rFlorida = ribosomal Florida?
August 8, 2025 at 1:01 AM
rFlorida = ribosomal Florida?
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
A new protein-dependent riboswitch activates ribosomal frameshifting
Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...
www.biorxiv.org
July 19, 2025 at 3:10 PM
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
High accuracy meets high throughput for near full-length 16S ribosomal RNA amplicon sequencing on the #Nanopore platform #microbiome
High accuracy meets high throughput for near full-length 16S ribosomal RNA amplicon sequencing on the Nanopore platform
Abstract. Small subunit (SSU) ribosomal RNA (rRNA) gene amplicon sequencing is a foundational method in microbial ecology. Currently, short-read platforms
academic.oup.com
November 15, 2024 at 5:00 PM
High accuracy meets high throughput for near full-length 16S ribosomal RNA amplicon sequencing on the #Nanopore platform #microbiome
Very happy something like this is now available. In protist diversity research we use the rDNA extensively, but I for one doesn't know enough about it's structure, variation, and implications www.annualreviews.org/content/jour...
Organization of Ribosomal RNA Genes in Eukaryotes
In eukaryotes, ribosomal RNA genes (rDNA) encode the major ribosomal RNA molecules and are typically organized into a distinctive genomic structure involving tandem repetition of a polycistronic codin...
www.annualreviews.org
July 26, 2026 at 9:17 AM
Very happy something like this is now available. In protist diversity research we use the rDNA extensively, but I for one doesn't know enough about it's structure, variation, and implications www.annualreviews.org/content/jour...
A jumbo cyanophage encodes the most complete ribosomal protein set in the known virosphere www.biorxiv.org/content/10.1...
March 4, 2026 at 3:43 AM
A jumbo cyanophage encodes the most complete ribosomal protein set in the known virosphere www.biorxiv.org/content/10.1...
Out now in @science.org
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes
Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...
www.science.org
February 20, 2026 at 11:06 AM
Out now in @science.org
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268
March 3, 2026 at 8:58 AM
With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268
📣 New preprint 📣
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis
Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...
www.biorxiv.org
August 2, 2025 at 5:50 PM
📣 New preprint 📣
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
My first #FluorescenceFriday pic, some neuronal ribosomal protein
December 6, 2024 at 9:34 PM
My first #FluorescenceFriday pic, some neuronal ribosomal protein
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...
rdcu.be
November 3, 2025 at 11:15 AM
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Ribosomal RNA tentacles are targets of free radical damage in mammalian cells during oxidative and inflammatory stress #ribosome #rnasky www.biorxiv.org/content/10.1...
Ribosomal RNA tentacles are targets of free radical damage in mammalian cells during oxidative and inflammatory stress
Chemical damage to ribosomal RNA (rRNA) during oxidative or inflammatory stress can impact protein synthesis. Human cells were exposed to a H2O2 titration series to induce oxidative stress or to tumor...
www.biorxiv.org
September 14, 2025 at 2:31 PM
Ribosomal RNA tentacles are targets of free radical damage in mammalian cells during oxidative and inflammatory stress #ribosome #rnasky www.biorxiv.org/content/10.1...
Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
February 19, 2026 at 7:09 PM
Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
Long in the making, but happy to present the Chlamydomonas chlororibosome!
Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv 📖: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧵
Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv 📖: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧵
February 10, 2026 at 8:35 AM
Long in the making, but happy to present the Chlamydomonas chlororibosome!
Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv 📖: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧵
Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv 📖: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧵
Thrilled to share that our paper describing protein-dependent frameshifting is now out in Molecular Cell @cellpress.bsky.social. Huge congratulations to @jemmabetts.bsky.social for publishing the first research paper from her PhD 🧬🧪🥳
www.sciencedirect.com/science/arti...
1/8
www.sciencedirect.com/science/arti...
1/8
A protein-dependent riboswitch activates ribosomal frameshifting in cardioviruses
Programmed −1 ribosomal frameshifting (PRF) is a translational control mechanism used by RNA viruses to regulate the relative abundance of proteins en…
www.sciencedirect.com
August 24, 2026 at 11:52 AM
Thrilled to share that our paper describing protein-dependent frameshifting is now out in Molecular Cell @cellpress.bsky.social. Huge congratulations to @jemmabetts.bsky.social for publishing the first research paper from her PhD 🧬🧪🥳
www.sciencedirect.com/science/arti...
1/8
www.sciencedirect.com/science/arti...
1/8
that typically target bacterial enzymes or known ribosomal sites, lariocidin binds to a completely NEW site on the ribosome. The ribosome is vital because it translates genetic instructions into proteins needed for bacterial growth. By interrupting this critical process, lariocidin effectively HALTS
March 31, 2025 at 4:06 PM
that typically target bacterial enzymes or known ribosomal sites, lariocidin binds to a completely NEW site on the ribosome. The ribosome is vital because it translates genetic instructions into proteins needed for bacterial growth. By interrupting this critical process, lariocidin effectively HALTS
New paper from the group!
We were curious if the longevity of naked mole-rats has anything to do with their protein synthesis machinery. It was shown that the ribosomal 28S is split into 3 subunits
Our cryo-EM study of the NMR ribosomes by @mehmetguel.bsky.social etal www.nature.com/articles/s41...
We were curious if the longevity of naked mole-rats has anything to do with their protein synthesis machinery. It was shown that the ribosomal 28S is split into 3 subunits
Our cryo-EM study of the NMR ribosomes by @mehmetguel.bsky.social etal www.nature.com/articles/s41...
Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA - Nature Communications
The long-living rodent naked mole-rat has a distinct break in its 28S ribosomal RNA. Here, the authors present cryo-EM structures showing this cleavage is stabilized by surrounding ribosomal proteins,...
www.nature.com
July 5, 2026 at 2:32 PM
New paper from the group!
We were curious if the longevity of naked mole-rats has anything to do with their protein synthesis machinery. It was shown that the ribosomal 28S is split into 3 subunits
Our cryo-EM study of the NMR ribosomes by @mehmetguel.bsky.social etal www.nature.com/articles/s41...
We were curious if the longevity of naked mole-rats has anything to do with their protein synthesis machinery. It was shown that the ribosomal 28S is split into 3 subunits
Our cryo-EM study of the NMR ribosomes by @mehmetguel.bsky.social etal www.nature.com/articles/s41...
Ribosomal frameshifting 😱
Schnappatmung bei den Querdullis in 3... 2... 1...
Schnappatmung bei den Querdullis in 3... 2... 1...
December 6, 2023 at 8:48 PM
Ribosomal frameshifting 😱
Schnappatmung bei den Querdullis in 3... 2... 1...
Schnappatmung bei den Querdullis in 3... 2... 1...
WOW!!! Beautiful new Nature paper from Burkart Lab UCSD reveals how non-ribosomal peptide natural product synthetases work together.
They use tetrazine click chemistry to capture these huge protein complexes mid-reaction. 3 different snapshots show different states.
www.nature.com/articles/s41...
They use tetrazine click chemistry to capture these huge protein complexes mid-reaction. 3 different snapshots show different states.
www.nature.com/articles/s41...
December 14, 2024 at 3:47 AM
WOW!!! Beautiful new Nature paper from Burkart Lab UCSD reveals how non-ribosomal peptide natural product synthetases work together.
They use tetrazine click chemistry to capture these huge protein complexes mid-reaction. 3 different snapshots show different states.
www.nature.com/articles/s41...
They use tetrazine click chemistry to capture these huge protein complexes mid-reaction. 3 different snapshots show different states.
www.nature.com/articles/s41...
A big mystery is how life got started without the enzymes essential to modern biology. One idea is that metals + phosphate provided the kick. Bacteria & archaea then developed independent paths to a living cell.
Who knows what other life forms didn't make it? 🧪
www.science.org/doi/10.1126/...
Who knows what other life forms didn't make it? 🧪
www.science.org/doi/10.1126/...
August 21, 2026 at 12:09 PM
A big mystery is how life got started without the enzymes essential to modern biology. One idea is that metals + phosphate provided the kick. Bacteria & archaea then developed independent paths to a living cell.
Who knows what other life forms didn't make it? 🧪
www.science.org/doi/10.1126/...
Who knows what other life forms didn't make it? 🧪
www.science.org/doi/10.1126/...
A jumbo cyanophage encodes the most comprehensive ribosomal protein set in the known virosphere academic.oup.com/ismej/articl...
A jumbo cyanophage encodes the most comprehensive ribosomal protein set in the known virosphere
Abstract. It has been proposed that a defining distinction between viruses and cells lies in the absence or presence of ribosomal genes, respectively. Rece
academic.oup.com
May 13, 2026 at 12:33 PM
A jumbo cyanophage encodes the most comprehensive ribosomal protein set in the known virosphere academic.oup.com/ismej/articl...
🔬 A new study by EMBL researchers, published in @science.org, about the pre-ribosome assembly pathways inside intact human cells, reveals — at molecular resolution — in-cell structural snapshots of both ribosomal subunit precursors, the SSU processome and the pre-60S, and novel configurations.
September 25, 2026 at 8:43 AM
🔬 A new study by EMBL researchers, published in @science.org, about the pre-ribosome assembly pathways inside intact human cells, reveals — at molecular resolution — in-cell structural snapshots of both ribosomal subunit precursors, the SSU processome and the pre-60S, and novel configurations.
And the 4th paper in this week contribution from our lab tells about ribosome biogenesis in yeast. A follow-up story from our wonderful collaborators in Graz - the Bergler Lab. Structural work was again done by the amazing @lgrundmann.bsky.social: academic.oup.com/nar/article/...
A comprehensive view on r-protein binding and rRNA domain structuring during early eukaryotic ribosome formation
Abstract. Formation of the eukaryotic ribosomal subunits follows a strict regime to assemble ribosomal proteins (r-protein) with ribosomal RNAs (rRNA) whil
academic.oup.com
January 22, 2026 at 5:27 PM
And the 4th paper in this week contribution from our lab tells about ribosome biogenesis in yeast. A follow-up story from our wonderful collaborators in Graz - the Bergler Lab. Structural work was again done by the amazing @lgrundmann.bsky.social: academic.oup.com/nar/article/...
Thrilled to share the lab's latest preprint on the phenotypic impact of SNVs and INDELs in human rDNA using UK Biobank data!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Germline sequence variation within the ribosomal DNA is associated with human complex traits
The ribosome is one of the core macromolecules in the cell. The ribosomal RNAs (rRNA), which are essential components of the ribosome, are coded by the multi-copy ribosomal DNA (rDNA). Despite its hig...
www.biorxiv.org
February 8, 2025 at 1:15 PM
Thrilled to share the lab's latest preprint on the phenotypic impact of SNVs and INDELs in human rDNA using UK Biobank data!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Using #SingleMolecule imaging we find that TFs:
-boost co-transcriptional #ribosomal #RNA processing!
-their binding #dynamics fundamentally differ for mRNA (transient) versus rRNA #transcription (stable)!
@biorxivpreprint.bsky.social Anastasiia Chaban @embl.org
www.biorxiv.org/content/10.6...
-boost co-transcriptional #ribosomal #RNA processing!
-their binding #dynamics fundamentally differ for mRNA (transient) versus rRNA #transcription (stable)!
@biorxivpreprint.bsky.social Anastasiia Chaban @embl.org
www.biorxiv.org/content/10.6...
March 29, 2026 at 2:38 PM
Using #SingleMolecule imaging we find that TFs:
-boost co-transcriptional #ribosomal #RNA processing!
-their binding #dynamics fundamentally differ for mRNA (transient) versus rRNA #transcription (stable)!
@biorxivpreprint.bsky.social Anastasiia Chaban @embl.org
www.biorxiv.org/content/10.6...
-boost co-transcriptional #ribosomal #RNA processing!
-their binding #dynamics fundamentally differ for mRNA (transient) versus rRNA #transcription (stable)!
@biorxivpreprint.bsky.social Anastasiia Chaban @embl.org
www.biorxiv.org/content/10.6...
One of those #cryoEM papers were using "near-atomic resolution" in the title would be entirely ok. 😉
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Visualizing the modification landscape of the human 60S ribosomal subunit at close to atomic resolution
Abstract. Chemical modifications of ribosomal RNAs (rRNAs) and proteins expand their topological repertoire, and together with the plethora of bound ligand
academic.oup.com
December 11, 2024 at 3:54 PM
One of those #cryoEM papers were using "near-atomic resolution" in the title would be entirely ok. 😉
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...