"But how will Big Pharma do the R&D for new big discoveries?!"
Newsflash: they don't.
Heard about those hot GLP-1 treatments? Yeah, all Big Pharma did was race to patent a bunch of highly similar chemicals, the very last step of R&D.
Y'know who funded the real research to get there?
Taxpayers.
Newsflash: they don't.
Heard about those hot GLP-1 treatments? Yeah, all Big Pharma did was race to patent a bunch of highly similar chemicals, the very last step of R&D.
Y'know who funded the real research to get there?
Taxpayers.
December 2, 2024 at 11:55 AM
"But how will Big Pharma do the R&D for new big discoveries?!"
Newsflash: they don't.
Heard about those hot GLP-1 treatments? Yeah, all Big Pharma did was race to patent a bunch of highly similar chemicals, the very last step of R&D.
Y'know who funded the real research to get there?
Taxpayers.
Newsflash: they don't.
Heard about those hot GLP-1 treatments? Yeah, all Big Pharma did was race to patent a bunch of highly similar chemicals, the very last step of R&D.
Y'know who funded the real research to get there?
Taxpayers.
Happy to share the final version of this work is now out in @natchembio.nature.com. Lots of additional exciting data! Congrats to all the authors!
May 5, 2026 at 1:37 PM
Happy to share the final version of this work is now out in @natchembio.nature.com. Lots of additional exciting data! Congrats to all the authors!
interested in all things Parp and ADP-ribosylation? arguably the weirdest posttranslational modification EVER? here is a starter pack, compiled by @leunglab.bsky.social
go.bsky.app/CiRKAXJ
go.bsky.app/CiRKAXJ
November 17, 2024 at 12:13 PM
interested in all things Parp and ADP-ribosylation? arguably the weirdest posttranslational modification EVER? here is a starter pack, compiled by @leunglab.bsky.social
go.bsky.app/CiRKAXJ
go.bsky.app/CiRKAXJ
Zero-shot de novo peptide sequencing with open posttranslational modification discovery - @uwcheritoncs.bsky.social go.nature.com/4ujx08d
Zero-shot de novo peptide sequencing with open posttranslational modification discovery - Nature Biotechnology
RNovA is an open-search de novo peptide sequencing model.
go.nature.com
May 19, 2026 at 2:50 PM
Zero-shot de novo peptide sequencing with open posttranslational modification discovery - @uwcheritoncs.bsky.social go.nature.com/4ujx08d
How do PTMs affect the binding of small molecule drugs to their target proteins?
Great to see @dereklowe.bsky.social highlight the recent paper by the group of @chrisgparker.bsky.social in "In the Pipeline".
Blog post: www.science.org/content/blog...
Paper: www.nature.com/articles/s41...
(1/4)
Great to see @dereklowe.bsky.social highlight the recent paper by the group of @chrisgparker.bsky.social in "In the Pipeline".
Blog post: www.science.org/content/blog...
Paper: www.nature.com/articles/s41...
(1/4)
Posttranslational modifications remodel proteome-wide ligandability - Nature Chemical Biology
A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphor...
www.nature.com
May 16, 2026 at 2:25 PM
How do PTMs affect the binding of small molecule drugs to their target proteins?
Great to see @dereklowe.bsky.social highlight the recent paper by the group of @chrisgparker.bsky.social in "In the Pipeline".
Blog post: www.science.org/content/blog...
Paper: www.nature.com/articles/s41...
(1/4)
Great to see @dereklowe.bsky.social highlight the recent paper by the group of @chrisgparker.bsky.social in "In the Pipeline".
Blog post: www.science.org/content/blog...
Paper: www.nature.com/articles/s41...
(1/4)
Our story on the mechanism of co-transcriptional histone mark deposition is now officially out: www.science.org/doi/10.1126/...
Structural basis of H3K36 trimethylation by SETD2 during chromatin transcription
During transcription, RNA polymerase II traverses through chromatin, and posttranslational modifications including histone methylations mark regions of active transcription. Histone protein H3 lysine ...
www.science.org
January 30, 2025 at 10:16 PM
Our story on the mechanism of co-transcriptional histone mark deposition is now officially out: www.science.org/doi/10.1126/...
Biochemical diversity of tubulin:
Carsten Janke, Zdenek Lansky and collaborators screen 46 microtubule-associated proteins to reveal their distinct affinities to tubulin isotypes and posttranslational modifications
link.springer.com/article/10.1...
Carsten Janke, Zdenek Lansky and collaborators screen 46 microtubule-associated proteins to reveal their distinct affinities to tubulin isotypes and posttranslational modifications
link.springer.com/article/10.1...
Microtubule posttranslational modifications provide unique recognition patterns for associated proteins - The EMBO Journal
Microtubules are key components of the eukaryotic cytoskeleton involved in vital functions in virtually every cell. Among the emerging molecular mechanisms to adapt microtubules to their diverse funct...
link.springer.com
September 14, 2026 at 8:26 AM
Biochemical diversity of tubulin:
Carsten Janke, Zdenek Lansky and collaborators screen 46 microtubule-associated proteins to reveal their distinct affinities to tubulin isotypes and posttranslational modifications
link.springer.com/article/10.1...
Carsten Janke, Zdenek Lansky and collaborators screen 46 microtubule-associated proteins to reveal their distinct affinities to tubulin isotypes and posttranslational modifications
link.springer.com/article/10.1...
this paper is one of the clearest demonstrations yet that proteoforms reshape druggability across the proteome. phosphorylation and glycosylation don’t just regulate protein function,they remodel small molecule recognition itself. state-dependent and cell context-rich
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Posttranslational modifications remodel proteome-wide ligandability - Nature Chemical Biology
A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphor...
www.nature.com
May 10, 2026 at 10:47 PM
this paper is one of the clearest demonstrations yet that proteoforms reshape druggability across the proteome. phosphorylation and glycosylation don’t just regulate protein function,they remodel small molecule recognition itself. state-dependent and cell context-rich
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Late-Stage Posttranslational Assembly of Fosfazinomycins https://www.biorxiv.org/content/10.64898/2026.09.23.753898v1
September 24, 2026 at 5:45 PM
Late-Stage Posttranslational Assembly of Fosfazinomycins https://www.biorxiv.org/content/10.64898/2026.09.23.753898v1
The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #ChemSky #ChemBio
#ABPP #ChemSky #ChemBio
March 31, 2025 at 5:33 AM
The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #ChemSky #ChemBio
#ABPP #ChemSky #ChemBio
y'all interested in posttranslational modifications and in particular in PARP, follow the amazing @leunglab.bsky.social
December 13, 2023 at 9:57 PM
y'all interested in posttranslational modifications and in particular in PARP, follow the amazing @leunglab.bsky.social
Posttranslational regulation of TOR kinase activity controls resource allocation between plant growth and immunity in Arabidopsis #research #MolecularPlant cell.com/molecular-pl...
December 25, 2025 at 8:08 AM
Posttranslational regulation of TOR kinase activity controls resource allocation between plant growth and immunity in Arabidopsis #research #MolecularPlant cell.com/molecular-pl...
Late-Stage Posttranslational Assembly of Fosfazinomycins https://www.biorxiv.org/content/10.64898/2026.09.23.753898v1
September 24, 2026 at 5:45 PM
Late-Stage Posttranslational Assembly of Fosfazinomycins https://www.biorxiv.org/content/10.64898/2026.09.23.753898v1
Iris Finkemeier talks about posttranslational modifications in plant metabolism
February 20, 2025 at 1:52 PM
Iris Finkemeier talks about posttranslational modifications in plant metabolism
Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome | PNAS🧪https://www.pnas.org/doi/10.1073/pnas.2413837121
Cool work from @alextoker.bsky.social & team
Cool work from @alextoker.bsky.social & team
Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome | PNAS
Tyrosine phosphorylation of metabolic enzymes is an evolutionarily conserved posttranslational
modification that facilitates rapid and reversible m...
www.pnas.org
November 17, 2024 at 6:38 AM
Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome | PNAS🧪https://www.pnas.org/doi/10.1073/pnas.2413837121
Cool work from @alextoker.bsky.social & team
Cool work from @alextoker.bsky.social & team
Work led by graduate student @trinitycookis.bsky.social and coauthors Alexandria Lydecker, @paulsauer.bsky.social, and @kasinath-lab.bsky.social is out today where we looked at the inhibition of PRC2 by histone PTMs associated with regions of active transcription.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications - Nature Structural & Molecular Biology
Structures reveal that histone H3K36me3 and H3K4me3 modifications reduce Polycomb repressive complex 2 (PRC2) function through the inhibition of histone tail engagement and antagonistic binding to the...
www.nature.com
January 8, 2025 at 1:36 AM
Work led by graduate student @trinitycookis.bsky.social and coauthors Alexandria Lydecker, @paulsauer.bsky.social, and @kasinath-lab.bsky.social is out today where we looked at the inhibition of PRC2 by histone PTMs associated with regions of active transcription.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Regulation of plant glycolysis and the tricarboxylic acid cycle by posttranslational modifications onlinelibrary.wiley.com/doi/10.1111/... @theplantjournal.bsky.social
Regulation of plant glycolysis and the tricarboxylic acid cycle by posttranslational modifications
This review explores how posttranslational modifications (PTMs) influence enzymes in glycolysis and the tricarboxylic acid cycle, key pathways that support plant growth and productivity. By examining...
onlinelibrary.wiley.com
April 6, 2025 at 1:42 AM
Regulation of plant glycolysis and the tricarboxylic acid cycle by posttranslational modifications onlinelibrary.wiley.com/doi/10.1111/... @theplantjournal.bsky.social
Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications [Trinity Cookis, Alexandria Lydecker, Paul Sauer, Vignesh Kasinath & Eva Nogales] www.nature.com/articles/s41...
January 8, 2025 at 10:06 AM
Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications [Trinity Cookis, Alexandria Lydecker, Paul Sauer, Vignesh Kasinath & Eva Nogales] www.nature.com/articles/s41...
Mao, Z., Peng, C., Chen, Y. et al. Zero-shot de novo peptide sequencing with open posttranslational modification discovery. Nat Biotechnol (2026). doi.org/10.1038/s415...
Zero-shot de novo peptide sequencing with open posttranslational modification discovery - Nature Biotechnology
RNovA is an open-search de novo peptide sequencing model.
doi.org
May 19, 2026 at 8:55 PM
Mao, Z., Peng, C., Chen, Y. et al. Zero-shot de novo peptide sequencing with open posttranslational modification discovery. Nat Biotechnol (2026). doi.org/10.1038/s415...
❄️♥️Our February issue is online♥️❄️
On the cover - how posttranslational modifications and intermolecular interactions of protein kinases allosterically regulate necrosome activation from @pseudokinase.bsky.social and colleagues.
Find this and the rest of the issue 👉 www.cell.com/trends/bioch...
On the cover - how posttranslational modifications and intermolecular interactions of protein kinases allosterically regulate necrosome activation from @pseudokinase.bsky.social and colleagues.
Find this and the rest of the issue 👉 www.cell.com/trends/bioch...
February 6, 2025 at 7:51 PM
❄️♥️Our February issue is online♥️❄️
On the cover - how posttranslational modifications and intermolecular interactions of protein kinases allosterically regulate necrosome activation from @pseudokinase.bsky.social and colleagues.
Find this and the rest of the issue 👉 www.cell.com/trends/bioch...
On the cover - how posttranslational modifications and intermolecular interactions of protein kinases allosterically regulate necrosome activation from @pseudokinase.bsky.social and colleagues.
Find this and the rest of the issue 👉 www.cell.com/trends/bioch...
Thank you to all speakers, presenters and the lively discussion at our Strasburger workshop ‚Co- and posttranslational control in chloroplasts‘ @uni-muenster #PTMs #chlorocontrol
November 20, 2024 at 7:32 PM
Thank you to all speakers, presenters and the lively discussion at our Strasburger workshop ‚Co- and posttranslational control in chloroplasts‘ @uni-muenster #PTMs #chlorocontrol
Happy birthday Ed! Like so many others I have learned a lot from collaborating with Ed’s group:
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
January 2, 2025 at 6:31 AM
Happy birthday Ed! Like so many others I have learned a lot from collaborating with Ed’s group:
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
"Using broad-spectrum photoaffinity probes, we identified more than 400 functionally diverse proteins whose ability to engage small molecules is impacted by phosphorylation or N-linked glycosylation status. " #glycotime @chrisgparker.bsky.social
rdcu.be/fg3BY
rdcu.be/fg3BY
Posttranslational modifications remodel proteome-wide ligandability
Nature Chemical Biology - A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent...
rdcu.be
May 5, 2026 at 4:33 PM
"Using broad-spectrum photoaffinity probes, we identified more than 400 functionally diverse proteins whose ability to engage small molecules is impacted by phosphorylation or N-linked glycosylation status. " #glycotime @chrisgparker.bsky.social
rdcu.be/fg3BY
rdcu.be/fg3BY