

Evidence from GPR146 KO
SMC-GPR146 KI & KO
AAV2-SM22a-GPR146 +SMC-Piezo1 KO🐭

#CircRes 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

#VascularCalcification Mechanobiology

#HydrostaticPressure 120 mmHg 7 d➡️
⏫#Piezo1➡️ (⏫ #ERStress GPR78 CHOP➡️)
⏫ #SmoothMuscleCell Calcification (~20% level by 4 mM Pi)

#BBAMolBasisDis 2025
www.sciencedirect.com/science/arti...

#YAP/TAZ #HydrostaticPressure #EndothelialCell

Effects of Pressure (20 mmHg capillary, 55 mmHg arteriole) on 2D & 3D EC behaviors
⏫#SproutingAngiogenesis
mouse aortic ring
3D EC microchannel
YAP/TAZ-dependent

⏫Partial #EndMT

⏫YAP nucleation

#CommsBio 2024
www.nature.com/articles/s42...

The #StarlingEquation explains fluid movement across capillaries, balancing #HydrostaticPressure & #OncoticPressure to regulate tissue #FluidExchange. Key for #Physiology, #MedicalEducation, and understanding #Edema formation.

New NIOO publication: Hydrostatic pressure impedes the degradation of sinking copepod carcasses and fecal pellets, by @bele_fc and others.
#zooplankton #particulateorganiccarbon #hydrostaticpressure
https://doi.org/10.1093/plankt/fbae002

Dowd Junction used Aquaerix®-HD PLDCC—lightweight, permeable backfill for landslide stabilization.

Learn more:
https://aerixindustries.com/featured-case-studies/

#Vail #Infrastructure #LandslideRemediation #AQUAERiX #HydrostaticPressure #AerixIndustries

Bulk + single-cell transcriptomics of #EndothelialCell (HUVEC) under #HydrostaticPressure (0, 20, 60 mmHg)

MYC signaling diminishes with⏫pressure
▶️permissive for arterialization or #EHT

Any force sensor for pressure identified? Piezo?😁

bioRxiv 2024
www.biorxiv.org/content/10.1...