SOD1 is one such gene, where toxic gain of function variants cause the SOD1 protein to misfold and aggregate, which leads to motorneuron death. Tofersen causes targeted cleavage of SOD1 transcripts (mutated and wild type), resulting in less SOD1 production and less misfolding.
July 10, 2026 at 8:26 AM
SOD1 is one such gene, where toxic gain of function variants cause the SOD1 protein to misfold and aggregate, which leads to motorneuron death. Tofersen causes targeted cleavage of SOD1 transcripts (mutated and wild type), resulting in less SOD1 production and less misfolding.
New research reveals that #ALS progresses in a domino effect beginning with early #MotorNeuron damage, followed by harmful #inflammation, which informs #PersonalizedTreatment and explains #DiseaseVariability.
#Neurodegeneratiion #ImmuneResponse
#Neurodegeneratiion #ImmuneResponse
ALS is driven by a domino‑like chain reaction that begins in nerve cells – BioNews Central
New research reveals that ALS progresses in a domino effect—beginning with early motor neuron damage, followed by harmful inflammation—which informs personalized treatment and explains disease variability. ...
sbee.link
May 14, 2026 at 4:26 PM
New research reveals that #ALS progresses in a domino effect beginning with early #MotorNeuron damage, followed by harmful #inflammation, which informs #PersonalizedTreatment and explains #DiseaseVariability.
#Neurodegeneratiion #ImmuneResponse
#Neurodegeneratiion #ImmuneResponse
RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2
By Jang et al., and Hynek Wichterle
➡️ https://genesdev.cshlp.org/content/40/5-6/384.full
Columbia University
#transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman
By Jang et al., and Hynek Wichterle
➡️ https://genesdev.cshlp.org/content/40/5-6/384.full
Columbia University
#transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman
March 12, 2026 at 6:00 PM
RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2
By Jang et al., and Hynek Wichterle
➡️ https://genesdev.cshlp.org/content/40/5-6/384.full
Columbia University
#transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman
By Jang et al., and Hynek Wichterle
➡️ https://genesdev.cshlp.org/content/40/5-6/384.full
Columbia University
#transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman
Spinal muscular atrophy (SMA) is caused by reduced levels of SMN protein, which leads to motorneuron death. Depending on the level of residual SMN protein disease severity varies, where the severest form cause infant lethality.
March 12, 2026 at 12:12 PM
Spinal muscular atrophy (SMA) is caused by reduced levels of SMN protein, which leads to motorneuron death. Depending on the level of residual SMN protein disease severity varies, where the severest form cause infant lethality.
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2
By Jang et al., and Hynek Wichterle
➡️ https://genesdev.cshlp.org/content/early/2026/01/12/gad.352886.125.abstract
#transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman
RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2
By Jang et al., and Hynek Wichterle
➡️ https://genesdev.cshlp.org/content/early/2026/01/12/gad.352886.125.abstract
#transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman
February 24, 2026 at 7:00 PM
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2
By Jang et al., and Hynek Wichterle
➡️ https://genesdev.cshlp.org/content/early/2026/01/12/gad.352886.125.abstract
#transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman
RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2
By Jang et al., and Hynek Wichterle
➡️ https://genesdev.cshlp.org/content/early/2026/01/12/gad.352886.125.abstract
#transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman
Electrophysiology showed that the rats muscles also responded less to motorneuron stimulation. Heart analysis revealed increased heart weight starting at 6 months. Fibrosis and inflammation already started at 3 months. Cardiac function became imparted starting at 9 months.
February 20, 2026 at 8:34 AM
Electrophysiology showed that the rats muscles also responded less to motorneuron stimulation. Heart analysis revealed increased heart weight starting at 6 months. Fibrosis and inflammation already started at 3 months. Cardiac function became imparted starting at 9 months.
The pipeline is openly available and readily extensible to other spinal circuits, motor tasks, and clinical populations
💻 All code: github.com/FrancoisDern...
📊 Data (raw EMG + edited MU spike trains): Figshare
#OpenScience #OpenData #Neuroscience #EMG #Motorneuron #MotorUnit #SpinalCircuit
💻 All code: github.com/FrancoisDern...
📊 Data (raw EMG + edited MU spike trains): Figshare
#OpenScience #OpenData #Neuroscience #EMG #Motorneuron #MotorUnit #SpinalCircuit
GitHub - FrancoisDernoncourt/Mapping_Recurrent_Inhibition: Repository of the scripts used to run analyses and simulations from the "From Large Scale Motor Neuron Recordings to Spinal Circuits: Mapping...
Repository of the scripts used to run analyses and simulations from the "From Large Scale Motor Neuron Recordings to Spinal Circuits: Mapping Recurrent Inhibition Across Muscles in Humans"...
github.com
December 22, 2025 at 10:25 AM
The pipeline is openly available and readily extensible to other spinal circuits, motor tasks, and clinical populations
💻 All code: github.com/FrancoisDern...
📊 Data (raw EMG + edited MU spike trains): Figshare
#OpenScience #OpenData #Neuroscience #EMG #Motorneuron #MotorUnit #SpinalCircuit
💻 All code: github.com/FrancoisDern...
📊 Data (raw EMG + edited MU spike trains): Figshare
#OpenScience #OpenData #Neuroscience #EMG #Motorneuron #MotorUnit #SpinalCircuit
Every time he does something like this I think back to when he mocked that journalist with motorneuron disease; that was our preview of the tween-boy-level cruel, clueless, odiousness that would be representing the US as head of state.
December 15, 2025 at 3:58 PM
Every time he does something like this I think back to when he mocked that journalist with motorneuron disease; that was our preview of the tween-boy-level cruel, clueless, odiousness that would be representing the US as head of state.
RESEARCH COMMUNICATION: A critical affinity window for IgSF proteins DIP-α and Dpr10 is required for proper motor neuron arborization
By Lopez et al. and Richard Mann
➡️ https://genesdev.cshlp.org/content/39/23-24/1426.full
#neuron #motorneuron #neurodevelopment #celladhesion #synapsis #Drosophila
By Lopez et al. and Richard Mann
➡️ https://genesdev.cshlp.org/content/39/23-24/1426.full
#neuron #motorneuron #neurodevelopment #celladhesion #synapsis #Drosophila
December 4, 2025 at 4:01 PM
RESEARCH COMMUNICATION: A critical affinity window for IgSF proteins DIP-α and Dpr10 is required for proper motor neuron arborization
By Lopez et al. and Richard Mann
➡️ https://genesdev.cshlp.org/content/39/23-24/1426.full
#neuron #motorneuron #neurodevelopment #celladhesion #synapsis #Drosophila
By Lopez et al. and Richard Mann
➡️ https://genesdev.cshlp.org/content/39/23-24/1426.full
#neuron #motorneuron #neurodevelopment #celladhesion #synapsis #Drosophila
Why are you able to move your hand away from something hot so fast? Your nerve cells! See how your cells work together to make your muscles move quickly with our Nerve Cells & Reflexes paper model! Find out more here: buff.ly/9w6coJV
#EduSky #motorneurone #motorneuron #reflexes #iteachbio
#EduSky #motorneurone #motorneuron #reflexes #iteachbio
November 17, 2025 at 1:26 PM
Why are you able to move your hand away from something hot so fast? Your nerve cells! See how your cells work together to make your muscles move quickly with our Nerve Cells & Reflexes paper model! Find out more here: buff.ly/9w6coJV
#EduSky #motorneurone #motorneuron #reflexes #iteachbio
#EduSky #motorneurone #motorneuron #reflexes #iteachbio
We found that NPS are required for proper cell identity for most – but not all – lineages, likely through nuclear & cytoplasmic reprogramming. Intriguingly, some mutant cells highly resembled primordial germ cells, while other mutant cells acquired defined motorneuron-like states. (4/6)
November 3, 2025 at 6:09 PM
We found that NPS are required for proper cell identity for most – but not all – lineages, likely through nuclear & cytoplasmic reprogramming. Intriguingly, some mutant cells highly resembled primordial germ cells, while other mutant cells acquired defined motorneuron-like states. (4/6)
doi.org/10.1126/scie...
This seems rad: overexpressing FruM in a set of proboscis-motorneuron-projecting neurons makes melanogaster males add food-sharing to their courtship repertoire.
It is fascinating to see evolutionary shifts in behavior be tied so concretely to shifts in brain development!
This seems rad: overexpressing FruM in a set of proboscis-motorneuron-projecting neurons makes melanogaster males add food-sharing to their courtship repertoire.
It is fascinating to see evolutionary shifts in behavior be tied so concretely to shifts in brain development!
Cross-species implementation of an innate courtship behavior by manipulation of the sex-determinant gene
In accepting a courting male, Drosophila subobscura females require nuptial gift giving in which a male gives regurgitated crop contents to her mouth to mouth. No similar behavior is found in D. melan...
doi.org
October 20, 2025 at 2:39 AM
doi.org/10.1126/scie...
This seems rad: overexpressing FruM in a set of proboscis-motorneuron-projecting neurons makes melanogaster males add food-sharing to their courtship repertoire.
It is fascinating to see evolutionary shifts in behavior be tied so concretely to shifts in brain development!
This seems rad: overexpressing FruM in a set of proboscis-motorneuron-projecting neurons makes melanogaster males add food-sharing to their courtship repertoire.
It is fascinating to see evolutionary shifts in behavior be tied so concretely to shifts in brain development!
Do all #NTFs regulate #MotorNeuron axonal transport in vivo?
Our new preprint shows they do not.
#BDNF enhances (shorturl.at/siwFi), #CNTF slows, and #HGF, #NRTN & #proBDNF show no effect.
#AxonalTransport regulation is selective, not universal.
@jamessleigh.bsky.social @uclqsion.bsky.social
Our new preprint shows they do not.
#BDNF enhances (shorturl.at/siwFi), #CNTF slows, and #HGF, #NRTN & #proBDNF show no effect.
#AxonalTransport regulation is selective, not universal.
@jamessleigh.bsky.social @uclqsion.bsky.social
October 15, 2025 at 6:48 AM
Do all #NTFs regulate #MotorNeuron axonal transport in vivo?
Our new preprint shows they do not.
#BDNF enhances (shorturl.at/siwFi), #CNTF slows, and #HGF, #NRTN & #proBDNF show no effect.
#AxonalTransport regulation is selective, not universal.
@jamessleigh.bsky.social @uclqsion.bsky.social
Our new preprint shows they do not.
#BDNF enhances (shorturl.at/siwFi), #CNTF slows, and #HGF, #NRTN & #proBDNF show no effect.
#AxonalTransport regulation is selective, not universal.
@jamessleigh.bsky.social @uclqsion.bsky.social
Inter-Night Variability of #NocturnalPulseOximetry in People Living With #MotorNeuron Disease: A Retrospective Observational Study
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
June 19, 2025 at 1:01 AM
Inter-Night Variability of #NocturnalPulseOximetry in People Living With #MotorNeuron Disease: A Retrospective Observational Study
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Just watched @DoddieWeir5 on @RugbyTonight.He played in my first @Scotlandteam match in 99. Boyhood sporting hero & a champion human being. Inspiration to all facing adversity. #MND #motorneuron #motorneurondisease #hero @MNDoddie5
January 29, 2025 at 8:04 PM
Just watched @DoddieWeir5 on @RugbyTonight.He played in my first @Scotlandteam match in 99. Boyhood sporting hero & a champion human being. Inspiration to all facing adversity. #MND #motorneuron #motorneurondisease #hero @MNDoddie5
Motorneuron-Dendriten von Taufliegen sind für grundlegende Funktionen entbehrlich - http://www.uni-mainz.de/presse/63736.php
December 22, 2024 at 11:57 PM
Motorneuron-Dendriten von Taufliegen sind für grundlegende Funktionen entbehrlich - http://www.uni-mainz.de/presse/63736.php
📢New paper out!!!🙌. In Spinal Muscular Atrophy, SMN deficiency induces alterations in myofibers, independent of motorneuron loss, that contribute to the pathogenesis of this neurodegenerative myopathy😱
@itb-ull.bsky.social @cienciaull.bsky.social
👉https://www.mdpi.com/1422-0067/25/22/12415
@itb-ull.bsky.social @cienciaull.bsky.social
👉https://www.mdpi.com/1422-0067/25/22/12415
December 11, 2024 at 3:29 PM
📢New paper out!!!🙌. In Spinal Muscular Atrophy, SMN deficiency induces alterations in myofibers, independent of motorneuron loss, that contribute to the pathogenesis of this neurodegenerative myopathy😱
@itb-ull.bsky.social @cienciaull.bsky.social
👉https://www.mdpi.com/1422-0067/25/22/12415
@itb-ull.bsky.social @cienciaull.bsky.social
👉https://www.mdpi.com/1422-0067/25/22/12415
Måste vara ett nedre motorneuron mtp det pyramidformade huvudet, vad som ser ut som schwannceller på mitten och de stora presynaptiska fötterna. Känns inte så realistiskt att periferanervceller skulle vara änglar, dock?
December 8, 2024 at 12:08 PM
Måste vara ett nedre motorneuron mtp det pyramidformade huvudet, vad som ser ut som schwannceller på mitten och de stora presynaptiska fötterna. Känns inte så realistiskt att periferanervceller skulle vara änglar, dock?
Scientists see motor neurons ‘walking’ in real time #motorneuron #als http://www.cell.com/neuron/abstract/S0896-6273(15)00680-7
November 26, 2024 at 6:40 PM
Scientists see motor neurons ‘walking’ in real time #motorneuron #als http://www.cell.com/neuron/abstract/S0896-6273(15)00680-7
going to see my unle tomorrrow. he's dying of a motorneuron-adjacent disorder, slowly losing all sense of language.
he had such fun with words, with wordplay, with languages, with swearing.. a deeply weird autistic dude who adores the beatles and classic rock and soon it will mean nothing to him
he had such fun with words, with wordplay, with languages, with swearing.. a deeply weird autistic dude who adores the beatles and classic rock and soon it will mean nothing to him
July 29, 2024 at 9:33 AM
going to see my unle tomorrrow. he's dying of a motorneuron-adjacent disorder, slowly losing all sense of language.
he had such fun with words, with wordplay, with languages, with swearing.. a deeply weird autistic dude who adores the beatles and classic rock and soon it will mean nothing to him
he had such fun with words, with wordplay, with languages, with swearing.. a deeply weird autistic dude who adores the beatles and classic rock and soon it will mean nothing to him
snRNAseq + #Visium #SpatialTranscriptomics
👤spinal cord + L3-5 #DorsalRootGanglia
6♂️+ 3♀️donors
vs🐭Spinal Cord
#MotorNeuron sex difference
Very informative paper, but still lack spatial resolution for microvessels ~3% total spots/nuclei
#eLife 2024
elifesciences.org/articles/92046
👤spinal cord + L3-5 #DorsalRootGanglia
6♂️+ 3♀️donors
vs🐭Spinal Cord
#MotorNeuron sex difference
Very informative paper, but still lack spatial resolution for microvessels ~3% total spots/nuclei
#eLife 2024
elifesciences.org/articles/92046
January 31, 2024 at 6:31 AM
snRNAseq + #Visium #SpatialTranscriptomics
👤spinal cord + L3-5 #DorsalRootGanglia
6♂️+ 3♀️donors
vs🐭Spinal Cord
#MotorNeuron sex difference
Very informative paper, but still lack spatial resolution for microvessels ~3% total spots/nuclei
#eLife 2024
elifesciences.org/articles/92046
👤spinal cord + L3-5 #DorsalRootGanglia
6♂️+ 3♀️donors
vs🐭Spinal Cord
#MotorNeuron sex difference
Very informative paper, but still lack spatial resolution for microvessels ~3% total spots/nuclei
#eLife 2024
elifesciences.org/articles/92046
Central pattern generators (CPG) are neural networks controlling motor behavior. Rattlesnakes have 2 CPGs, 1 for locomotion and for the rattle. A new study @CurrentBiology shows that K-channels are responsible for the precision of motorneuron activity....
January 18, 2025 at 2:02 AM
Central pattern generators (CPG) are neural networks controlling motor behavior. Rattlesnakes have 2 CPGs, 1 for locomotion and for the rattle. A new study @CurrentBiology shows that K-channels are responsible for the precision of motorneuron activity....