Scientists identify #OXCT1 as a #TumorSuppressor in #ColorectalLiverMetastasis, where its loss drives migration and #metastasis via CDK8–Wnt/β‑catenin signaling; low OXCT1 correlates with poor outcomes, highlighting therapeutic potential.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
January 4, 2026 at 12:31 AM
Scientists identify #OXCT1 as a #TumorSuppressor in #ColorectalLiverMetastasis, where its loss drives migration and #metastasis via CDK8–Wnt/β‑catenin signaling; low OXCT1 correlates with poor outcomes, highlighting therapeutic potential.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Glucose deprivation promotes OXCT1 phosphorylation and nuclear translocation, which leads to repressed transcription of MHC-I and chemokine genes and reduced immunotherapy responsiveness
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nuclear OXCT1 attenuates histone β-hydroxybutyrylation-mediated MHC-I transcription - Nature Chemical Biology
Metabolic reprogramming in cancer cells can contribute to responsiveness to immunotherapy. In this study, glucose deprivation in hepatocellular carcinoma cells was found to promote OXCT1 S113 phosphor...
www.nature.com
June 8, 2026 at 4:12 PM
Glucose deprivation promotes OXCT1 phosphorylation and nuclear translocation, which leads to repressed transcription of MHC-I and chemokine genes and reduced immunotherapy responsiveness
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Low expression of OXCT1 promotes #TumorMigration & #ColorectalCancer liver #metastasis (#CRLM), while its upregulation suppresses the Wnt signaling pathway by downregulating CDK8 expression and histone H3 acetylation. #epigenetics #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
April 19, 2025 at 11:00 PM
Low expression of OXCT1 promotes #TumorMigration & #ColorectalCancer liver #metastasis (#CRLM), while its upregulation suppresses the Wnt signaling pathway by downregulating CDK8 expression and histone H3 acetylation. #epigenetics #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
Online Now: RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer Online now:
RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer
Wang et al. show that OXCT1 and HDAC11 regulate RAD51 K285 succinylation, thereby suppressing homologous recombination repair and enhancing chemosensitivity.
dlvr.it
February 11, 2026 at 8:14 PM
Online Now: RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer Online now:
RRIDs were included in this in The FASEB Journal paper. RRIDs improve reproducibility in scientific research. #BetterScience #methodsmatter #OpenResearch
Ketone Body Supplementation Exerts Renoprotective Effects Against Adenine‐Induced Kidney Injury via OXCT1‐Mediated Ketolysis in Mice
Read the full paper: Ketone Body Supplementation Exerts Renoprotective Effects Against Adenine‐Induced Kidney Injury via OXCT1‐Mediated Ketolysis in Mice
doi.org
March 12, 2026 at 7:01 AM
RRIDs were included in this in The FASEB Journal paper. RRIDs improve reproducibility in scientific research. #BetterScience #methodsmatter #OpenResearch
RRIDs were included in this in Cell Death & Disease paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #methodsmatter #STMpublishing
β-catenin mutation reprograms ketone body metabolism to drive hepatocellular carcinoma metastasis and resistance to ketogenic therapy via transcriptional activation of OXCT1 - Cell Death & Disease
Read the full paper: β-catenin mutation reprograms ketone body metabolism to drive hepatocellular carcinoma metastasis and resistance to ketogenic therapy via transcriptional activation of OXCT1
doi.org
April 4, 2026 at 7:01 AM
RRIDs were included in this in Cell Death & Disease paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #methodsmatter #STMpublishing
A paper using RRID:AB_2818996 from @proteintech.bsky.social was just published in Free Radical Biology and Medicine. RRIDs improve reproducibility in scientific research. #accelerateopenscience #BetterScience #ReproducibleResearch
OXCT1-induced Succinylation at K81 Shields HADH from HSPA8-Mediated Degradation in alveolar epithelial cells to Attenuate Lung Ischemia-Reperfusion Injury
Read the full paper: OXCT1-induced Succinylation at K81 Shields HADH from HSPA8-Mediated Degradation in alveolar epithelial cells to Attenuate Lung Ischemia-Reperfusion Injury
doi.org
March 4, 2026 at 8:01 AM
A paper using RRID:AB_2818996 from @proteintech.bsky.social was just published in Free Radical Biology and Medicine. RRIDs improve reproducibility in scientific research. #accelerateopenscience #BetterScience #ReproducibleResearch
KCB's resource, RRID:CVCL_0326, was just reported to be used in "OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth". RRIDs like this improve reproducibility in scientific research. #ReproducibleResearch #ReproducibleResearch
doi.org
February 11, 2025 at 8:01 AM
KCB's resource, RRID:CVCL_0326, was just reported to be used in "OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth". RRIDs like this improve reproducibility in scientific research. #ReproducibleResearch #ReproducibleResearch
What determines whether #ColorectalCancer spreads to the liver?
This study identifies OXCT1 as a #TumourSuppressor that inhibits #WntSignalling, revealing the OXCT1/Wnt axis as a promising target for colorectal liver metastasis.
#GenesAndDiseases: doi.org/10.1016/j.ge...
This study identifies OXCT1 as a #TumourSuppressor that inhibits #WntSignalling, revealing the OXCT1/Wnt axis as a promising target for colorectal liver metastasis.
#GenesAndDiseases: doi.org/10.1016/j.ge...
August 2, 2026 at 3:06 PM
What determines whether #ColorectalCancer spreads to the liver?
This study identifies OXCT1 as a #TumourSuppressor that inhibits #WntSignalling, revealing the OXCT1/Wnt axis as a promising target for colorectal liver metastasis.
#GenesAndDiseases: doi.org/10.1016/j.ge...
This study identifies OXCT1 as a #TumourSuppressor that inhibits #WntSignalling, revealing the OXCT1/Wnt axis as a promising target for colorectal liver metastasis.
#GenesAndDiseases: doi.org/10.1016/j.ge...
Fascinating new publication in JIMD Reports, detailing the use of modified cornstarch and pancreatic enzyme to achieve metabolic stability in an infant affected by a previously unreported, severe OXCT1 gene deletion leading to SCOT deficiency.
Read it here 👉 doi.org/10.1002/jmd2...
Read it here 👉 doi.org/10.1002/jmd2...
May 23, 2025 at 5:33 PM
Fascinating new publication in JIMD Reports, detailing the use of modified cornstarch and pancreatic enzyme to achieve metabolic stability in an infant affected by a previously unreported, severe OXCT1 gene deletion leading to SCOT deficiency.
Read it here 👉 doi.org/10.1002/jmd2...
Read it here 👉 doi.org/10.1002/jmd2...
This research highlights how #Hypoxia modulates #Ketone #Metabolism by upregulating SCOT/OXCT1, ACAT1, & BDH2, while reducing succinyl-CoA levels, advancing our understanding of #KetoneBody regulation in #IschemicHeartDisease. #medsky
Read: link.springer.com/article/10.1...
Read: link.springer.com/article/10.1...
November 1, 2025 at 1:30 PM
This research highlights how #Hypoxia modulates #Ketone #Metabolism by upregulating SCOT/OXCT1, ACAT1, & BDH2, while reducing succinyl-CoA levels, advancing our understanding of #KetoneBody regulation in #IschemicHeartDisease. #medsky
Read: link.springer.com/article/10.1...
Read: link.springer.com/article/10.1...
This study confirms the critical role of #KetoneMetabolism in myocardial hypoxia by showing that #hypoxia promotes elevated expression of the #cardiomyocyte ketone body-metabolizing enzymes SCOT/OXCT1, ACAT1, and BDH2 and decreases the levels of #succinylCoA. #medsky.
Read more: buff.ly/38Y5ufa
Read more: buff.ly/38Y5ufa
May 29, 2025 at 11:01 PM
This study confirms the critical role of #KetoneMetabolism in myocardial hypoxia by showing that #hypoxia promotes elevated expression of the #cardiomyocyte ketone body-metabolizing enzymes SCOT/OXCT1, ACAT1, and BDH2 and decreases the levels of #succinylCoA. #medsky.
Read more: buff.ly/38Y5ufa
Read more: buff.ly/38Y5ufa
YO BRO 🔥 KETOSIS JUST SMASHED FRDA IN ANIMAL MODELS—RESCUING FRATAXIN DEFICIENCY AND WIPING OUT DISEASE SYMPTOMS 💥 Frataxin deficiency tanks OXCT1, blocking ketone power, but this study flips the script—ketosis FIRES UP MITO FUNCTION like a beast mode fasted lift sesh LessCarbs squad, TIME
January 15, 2026 at 5:00 AM
YO BRO 🔥 KETOSIS JUST SMASHED FRDA IN ANIMAL MODELS—RESCUING FRATAXIN DEFICIENCY AND WIPING OUT DISEASE SYMPTOMS 💥 Frataxin deficiency tanks OXCT1, blocking ketone power, but this study flips the script—ketosis FIRES UP MITO FUNCTION like a beast mode fasted lift sesh LessCarbs squad, TIME
YO BRO 🔥 KETOSIS JUST SMASHED FRDA in animal models—rescuing frataxin deficiency and FIXING those brutal disease phenotypes Low-carb warriors, this is your GREEN LIGHT: ketones bypassing the OXCT1 glitch, fueling mitochondria like a beast mode hack Dive into keto, crush inflammation, stac
January 15, 2026 at 4:45 AM
YO BRO 🔥 KETOSIS JUST SMASHED FRDA in animal models—rescuing frataxin deficiency and FIXING those brutal disease phenotypes Low-carb warriors, this is your GREEN LIGHT: ketones bypassing the OXCT1 glitch, fueling mitochondria like a beast mode hack Dive into keto, crush inflammation, stac
RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer
RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer
Wang et al. show that OXCT1 and HDAC11 regulate RAD51 K285 succinylation, thereby suppressing homologous recombination repair and enhancing chemosensitivity.
dlvr.it
February 23, 2026 at 4:19 PM
RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer
But one of these gene regions (SLC2A4) had pleiotropic associations with blood pressure, and the other two (HMGCS2, OXCT1) did not have clear and consistent associations with positive control variables.
June 10, 2025 at 8:55 AM
But one of these gene regions (SLC2A4) had pleiotropic associations with blood pressure, and the other two (HMGCS2, OXCT1) did not have clear and consistent associations with positive control variables.
Nuclear OXCT1, a key enzyme in ketone metabolism, lowers MHC-I transcription by reducing histone β-hydroxybutyrylation. High OXCT1 linked to poor immunotherapy outcomes; inversely, β-hydroxybutyrate boosts… PMID:42204309, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02229-7
Nuclear OXCT1 attenuates histone β-hydroxybutyrylation-mediated MHC-I transcription | Nature Chemical Biology
Understanding of the metabolic determinants influencing immunotherapy responsiveness remains limited. Here we performed a multiomics analysis of tumor biopsies from patients with hepatocellular carcinoma (HCC) treated with immune checkpoint blockade (ICB) and revealed that heightened expression of OXCT1, a rate-limiting enzyme in ketone body metabolism, was negatively correlated with ICB efficacy, whereas its metabolic substrate, β-hydroxybutyrate (BHB), displayed an opposite effect. Mechanistically, glucose deprivation in HCC cells promotes AMPK-mediated OXCT1 S113 phosphorylation, which exposes the nuclear localization sequence of OXCT1 to trigger its nuclear translocation. Nucleus-translocated OXCT1 associates with IRF1 to locally consume BHB and suppress histone H3K9 BHB at the major histocompatibility complex class I (MHC-I) and chemokine gene loci, leading to repressed transcription of these immune genes. Targeting the AMPK−OXCT1−IRF1 axis sensitizes tumor cells to ICB upon ketog
doi.org
June 28, 2026 at 12:00 PM
Nuclear OXCT1, a key enzyme in ketone metabolism, lowers MHC-I transcription by reducing histone β-hydroxybutyrylation. High OXCT1 linked to poor immunotherapy outcomes; inversely, β-hydroxybutyrate boosts… PMID:42204309, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02229-7