Septins at the origin?
New Opinion piece with
@onishilab.bsky.social
@wallaceucsf.bsky.social
@gautamdey.bsky.social
New Opinion piece with
@onishilab.bsky.social
@wallaceucsf.bsky.social
@gautamdey.bsky.social
'Cell-autonomous immunity and the endosymbiotic theory: Septins at the origin?' doi.org/10.32942/X2X...
August 29, 2026 at 10:44 AM
Septins at the origin?
New Opinion piece with
@onishilab.bsky.social
@wallaceucsf.bsky.social
@gautamdey.bsky.social
New Opinion piece with
@onishilab.bsky.social
@wallaceucsf.bsky.social
@gautamdey.bsky.social
New preprint out! 🚀
biorxiv.org/content/10.6...
We mapped how septins organise infection in the rice blast fungus—and found they are far more dynamic than previously thought.
Thread 👇
#FungalPathogenesis #CellBiology #septins
biorxiv.org/content/10.6...
We mapped how septins organise infection in the rice blast fungus—and found they are far more dynamic than previously thought.
Thread 👇
#FungalPathogenesis #CellBiology #septins
April 7, 2026 at 11:40 AM
New preprint out! 🚀
biorxiv.org/content/10.6...
We mapped how septins organise infection in the rice blast fungus—and found they are far more dynamic than previously thought.
Thread 👇
#FungalPathogenesis #CellBiology #septins
biorxiv.org/content/10.6...
We mapped how septins organise infection in the rice blast fungus—and found they are far more dynamic than previously thought.
Thread 👇
#FungalPathogenesis #CellBiology #septins
Our newest review on septins as makers & breakers of membrane contacts in J Neurochem
Fun writing with new PhD grad (and FASEB Septin Conference A/V Assistant Extrordinaire) TJ Holt
Thanks @mcmurraylab.bsky.social @sergemostowylab.bsky.social for input.
onlinelibrary.wiley.com/doi/10.1111/...
Fun writing with new PhD grad (and FASEB Septin Conference A/V Assistant Extrordinaire) TJ Holt
Thanks @mcmurraylab.bsky.social @sergemostowylab.bsky.social for input.
onlinelibrary.wiley.com/doi/10.1111/...
Septins in the Middle—Makers and Breakers of Membrane Contact Sites
Septins are a family of GTP-binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. G...
onlinelibrary.wiley.com
June 12, 2026 at 1:49 PM
Our newest review on septins as makers & breakers of membrane contacts in J Neurochem
Fun writing with new PhD grad (and FASEB Septin Conference A/V Assistant Extrordinaire) TJ Holt
Thanks @mcmurraylab.bsky.social @sergemostowylab.bsky.social for input.
onlinelibrary.wiley.com/doi/10.1111/...
Fun writing with new PhD grad (and FASEB Septin Conference A/V Assistant Extrordinaire) TJ Holt
Thanks @mcmurraylab.bsky.social @sergemostowylab.bsky.social for input.
onlinelibrary.wiley.com/doi/10.1111/...
📣 New preprint from our lab!
How does the cell place septins to actin or microtubules (MTs) with septins being ~10-100 times less than actin/tubulin?
We found a phosphorylation switch controlled by GSK3 that makes that call 🧫🔬🧵
biorxiv.org/content/10.64898/2026.05.06.723191v1
1/7
How does the cell place septins to actin or microtubules (MTs) with septins being ~10-100 times less than actin/tubulin?
We found a phosphorylation switch controlled by GSK3 that makes that call 🧫🔬🧵
biorxiv.org/content/10.64898/2026.05.06.723191v1
1/7
biorxiv.org
May 10, 2026 at 12:22 PM
📣 New preprint from our lab!
How does the cell place septins to actin or microtubules (MTs) with septins being ~10-100 times less than actin/tubulin?
We found a phosphorylation switch controlled by GSK3 that makes that call 🧫🔬🧵
biorxiv.org/content/10.64898/2026.05.06.723191v1
1/7
How does the cell place septins to actin or microtubules (MTs) with septins being ~10-100 times less than actin/tubulin?
We found a phosphorylation switch controlled by GSK3 that makes that call 🧫🔬🧵
biorxiv.org/content/10.64898/2026.05.06.723191v1
1/7
'Cell-autonomous immunity and the endosymbiotic theory: Septins at the origin?' doi.org/10.32942/X2X...
August 28, 2026 at 7:01 PM
'Cell-autonomous immunity and the endosymbiotic theory: Septins at the origin?' doi.org/10.32942/X2X...
Septins act as scaffolds for actin polymerization through the Cdc42 effector protein 3
pubmed.ncbi.nlm.nih.gov/39971161/
pubmed.ncbi.nlm.nih.gov/39971161/
Cdc42EP3-bound septin scaffolds promote actin polymerization - PubMed
Septins are cytoskeletal filament-forming proteins that typically associate with membranes and perform critical functions in a variety of cellular processes. Septins often colocalize with actin and mi...
pubmed.ncbi.nlm.nih.gov
February 25, 2025 at 11:09 AM
Septins act as scaffolds for actin polymerization through the Cdc42 effector protein 3
pubmed.ncbi.nlm.nih.gov/39971161/
pubmed.ncbi.nlm.nih.gov/39971161/
We are excited to share our next installment of insights into how septins sense micron-scale curvature via detecting lipid packing! www.biorxiv.org/content/10.1...
Lipid packing and local geometry influence septin curvature sensing
Septins assemble into scaffolds that direct cell growth and morphology that are often localized to the plasma membrane. While septins preferentially bind convex membranes via amphipathic helices, thei...
www.biorxiv.org
February 18, 2025 at 10:23 PM
We are excited to share our next installment of insights into how septins sense micron-scale curvature via detecting lipid packing! www.biorxiv.org/content/10.1...
A new study from our group, led by Iris Eisermann, of the septin interactome during appressorium development, revealing many new interactors and significantly widening the biological function of septins in fungal pathogenesis. 👇
@thesainsburylab.bsky.social
@thesainsburylab.bsky.social
A stage-resolved map of dynamic septin interactions required for infection by the rice blast fungus https://www.biorxiv.org/content/10.64898/2026.04.02.716073v1
April 7, 2026 at 10:52 AM
A new study from our group, led by Iris Eisermann, of the septin interactome during appressorium development, revealing many new interactors and significantly widening the biological function of septins in fungal pathogenesis. 👇
@thesainsburylab.bsky.social
@thesainsburylab.bsky.social
"Cell-autonomous immunity and the endosymbiotic theory: Septins at the origin?”
doi.org/10.32942/X2X...
We explore how ancestral septins may have recognized foreign cells - linking endosymbiosis, organelle fission, and innate immunity.
doi.org/10.32942/X2X...
We explore how ancestral septins may have recognized foreign cells - linking endosymbiosis, organelle fission, and innate immunity.
Cell-autonomous immunity and the endosymbiotic theory: Septins at the origin?
doi.org
August 28, 2026 at 1:54 PM
"Cell-autonomous immunity and the endosymbiotic theory: Septins at the origin?”
doi.org/10.32942/X2X...
We explore how ancestral septins may have recognized foreign cells - linking endosymbiosis, organelle fission, and innate immunity.
doi.org/10.32942/X2X...
We explore how ancestral septins may have recognized foreign cells - linking endosymbiosis, organelle fission, and innate immunity.
#SeptSRC @talbotlabtsl.bsky.social takes the podium on septins as the mastermind of the fungus that wreaks havoc on rice plants. Know your septins, if you care about 🍚 rice for your dinner.
June 16, 2025 at 12:05 AM
#SeptSRC @talbotlabtsl.bsky.social takes the podium on septins as the mastermind of the fungus that wreaks havoc on rice plants. Know your septins, if you care about 🍚 rice for your dinner.
Helge @ewerslab.bsky.social knows not only how to organize conferences (#BiomembraneDays25) but also how septins organize. Exceptional imaging #ExpansionMicroscopy of cytokinesis
October 1, 2025 at 1:06 PM
Helge @ewerslab.bsky.social knows not only how to organize conferences (#BiomembraneDays25) but also how septins organize. Exceptional imaging #ExpansionMicroscopy of cytokinesis
Jian-Qiu Wu takes the stage to talk about septins old friend and my gateway molecule to septins - the exocyst. #SeptSRC
New insights into septin-exocyst interactions from fission yeast.
New insights into septin-exocyst interactions from fission yeast.
June 17, 2025 at 4:33 PM
Jian-Qiu Wu takes the stage to talk about septins old friend and my gateway molecule to septins - the exocyst. #SeptSRC
New insights into septin-exocyst interactions from fission yeast.
New insights into septin-exocyst interactions from fission yeast.
#SeptSRC pathogenesis session continues with Serge “cageman” Mostowy @sergemostowylab.bsky.social presenting compelling new data on septins as a unique cytoskektal system that curtails Shigella infection.
June 15, 2025 at 11:31 PM
#SeptSRC pathogenesis session continues with Serge “cageman” Mostowy @sergemostowylab.bsky.social presenting compelling new data on septins as a unique cytoskektal system that curtails Shigella infection.
Septins and the exocyst complex work together to guide membrane trafficking during cell division in fission yeast, revealing one of the most conserved functions of septins in exocytosis.
buff.ly/rkEfQZY
buff.ly/rkEfQZY
November 13, 2025 at 11:28 PM
Septins and the exocyst complex work together to guide membrane trafficking during cell division in fission yeast, revealing one of the most conserved functions of septins in exocytosis.
buff.ly/rkEfQZY
buff.ly/rkEfQZY
Two new 🔥pre-prints 🔥 TODAY by us & @pwoakes.bsky.social @myosincity.bsky.social
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
a woman in a suit and tie has the words wait what written on her face
ALT: a woman in a suit and tie has the words wait what written on her face
media.tenor.com
January 21, 2026 at 9:18 PM
Two new 🔥pre-prints 🔥 TODAY by us & @pwoakes.bsky.social @myosincity.bsky.social
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
September is for Septins!
#SeptforSeptins
Time for septin spice lattes... and submitting your septin paper to the MBoC Special Issue: Cell Biology of Septins
Still accepting papers @ascbiology.bsky.social
www.molbiolcell.org/cell-biology...
#SeptforSeptins
Time for septin spice lattes... and submitting your septin paper to the MBoC Special Issue: Cell Biology of Septins
Still accepting papers @ascbiology.bsky.social
www.molbiolcell.org/cell-biology...
Molecular Biology of the Cell (MBoC)
www.molbiolcell.org
September 15, 2026 at 11:15 AM
September is for Septins!
#SeptforSeptins
Time for septin spice lattes... and submitting your septin paper to the MBoC Special Issue: Cell Biology of Septins
Still accepting papers @ascbiology.bsky.social
www.molbiolcell.org/cell-biology...
#SeptforSeptins
Time for septin spice lattes... and submitting your septin paper to the MBoC Special Issue: Cell Biology of Septins
Still accepting papers @ascbiology.bsky.social
www.molbiolcell.org/cell-biology...
Fantastic talk of @ewerslab.bsky.social with ExM data on Septins and Unroof Cells in #GEF25!
September 28, 2025 at 7:35 AM
Fantastic talk of @ewerslab.bsky.social with ExM data on Septins and Unroof Cells in #GEF25!
It'll be a slightly smaller crew than previous years but we'll still be at #cellbio24 #ASCB! If you like LIM proteins or septins come check out our posters:
December 12, 2024 at 4:51 PM
It'll be a slightly smaller crew than previous years but we'll still be at #cellbio24 #ASCB! If you like LIM proteins or septins come check out our posters:
@maggieutgaard.bsky.social from @pwoakes.bsky.social and @myosincity.bsky.social labs with a killer talk on the coupling of the nucleus to septins in response to mechanical stress.
#SeptSRC
#SeptSRC
June 18, 2025 at 2:05 PM
@maggieutgaard.bsky.social from @pwoakes.bsky.social and @myosincity.bsky.social labs with a killer talk on the coupling of the nucleus to septins in response to mechanical stress.
#SeptSRC
#SeptSRC
SEPTIN9 locally activates the RhoGEF ARHGEF18 to promote early stages of mitochondrial fission, say Rachel Shannon, William Trimble and colleagues @sickkidsto.bsky.social @utoronto.ca: rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry #Mitochondria #septins
#Cytoskeleton #Biochemistry #Mitochondria #septins
September 15, 2025 at 6:15 PM
SEPTIN9 locally activates the RhoGEF ARHGEF18 to promote early stages of mitochondrial fission, say Rachel Shannon, William Trimble and colleagues @sickkidsto.bsky.social @utoronto.ca: rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry #Mitochondria #septins
#Cytoskeleton #Biochemistry #Mitochondria #septins
🚨 Our new @elife.bsky.social study dissects how a dividing cell keeps its septin scaffold and its contractile ring in step.
👉 elifesciences.org/articles/106...
Spearheaded by @bindubhojappa.bsky.social
#cellbiology #celldivision #septins #yeast #kinases
👉 elifesciences.org/articles/106...
Spearheaded by @bindubhojappa.bsky.social
#cellbiology #celldivision #septins #yeast #kinases
September 10, 2026 at 10:52 AM
🚨 Our new @elife.bsky.social study dissects how a dividing cell keeps its septin scaffold and its contractile ring in step.
👉 elifesciences.org/articles/106...
Spearheaded by @bindubhojappa.bsky.social
#cellbiology #celldivision #septins #yeast #kinases
👉 elifesciences.org/articles/106...
Spearheaded by @bindubhojappa.bsky.social
#cellbiology #celldivision #septins #yeast #kinases
Looking a little closer with the help of the @aicjanelia.bsky.social we used iPALM to see where septins were in relation to the actin. While they colocalize in the X-Y plane, septins are actually consistently below the actin stress fibers, closer to the membrane.
January 23, 2026 at 5:45 PM
Looking a little closer with the help of the @aicjanelia.bsky.social we used iPALM to see where septins were in relation to the actin. While they colocalize in the X-Y plane, septins are actually consistently below the actin stress fibers, closer to the membrane.
Excited to finally share this pre-print on the eve of my viva: ‘C. elegans septins regulate a subset of sensory neuronal cilia via cell-non autonomous mechanisms in supporting glia’ www.biorxiv.org/content/10.1...
C. elegans septins regulate a subset of sensory neuronal cilia via cell-non autonomous mechanisms in supporting glia
The sensory and signaling roles of primary cilia rely on compartmentalization mechanisms that establish the organelle's protein and lipid composition. Septins, a family of cytoskeletal GTPases, are pr...
www.biorxiv.org
October 16, 2025 at 7:16 AM
Excited to finally share this pre-print on the eve of my viva: ‘C. elegans septins regulate a subset of sensory neuronal cilia via cell-non autonomous mechanisms in supporting glia’ www.biorxiv.org/content/10.1...
Septins underwent extensive diversification in the Opisthokonts, particularly fungi and animals where hetero-oligomer formation defines their mechanism, but this is distinct from Archaeplastida & Chromista. Amazing evolutionary story. Amazing evolutionary story. @mcmomany.bsky.social #SeptSRC
#SeptSRC Monday morning session on septin assembly kicks off with insights into septin evolution by @mcmomany.bsky.social
June 16, 2025 at 1:23 PM
Septins underwent extensive diversification in the Opisthokonts, particularly fungi and animals where hetero-oligomer formation defines their mechanism, but this is distinct from Archaeplastida & Chromista. Amazing evolutionary story. Amazing evolutionary story. @mcmomany.bsky.social #SeptSRC