#MolecularEvolution
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aidaandres.bsky.social
Balancing selection alert!! 🧬🧪

New preprint where we try to quantify how likely (or rather, unlikely) it is for balancing selection to maintain stable polymorphism, and how easy (or rather, challenging) it is to identify its signatures in genomes.

#Popgen #MolecularEvolution #EvoBio #Science
maxreuter.bsky.social Max Reuter @maxreuter.bsky.social · Jan 21
A new preprint from the lab, with postdoc @deboraycb.bsky.social and collaborators @aidaandres.bsky.social and Tim Connallon:

“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 21, 2026 at 4:11 PM
kaplipa.bsky.social
Delighted to be joining MBE as an Associate Editor! Looking forward to being part of such a strong editorial team! #phylogenomics #MolecularEvolution #genomics
molbioevol.bsky.social Molecular Biology and Evolution @molbioevol.bsky.social · Jan 13
Paschalia Kapli (@kaplipa.bsky.social), Research Leader at the Natural History Museum in the UK (@nhm-london.bsky.social), joins MBE as an Associate Editor, bringing in expertise on phylogenomics, phylogenetic discordance, and evolutionary radiations.

#societyjournal
Paschalia Kapli (Natural History Museum, London, UK)
January 13, 2026 at 10:42 PM
sheilateves.bsky.social
How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.

Read it here 👉

www.biorxiv.org/content/10.1...

#MolecularEvolution #Transcription
Molecular determinants underlying functional divergence of TBP homologs
The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...
www.biorxiv.org
October 7, 2025 at 7:43 PM
marcrr.bsky.social
New lab preprint! I'll write a thread about it as soon as I have time, but we show that gene expression variability between outbred fish is under organ-specific selection
www.biorxiv.org/content/10.1...
@dee-unil.bsky.social #EvoDevo #MolecularEvolution
photos of a gar, a pike and a zebrafish
November 14, 2024 at 4:16 PM
evolutionsoup.bsky.social
A new theory of molecular evolution
#evolutionsoup #evolution #molecularevolution #science #fossils
👇🏿👇🏽
is.gd/AEgCMT
A new theory of molecular evolution
November 15, 2025 at 5:49 PM
genomebiolevol.bsky.social
March issue: Amino acids that are more different do have lower rates of exchange over evolutionary time, and this result is general to different taxonomic groups.
doi.org/10.1093/gbe/...
#MolecularEvolution #AminoAcids #OpenAccess
Amino Acid Properties, Substitution Rates, and the Nearly Neutral Theory
Abstract. Do the properties of amino acids affect their rates of substitution? The neutral theory predicts that greater selective constraint leads to slowe
doi.org
March 9, 2025 at 1:12 PM
marcrr.ecoevo.social.ap.brid.gy
Congratulations to @nextstrain for this great paper! Studying the evolution of moulting beyond insects has been challenging, and we are starting to see how moulting is both deeply conserved and evolving differently in pancrustacean lineages. #evodevo #arthropodevolution #MolecularEvolution
nextstrain.bsky.social Kenny Kim @nextstrain.bsky.social · Feb 20
New Preprint!! 🦐🪰🦀

In this study we compared moulting gene expression across insects and crustaceans. #insects #crustaceans

Thread ⬇️ (1/6) www.biorxiv.org/content/10.6...
www.biorxiv.org
February 20, 2026 at 1:53 PM
marcrr.ecoevo.social.ap.brid.gy
I'm excited to present this new model to detect positive selection on regulatory sequences, which has been 3 years in the making!
Thanks to Alexandre Laverré and @Phylogenetrips for their amazing work on this project. 😃
https://doi.org/10.1101/2025.11.26.690685 #bioinformatics #MolecularEvolution
Graphical summary of the evolutionary model, in 4 rows, A to D. A: left, bell shaped distribution of phenotypic changes; right, observed substitutions between an ancestral sequence and a modern one, using an outgroup. B: 4 fitness landscapes: no selection, alpha=beta=1, uniform distribution; stabilizing selection, alpha=beta≠1, bell shape; directional selection, either alpha>beta, curve skewed right, or alpha<beta, curve skewed left. C: 4 distributions which are the product of the distribution in A and each of the fitness landscapes. Observed subtitutions are mapped onto them, falling outside of the high density area except for the third, i.e. directional selection alpah>beta. D: cartoon likelihood indicating that only the third fitness landscape is supported.
December 3, 2025 at 2:09 PM
crc392molevo.bsky.social
🚀 The #CRC392 is at Winter School in beautiful Brixen, Italy! ❄️⛰️ Exciting talks, deep discussions, and inspiring mountain view. We’re thrilled to have three amazing invited speakers with us: Moran Frenkel-Pinter, Robert Pascal, and Matt Powner! 🧬 #MolecularEvolution #OriginOfLife
February 19, 2025 at 7:58 PM
christianlandry.bsky.social
Is there a multiple sequence alignment that people use to construct phylogenetic trees in ugrad teaching labs with organisms that students relate to? Maybe some involving gene duplications? #molecularevolution #phylogenetics
March 25, 2025 at 6:29 PM
crc392molevo.bsky.social
👋 Welcome to the official CRC 392 channel on Bluesky!
We’re a cross-disciplinary network from biochemistry, biophysics, chemistry, geosciences, and theoretical physics to understand how life emerged. 🌍🌌🔬🧬
Follow us for updates on our research and events!
#Science #MolecularEvolution #OriginsOfLife
February 5, 2025 at 12:22 PM
phessenauer.bsky.social
Presenting about the importance of soil variables in local adaption in Dutch elm disease pathogens at #AQSSSSPPQ2025

#forestpathology #localadaptation #molecularevolution
June 11, 2025 at 2:16 AM
physaliacourses.bsky.social
Registrations are now open for the next edition of the #Phylogenomics course with this amazing lineup of instructors @sabifo4.bsky.social @PKapli @mariodosreis
Tomas Flouri and @zihengyang
Do not miss this opportunity in December: physalia-courses.org/courses-work... #MolecularEvolution
Phylogenomics
2-6 December 2024
physalia-courses.org
May 29, 2024 at 1:36 PM
marcrr.ecoevo.social.ap.brid.gy
Here this sum over organs/tissues shows a strong excess of positive selection on regulatory sequences in human nervous system evolution 😎. And to a lesser extent in male reproductive system. #MolecularEvolution #evodevo
Graph showing the SUMSTAT statistic for different organs or tissues, colored by system. Values from the Nervous and Male reproductive systems have the highest values, while all others are quite similar.
March 6, 2026 at 2:14 PM
loreament.bsky.social
Hello Bsky World! Can somebody explain to me the difference between dN/dS and Ka/Ks?? I see some sources saying they are the same thing, but then I go and see papers where they use *both* terminologies. Does anybody have sources? Help! 🤔
#genomics #PopGen #MolecularEvolution
November 19, 2024 at 5:58 PM
marcrr.ecoevo.social.ap.brid.gy
This is the best explanation I've ever seen for lungfish genome sizes
https://xkcd.com/3064/
#xkcd #genomes #MolecularEvolution #lungfish
March 17, 2025 at 5:07 PM
christinatoft.bsky.social
📢 Journal of Molecular Evolution: A European Meeting 📢

📍 Madrid, Spain 🗓️ Aug 25-28, 2025
🔹 Talks & posters on molecular evolution
🔹 Special symposium: "Evolutionary Intelligence & AlphaFold"
🔹 Free registration (limited spots!) – priority by March 1

#MolecularEvolution #AlphaFold
February 12, 2025 at 2:10 PM
jomcinerney.bsky.social
🔗 Ready to analyze your codon usage? GCUA makes sophisticated codon bias analysis accessible to everyone.
#Bioinformatics #CodingSequences #CodonUsage #Python #Genomics #MolecularEvolution #SyntheticBiology #GeneExpression #Optimization
June 1, 2025 at 7:28 PM
jeffreytownsend.bsky.social
🔍 Measuring how fast expression evolves opens a path to understanding how organisms evolve—not just what evolves.
This is just the beginning: from single genes to networks, expression clocks can help decode the tempo of evolution.

doi.org/10.1093/molb...

#MolecularEvolution #GeneExpression #MBE
July 22, 2025 at 2:42 PM
marcrr.ecoevo.social.ap.brid.gy
Ah now for something lighter: a horseshoe crab genome, whole genome duplications, and a cartoon:
https://doi.org/10.1093/molbev/msaf021
https://tapas.io/episode/3123425
#evodevo #MolecularEvolution #Genomics
Read Sarah's Scribbles :: Horseshoe Crab | Tapas Community
Read Sarah's Scribbles and more premium Comedy Community series now on Tapas!
tapas.io
February 11, 2025 at 5:37 PM
marcrr.ecoevo.social.ap.brid.gy
New lab preprint! I'll write a thread about it as soon as I have time, but we show that gene expression variability between outbred fish is under organ-specific selection
https://www.biorxiv.org/content/10.1101/2024.11.11.623020v1
@dee_unil #evodevo #MolecularEvolution
photos of a gar, a pike and a zebrafish
November 14, 2024 at 4:14 PM
crc392molevo.bsky.social
Online Conference | Molecular Origins of Life – Munich 2025
Join us for talks & posters across disciplines.
📅 July 16–18
❗Poster registration deadline: 30 June
💻 Online & free
🔗 Registration is open now indico.physik.uni-muenchen.de/event/537/
#OriginOfLife #MolecularEvolution #Conference
(1/2)
Poster for the “Molecular Origins of Life 2025” online conference, held July 16–18, 2025. The vibrant artwork by Priyanka Oberoi features an abstract early Earth scene: volcanic landscapes, DNA, molecules, and a rainbow prism bursting from a cracked sphere, symbolizing the emergence of life. Lightning bolts and suns add dynamic energy. A QR code links to www.lmu.de/mom2025. At the bottom, the list of invited speakers is shown in colorful text: Donna Blackmond, Jasna Brujic, Irene Chen, Daniel Duzdevich, Kosuke Fujishima, Paul Higgs, Marcel Hollenstein, Philipp Holliger, Frieder Klein, Corinna Kupfer, Sergei Maslov, Ulrich Müller, Arvind Murugan, Henrike Niederholtmeyer, Takumi Okuda, Matthew Pasek, Alexey Potapov, James Saenz, Anja Spang, Dora Tang, Zoe Todd, Yuichiro Ueno
May 16, 2025 at 12:04 PM
proteinmechanic.bsky.social
If you do deep evolutionary analysis - structure-aware characters can help. To ensure correct alignments - give it a try: biosig.lab.uq.edu.au/structome_al...

If you would like any features added, drop a message and will give it a shot.

#Science #Evolution #MolecularEvolution #DeepEvolution
June 4, 2025 at 12:31 AM
proteinmechanic.bsky.social
🧵: It's out. Structome-AlignViewer, a web-based resource for evaluating protein structure-aware sequence alignments. It maps alignment columns directly onto structures and helps identify conserved regions. Feedback encouraged. www.biorxiv.org/content/10.1...

#Evolution #MolecularEvolution #Science
Structome-AlignViewer: On Confidence Assessment in Structure-Aware Alignments
Protein structure-based comparison provides a framework for uncovering deep evolutionary relationships that can escape conventional sequence-based approaches. Encoding three-dimensional protein struct...
www.biorxiv.org
June 4, 2025 at 12:10 AM
scholarcast.bsky.social
Prokaryotic genome evolution lacks a unified model explaining how nucleotide composition and gene distribution evolve together. We analyzed 4,012 complete prokaryotic genomes to fill this gap.
Paper: doi.org/10.1111/jse....
#GenomeEvolution #Prokaryotes #MolecularEvolution
Genomic coordination of nucleotide skews and gene strand distribution driven by GC‐content in prokaryotes
The genome organization of 4218 prokaryotic representative genomes was analyzed, contributing to a novel mechanistic framework centered around the variation in GC-content. The variation in GC-content...
doi.org
August 10, 2026 at 7:29 AM