The @Norrislab at MUSC unveiled their genetic finding in June 2024 behind some #hEDS patients: a Kallikrein gene. (Not a collegen defect!) Still needs peer review, but it may explain some comorbidities too:
buff.ly/4cj40El
#EDS #HSD #MCAS #Genetics #NEISvoid #Zebras
Norris Lab Finds HEDS Gene: Kallikrein – EDSAwareness.com
Chronic Pain Partners is excited to share a significant breakthrough from the Norris Lab regarding hypermobile Ehlers-Danlos Syndrome (hEDS). After a long wait, the research, spearheaded by Dr. Cortne...
buff.ly
November 19, 2024 at 8:43 AM
quantifizierbaren radiologischen Anomalien zurück, und dennoch zeigten alle Patienten im Vergleich zu gesunden Personen eine anhaltende Aktivierung zellulärer Reparaturprozesse und eine Hemmung der Renin-Kallikrein-Kinin-, Gerinnungs- und Komplementsysteme. Ob die anhaltende
July 8, 2024 at 11:40 PM
quantifizierbaren radiologischen Anomalien zurück, und dennoch zeigten alle Patienten im Vergleich zu gesunden Personen eine anhaltende Aktivierung zellulärer Reparaturprozesse und eine Hemmung der Renin-Kallikrein-Kinin-, Gerinnungs- und Komplementsysteme. Ob die anhaltende
Researchers at Medical University of South Carolina found a missense variant in Kallikrein-15 (KLK15 p. Gly226Asp) in two families, and 197 sporadic hEDS patients revealed enrichment of variants within the Kallikrein gene family as well. (2/3) www.researchsquare.com/article/rs-4...
Variants in the Kallikrein Gene Family and Hypermobile Ehlers-Danlos Syndrome
Hypermobile Ehlers-Danlos syndrome (hEDS) is a common heritable connective tissue disorder that lacks a known genetic etiology. To identify genetic contributions to hEDS, whole exome sequencing was pe...
www.researchsquare.com
June 12, 2024 at 7:27 PM
Researchers at Medical University of South Carolina found a missense variant in Kallikrein-15 (KLK15 p. Gly226Asp) in two families, and 197 sporadic hEDS patients revealed enrichment of variants within the Kallikrein gene family as well. (2/3) www.researchsquare.com/article/rs-4...
The contact pathway is deeply interconnected with the kallikrein-kinin bradykinin-angiotensin pathways. It is just an extension of the RAAS pathways, but more connected with thrombosis, which you get from activating RAAS pathways leading to MACE. #ISTH2025 www.sciencedirect.com/science/arti...
The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities
The contact activation system (CAS) and kallikrein/kinin system (KKS) are older recognized biochemical pathways that include several proteins that ski…
www.sciencedirect.com
June 23, 2025 at 12:22 PM
The contact pathway is deeply interconnected with the kallikrein-kinin bradykinin-angiotensin pathways. It is just an extension of the RAAS pathways, but more connected with thrombosis, which you get from activating RAAS pathways leading to MACE. #ISTH2025 www.sciencedirect.com/science/arti...
From 2024 - Norris Lab Finds an hEDS Gene: Kallikrein
While only a preprint yet, this pushes the science forward for those with #hEDS
https://buff.ly/4cj40El
#EDS #hEDS #EhlersDanlosSyndrome #NEISvoid #Science #Research #Medicine #Genetics #MedEd #Doctors #Zebras #MedSky
While only a preprint yet, this pushes the science forward for those with #hEDS
https://buff.ly/4cj40El
#EDS #hEDS #EhlersDanlosSyndrome #NEISvoid #Science #Research #Medicine #Genetics #MedEd #Doctors #Zebras #MedSky
Norris Lab Finds HEDS Gene: Kallikrein – EDSAwareness.com
Chronic Pain Partners is excited to share a significant breakthrough from the Norris Lab regarding hypermobile Ehlers-Danlos Syndrome (hEDS). After a long wait, the research, spearheaded by Dr.…
buff.ly
February 7, 2025 at 3:14 PM
Given its function, damaging the ECM= not great. You'll see a lot re: kallikrein and cancer, because of the ECM's connection to cellular proliferation and ultimate cellular fate. Some think kallikrein-15 is related to metastasis in cancer. (6/3) #SciSky 🧪
pubmed.ncbi.nlm.nih.gov?term=Kallikr...
pubmed.ncbi.nlm.nih.gov?term=Kallikr...
Kallikrein-15 - Search Results - PubMed
Kallikrein-15 - Search Results - PubMed
pubmed.ncbi.nlm.nih.gov
June 14, 2024 at 4:33 AM
Given its function, damaging the ECM= not great. You'll see a lot re: kallikrein and cancer, because of the ECM's connection to cellular proliferation and ultimate cellular fate. Some think kallikrein-15 is related to metastasis in cancer. (6/3) #SciSky 🧪
pubmed.ncbi.nlm.nih.gov?term=Kallikr...
pubmed.ncbi.nlm.nih.gov?term=Kallikr...
Great news - Norris Lab Finds a possible hEDS Gene: Kallikrein
While only a preprint yet, this pushes the science forward for many with #hEDS
https://buff.ly/4cj40El
#EDS #hEDS #EhlersDanlosSyndrome #NEISvoid #Science #Research #Medicine #Genetics #MedEd #Doctors #Zebras
While only a preprint yet, this pushes the science forward for many with #hEDS
https://buff.ly/4cj40El
#EDS #hEDS #EhlersDanlosSyndrome #NEISvoid #Science #Research #Medicine #Genetics #MedEd #Doctors #Zebras
Norris Lab Finds HEDS Gene: Kallikrein – EDSAwareness.com
Chronic Pain Partners is excited to share a significant breakthrough from the Norris Lab regarding hypermobile Ehlers-Danlos Syndrome (hEDS). After a long wait, the research, spearheaded by Dr.…
buff.ly
December 1, 2024 at 3:14 PM
This is a pretty big deal: a huge team of researchers found a gene associated with hypermobile Ehlers-Danlos Syndrome! Up to now, other kinds of EDS have been associated with genetic mutations, but not hEDS, the most common kind of EDS. (1/3)
www.researchsquare.com/article/rs-4...
www.researchsquare.com/article/rs-4...
Variants in the Kallikrein Gene Family and Hypermobile Ehlers-Danlos Syndrome
Hypermobile Ehlers-Danlos syndrome (hEDS) is a common heritable connective tissue disorder that lacks a known genetic etiology. To identify genetic contributions to hEDS, whole exome sequencing was pe...
www.researchsquare.com
June 12, 2024 at 7:06 PM
This is a pretty big deal: a huge team of researchers found a gene associated with hypermobile Ehlers-Danlos Syndrome! Up to now, other kinds of EDS have been associated with genetic mutations, but not hEDS, the most common kind of EDS. (1/3)
www.researchsquare.com/article/rs-4...
www.researchsquare.com/article/rs-4...
Reminder to those of us with #hEDS:
You can add this paper to your medical folder to ward off ignorant physicians who argue that hEDS is unlike other forms of EDS because the gene hasn't been found and it's therefore a bit more "all in your head."
⚡️ #NEISvoid www.researchsquare.com/article/rs-4...
You can add this paper to your medical folder to ward off ignorant physicians who argue that hEDS is unlike other forms of EDS because the gene hasn't been found and it's therefore a bit more "all in your head."
⚡️ #NEISvoid www.researchsquare.com/article/rs-4...
June 12, 2025 at 12:51 AM
Reminder to those of us with #hEDS:
You can add this paper to your medical folder to ward off ignorant physicians who argue that hEDS is unlike other forms of EDS because the gene hasn't been found and it's therefore a bit more "all in your head."
⚡️ #NEISvoid www.researchsquare.com/article/rs-4...
You can add this paper to your medical folder to ward off ignorant physicians who argue that hEDS is unlike other forms of EDS because the gene hasn't been found and it's therefore a bit more "all in your head."
⚡️ #NEISvoid www.researchsquare.com/article/rs-4...
A recent study shows that the Kallikrein-related peptidase 13 (KLK13) can also cleave the spike protein - but instead of activating it, KLK13 inactivates spike.
In animal models, recombinant KLK13 reduces viral spread, suggesting a potential protective effect.
In animal models, recombinant KLK13 reduces viral spread, suggesting a potential protective effect.
October 27, 2025 at 10:11 PM
A recent study shows that the Kallikrein-related peptidase 13 (KLK13) can also cleave the spike protein - but instead of activating it, KLK13 inactivates spike.
In animal models, recombinant KLK13 reduces viral spread, suggesting a potential protective effect.
In animal models, recombinant KLK13 reduces viral spread, suggesting a potential protective effect.
Right? Great name... Kallikrein. We're still hoping they get published.
December 2, 2024 at 2:41 AM
Right? Great name... Kallikrein. We're still hoping they get published.
This is not likely the only gene associated with hEDS but it's an exciting start! (3/3) www.researchsquare.com/article/rs-4...
Variants in the Kallikrein Gene Family and Hypermobile Ehlers-Danlos Syndrome
Hypermobile Ehlers-Danlos syndrome (hEDS) is a common heritable connective tissue disorder that lacks a known genetic etiology. To identify genetic contributions to hEDS, whole exome sequencing was pe...
www.researchsquare.com
June 12, 2024 at 7:28 PM
This is not likely the only gene associated with hEDS but it's an exciting start! (3/3) www.researchsquare.com/article/rs-4...
Proteomic discoveries in hypermobile Ehlers–Danlos syndrome reveal insights into disease pathophysiology #hEDS #MECFS #LongCovid
academic.oup.com/immunohorizo...
academic.oup.com/immunohorizo...
September 20, 2025 at 1:42 AM
Proteomic discoveries in hypermobile Ehlers–Danlos syndrome reveal insights into disease pathophysiology #hEDS #MECFS #LongCovid
academic.oup.com/immunohorizo...
academic.oup.com/immunohorizo...
A new classification of hereditary EDDs highlights shared disease mechanisms—unlocking targeted, pathogenesis-based treatments. From lovastatin-cholesterol to kallikrein inhibitors and gene editing, care for syndromic ichthyosis is evolving.
doi.org/10.1093/bjd/...
#raredisease #MedSky #DermSky
doi.org/10.1093/bjd/...
#raredisease #MedSky #DermSky
April 5, 2025 at 3:47 PM
A new classification of hereditary EDDs highlights shared disease mechanisms—unlocking targeted, pathogenesis-based treatments. From lovastatin-cholesterol to kallikrein inhibitors and gene editing, care for syndromic ichthyosis is evolving.
doi.org/10.1093/bjd/...
#raredisease #MedSky #DermSky
doi.org/10.1093/bjd/...
#raredisease #MedSky #DermSky
One of the first-line options for long term prophylaxis in HAE patients is lanadelumab, a fully human monoclonal antibody inhibiting plasma kallikrein. The authors report findings from 2 prospective, noninterventional, multicenter phase 4 studies. Learn more: https://loom.ly/gMx757w
November 18, 2025 at 8:10 PM
One of the first-line options for long term prophylaxis in HAE patients is lanadelumab, a fully human monoclonal antibody inhibiting plasma kallikrein. The authors report findings from 2 prospective, noninterventional, multicenter phase 4 studies. Learn more: https://loom.ly/gMx757w
🔹 Capucine Baldini, DITEP at @gustaveroussy.fr, presenting pasritamig, a first in human, first in class, bispecific T-cell engager targeting Kallikrein 2 (KLK2-CD3) in CRPC - a potential game changer ! Simultaneous publication in J Clin Oncol.
@ascocancer.bsky.social #ASCO
@ascocancer.bsky.social #ASCO
June 2, 2025 at 7:51 AM
🔹 Capucine Baldini, DITEP at @gustaveroussy.fr, presenting pasritamig, a first in human, first in class, bispecific T-cell engager targeting Kallikrein 2 (KLK2-CD3) in CRPC - a potential game changer ! Simultaneous publication in J Clin Oncol.
@ascocancer.bsky.social #ASCO
@ascocancer.bsky.social #ASCO
Are there drugs out there that affect kallikrein? Yes, there are quite a few leads, because remember: this gene is associated with cancer pathology as well. (11/3) #SciSky 🧪
nature.com/articles/s41...
nature.com/articles/s41...
Table 2 Potential therapeutic approaches targeting KLKs
nature.com
June 14, 2024 at 4:36 AM
Are there drugs out there that affect kallikrein? Yes, there are quite a few leads, because remember: this gene is associated with cancer pathology as well. (11/3) #SciSky 🧪
nature.com/articles/s41...
nature.com/articles/s41...
Quick 5 min read by Linda Bluestein, M.D. on what the Norris Lab actually found, and how it affects us bendies
#hEDS #hypermobility #hypermobileelhersdanlossyndrome #elhersdanlossyndrome #lindabluestein #norrislab #chronicillness
www.hypermobilitymd.com/post/norris-...
#hEDS #hypermobility #hypermobileelhersdanlossyndrome #elhersdanlossyndrome #lindabluestein #norrislab #chronicillness
www.hypermobilitymd.com/post/norris-...
Did the Norris Lab Discover the Hypermobile EDS Gene?
With first author Cortney Gensemer PhD, the Norris Lab at Medical University of South Carolina released a preprint last week titled “Variants in the Kallikrein Gene Family and Hypermobile Ehlers-Danlo...
www.hypermobilitymd.com
November 15, 2024 at 4:07 PM
Quick 5 min read by Linda Bluestein, M.D. on what the Norris Lab actually found, and how it affects us bendies
#hEDS #hypermobility #hypermobileelhersdanlossyndrome #elhersdanlossyndrome #lindabluestein #norrislab #chronicillness
www.hypermobilitymd.com/post/norris-...
#hEDS #hypermobility #hypermobileelhersdanlossyndrome #elhersdanlossyndrome #lindabluestein #norrislab #chronicillness
www.hypermobilitymd.com/post/norris-...
Loss of kallikrein 5 expression exacerbates allergic skin inflammation including impairing filaggrin processing, promoting Th2 differentiation and inducing dysbiosis
@cincyresearch.bsky.social @mucosalimmunol.bsky.social
www.sciencedirect.com/science/arti...
@cincyresearch.bsky.social @mucosalimmunol.bsky.social
www.sciencedirect.com/science/arti...
Loss of kallikrein 5 expression exacerbates allergic skin inflammation including impairing filaggrin processing, promoting Th2 differentiation and inducing dysbiosis
Atopic dermatitis (AD) is a chronic allergic skin disease with T helper 2 (Th2) cell predominance and epithelial barrier impairment. The serine protea…
www.sciencedirect.com
September 21, 2026 at 3:20 PM
Loss of kallikrein 5 expression exacerbates allergic skin inflammation including impairing filaggrin processing, promoting Th2 differentiation and inducing dysbiosis
@cincyresearch.bsky.social @mucosalimmunol.bsky.social
www.sciencedirect.com/science/arti...
@cincyresearch.bsky.social @mucosalimmunol.bsky.social
www.sciencedirect.com/science/arti...
KLK15's kallikrein angle — inflammation meeting connective tissue — is genuinely interesting, but interesting is pre-clinical. It's a lead, not a test, and nobody's diagnosis changes because of it.
October 2, 2026 at 1:23 AM
KLK15's kallikrein angle — inflammation meeting connective tissue — is genuinely interesting, but interesting is pre-clinical. It's a lead, not a test, and nobody's diagnosis changes because of it.
Loss of kallikrein 5 expression exacerbates allergic skin inflammation including impairing filaggrin processing, promoting Th2 differentiation and inducing dysbiosis from @cincychildrens.bsky.social www.mucosalimmunology.org/article/S193...
September 25, 2026 at 12:18 PM
Loss of kallikrein 5 expression exacerbates allergic skin inflammation including impairing filaggrin processing, promoting Th2 differentiation and inducing dysbiosis from @cincychildrens.bsky.social www.mucosalimmunology.org/article/S193...
Heme-induced kallikrein-kinin system activation in hemolytic uremic syndrome
doi.org/10.1016/j.kint.2026.05.034
#MedSky #NephSky #OpenAccess #HUS
doi.org/10.1016/j.kint.2026.05.034
#MedSky #NephSky #OpenAccess #HUS
August 11, 2026 at 6:31 PM
Heme-induced kallikrein-kinin system activation in hemolytic uremic syndrome
doi.org/10.1016/j.kint.2026.05.034
#MedSky #NephSky #OpenAccess #HUS
doi.org/10.1016/j.kint.2026.05.034
#MedSky #NephSky #OpenAccess #HUS