好きなレトロゲーム🍚
youtube.com/watch?v=RnaS...
youtube.com/watch?v=RnaS...
May 29, 2026 at 10:45 AM
好きなレトロゲーム🍚
youtube.com/watch?v=RnaS...
youtube.com/watch?v=RnaS...
New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵
June 11, 2026 at 2:59 PM
New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵
World’s Only Airworthy Supermarine Seafire XVII Returns Home to RNAS Yeovilton.
➡️ vintageaviationnews.com/restorations...
➡️ vintageaviationnews.com/restorations...
September 19, 2026 at 4:58 PM
World’s Only Airworthy Supermarine Seafire XVII Returns Home to RNAS Yeovilton.
➡️ vintageaviationnews.com/restorations...
➡️ vintageaviationnews.com/restorations...
A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins
Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz
doi.org
August 1, 2026 at 7:19 PM
A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
DNA isn't a blueprint, it is RNAs college notebook complete with doodles in the margins.
February 13, 2026 at 2:47 PM
DNA isn't a blueprint, it is RNAs college notebook complete with doodles in the margins.
April 17, 2026 at 10:13 AM
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
March 3, 2025 at 3:55 PM
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
What a great start to the year 2025. Just published online is our PNAS paper - Diverse plant RNAs coat Arabidopsis leaves and are distinct from apoplastic RNAs www.pnas.org/doi/10.1073/...
@pbaldrich.bsky.social @meghahs28.bsky.social @inneslab.bsky.social
@pbaldrich.bsky.social @meghahs28.bsky.social @inneslab.bsky.social
Diverse plant RNAs coat Arabidopsis leaves and are distinct from apoplastic RNAs | PNAS
Transgenic expression of a double-stranded RNA in plants can induce silencing of homologous
mRNAs in fungal pathogens. Although such host-induced g...
www.pnas.org
January 3, 2025 at 8:17 PM
What a great start to the year 2025. Just published online is our PNAS paper - Diverse plant RNAs coat Arabidopsis leaves and are distinct from apoplastic RNAs www.pnas.org/doi/10.1073/...
@pbaldrich.bsky.social @meghahs28.bsky.social @inneslab.bsky.social
@pbaldrich.bsky.social @meghahs28.bsky.social @inneslab.bsky.social
Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)
June 18, 2026 at 8:08 AM
Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)
And another interesting paper from Bonasio lab @upenn.edu www.biorxiv.org/content/10.1... "Pseudouridine selects RNAs for extracellular transport" noting among other things "..that MYL6 is a pU-binding protein required for secretion of RNAs." notable MYL6 is found in the Kossiakoff work as a csRBP!
Pseudouridine selects RNAs for extracellular transport
RNAs move through the extracellular space to transmit information between cells, including mammalian neurons, yet how specific RNAs are channeled into these extracellular routes is unknown. Using geno...
www.biorxiv.org
November 2, 2025 at 7:44 PM
And another interesting paper from Bonasio lab @upenn.edu www.biorxiv.org/content/10.1... "Pseudouridine selects RNAs for extracellular transport" noting among other things "..that MYL6 is a pU-binding protein required for secretion of RNAs." notable MYL6 is found in the Kossiakoff work as a csRBP!
As with small molecules and RNAs, Ab-Ag complexes are only correctly predicted by modern structure prediction NNs when they closely match training set examples
July 22, 2025 at 3:31 PM
As with small molecules and RNAs, Ab-Ag complexes are only correctly predicted by modern structure prediction NNs when they closely match training set examples
A method for examining RNAs in blood samples offers a clinical tool to detect and monitor cancer and to assess immune responses to vaccination
https://go.nature.com/42B2sSS
https://go.nature.com/42B2sSS
Highly sensitive method captures rare RNAs in blood to search for disease
A method for examining RNAs in blood samples offers a clinical tool to detect and monitor cancer and to assess immune responses to vaccination.
go.nature.com
April 17, 2025 at 10:59 AM
A method for examining RNAs in blood samples offers a clinical tool to detect and monitor cancer and to assess immune responses to vaccination
https://go.nature.com/42B2sSS
https://go.nature.com/42B2sSS
New method for detecting cell surface RNAs highlights Y RNAs as having a role for modulating extracellular histone binding
Exciting overlap between #glycoRNA transcripts and those characterized here
www.biorxiv.org/content/10.1...
Exciting overlap between #glycoRNA transcripts and those characterized here
www.biorxiv.org/content/10.1...
www.biorxiv.org
April 13, 2025 at 5:32 PM
New method for detecting cell surface RNAs highlights Y RNAs as having a role for modulating extracellular histone binding
Exciting overlap between #glycoRNA transcripts and those characterized here
www.biorxiv.org/content/10.1...
Exciting overlap between #glycoRNA transcripts and those characterized here
www.biorxiv.org/content/10.1...
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 28, 2025 at 4:02 PM
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
FYI: NEW ONLINE! New online! The therapeutic potential of circular RNAs
The therapeutic potential of circular RNAs
Nature Reviews Genetics, Published online: 09 January 2025; doi:10.1038/s41576-024-00806-xCircular RNAs have gained attention for their stability, immunological advantages and regulatory functions, making them a promising modality in multiple therapies.…
www.nature.com
January 30, 2025 at 12:02 PM
FYI: NEW ONLINE! New online! The therapeutic potential of circular RNAs
🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social
A few highlights below... 🧵👇
A few highlights below... 🧵👇
Noncoding transcription controls the developmental dynamics of long-range gene regulation
The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...
www.science.org
September 10, 2026 at 10:05 PM
🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social
A few highlights below... 🧵👇
A few highlights below... 🧵👇
I am excited to offer a postdoctoral research position in my lab in Oxford studying the distribution of small RNAs during plant sexual reproduction. shorturl.at/7Goxt
Reposts appreciated!
Obligatory cat video to brighten your day. :-)
Reposts appreciated!
Obligatory cat video to brighten your day. :-)
January 26, 2026 at 4:31 PM
I am excited to offer a postdoctoral research position in my lab in Oxford studying the distribution of small RNAs during plant sexual reproduction. shorturl.at/7Goxt
Reposts appreciated!
Obligatory cat video to brighten your day. :-)
Reposts appreciated!
Obligatory cat video to brighten your day. :-)
👀
Multiple human enhancer RNAs contain long translated open reading frames
genesdev.cshlp.org/content/earl...
Multiple human enhancer RNAs contain long translated open reading frames
genesdev.cshlp.org/content/earl...
Multiple human enhancer RNAs contain long translated open reading frames
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
September 11, 2025 at 9:17 AM
👀
Multiple human enhancer RNAs contain long translated open reading frames
genesdev.cshlp.org/content/earl...
Multiple human enhancer RNAs contain long translated open reading frames
genesdev.cshlp.org/content/earl...
A genome language model reveals the interactions hidden in non-coding DNA, pointing to new putative RNAs and repetitive elements in bacterial genomes.
@garykbrixi.bsky.social @maxewilkinson.bsky.social @mfgrp.bsky.social @brianhie.bsky.social
www.biorxiv.org/content/10.6...
@garykbrixi.bsky.social @maxewilkinson.bsky.social @mfgrp.bsky.social @brianhie.bsky.social
www.biorxiv.org/content/10.6...
September 23, 2026 at 8:21 PM
A genome language model reveals the interactions hidden in non-coding DNA, pointing to new putative RNAs and repetitive elements in bacterial genomes.
@garykbrixi.bsky.social @maxewilkinson.bsky.social @mfgrp.bsky.social @brianhie.bsky.social
www.biorxiv.org/content/10.6...
@garykbrixi.bsky.social @maxewilkinson.bsky.social @mfgrp.bsky.social @brianhie.bsky.social
www.biorxiv.org/content/10.6...
RNAs outside of cells?! How did they get there?
(Thread coming soon 👀)
www.biorxiv.org/content/10.1...
(Thread coming soon 👀)
www.biorxiv.org/content/10.1...
Pseudouridine selects RNAs for extracellular transport
RNAs move through the extracellular space to transmit information between cells, including mammalian neurons, yet how specific RNAs are channeled into these extracellular routes is unknown. Using geno...
www.biorxiv.org
October 30, 2025 at 8:07 PM
RNAs outside of cells?! How did they get there?
(Thread coming soon 👀)
www.biorxiv.org/content/10.1...
(Thread coming soon 👀)
www.biorxiv.org/content/10.1...