#ILC3s
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natmicrobiol.nature.com
OUT NOW: ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice

#microsky #immunosky

www.nature.com/articles/s41...
ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice - Nature Microbiology
Akkermansia muciniphila can promote intestinal pathogen infection in mice via microbial metabolite succinate production, but the expansion of A. muciniphila is strictly controlled by ILC3s through the...
www.nature.com
February 18, 2025 at 10:10 AM
daltmann.bsky.social
ILC3s sense gut microbiota through STING to initiate immune tolerance: Immunity www.cell.com/immunity/ful...
ILC3s sense gut microbiota through STING to initiate immune tolerance
Maintaining immune tolerance to the microbiota is essential for gut health. Zhou et al. demonstrate that ILC3s are a RORγt+ APC that sense the microbiota through STING to induce microbiota-specific Tr...
www.cell.com
June 23, 2025 at 5:31 AM
ejvillablanca.bsky.social
ILC3s behaving like iLC2s

“ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling”

Science Immunology

www.science.org/doi/10.1126/...
ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling
Gut ILC3s help type 2 immunity by boosting tuft cell differentiation.
www.science.org
May 17, 2025 at 8:04 PM
theonlylabever.bsky.social
Happy to share new work from #theonlylabever, lead by the phenomenal @sltai.bsky.social - who developed a tool to study the biology of ILC3s, identifying their role in controlling CSF2-dependent myeloid cells. 🤗
@mucosalimmunol.bsky.social @societymucosalimm.bsky.social
OA: doi.org/10.1016/j.mu...
October 15, 2025 at 5:11 AM
nizet.bsky.social
New immune cell population just dropped!

Unique group of ILC3s lives 𝙄𝙉𝙎𝙄𝘿𝙀 lung blood vessels, not the tissue. Upon 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 infection, they quickly mobilize CCL4 to summon neutrophils

Without them, bacterial clearance is delayed and inflammation lingers

www.nature.com/articles/s41...
April 19, 2025 at 7:55 PM
labwaggoner.bsky.social
Gut ILC3s help type 2 immunity by boosting tuft cell differentiation @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
May 17, 2025 at 7:57 PM
labwaggoner.bsky.social
Within hours of initiating high fat diet, microbiota-driven inflammation coordinates with lipid accumulation in ILC3s to trigger mitochondrial lipid peroxidation and ILC3 cell death @cp-immunity.bsky.social @harvardmed.bsky.social
www.cell.com/immunity/ful...
March 31, 2026 at 6:15 PM
labwaggoner.bsky.social
ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice @naturemicrobiol.bsky.social
www.nature.com/articles/s41...
ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice - Nature Microbiology
Akkermansia muciniphila can promote intestinal pathogen infection in mice via microbial metabolite succinate production, but the expansion of A. muciniphila is strictly controlled by ILC3s through the...
www.nature.com
February 18, 2025 at 4:23 AM
immunoeditor.bsky.social
In the latest #Science #Immunology: researchers @ Tsinghua U report that #ILC3 augment group #ILC2 #anthelmintic immune responses in 🐁! Upon N. braziliensis infection, ILC3-derived #RANKL synergizes w/ #IL13 to facilitate intestinal #TuftCell expansion, which amplifies ILC2 responses!
ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling
Gut ILC3s help type 2 immunity by boosting tuft cell differentiation.
www.science.org
May 23, 2025 at 9:51 AM
mspivakov.bsky.social
Very happy to see this story finally out (link in comments)!

We used low-input Capture Hi-C to profile promoter-anchored chromosomal interactions in Type 3 innate lymphoid cells (ILC3s) - rare tissue-resident lymphocytes that lack antigen receptors and regulate barrier immunity.
August 4, 2026 at 11:41 AM
cp-immunity.bsky.social
ILC3s sense gut microbiota through STING to initiate immune tolerance
Maintaining immune tolerance to the microbiota is essential for gut health. Zhou et al. demonstrate that ILC3s are a RORγt+ APC that sense the microbiota through STING to induce microbiota-specific Treg cells. However, if this pathway becomes uncontrolled, as in the context of intestinal inflammation, it provokes the depletion of these tissue-protective ILC3s.
dlvr.it
July 11, 2025 at 10:38 PM
mucosalimmunol.bsky.social
ILC3s mediate intestinal immune-epithelial interactions via TGF-β1 activation from @nevesjf.bsky.social: www.mucosalimmunology.org/article/S193...
December 15, 2025 at 3:09 PM
labwaggoner.bsky.social
PGD2 released after NAIP-NLRC4 inflammasome activation in tuft cells signals onto ILC3s and mediates host defense mechanisms against Salmonella Typhimurium within the small intestine @jem.org
@rauchlab.bsky.social
doi.org/10.1084/jem....
March 13, 2025 at 6:31 PM
labwaggoner.bsky.social
@biorxivpreprint.bsky.social ILC3s are Required for Enterocyte Homeostasis to Food Intake
www.biorxiv.org/content/10.6... @arthremys.bsky.social @institutpasteur.bsky.social
May 1, 2026 at 7:15 PM
nevesjf.bsky.social
Very proud of this amazing work by @diacoman.bsky.social and all the team/collaborators (specially @lukeocyte.bsky.social) that show how ILC3s mediate immune-epithelial interactions via production & activation of TGFb. #ILC #gut #IBD #organoids www.mucosalimmunology.org/article/S193...
ILC3s mediate intestinal immune-epithelial interactions via TGF-β1 activation
Inflammatory Bowel Disease (IBD), which encompasses Crohn’s disease (CD) and ulcerative colitis (UC), is a multifactorial disease that exhibits abnormal cellular interactions between the intestinal ep...
www.mucosalimmunology.org
December 4, 2025 at 12:55 PM
labwaggoner.bsky.social
ILC3s are a RORγt+ APC that sense the microbiota through STING to induce microbiota-specific Treg cells
www.cell.com/immunity/ful... @cp-immunity.bsky.social
June 16, 2025 at 3:24 PM
jem.org
Kabil, Hughes, McNagny et al. identify a balance between ILC2s & ILC3s as critical for gut tissue repair. Selective deletion experiments reveal that ILC2 loss promotes #fibrosis, while ILC3 depletion protects against it. rupress.org/jem/article/...

#MucosalImmunology #InnateImmunity #inflammation
May 28, 2025 at 4:25 PM
discovimmunol.bsky.social
🧬 ILC3s show dynamic, stage-specific roles in endometrial repair and regeneration - supporting healthy cycling and potentially disrupted in endometriosis.

Explore the findings: https://bit.ly/448zYm7
June 15, 2025 at 10:53 AM
ruichaoliu.bsky.social
6/ Surprisingly, loss of IGF1R did not alter ILC3 abundance or IL-22 production. Instead, IGF1 restrained IFNγ-induced CXCL10 production by ILC3s. Deleting Cxcl10 in ILC3s rescued the worsened colitis caused by IGF1R loss, revealing an IL-22-independent mechanism.
September 24, 2026 at 6:49 PM
wehi-research.bsky.social
A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health.

Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity.

www.wehi.edu.au/news/fast-fo...
Innate lymphoid cells 3 (ILC3s) are a subset of immune cells that are critical to gut immunity. When there is excess fat, such as after a rich meal, ILC3s store this fat in tiny lipid droplets to maintain their function. In this 3D illustration, we can see a lipid droplet (in orange) inside an ILC3.
May 19, 2025 at 1:41 AM
adlunglab.com
🔁 Good news: returning to a regular diet restores IL-22, microbiota diversity, and barrier gene expression; though some metabolic scars on ILC3s linger.

5/6
April 16, 2025 at 6:04 AM
kmcnagny.bsky.social
So happy to share our latest work on a model for a very important disease. Congrats Ahmed!
Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal fibrosis and homeostasis url:https://rupress.org/jem/article/222/7/e20241671/277979/Functional-targeting-of-ILC2s-and-ILC3s-reveals
May 29, 2025 at 2:14 PM
labwaggoner.bsky.social
Preview @cp-immunity.bsky.social
Dietary fuel or fire: Fatty acids rewire gut ILC3s
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Dietary fuel or fire: Fatty acids rewire gut ILC3s
Long-term consumption of diets high in fats has detrimental impacts on the immune system, but the window necessary for initiating these effects is unclear. In this issue of Immunity, Xiong et al. demo...
www.cell.com
May 13, 2025 at 4:52 PM
labwaggoner.bsky.social
12R-HETE, a natural lipid found in the intestine, boosts gut immunity in early like by binding Nur77, regulating Impdh1, increasing T-bet, & promoting shift to more NKp46+ ILC3s & IFN-γ
www.science.org/doi/10.1126/...
February 20, 2026 at 7:56 PM
seilletlab.bsky.social
🧠🍔 Just 48 hours on a high-fat diet can weaken gut immunity. Our new study shows saturated fats rapidly impair ILC3s!
Proud to see this featured by
@wehi-research.bsky.social as I continue to explore these questions @monashuniversity.bsky.social with the IMI Lab!
wehi-research.bsky.social WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · May 19
A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health.

Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity.

www.wehi.edu.au/news/fast-fo...
Innate lymphoid cells 3 (ILC3s) are a subset of immune cells that are critical to gut immunity. When there is excess fat, such as after a rich meal, ILC3s store this fat in tiny lipid droplets to maintain their function. In this 3D illustration, we can see a lipid droplet (in orange) inside an ILC3.
May 19, 2025 at 3:45 AM