The central nervous system is a critical reservoir for cancer metastasis, underscoring the urgent need for effective strategies for targeted drug delivery that minimize systemic side effects. Here, we present a zwitterionic polycarboxybetaine (PCB) designed to achieve selective accumulation within the tumor vasculature of brain metastases, thereby facilitating the rapid release of therapeutics without relying on external stimuli in preclinical models. PCB selectively targets the betaine-γ-aminobutyric acid transporter 1 (BGT1) at the blood-brain-tumor barrier (BBTB), enabling localized enrichment of nanoparticles within the tumor vasculature. The intrinsic mechanical flexibility of PCB activates the Piezo1 ion channel in endothelial cells, resulting in calcium ion influx and enhanced calpain activity, which together facilitate the degradation of VE-cadherin. The burst-release mechanism improves vascular permeability and compromises the integrity of the tumor vascular barrier, allowing

Færre kontingentbetalende landmænd og store udgifter til PCB på Axelborg presser økonomien i L&F. Nu skærer organisationen 25 procent af lederne væk. Målet er at styrke den politiske indsats med færre...

Following a successful assembly of the Water Tank Sensor adapter PCB, I continued with the RT85 CTCSS module. Continue reading → The post RT85 CTCSS PCB Assembly first appeared on Narf.