Chronic pain is a leading cause of disability, affecting more women than men. Different immune cells contribute to this sexual divergence, but the mec…

Panx1 channels mediate sex-specific immune mechanisms in neuropathic pain: leptin from CD8+ T cells drives pain in females, while VEGF from microglia mediates pain in males. Panx1-targeted therapies o...

These results suggest a key role for Panx1 in controlling ATP signaling through the P2Y_11L/AC5/AKAP5/PKA/Ca_V1.2 axis in arterial myocytes. This Panx1-led complex modulates cAMP levels, Ca_V1.2 activity, and vascular reactivity in response to diabetic hyperglycemia. Th …

Panx1 channels mediate sex-specific immune mechanisms in neuropathic pain: leptin from CD8+ T cells drives pain in females, while VEGF from microglia mediates pain in males. Panx1-targeted therapies o...

Panx1 channels mediate sex-specific immune mechanisms in neuropathic pain: leptin from CD8+ T cells drives pain in females, while VEGF from microglia mediates pain in males. Panx1-targeted therapies o...

PANX1とP2Y12がつなぐアストロサイト・ミクログリア連携――神経低活動時のシナプス制御を解明 Prepr…

BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Previous studies have suggested a significant role of pannexin 1 (Panx1)/P2X7 receptor complex in cardioprotective mechanism of ischemic preconditioni…

Acute kidney injury (AKI) can lead to chronic kidney disease (CKD), a transition driven by cellular senescence, a state of irreversible cell-cycle arrest. However, the molecular mechanisms promoting this pathological process remain unclear. Here we show that the channel protein Pannexin1 (Panx1) promotes this detrimental senescence and subsequent kidney fibrosis. We found that Panx1 functions in a noncanonical role as a calcium (Ca2+) leak channel within the endoplasmic reticulum (ER), a key intracellular calcium store. This Panx1-mediated leak occurs at contact sites between the ER and mitochondria, leading to mitochondrial calcium overload, dysfunction, and the generation of pro-senescence signals. Genetically deleting Panx1 in male mouse models of AKI attenuates renal senescence and fibrosis. These findings, validated in human kidney tissue, identify ER-resident Panx1 as a critical driver of kidney disease progression and a potential therapeutic target. In a model of acute kidney in

Ischemic stroke is a leading cause of morbidity and mortality. We have previously shown that deletion of endothelial cell (EC) Panx1 reduces ischemic stroke infarct volume and reduces cerebral arteria...

Read the full paper: Panx1 deficiency exacerbates GAN diet-induced obesity by destabilizing β-catenin via GSK3β

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d20943211e108">Cardiovascular diseases (CVDs), a leading global cause of mortality, are characterized by complex pathogenesis involving multifactorial molecular and cellular processes. Pannexin-1 (Panx1), a transmembrane channel protein, facilitates intercellular signaling through regulated release of small molecules such as adenosine triphosphate (ATP), thereby modulating diverse physiological and pathological pathways. This review explores the structural and functional landscape of Panx1, including its physiological roles, post-translational modifications and activation mechanisms. Its contributions to the pathophysiology of myocardial ischemia-reperfusion injury, cardiac remodeling, electrophysiological abnormalities, and diabetic cardiomyopathy are emphasized. Current evidence highlights the dual pathophysiological roles of Panx1 channels in CVDs: whereas ATP-mediated activation initiates cytoprotective signaling cascades, channel hyperactivation exacerbates pathological progression. Future research should prioritize mechanistic elucidation of Panx1’s molecular biology, and the development of targeted inhibitors with enhanced specificity and therapeutic efficacy, to advance novel therapeutic strategies for cardiovascular disorders. </p>

Pannexins (PANX1, PANX2, PANX3) are a family of large-pore, ion and metabolite channels present throughout the blood and lymphatic vascular networks. PANX1 has near-ubiquitous expression in the cardio...

Panx1 channels mediate sex-specific immune mechanisms in neuropathic pain: leptin from CD8+ T cells drives pain in females, while VEGF from microglia mediates pain in males. Panx1-targeted therapies offer broad potential for managing neuropathic pain,…