#MultipleSclerosis-impaired
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lpjlab.org
#Microglia and Immune cells interactions in #multiplesclerosis #cognitive impairment
#neuroskyence
#neuroscience
link.springer.com/article/10.1...
Microglia and Immune cells interactions in multiple sclerosis cognitive impairment: a postmortem study - Journal of Neuroinflammation
Multiple Sclerosis (MS), a neuroinflammatory disease of the central nervous system, is one of the commonest causes of non-traumatic disability among young adults. Impaired cognition arises as an impac...
link.springer.com
January 2, 2025 at 2:43 PM
wheelieoutthere.bsky.social
Meet "Uncle Mike"! Er, not the guy -- the guy is me. Uncle Mike is my drinkholder. I have #MultipleSclerosis-impaired hands.

My flesh-and-blood Uncle Mike made two of these for me. Guess he got tired of holding my drink! :)

Cheers!

#caregiving #ChronicIllness #newlydiagnosed #disability (1/2)
May 16, 2026 at 11:26 PM
gliameeting.bsky.social
Spotlight on Emerging Talent

Congrats to Melanie Loix (Hasselt University), a #GLIA2025 stipend winner!

Her research identifies UBE3A as a driver of foamy macrophages, impaired remyelination, and faulty lipid metabolism in #MultipleSclerosis.

#NetworkGlia
August 21, 2026 at 7:00 AM
ceijournal.bsky.social
🔬 This #MSAwarenessWeek, we spotlight new research on neutrophil dysregulation in #MultipleSclerosis.

The study shows altered granule proteins & impaired T cell suppression - highlighting a role for innate immunity in MS.

Read more: bit.ly/42yJFZI

#MSConversations
April 30, 2025 at 12:56 PM
abfbrain.bsky.social
This past blog discusses how #MultipleSclerosis damages #myelin, the protective coating around nerve cells, and can then lead to #VisionLoss. However, researchers have found a promising drug that boosted myelin repair in mice and restored their lost sight.

Read the blog ➡️ buff.ly/WxEOPnj
Image: A blank image that gradually fades into an image of a walking path in a park to represent restoring the vision of patients with vision loss caused by demyelination. Text: Restoring impaired vision for patients with MS.
May 16, 2026 at 10:00 PM
abudd.bsky.social
multiplesclerosisnewstoday.com/news-posts/2...

#MultipleSclerosis
Fatigue in MS significantly contributes to impaired well-being: Study
Nearly 50% of MS patients report pronounced fatigue, which has a significantly negative impact on their well-being, a Finnish study found.
multiplesclerosisnewstoday.com
March 26, 2025 at 3:22 PM
wheelieoutthere.bsky.social
Bob Wagner is hearing impaired. His wife Kristen has #multiplesclerosis. Their marketing agency Doable is the 1st led by & centering people w #disabilities.

“We...help consumers w disabilities have a voice." Doable's work shows businesses the diversity & creativity of the disabled community. 1/2
September 8, 2026 at 12:09 PM
wheelieoutthere.bsky.social
MS Visually Impaired People (VIP) Virtual Self-Help Group — Tues. 2/4

Whether fully blind or have low vision, all are welcome. Contact group leader to participate by Zoom or phone.

Contact Dave Rutkowski, 703-795-4089, dave.msfriend@gmail.com

#visual #multiplesclerosis
February 2, 2025 at 12:10 PM
abfbrain.bsky.social
Three blind mice? Not anymore. A recent study found a drug that can speed up myelin repair and heal related vision loss in mice. This discovery could be a gamechanger for treating #MultipleSclerosis. #LowVisionAwarenessMonth

Read more in our new blog: https://buff.ly/436srne
Text: Restoring impaired vision for patients with Multiple Sclerosis. Image: A blank image that gradually fades into an image of a walking path in a park to represent restoring the vision of patients with vision loss caused by demyelination.
February 25, 2025 at 11:45 PM
abudd.bsky.social
translational-medicine.biomedcentral.com/articles/10....

#MultipleSclerosis
From diagnosis to treatment: exploring the mechanisms underlying optic neuritis in multiple sclerosis - Journal of Translational Medicine
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, commonly causing sensory disturbances, motor weakness, impaired gait, incoordination and optic neuritis (O...
translational-medicine.biomedcentral.com
January 22, 2025 at 12:31 PM
ijmsc.bsky.social
"The ability to #communicate may be impaired in people with #MultipleSclerosis (MS), as both speech and language may be affected. Although #WordFinding difficulty is a common impairment, little is known about how this affects everyday life for people with MS."
doi.org/10.7224/1537...
Experiences of Word-Finding Difficulties in Multiple Sclerosis: A Qualitative Interview Study
doi.org
August 11, 2025 at 1:57 PM
gregoryai.bsky.social
https://gregory-ms.com/articles/298410/
B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity

#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
July 15, 2025 at 1:30 PM
sallybourliakas.bsky.social
🧪 #LongCovid #MECFS

x.com/dysclinic/st...
Neuroimmunology ME/CFS Long COVID POTS Autoimmunity Postive ANA, assephospholipid and other antibodies High prevalence of comorbie autoimmune disorders Elevated adrenergic and IgG t0 thyroglobulin and IF NO Postive response to Immunotherapies in a subset of Immune dysregulation Teel exhauston Chronic activation of subset of COS•T cels Increased naive B-cell numbers Increased prontammator cytokines Mast cel hyperactivity Sympathetic overactivty Impaired infammatory refer via Neuroinflammation Microglial activation Elevated peoinflammatory cytokines Altered blood-brain barrier Central autonomie networks aterations Abnomal 7T MRI Indings Brain glucose metabolism alteration Cerebral hypoperfusion Reduced cardiac stroke volume Glymphatie system alterations Venous congestion Endothelial dysfunction. Hypecoagulable state Possible microciots Systemic hypovolemia Autonomic dysregulation Connective tissue abnormalites improved cerebral pertusion with supine vs. standing position Mitochondrial dysfunction Chronie taique and posti Respration, bionnergeties and mitochondria-related gene expression changes Oxidative stress and mitochondrial damage biomarkers with elevated lactate, peroxide and superoxide Impared ATP production Abnormal 2-day CPET Reduced systemie oxygen 06:35 94 Hot off the press: my new paper that moves this field forward & • and changes the narrative on what #POTS, #MECFS and #LongCOVID are... Neuroimmune Disorders! The brain and the autonomic nervous system are involved in the immune system regulation. There is evidence of autoimmunity, immune dysregulation, cerebral hypoperfusion, neuroinflammation and other mechanisms in all three disorders. #Neuroimmunology is a field that should embrace these disorders: #MultipleSclerosis, the staple of neuroimmunology, used to be called hysterical paralysis before CT and MRI were invented. We're at the same crossroads with these disorders. X These disorders are not "mysterious", "anxiety", "deconditioning," "functional neurologic" etc. etc. !! Classifying these disorders as neuroimmune and including them as part of neuroimmunology training is critical. • #PatientCare and lives of millions of people living with these disabling conditions are at stake! Post your reply
February 3, 2026 at 6:43 AM
gregoryai.bsky.social
Impaired myelin repair is a hallmark of progressive multiple sclerosis. Neuregulin-1 is an endogenous target to facilitate microglia mediated-repair in progressive MS.
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination
Impaired myelin repair is a hallmark of progressive multiple sclerosis. Neuregulin-1 is an endogenous target to facilitate microglia mediated-repair in progressive MS.
gregory-ms.com
May 11, 2026 at 3:00 PM
jeroenvs.bsky.social
Great work by Fahimeh Akbarian on task-induced 1/f slope modulations in #MultipleSclerosis!
November 7, 2025 at 2:15 PM
asnrehab.bsky.social
This study found people with #MultipleSclerosis had similar neural activation patterns in regions associated with motor planning & movement control as controls during motor imagery. This suggests motor deficits may not be solely due to impaired motor planning. 🧠🔄 journals.sagepub.com/doi/10.1177/...
Supplementary and Premotor Cortical Activation During Manual Dexterity Involving Motor Imagery in Multiple Sclerosis: A Functional Near-Infrared Spectroscopy Study - Shaked Sadot, Sapir Dreyer-Alster,...
Background Investigating brain activation during motor imagery (MI) tasks in people with multiple sclerosis (pwMS) can increase the knowledge of the neural mech...
journals.sagepub.com
May 9, 2025 at 3:03 PM
gregoryai.bsky.social
Thymus-derived Treg cells infiltrate the injured spinal cord around 3 days post-SCI. Treg cell depletion worsened SCI and impaired long-term recovery. Transcriptomic profiling revealed strong anti-inflammatory functions and the potential...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Treg-microglia partnership in the injured spinal cord preserves Treg cell function and regulates microglial cholesterol metabolism
Thymus-derived Treg cells infiltrate the injured spinal cord around 3 days post-SCI. Treg cell depletion worsened SCI and impaired long-term recovery. Transcriptomic profiling revealed strong anti-inf
gregory-ms.com
October 1, 2025 at 7:10 AM
gregoryai.bsky.social
Demyelinating diseases lead to impaired nerve conduction and sensorimotor dysfunctions. Traditional tonic Chinese herbal medicines have potential to treat demyelinating disease.
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
The therapeutic effects of various tonic traditional Chinese medicines on demyelinating diseases
Demyelinating diseases lead to impaired nerve conduction and sensorimotor dysfunctions. Traditional tonic Chinese herbal medicines have potential to treat demyelinating disease.
gregory-ms.com
September 10, 2025 at 7:50 AM
gregoryai.bsky.social
The recovery of neurological function following spinal cord injury is constrained by neuroinflammation and impaired tissue regeneration. Extracellular vesicles (EVs) have emerged as a promising therapeutic approach, but their clinical tr...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Multidimensional Engineering of Extracellular Vesicles for Targeted Delivery and Microglial Reprograming in Spinal Cord Injury Repair
The recovery of neurological function following spinal cord injury is constrained by neuroinflammation and impaired tissue regeneration. Extracellular vesicles (EVs) have emerged as a promising therap
gregory-ms.com
August 23, 2025 at 7:00 AM
gregoryai.bsky.social
Quinoxaline derivative (IFA005) converts human memory CD4+T cells into suppressive Foxp3-expressing Tregs in vitro. Mechanistically, IFA005 regulated the expression of naked cuticle homolog 2 and impaired the phosphorylation of glycogen ...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Generation of Regulatory T Cells From Human Memory CD4<sup>+</sup>T Cells by Upregulation of Naked Cuticle Homolog 2
Quinoxaline derivative (IFA005) converts human memory CD4+T cells into suppressive Foxp3-expressing Tregs in vitro. Mechanistically, IFA005 regulated the expression of naked cuticle homolog 2 and impa
gregory-ms.com
August 5, 2025 at 1:50 PM
gregoryai.bsky.social
Myotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of upper and lower motor neurons. In the hSOD1G93A mouse model of ALS, neural progenitor cells (NPCs) derived from the mutation showed inc...

#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
An impaired splicing program underlies differentiation defects in hSOD1<sup>G93A</sup> neural progenitor cells
Myotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of upper and lower motor neurons. In the hSOD1G93A mouse model of ALS, neural progenitor cells (NPCs) derive
gregory-ms.com
July 26, 2025 at 8:20 AM
gregoryai.bsky.social
Effectiveness of a One-year Group Program for Fatigue Management in Minimally Impaired People With Multiple Sclerosis

#MSchat #Neurology #MultipleSclerosis #ClinicalTrial #botsFightMS
July 15, 2025 at 3:46 PM
gregoryai.bsky.social
ReHabGame: a game-based rehabilitation system for motor-impaired individuals

#MSchat #Neurology #MultipleSclerosis #ClinicalTrial #botsFightMS
June 4, 2025 at 4:38 PM
gregoryai.bsky.social
https://gregory-ms.com/articles/293284/
Enhancing myelinogenesis through LIN28A rescues impaired cognition in PWMI mice

#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
March 21, 2025 at 6:30 PM
gregoryai.bsky.social
https://gregory-ms.com/articles/258941/
Natural compounds and mesenchymal stem cells: implications for inflammatory-impaired tissue regeneration

#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
March 29, 2024 at 8:50 AM