Could PGE2 Hold Clues to Long COVID?
At #ISLCPAIS, citizen scientist Vera Ramer presents her hypothesis exploring how prostaglandin E2 (PGE2) and its receptors may influence inflammation, pain and fatigue in Long COVID.
An intriguing hypothesis for researchers to explore.
#LongCOVID #PGE2 #PAIS
At #ISLCPAIS, citizen scientist Vera Ramer presents her hypothesis exploring how prostaglandin E2 (PGE2) and its receptors may influence inflammation, pain and fatigue in Long COVID.
An intriguing hypothesis for researchers to explore.
#LongCOVID #PGE2 #PAIS
August 29, 2026 at 8:38 PM
Could PGE2 Hold Clues to Long COVID?
At #ISLCPAIS, citizen scientist Vera Ramer presents her hypothesis exploring how prostaglandin E2 (PGE2) and its receptors may influence inflammation, pain and fatigue in Long COVID.
An intriguing hypothesis for researchers to explore.
#LongCOVID #PGE2 #PAIS
At #ISLCPAIS, citizen scientist Vera Ramer presents her hypothesis exploring how prostaglandin E2 (PGE2) and its receptors may influence inflammation, pain and fatigue in Long COVID.
An intriguing hypothesis for researchers to explore.
#LongCOVID #PGE2 #PAIS
Cancer cells blunt monocyte IFN while increasing PGE2 to inhibit T cell immunity @obenaufa.bsky.social @aelewaut.bsky.social @guillemxtivill.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 28, 2024 at 12:26 PM
Cancer cells blunt monocyte IFN while increasing PGE2 to inhibit T cell immunity @obenaufa.bsky.social @aelewaut.bsky.social @guillemxtivill.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congratulations #ObenaufLab on this amazing study of how MAPK-induced PGE2 secretion induces tumor immunosuppression. Impressive work!
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 9:55 PM
Congratulations #ObenaufLab on this amazing study of how MAPK-induced PGE2 secretion induces tumor immunosuppression. Impressive work!
Excited to share our new collaborative study with the Sebastian Kobold lab! www.nature.com/articles/s41...
By deleting the PGE2 receptors EP2/EP4, we render CAR T cells resistant to suppression in solid tumors - boosting persistence and anticancer activity in preclinical models and patient samples.
By deleting the PGE2 receptors EP2/EP4, we render CAR T cells resistant to suppression in solid tumors - boosting persistence and anticancer activity in preclinical models and patient samples.
Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours - Nature Biomedical Engineering
Targeted ablation of prostaglandin E2 (PGE2) signalling in CAR T cells enhances their activity in PGE2-rich solid tumours, with demonstrations of efficacy in vitro, in mouse xenografts and in patient-...
www.nature.com
February 12, 2026 at 3:51 PM
Excited to share our new collaborative study with the Sebastian Kobold lab! www.nature.com/articles/s41...
By deleting the PGE2 receptors EP2/EP4, we render CAR T cells resistant to suppression in solid tumors - boosting persistence and anticancer activity in preclinical models and patient samples.
By deleting the PGE2 receptors EP2/EP4, we render CAR T cells resistant to suppression in solid tumors - boosting persistence and anticancer activity in preclinical models and patient samples.
14/23 Clinical relevance: Our findings help explain why NSAID use (which block PGE2 production) correlates with better immunotherapy responses in melanoma and lung cancer patients 🏥
November 27, 2024 at 5:58 PM
14/23 Clinical relevance: Our findings help explain why NSAID use (which block PGE2 production) correlates with better immunotherapy responses in melanoma and lung cancer patients 🏥
Excited to share that our story on PGE2-mediated control of NK cell metastasis surveillance in lung tissue is now published in @Cell Reports
🤝 Thanks to the many great colleagues who helped conduct this study!
👏Congratulations to first author Anna-Marie Pedde
🤝 Thanks to the many great colleagues who helped conduct this study!
👏Congratulations to first author Anna-Marie Pedde
November 14, 2024 at 9:13 AM
Excited to share that our story on PGE2-mediated control of NK cell metastasis surveillance in lung tissue is now published in @Cell Reports
🤝 Thanks to the many great colleagues who helped conduct this study!
👏Congratulations to first author Anna-Marie Pedde
🤝 Thanks to the many great colleagues who helped conduct this study!
👏Congratulations to first author Anna-Marie Pedde
New preprint from the lab, led by Bradley Cutler. With the @james-gagnon.bsky.social lab we use zebrafish to show that fever is not a reduction in the perception of warmth. Immune signals instead increase the valence of warming stimuli while cooling turns aversive.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
May 13, 2026 at 1:04 PM
New preprint from the lab, led by Bradley Cutler. With the @james-gagnon.bsky.social lab we use zebrafish to show that fever is not a reduction in the perception of warmth. Immune signals instead increase the valence of warming stimuli while cooling turns aversive.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Interesting role for PGE2 - EP2/4 axis in immunosuppression in tumours
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells - Nature Communications
Mechanisms of prostaglandin E2 (PGE2)-mediated immunosuppression in the tumor microenvironment (TME) have been previously reported. Here, the authors profile PGE2 functions in human cancer, suggesting...
www.nature.com
November 18, 2024 at 9:47 PM
Interesting role for PGE2 - EP2/4 axis in immunosuppression in tumours
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2 @naturecomms.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 28, 2025 at 7:20 PM
Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2 @naturecomms.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Another paper in the continuing quest to understand the MOA of Angiotensin Receptor Type 2 (AT2R) antagonists for pain: www.sciencedirect.com/science/arti... They also find no evidence for expression in DRG neurons and propose that AT2R activation increases PGE2 production causing inflammatory pain.
PGE2 and HCN2 ion channels are critical mediators of pain initiated by angiotensin II
Angiotensin II is well known to have an important influence on blood pressure, mediated via the angiotensin II type 1 receptor (AT1R), and more recent…
www.sciencedirect.com
December 31, 2024 at 1:36 PM
Another paper in the continuing quest to understand the MOA of Angiotensin Receptor Type 2 (AT2R) antagonists for pain: www.sciencedirect.com/science/arti... They also find no evidence for expression in DRG neurons and propose that AT2R activation increases PGE2 production causing inflammatory pain.
2/23 The fabulous @AnaisElewaut and @guillemxtivill uncovered how inflammatory 🔥monocytes stimulate CD8+ T cells within #InflammatoryHubs in the TME and how cancer cells evade immunity by MAPK-orchestrated secretion of prostaglandin E2 (PGE2) and reduction of IFN-I.
November 27, 2024 at 5:58 PM
2/23 The fabulous @AnaisElewaut and @guillemxtivill uncovered how inflammatory 🔥monocytes stimulate CD8+ T cells within #InflammatoryHubs in the TME and how cancer cells evade immunity by MAPK-orchestrated secretion of prostaglandin E2 (PGE2) and reduction of IFN-I.
MHC class II+ macrophage differentiation is impaired in metastasized lungs via PGE2 receptor EP2
MHC class II+ macrophage differentiation is impaired in metastasized lungs via PGE2 receptor EP2
The monocyte-to-macrophage transition in metastasized lungs is not fully understood. Jeong et al. show that MHC class II+ macrophage differentiation is impaired in metastasized lungs, accompanied by PGE2-EP2-driven DNA hypermethylation of genes associated with non-neoplastic myeloid cells. Deletion of the PGE2 receptor EP2 promoted MHC class II+ macrophage differentiation and attenuated lung metastasis.
dlvr.it
April 19, 2025 at 12:35 PM
MHC class II+ macrophage differentiation is impaired in metastasized lungs via PGE2 receptor EP2
#InterferonPower! Elewaut, @obenaufa.bsky.social &co show @ Nature that inflammatory monocytes can acquire MHC-class I from tumor cells & locally activate CD8 T cells, given that the capacity of the tumor to shut down type I #IFNs & upreg PGE2 is reverted! www.nature.com/articles/s41...
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature
Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.
www.nature.com
November 27, 2024 at 5:38 PM
#InterferonPower! Elewaut, @obenaufa.bsky.social &co show @ Nature that inflammatory monocytes can acquire MHC-class I from tumor cells & locally activate CD8 T cells, given that the capacity of the tumor to shut down type I #IFNs & upreg PGE2 is reverted! www.nature.com/articles/s41...
12/23 In RTT tumors, high PGE2 and low IFN-I levels prevent monocytes from acquiring an inflammatory state. Instead, they differentiate into immunosuppressive macrophages that block anti-tumor immunity 🛑
November 27, 2024 at 5:58 PM
12/23 In RTT tumors, high PGE2 and low IFN-I levels prevent monocytes from acquiring an inflammatory state. Instead, they differentiate into immunosuppressive macrophages that block anti-tumor immunity 🛑
MHC class II+ macrophage differentiation is impaired in metastasized lungs via PGE2 receptor EP2 @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
April 15, 2025 at 3:07 AM
MHC class II+ macrophage differentiation is impaired in metastasized lungs via PGE2 receptor EP2 @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Opposing Regulation of TNF Responses and IL-1b+ Macrophages by PGE2-cAMP and IFN-g Signaling https://www.biorxiv.org/content/10.1101/2024.11.11.623039v1
Opposing Regulation of TNF Responses and IL-1b+ Macrophages by PGE2-cAMP and IFN-g Signaling https://www.biorxiv.org/content/10.1101/2024.11.11.623039v1
IL-1b-expressing macrophages have been described in rheumatoid arthritis (RA), immune checkpoint inh
www.biorxiv.org
November 13, 2024 at 1:16 AM
Opposing Regulation of TNF Responses and IL-1b+ Macrophages by PGE2-cAMP and IFN-g Signaling https://www.biorxiv.org/content/10.1101/2024.11.11.623039v1
💬 Dr Santiago Zelenay, Senior Group Leader at @cruk-mi.bsky.social, delivered a presentation titled "COX-2/PGE2 axis: a dominant pathway underlying cancer immune evasion"
April 29, 2025 at 8:14 AM
💬 Dr Santiago Zelenay, Senior Group Leader at @cruk-mi.bsky.social, delivered a presentation titled "COX-2/PGE2 axis: a dominant pathway underlying cancer immune evasion"
As we showed for pancratic cancer, IL-1b+ Macs are a thing in arthritis - their phenotype driven by PGE2+TNF. Lionel Ivashkiv Lab defines the molecular determinants of this synergistic interplay and reveals new ways to target pathogenic inflammation. Congrats!!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Opposing Regulation of TNF Responses and IL-1β+ Macrophages by PGE2-cAMP and IFN-γ Signaling
IL-1β-expressing macrophages have been described in rheumatoid arthritis (RA), immune checkpoint inhibitor-induced inflammatory arthritis (ICI-arthritis), and pancreatic cancer and proposed to be path...
www.biorxiv.org
November 17, 2024 at 3:03 PM
As we showed for pancratic cancer, IL-1b+ Macs are a thing in arthritis - their phenotype driven by PGE2+TNF. Lionel Ivashkiv Lab defines the molecular determinants of this synergistic interplay and reveals new ways to target pathogenic inflammation. Congrats!!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Recent findings in @JOrthopRes.bsky.social show loss of effective lubricating viscosity is the primary mechanical marker of synovial inflammation in equine OA, linked to inflammation biochemical markers like white blood cell count & PGE2.
buff.ly/gwOPVsK
#ORSxDerby #ORSSMC
@ORSsociety.bsky.social
buff.ly/gwOPVsK
#ORSxDerby #ORSSMC
@ORSsociety.bsky.social
May 3, 2025 at 2:45 PM
Recent findings in @JOrthopRes.bsky.social show loss of effective lubricating viscosity is the primary mechanical marker of synovial inflammation in equine OA, linked to inflammation biochemical markers like white blood cell count & PGE2.
buff.ly/gwOPVsK
#ORSxDerby #ORSSMC
@ORSsociety.bsky.social
buff.ly/gwOPVsK
#ORSxDerby #ORSSMC
@ORSsociety.bsky.social
AML blasts suppress NK cells by secreting PGE2, leading to a blockade of LCK and consequently to a functional blockade of NK cells. buff.ly/Shmtucq #hemesky #immunobiologyandimmunotherapy #myeloidneoplasia
March 31, 2025 at 5:00 PM
AML blasts suppress NK cells by secreting PGE2, leading to a blockade of LCK and consequently to a functional blockade of NK cells. buff.ly/Shmtucq #hemesky #immunobiologyandimmunotherapy #myeloidneoplasia
New #CellStemCell paper from Helen Blau and colleagues: Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. #Myoblue tinyurl.com/yvf4cdch
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength
Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that
is critical for their regenerative function. Treatment with exogenous PGE2 reverses
age-related defects in muscle s...
tinyurl.com
June 12, 2025 at 4:10 PM
New #CellStemCell paper from Helen Blau and colleagues: Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. #Myoblue tinyurl.com/yvf4cdch
15/23 Based on these insights, we developed combination therapies targeting both pathways to improve the outcome of immunotherapies:
COX2 inhibitors (to block PGE2)
5-Azacitidine (to boost IFN-I)
Flt3L (to expand antigen-presenting cells)
COX2 inhibitors (to block PGE2)
5-Azacitidine (to boost IFN-I)
Flt3L (to expand antigen-presenting cells)
November 27, 2024 at 5:58 PM
15/23 Based on these insights, we developed combination therapies targeting both pathways to improve the outcome of immunotherapies:
COX2 inhibitors (to block PGE2)
5-Azacitidine (to boost IFN-I)
Flt3L (to expand antigen-presenting cells)
COX2 inhibitors (to block PGE2)
5-Azacitidine (to boost IFN-I)
Flt3L (to expand antigen-presenting cells)
New fundamental insights into the battle between immune cells & tumor cells: Anna @obenaufa.bsky.social's lab @impvienna.bsky.social discovered that T cells get stimulated in tumors by inflammatory monocytes, an activity blocked by oncogenic signalling through counter-regulation of PGE2 and IFN-I.
Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...
November 28, 2024 at 4:22 PM
New fundamental insights into the battle between immune cells & tumor cells: Anna @obenaufa.bsky.social's lab @impvienna.bsky.social discovered that T cells get stimulated in tumors by inflammatory monocytes, an activity blocked by oncogenic signalling through counter-regulation of PGE2 and IFN-I.
Fantastic study (and thread👇) by the awesome @obenaufa.bsky.social lab!!! Cancer cells shut down antigen cross-dressing and T cell activation via PGE2 @natureportfolio.bsky.social
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 9:04 PM
Fantastic study (and thread👇) by the awesome @obenaufa.bsky.social lab!!! Cancer cells shut down antigen cross-dressing and T cell activation via PGE2 @natureportfolio.bsky.social
Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells
#immunometabolism #TME #immunosuppression
www.nature.com/articles/s41...
#immunometabolism #TME #immunosuppression
www.nature.com/articles/s41...
Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells - Nature Communications
Mechanisms of prostaglandin E2 (PGE2)-mediated immunosuppression in the tumor microenvironment (TME) have been previously reported. Here, the authors profile PGE2 functions in human cancer, suggesting...
www.nature.com
November 16, 2024 at 10:43 PM
Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells
#immunometabolism #TME #immunosuppression
www.nature.com/articles/s41...
#immunometabolism #TME #immunosuppression
www.nature.com/articles/s41...