An antibody that blocked immune cells from entering the brains of mice reduced tau-related neurodegeneration, preserved brain tissue, and improved memory, suggesting a potential immune-targeted treatment for Alzheimer’s disease. ...

Research frequently crosses disciplines within Yale School of Medicine. It can also happen within a single lab.

Degradation of the immune system’s critical maintenance work could be a target for extending a healthy lifespan.

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New research reveals foamy immune cells packed with fat may be a hidden driver of severe multiple sclerosis progression. Scientists fo… #Diseaseprogression #Immunecells #Lipidmetabolism #Multiplesclerosis #Neuroinflammation

Actin—found in nearly every cell—powers muscle contraction, immune cell chase, and cell division through dynamic self-organization. No blueprint needed. Cells reb… #Actin #Celldivision #Cellbiology #Cytoskeleton #Immunecells

UC San Diego researchers have found a

A comprehensive study analyzing over 1.1 million lung tissue-resident immune cells reveals insights into how their dysfunction may contribute to lung inflammation and autoimmune diseases like lupus, rheumatoid arthritis, and scleroderma. ...

Off-the-shelf, mass-producible immune cells that fight solid human tumors engrafted into mice represent a significant advancement toward faster and more affordable cancer immunotherapy. ...

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An experimental molecule, N-oleoyl-Leucine (OLE), reprograms brain immune cells to reduce beta-amyloid plaques and improve cognitive performance in Alzheimer's animal models. ...

A new type of cancer immunotherapy links immune cells to tumor cells by targeting a tumor protein and an immune cell marker, activating the immune system to destroy advanced solid tumors. ...

New study identifies a surprising mechanism for sensing Earth’s magnetic field

Scientists observed immune cells eating live melanoma cells in real time, revealing new insights that may improve cancer immunotherapy treatments.

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A recent study from New York University suggests that depression could one day be detected with a simple blood test measuring the aging of certain immune cells, particularly monocytes. Researchers studied 440 women, including those living with and without HIV, using blood samples and epigenetic clocks to track cellular aging. The study found that accelerated aging in monocytes is closely linked to emotional and cognitive symptoms of depression—such as hopelessness, loss of pleasure, and difficulty concentrating—rather than physical symptoms like fatigue. This discovery could provide a biological marker for depression, which is currently diagnosed solely through self-reported symptoms. The findings may be especially significant for high-risk groups, such as women with HIV, for whom early detection of depression can improve overall health and treatment adherence. Although more research is needed before clinical application, these results move mental health care toward more personalized, precise approaches by combining subjective experiences with measurable biological indicators. The study emphasizes that depression is not a uniform condition and highlights the potential of epigenetic testing in future diagnostics and treatment planning.

Maintenance of cellular volume is essential for cell homeostasis. Immune cells experience marked osmotic changes during activation and migration, and …